JPS62207208A - 経口フイルム状徐放性製剤 - Google Patents
経口フイルム状徐放性製剤Info
- Publication number
- JPS62207208A JPS62207208A JP4851586A JP4851586A JPS62207208A JP S62207208 A JPS62207208 A JP S62207208A JP 4851586 A JP4851586 A JP 4851586A JP 4851586 A JP4851586 A JP 4851586A JP S62207208 A JPS62207208 A JP S62207208A
- Authority
- JP
- Japan
- Prior art keywords
- film
- polyacrylic acid
- layer film
- lower alkyl
- inner layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 46
- 239000003814 drug Substances 0.000 claims abstract description 46
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- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 38
- 229920002678 cellulose Polymers 0.000 claims abstract description 26
- 239000001913 cellulose Substances 0.000 claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 150000005215 alkyl ethers Chemical class 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 12
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 12
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 12
- 239000004014 plasticizer Substances 0.000 claims abstract description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 4
- 150000007524 organic acids Chemical class 0.000 claims abstract description 3
- 238000010030 laminating Methods 0.000 claims abstract 2
- 239000003405 delayed action preparation Substances 0.000 claims description 11
- 238000013268 sustained release Methods 0.000 claims description 11
- 239000012730 sustained-release form Substances 0.000 claims description 11
- 239000004604 Blowing Agent Substances 0.000 claims description 10
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 4
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 239000004088 foaming agent Substances 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 6
- 230000000246 remedial effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- -1 hydrotalcitate Chemical compound 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
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- 229920006362 Teflon® Polymers 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000002496 gastric effect Effects 0.000 description 6
- 229960000876 cinnarizine Drugs 0.000 description 5
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 3
- 150000003180 prostaglandins Chemical class 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 125000005011 alkyl ether group Chemical group 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- PGZIKUPSQINGKT-UHFFFAOYSA-N dialuminum;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O PGZIKUPSQINGKT-UHFFFAOYSA-N 0.000 description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
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- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229920003112 high viscosity grade hydroxypropyl cellulose Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000395 magnesium oxide Substances 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 description 2
- 235000019792 magnesium silicate Nutrition 0.000 description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 2
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
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- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
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- LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
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- 229950004678 tripamide Drugs 0.000 description 1
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- 239000002432 uterotonic agent Substances 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4851586A JPS62207208A (ja) | 1986-03-07 | 1986-03-07 | 経口フイルム状徐放性製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4851586A JPS62207208A (ja) | 1986-03-07 | 1986-03-07 | 経口フイルム状徐放性製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62207208A true JPS62207208A (ja) | 1987-09-11 |
| JPH0457645B2 JPH0457645B2 (enrdf_load_stackoverflow) | 1992-09-14 |
Family
ID=12805502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4851586A Granted JPS62207208A (ja) | 1986-03-07 | 1986-03-07 | 経口フイルム状徐放性製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62207208A (enrdf_load_stackoverflow) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523359A (ja) * | 1998-08-17 | 2002-07-30 | エルテーエス ローマン テラピー−ジステーム アーゲー | フィルム状活性物質担体 |
| JP2002535269A (ja) * | 1999-01-21 | 2002-10-22 | ラヴィファーム ラボラトリーズ， インコーポレイテッド | 粘膜分配用組成物と方法 |
| WO2002087622A1 (fr) | 2001-04-24 | 2002-11-07 | Lintec Corporation | Preparations orales et supports pour preparations orales |
| JP2005289868A (ja) * | 2004-03-31 | 2005-10-20 | Lintec Corp | 経口投与剤 |
| JP2005537233A (ja) * | 2002-06-04 | 2005-12-08 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 活性物質放出のためのフィルム成形された溶解可能な製剤およびこれらの製造方法 |
| WO2011118453A1 (ja) * | 2010-03-23 | 2011-09-29 | リンテック株式会社 | 固形製剤 |
| JP2012041366A (ja) * | 2011-11-17 | 2012-03-01 | Lintec Corp | 経口投与剤 |
| US8268333B2 (en) | 2001-04-24 | 2012-09-18 | Lintec Corporation | Orally administered agent and an orally administered agent/supporting substrate complex |
| JP2016507485A (ja) * | 2012-12-04 | 2016-03-10 | サムスン ファイン ケミカルズ カンパニー リミテッドＳａｍｓｕｎｇｆｉｎｅ Ｃｈｅｍｉｃａｌｓ Ｃｏ．，Ｌｔｄ． | 積層フィルム及びフィルム積層方法 |
| CN114053249A (zh) * | 2020-08-10 | 2022-02-18 | 山东百多安医疗器械股份有限公司 | 一种可治疗全身骨质疏松的可降解载药薄膜及其制备工艺 |
| US11446255B2 (en) | 2019-03-20 | 2022-09-20 | Ricoh Company, Ltd. | Sheet, sheet laminate, pharmaceutical drug, sheet producing method, sheet producing apparatus, sheet laminate producing method, and sheet laminate producing apparatus |
-
1986
- 1986-03-07 JP JP4851586A patent/JPS62207208A/ja active Granted
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010280679A (ja) * | 1998-08-17 | 2010-12-16 | Lts Lohmann Therapie-Systeme Ag | フィルム状活性物質担体 |
| JP2002523359A (ja) * | 1998-08-17 | 2002-07-30 | エルテーエス ローマン テラピー−ジステーム アーゲー | フィルム状活性物質担体 |
| JP2002535269A (ja) * | 1999-01-21 | 2002-10-22 | ラヴィファーム ラボラトリーズ， インコーポレイテッド | 粘膜分配用組成物と方法 |
| JP2012051951A (ja) * | 2001-04-24 | 2012-03-15 | Lintec Corp | 経口投与剤及び経口投与剤保持体 |
| WO2002087622A1 (fr) | 2001-04-24 | 2002-11-07 | Lintec Corporation | Preparations orales et supports pour preparations orales |
| JPWO2002087622A1 (ja) * | 2001-04-24 | 2004-08-12 | リンテック株式会社 | 経口投与剤及び経口投与剤保持体 |
| US8268333B2 (en) | 2001-04-24 | 2012-09-18 | Lintec Corporation | Orally administered agent and an orally administered agent/supporting substrate complex |
| JP2009007379A (ja) * | 2001-04-24 | 2009-01-15 | Lintec Corp | 経口投与剤及び経口投与剤保持体 |
| KR100890180B1 (ko) * | 2001-04-24 | 2009-03-25 | 린텍 가부시키가이샤 | 경구투여제 및 경구투여제 유지체 |
| JP2005537233A (ja) * | 2002-06-04 | 2005-12-08 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 活性物質放出のためのフィルム成形された溶解可能な製剤およびこれらの製造方法 |
| JP2010209104A (ja) * | 2002-06-04 | 2010-09-24 | Lts Lohmann Therapie-Systeme Ag | 活性物質放出のためのフィルム成形された溶解可能な製剤およびこれらの製造方法 |
| EP1757273A4 (en) * | 2004-03-31 | 2011-02-09 | Lintec Corp | PREPARATION FOR ORAL ADMINISTRATION |
| JP2005289868A (ja) * | 2004-03-31 | 2005-10-20 | Lintec Corp | 経口投与剤 |
| EP2497466A3 (en) * | 2004-03-31 | 2012-11-21 | LINTEC Corporation | Preparation for oral administration |
| TWI401095B (zh) * | 2004-03-31 | 2013-07-11 | Lintec Co Ltd | Oral Pharmacy (2) |
| WO2011118453A1 (ja) * | 2010-03-23 | 2011-09-29 | リンテック株式会社 | 固形製剤 |
| JP2012041366A (ja) * | 2011-11-17 | 2012-03-01 | Lintec Corp | 経口投与剤 |
| JP2016507485A (ja) * | 2012-12-04 | 2016-03-10 | サムスン ファイン ケミカルズ カンパニー リミテッドＳａｍｓｕｎｇｆｉｎｅ Ｃｈｅｍｉｃａｌｓ Ｃｏ．，Ｌｔｄ． | 積層フィルム及びフィルム積層方法 |
| US11446255B2 (en) | 2019-03-20 | 2022-09-20 | Ricoh Company, Ltd. | Sheet, sheet laminate, pharmaceutical drug, sheet producing method, sheet producing apparatus, sheet laminate producing method, and sheet laminate producing apparatus |
| CN114053249A (zh) * | 2020-08-10 | 2022-02-18 | 山东百多安医疗器械股份有限公司 | 一种可治疗全身骨质疏松的可降解载药薄膜及其制备工艺 |
| CN114053249B (zh) * | 2020-08-10 | 2023-06-02 | 山东百多安医疗器械股份有限公司 | 一种可治疗全身骨质疏松的可降解载药薄膜及其制备工艺 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0457645B2 (enrdf_load_stackoverflow) | 1992-09-14 |
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Legal Events
| Date | Code | Title | Description |
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| EXPY | Cancellation because of completion of term |