JPS6310998B2 - - Google Patents

Info

Publication number
JPS6310998B2
JPS6310998B2 JP52137356A JP13735677A JPS6310998B2 JP S6310998 B2 JPS6310998 B2 JP S6310998B2 JP 52137356 A JP52137356 A JP 52137356A JP 13735677 A JP13735677 A JP 13735677A JP S6310998 B2 JPS6310998 B2 JP S6310998B2
Authority
JP
Japan
Prior art keywords
fractions
antibiotic
medium
combined
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52137356A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5363397A (en
Inventor
Jee Kashidei Patoritsuku
Bii Tsuinmaaman Sherudon
Bii Chunatsuku Josefuiino
Erunanden Sebasuchian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5363397A publication Critical patent/JPS5363397A/ja
Publication of JPS6310998B2 publication Critical patent/JPS6310998B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP13735677A 1976-11-17 1977-11-17 Antibiotics 890a Granted JPS5363397A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74295876A 1976-11-17 1976-11-17

Publications (2)

Publication Number Publication Date
JPS5363397A JPS5363397A (en) 1978-06-06
JPS6310998B2 true JPS6310998B2 (enrdf_load_stackoverflow) 1988-03-10

Family

ID=24986929

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13735677A Granted JPS5363397A (en) 1976-11-17 1977-11-17 Antibiotics 890a

Country Status (10)

Country Link
JP (1) JPS5363397A (enrdf_load_stackoverflow)
CH (1) CH634104A5 (enrdf_load_stackoverflow)
DE (1) DE2751303A1 (enrdf_load_stackoverflow)
DK (1) DK487977A (enrdf_load_stackoverflow)
ES (1) ES463973A1 (enrdf_load_stackoverflow)
FR (1) FR2371448A1 (enrdf_load_stackoverflow)
GB (1) GB1595233A (enrdf_load_stackoverflow)
NL (1) NL7712092A (enrdf_load_stackoverflow)
PT (1) PT67268B (enrdf_load_stackoverflow)
SE (1) SE433621B (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1483142A (en) * 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.

Also Published As

Publication number Publication date
DE2751303A1 (de) 1978-05-18
PT67268A (en) 1977-12-01
NL7712092A (nl) 1978-05-19
SE433621B (sv) 1984-06-04
SE7712430L (sv) 1978-05-18
PT67268B (en) 1979-10-08
DK487977A (da) 1978-05-18
ES463973A1 (es) 1978-11-16
JPS5363397A (en) 1978-06-06
GB1595233A (en) 1981-08-12
FR2371448A1 (fr) 1978-06-16
CH634104A5 (en) 1983-01-14
FR2371448B1 (enrdf_load_stackoverflow) 1980-03-14

Similar Documents

Publication Publication Date Title
EP0182315B1 (en) Novel antibiotic nk84-0218 pharmaceutical compositions containing it and process for the production of the same
US6218380B1 (en) Pharmaceutical compositions
US4141986A (en) Antibiotics 890A2 and 890A5
US4162323A (en) Antibiotic N-acetyl-dehydro-thienamycin
US4006060A (en) Thienamycin production
US4162324A (en) Antibiotics 890A1 and 890A3
JP2860370B2 (ja) 抗生物質bu―3608dおよびbu―3608e
JPH0219320A (ja) 新規免疫抑制剤
JPS60259191A (ja) Cl−1724抗微生物/抗腫瘍化合物、その製造および用途
US7375230B2 (en) Fermentation and purification of migrastatin and analog
US4282322A (en) Process for enzymatic deacylation of antibiotics
US4235967A (en) Process for producing antibiotics by cultivation of Streptomyces flavogriseus
JPS6310998B2 (enrdf_load_stackoverflow)
EP0468504B1 (en) A novel antibiotic, balhimycin, a process for its production and its use as pharmaceutical
US4229534A (en) Acetylthienamycin production
JPH1045738A (ja) 抗生物質エポキシキノマイシンcおよびdとその製造法ならびに抗リウマチ剤
US4264736A (en) Antibiotic 890A10
US4137224A (en) Process for the preparation of antibiotic W-10 complex and for the isolation of antibiotic 20561 and antibiotic 20562 therefrom
US4304867A (en) Culture of Streptomyces cattleya
US4232006A (en) Antibiotic W-10 complex, antibiotic 20561 and antibiotic 20562 as antifungal agents
US3061516A (en) Telomycin and its production
US4264734A (en) Process for producing antibiotic desacetyl 890A10
JP3523290B2 (ja) 化合物31668pおよび31668u、それらの製造方法およびそれらの使用
JPH0430400B2 (enrdf_load_stackoverflow)
CA1220746A (en) Luzopeptin e.sub.2