JPS6229570A - ３，５−ジイソプロピルベンジリデン複素環式化合物 - Google Patents

３，５−ジイソプロピルベンジリデン複素環式化合物

Info

Publication number
JPS6229570A
JPS6229570A JP16799985A JP16799985A JPS6229570A JP S6229570 A JPS6229570 A JP S6229570A JP 16799985 A JP16799985 A JP 16799985A JP 16799985 A JP16799985 A JP 16799985A JP S6229570 A JPS6229570 A JP S6229570A
Authority
JP
Japan
Prior art keywords
diisopropylbenzylidene
salt
compound
heterocyclic compound
formable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16799985A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0574587B2 (enrdf_load_stackoverflow
Inventor
Naohiro Imai
直博 今井
Tadayoshi Shiraishi
忠義 白石
Ikuo Katsumi
勝見　郁男
Katsuji Yamashita
山下　勝治
Yutaka Ariki
有木　豊
Toshiaki Yamashita
山下　俊章
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP16799985A priority Critical patent/JPS6229570A/ja
Publication of JPS6229570A publication Critical patent/JPS6229570A/ja
Publication of JPH0574587B2 publication Critical patent/JPH0574587B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP16799985A 1985-07-29 1985-07-29 ３，５−ジイソプロピルベンジリデン複素環式化合物 Granted JPS6229570A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16799985A JPS6229570A (ja) 1985-07-29 1985-07-29 ３，５−ジイソプロピルベンジリデン複素環式化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16799985A JPS6229570A (ja) 1985-07-29 1985-07-29 ３，５−ジイソプロピルベンジリデン複素環式化合物

Publications (2)

Publication Number Publication Date
JPS6229570A true JPS6229570A (ja) 1987-02-07
JPH0574587B2 JPH0574587B2 (enrdf_load_stackoverflow) 1993-10-18

Family

ID=15859921

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16799985A Granted JPS6229570A (ja) 1985-07-29 1985-07-29 ３，５−ジイソプロピルベンジリデン複素環式化合物

Country Status (1)

Country Link
JP (1) JPS6229570A (enrdf_load_stackoverflow)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897406A (en) * 1987-11-13 1990-01-30 Nisshin Flour Milling Co., Ltd. Rhodanine derivatives and pharmaceutical compositions
WO1992012966A1 (fr) * 1991-01-21 1992-08-06 Shionogi Seiyaku Kabushiki Kaisha Analogue de 3-benzylidene-1-carbamoyl-2-pyrrolidone
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
US5208250A (en) * 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
US5306822A (en) * 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
US5382593A (en) * 1992-07-21 1995-01-17 Adir Et Compagnie New 3-(hydroxybenzylidenyl)-indolin-2-ones
EP0779282A1 (en) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinone compounds for treating multiple sclerosis
US5792783A (en) * 1995-06-07 1998-08-11 Sugen, Inc. 3-heteroaryl-2-indolinone compounds for the treatment of disease
US5977130A (en) * 1996-01-17 1999-11-02 Taiho Pharmeutical Co., Ltd. Intimal hypertrophy inhibitors
US6380186B1 (en) 1996-09-30 2002-04-30 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
WO2001009121A3 (en) * 1999-07-30 2002-05-02 Basf Ag 2-pyrazolin-5-ones_as tyrosine kinase inhibitors
WO2001093841A3 (en) * 2000-06-05 2002-06-06 Prolifix Ltd Barbituric acid analogs as therapeutic agents
US6423708B1 (en) 1996-09-30 2002-07-23 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
US6451838B1 (en) 2000-05-24 2002-09-17 Pharmacia & Upjohn Company 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
US6706709B2 (en) 2000-06-02 2004-03-16 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US7125905B2 (en) 2000-02-15 2006-10-24 Agouron Pharmaceuticals, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
US7179910B2 (en) 2001-02-15 2007-02-20 Agouron Pharmaceuticals, Inc. 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US7202265B2 (en) 1997-08-20 2007-04-10 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57130950A (en) * 1981-02-05 1982-08-13 Kanegafuchi Chem Ind Co Ltd 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation
JPS5879944A (ja) * 1981-11-09 1983-05-13 Kanegafuchi Chem Ind Co Ltd ３，５−ジ・タ−シヤリ−・ブチルスチレン誘導体及び抗炎症、鎮痛、解熱剤並びに血小板凝集阻害剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57130950A (en) * 1981-02-05 1982-08-13 Kanegafuchi Chem Ind Co Ltd 3,5-di-tert-butyl-4-hydroxystyrene derivative and anti- inflammatory, analgesic, antipyretic agent and inhibitor for blood platelet aggregation
JPS5879944A (ja) * 1981-11-09 1983-05-13 Kanegafuchi Chem Ind Co Ltd ３，５−ジ・タ−シヤリ−・ブチルスチレン誘導体及び抗炎症、鎮痛、解熱剤並びに血小板凝集阻害剤

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897406A (en) * 1987-11-13 1990-01-30 Nisshin Flour Milling Co., Ltd. Rhodanine derivatives and pharmaceutical compositions
US5306822A (en) * 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
US5464856A (en) * 1988-05-25 1995-11-07 Warner-Lambert Company Arylmethylenyl derivatives of imidazolidinones useful as antiinflammatory agents
US5208250A (en) * 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
US5494927A (en) * 1990-03-27 1996-02-27 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
US5290800A (en) * 1990-03-27 1994-03-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
US5319099A (en) * 1991-01-21 1994-06-07 Shionogi Seiyaku Kabushiki Kaisha 3-benzylidene-1-carbamoyl-2-pyrrolidone compounds useful as antiinflammatory agents
US5319100A (en) * 1991-01-21 1994-06-07 Shionogi Seiyaku Kabushiki Kaisha 3-benzylidene-1-carbamoyl-2-pyrrolidone analogues
WO1992012966A1 (fr) * 1991-01-21 1992-08-06 Shionogi Seiyaku Kabushiki Kaisha Analogue de 3-benzylidene-1-carbamoyl-2-pyrrolidone
US5382593A (en) * 1992-07-21 1995-01-17 Adir Et Compagnie New 3-(hydroxybenzylidenyl)-indolin-2-ones
US5834504A (en) * 1995-06-07 1998-11-10 Sugen, Inc. 3-(2'-halobenzylidenyl)-2-indolinone compounds for the treatment of disease
US5792783A (en) * 1995-06-07 1998-08-11 Sugen, Inc. 3-heteroaryl-2-indolinone compounds for the treatment of disease
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US5883116A (en) * 1995-06-07 1999-03-16 Sugen, Inc. 3-(2'-alkoxybenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease
US5883113A (en) * 1995-06-07 1999-03-16 Sugen, Inc. 3-(4'-Bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease
US5886020A (en) * 1995-06-07 1999-03-23 Sugen, Inc. 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease
US6225335B1 (en) 1995-06-07 2001-05-01 Sugen, Inc. 3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6469032B2 (en) 1995-06-07 2002-10-22 Sugen, Inc. 3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease
EP0779282A1 (en) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinone compounds for treating multiple sclerosis
US5977130A (en) * 1996-01-17 1999-11-02 Taiho Pharmeutical Co., Ltd. Intimal hypertrophy inhibitors
US6423708B1 (en) 1996-09-30 2002-07-23 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
US6403592B1 (en) 1996-09-30 2002-06-11 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
US6472388B2 (en) 1996-09-30 2002-10-29 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
US6562813B2 (en) 1996-09-30 2003-05-13 Pfizer Inc. Aralkyl and aralkylidene heterocyclic lactams and imides
US6380186B1 (en) 1996-09-30 2002-04-30 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
US7202265B2 (en) 1997-08-20 2007-04-10 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US6855730B2 (en) 1998-08-05 2005-02-15 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase
WO2001009121A3 (en) * 1999-07-30 2002-05-02 Basf Ag 2-pyrazolin-5-ones_as tyrosine kinase inhibitors
US7572924B2 (en) 2000-02-15 2009-08-11 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
US7125905B2 (en) 2000-02-15 2006-10-24 Agouron Pharmaceuticals, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
US6716870B2 (en) 2000-05-24 2004-04-06 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US7112603B2 (en) 2000-05-24 2006-09-26 Agouron Pharmaceuticals, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6451838B1 (en) 2000-05-24 2002-09-17 Pharmacia & Upjohn Company 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6482848B2 (en) 2000-05-24 2002-11-19 Sugen Incorporated Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US7008943B2 (en) 2000-05-24 2006-03-07 Pharmacia & Upjohn Company 1-(Pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US7053113B2 (en) 2000-05-24 2006-05-30 Sugen, Inc. Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives
US6710067B2 (en) 2000-05-24 2004-03-23 Sugen Incorporated Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US7071332B2 (en) 2000-06-02 2006-07-04 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6706709B2 (en) 2000-06-02 2004-03-16 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
WO2001093841A3 (en) * 2000-06-05 2002-06-06 Prolifix Ltd Barbituric acid analogs as therapeutic agents
US7179910B2 (en) 2001-02-15 2007-02-20 Agouron Pharmaceuticals, Inc. 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US7256189B2 (en) 2001-02-15 2007-08-14 Sugen, Inc. 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
US7582756B2 (en) 2001-02-15 2009-09-01 Sugen, Inc. 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
US6599902B2 (en) 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
JPH0574587B2 (enrdf_load_stackoverflow) 1993-10-18

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