JPS6223823B2 - - Google Patents
Info
- Publication number
- JPS6223823B2 JPS6223823B2 JP2049180A JP2049180A JPS6223823B2 JP S6223823 B2 JPS6223823 B2 JP S6223823B2 JP 2049180 A JP2049180 A JP 2049180A JP 2049180 A JP2049180 A JP 2049180A JP S6223823 B2 JPS6223823 B2 JP S6223823B2
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- type
- bound
- aggregate
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 239000007790 solid phase Substances 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 5
- 238000003018 immunoassay Methods 0.000 claims description 4
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 20
- 108010044467 Isoenzymes Proteins 0.000 description 16
- 229940088598 enzyme Drugs 0.000 description 14
- 239000000243 solution Substances 0.000 description 12
- 239000000282 fibrinogen degradation product Substances 0.000 description 11
- 239000012634 fragment Substances 0.000 description 10
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 7
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 7
- 102000004420 Creatine Kinase Human genes 0.000 description 5
- 108010042126 Creatine kinase Proteins 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 108010005774 beta-Galactosidase Proteins 0.000 description 4
- 102000005936 beta-Galactosidase Human genes 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 230000009260 cross reactivity Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 108010093031 Galactosidases Proteins 0.000 description 2
- 102000002464 Galactosidases Human genes 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 101000588258 Taenia solium Paramyosin Proteins 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010517 secondary reaction Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000012064 sodium phosphate buffer Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
- 101900264058 Escherichia coli Beta-galactosidase Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 1
- 101710162629 Trypsin inhibitor Proteins 0.000 description 1
- 229940122618 Trypsin inhibitor Drugs 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000710 homodimer Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Rehabilitation Therapy (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2049180A JPS56118671A (en) | 1980-02-22 | 1980-02-22 | Measuring method of specific enzyme immunity of hybrid type protein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2049180A JPS56118671A (en) | 1980-02-22 | 1980-02-22 | Measuring method of specific enzyme immunity of hybrid type protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56118671A JPS56118671A (en) | 1981-09-17 |
| JPS6223823B2 true JPS6223823B2 (de) | 1987-05-25 |
Family
ID=12028613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2049180A Granted JPS56118671A (en) | 1980-02-22 | 1980-02-22 | Measuring method of specific enzyme immunity of hybrid type protein |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56118671A (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016575A1 (de) * | 1980-04-30 | 1981-11-05 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur immunologischen bestimmung von enzymen, mittel zur durchfuehrung des verfahrens und seine verwandung |
| GB2078953B (en) * | 1980-06-30 | 1984-06-13 | Int Immunoassay Lab Inc | Two site cross-reaction immunometric sandwich assay method |
| DE3172143D1 (en) * | 1980-09-30 | 1985-10-10 | Cornell Res Foundation Inc | Process for determining inhibitor-enzyme complexes |
| JPS5899758A (ja) * | 1981-12-09 | 1983-06-14 | Amano Pharmaceut Co Ltd | セクレタリ−・コンポ−ネントの定量法 |
| JPS58198758A (ja) * | 1982-05-15 | 1983-11-18 | Amano Pharmaceut Co Ltd | ヒトエノラーゼの定量方法 |
| US4515890A (en) * | 1982-11-08 | 1985-05-07 | Abbott Laboratories | Immunoassay of terminal deoxynucleotidyl transferase |
| JPS59111062A (ja) * | 1982-12-16 | 1984-06-27 | Amano Pharmaceut Co Ltd | β型エノラ−ゼの測定法 |
| ATE121197T1 (de) * | 1988-01-19 | 1995-04-15 | Pasteur Institut | Immunometrisches verfahren zum nachweis von lipoprotein-teilchen, anti-lp(a) monoklonale antikörper und ihre anwendung zur diagnose von atherosklerose. |
-
1980
- 1980-02-22 JP JP2049180A patent/JPS56118671A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56118671A (en) | 1981-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1206877A (en) | Immunoassay for nonenzymatically glucosylated proteins and protein fragments - an index of glycemia | |
| KR920005963B1 (ko) | 특이적으로 결합가능한 물질의 측정방법 | |
| US4894347A (en) | Erythrocyte agglutination assay | |
| WO1994017408A1 (en) | Assays and kits for detecting analytes in the presence of cross-reacting substances | |
| EP0149602A1 (de) | Immunometrische bestimmung in der polyklonale und monoklonale antikörper verwendet werden und ein testsatz dafür | |
| CN107589249B (zh) | 用于通过免疫复合物转移法检测被检物质的抗体试剂及其制造方法、以及该抗体试剂的用途 | |
| JP3392868B2 (ja) | マルチクローナル抗体フォーマットで結合タンパク質を用いた競合イムノアッセイ | |
| US4624916A (en) | Process and composition for the rapid quantitation of small levels of creative kinase-MB isoenzyme | |
| JPS6223823B2 (de) | ||
| AU628298B2 (en) | Method for measuring human insulin | |
| US5437981A (en) | Method for the immunological determination of ligands | |
| CA2835068C (en) | Method for immunologically measuring soluble lr11 | |
| CN107860930A (zh) | 一种心型脂肪酸结合蛋白的免疫比浊检测试剂和方法 | |
| US20100081149A1 (en) | Novel oxidized ldl complex and method for detection thereof | |
| JPH0476628B2 (de) | ||
| EP0084807B1 (de) | Verfahren zur quantitativen Bestimmung einer gesuchten Substanz | |
| JP2651438B2 (ja) | 酵素標識抗体感作ラテックス及びそれを用いた酵素免疫測定法 | |
| JP2000162213A (ja) | 免疫検定法における干渉を減らすためのシステム | |
| JPH05223817A (ja) | 免疫学的に結合可能な物質の定量方法 | |
| KR940008091B1 (ko) | 리간드의 면역학적 검출방법 | |
| EP0140242B1 (de) | Methode zur Bestimmung des basischen Fetoproteins und Reagens hierfür | |
| JP3171681B2 (ja) | 糖化蛋白の測定方法 | |
| JPS61243363A (ja) | Ｃｒｐの高感度定量法 | |
| Bekman et al. | Simultaneous detection of thyroid-stimulating hormone and free thyroxin in dried spots of human blood by using phosphorescent nanoparticles | |
| WO2023163176A1 (ja) | セリンプロテアーゼの検出用または測定用試薬 |