JPS6327360B2 - - Google Patents
Info
- Publication number
- JPS6327360B2 JPS6327360B2 JP53151163A JP15116378A JPS6327360B2 JP S6327360 B2 JPS6327360 B2 JP S6327360B2 JP 53151163 A JP53151163 A JP 53151163A JP 15116378 A JP15116378 A JP 15116378A JP S6327360 B2 JPS6327360 B2 JP S6327360B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- acid
- polypeptides
- ala
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
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- 238000001704 evaporation Methods 0.000 description 1
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- ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
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- 239000001530 fumaric acid Substances 0.000 description 1
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- 229960002989 glutamic acid Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 125000004970 halomethyl group Chemical group 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
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- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
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- 238000000099 in vitro assay Methods 0.000 description 1
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- 239000004310 lactic acid Substances 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
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- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
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- 229920003053 polystyrene-divinylbenzene Polymers 0.000 description 1
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- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
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- 229940043230 sarcosine Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229940016590 sarkosyl Drugs 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical group [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/062—Serum thymic factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85849677A | 1977-12-08 | 1977-12-08 | |
| US94053178A | 1978-09-08 | 1978-09-08 | |
| US05/960,550 US4232008A (en) | 1978-11-17 | 1978-11-17 | Tetrapeptides and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5498719A JPS5498719A (en) | 1979-08-03 |
| JPS6327360B2 true JPS6327360B2 (zh) | 1988-06-02 |
Family
ID=27420392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15116378A Granted JPS5498719A (en) | 1977-12-08 | 1978-12-08 | Novel tetrapeptide and its method |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5498719A (zh) |
| CA (1) | CA1120031A (zh) |
| CH (1) | CH642058A5 (zh) |
| DE (1) | DE2853002A1 (zh) |
| DK (1) | DK149595C (zh) |
| ES (1) | ES475857A1 (zh) |
| FI (1) | FI67368C (zh) |
| FR (1) | FR2411174A1 (zh) |
| GB (1) | GB2014581B (zh) |
| GR (1) | GR65013B (zh) |
| IE (1) | IE47611B1 (zh) |
| IL (1) | IL56150A (zh) |
| IT (1) | IT1110889B (zh) |
| NL (1) | NL7812004A (zh) |
| NO (1) | NO149631C (zh) |
| NZ (1) | NZ189101A (zh) |
| PT (1) | PT68883A (zh) |
| SE (1) | SE444687B (zh) |
| YU (1) | YU41322B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215112A (en) * | 1979-03-14 | 1980-07-29 | Ortho Pharmaceutical Corporation | Tripeptides and methods |
| US4215111A (en) * | 1979-03-14 | 1980-07-29 | Ortho Pharmaceutical Corporation | Peptides having ubiquitin-like activity |
| CA1156220A (en) * | 1979-04-26 | 1983-11-01 | George Heavner | Method and composition for preparation of h-sar-lys-sar-gln-nh.sub.2 |
| US4426324A (en) * | 1979-09-28 | 1984-01-17 | Hoffmann-La Roche Inc. | Immunopotentiating peptides |
| JPS5711950A (en) | 1980-06-25 | 1982-01-21 | Kureha Chem Ind Co Ltd | Peptide and its synthesis |
| FR2546164B1 (fr) * | 1983-05-16 | 1987-07-17 | Centre Nat Rech Scient | Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase |
| FR2741076B1 (fr) | 1995-11-15 | 1998-01-30 | Rech De Pathologie Appliquee S | Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant |
| RU2210382C1 (ru) * | 2002-07-09 | 2003-08-20 | Терентьев Александр Александрович | Пептид, обладающий иммунорегуляторным свойством, и его композиция |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2544348C3 (de) * | 1975-10-03 | 1979-12-13 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L-Leucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel |
| IT1156766B (it) * | 1977-05-25 | 1987-02-04 | Anvar | Polipeptidi dotati di attivita' timica o antagonista e procedimento per la loro sintesi |
| FR2391994A1 (fr) * | 1977-05-25 | 1978-12-22 | Anvar | Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese |
| FR2423481A2 (fr) * | 1978-04-21 | 1979-11-16 | Anvar | Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese |
-
1978
- 1978-12-06 NZ NZ189101A patent/NZ189101A/en unknown
- 1978-12-07 DK DK554078A patent/DK149595C/da not_active IP Right Cessation
- 1978-12-07 FR FR7834508A patent/FR2411174A1/fr active Granted
- 1978-12-07 CA CA000317547A patent/CA1120031A/en not_active Expired
- 1978-12-07 ES ES475857A patent/ES475857A1/es not_active Expired
- 1978-12-07 GR GR57816A patent/GR65013B/el unknown
- 1978-12-07 IE IE2423/78A patent/IE47611B1/en unknown
- 1978-12-07 FI FI783769A patent/FI67368C/fi not_active IP Right Cessation
- 1978-12-07 DE DE19782853002 patent/DE2853002A1/de not_active Withdrawn
- 1978-12-07 GB GB7847642A patent/GB2014581B/en not_active Expired
- 1978-12-07 NO NO784128A patent/NO149631C/no unknown
- 1978-12-07 IT IT52239/78A patent/IT1110889B/it active
- 1978-12-07 PT PT68883A patent/PT68883A/pt unknown
- 1978-12-07 SE SE7812614A patent/SE444687B/sv not_active IP Right Cessation
- 1978-12-07 IL IL56150A patent/IL56150A/xx unknown
- 1978-12-08 YU YU2880/78A patent/YU41322B/xx unknown
- 1978-12-08 NL NL7812004A patent/NL7812004A/xx not_active Application Discontinuation
- 1978-12-08 JP JP15116378A patent/JPS5498719A/ja active Granted
- 1978-12-08 CH CH1256678A patent/CH642058A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO784128L (no) | 1979-06-11 |
| GB2014581B (en) | 1982-05-19 |
| FR2411174A1 (fr) | 1979-07-06 |
| NZ189101A (en) | 1984-07-06 |
| DK554078A (da) | 1979-06-09 |
| IT7852239A0 (it) | 1978-12-07 |
| IE47611B1 (en) | 1984-05-02 |
| YU288078A (en) | 1983-02-28 |
| NO149631C (no) | 1984-05-23 |
| FR2411174B1 (zh) | 1984-05-25 |
| PT68883A (en) | 1979-01-01 |
| FI783769A (fi) | 1979-06-09 |
| IT1110889B (it) | 1986-01-06 |
| ES475857A1 (es) | 1980-01-16 |
| SE7812614L (sv) | 1979-06-09 |
| FI67368B (fi) | 1984-11-30 |
| DE2853002A1 (de) | 1979-06-13 |
| FI67368C (fi) | 1985-03-11 |
| NO149631B (no) | 1984-02-13 |
| GB2014581A (en) | 1979-08-30 |
| DK149595B (da) | 1986-08-04 |
| JPS5498719A (en) | 1979-08-03 |
| CA1120031A (en) | 1982-03-16 |
| NL7812004A (nl) | 1979-06-12 |
| IL56150A0 (en) | 1979-03-12 |
| IE782423L (en) | 1979-06-08 |
| DK149595C (da) | 1987-03-23 |
| GR65013B (en) | 1980-06-12 |
| SE444687B (sv) | 1986-04-28 |
| YU41322B (en) | 1987-02-28 |
| CH642058A5 (de) | 1984-03-30 |
| IL56150A (en) | 1982-02-28 |
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