JPS629567B2 - - Google Patents
Info
- Publication number
- JPS629567B2 JPS629567B2 JP54109838A JP10983879A JPS629567B2 JP S629567 B2 JPS629567 B2 JP S629567B2 JP 54109838 A JP54109838 A JP 54109838A JP 10983879 A JP10983879 A JP 10983879A JP S629567 B2 JPS629567 B2 JP S629567B2
- Authority
- JP
- Japan
- Prior art keywords
- urokinase
- thrombolytic
- extracts
- crude drug
- herbal medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 35
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 35
- 229960005356 urokinase Drugs 0.000 claims description 35
- 239000000284 extract Substances 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- 241000411851 herbal medicine Species 0.000 claims description 11
- 239000003527 fibrinolytic agent Substances 0.000 claims description 9
- 229960000103 thrombolytic agent Drugs 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 244000144730 Amygdalus persica Species 0.000 claims description 7
- 241000545744 Hirudinea Species 0.000 claims description 7
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 7
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 7
- 235000008434 ginseng Nutrition 0.000 claims description 7
- 244000018633 Prunus armeniaca Species 0.000 claims description 5
- 235000009827 Prunus armeniaca Nutrition 0.000 claims description 5
- 241000195955 Equisetum hyemale Species 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- 230000002537 thrombolytic effect Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 6
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 102100033806 Alpha-protein kinase 3 Human genes 0.000 description 1
- 101710082399 Alpha-protein kinase 3 Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 241000758993 Equisetidae Species 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10983879A JPS5632423A (en) | 1979-08-28 | 1979-08-28 | Promotion of thrombolytic activity of urokinase with crude drug extract, and pharmaceutical preparation containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10983879A JPS5632423A (en) | 1979-08-28 | 1979-08-28 | Promotion of thrombolytic activity of urokinase with crude drug extract, and pharmaceutical preparation containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5632423A JPS5632423A (en) | 1981-04-01 |
| JPS629567B2 true JPS629567B2 (enrdf_load_stackoverflow) | 1987-02-28 |
Family
ID=14520478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10983879A Granted JPS5632423A (en) | 1979-08-28 | 1979-08-28 | Promotion of thrombolytic activity of urokinase with crude drug extract, and pharmaceutical preparation containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5632423A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57123121A (en) * | 1981-01-26 | 1982-07-31 | Sunstar Inc | Thrombolytic agent |
| JPH01207243A (ja) * | 1988-02-12 | 1989-08-21 | Tsumura & Co | 血小板凝集抑制剤 |
| JP4797030B2 (ja) * | 2008-02-04 | 2011-10-19 | 有限会社 本町薬品 | 血栓溶解剤の製造方法 |
| US8928446B2 (en) | 2011-05-25 | 2015-01-06 | Mitsubishi Electric Corporation | Transformer |
-
1979
- 1979-08-28 JP JP10983879A patent/JPS5632423A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5632423A (en) | 1981-04-01 |
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