JPS62153218A - 制癌剤 - Google Patents
制癌剤Info
- Publication number
- JPS62153218A JPS62153218A JP60292860A JP29286085A JPS62153218A JP S62153218 A JPS62153218 A JP S62153218A JP 60292860 A JP60292860 A JP 60292860A JP 29286085 A JP29286085 A JP 29286085A JP S62153218 A JPS62153218 A JP S62153218A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- carcinostatic
- furan
- integer
- epoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003327 cancerostatic effect Effects 0.000 title abstract 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 27
- 229930195729 fatty acid Natural products 0.000 claims abstract description 27
- 239000000194 fatty acid Substances 0.000 claims abstract description 27
- -1 furan cyclic fatty acids Chemical class 0.000 claims description 16
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 13
- 239000002246 antineoplastic agent Substances 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 abstract description 11
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 239000000839 emulsion Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 4
- 231100000053 low toxicity Toxicity 0.000 abstract description 4
- 239000002253 acid Substances 0.000 abstract description 3
- 210000004185 liver Anatomy 0.000 abstract description 3
- HDHYFCAMRUJRJJ-UHFFFAOYSA-N 11-(3,4-dimethyl-5-propylfuran-2-yl)undecanoic acid Chemical compound CCCC=1OC(CCCCCCCCCCC(O)=O)=C(C)C=1C HDHYFCAMRUJRJJ-UHFFFAOYSA-N 0.000 abstract description 2
- 241000251468 Actinopterygii Species 0.000 abstract description 2
- 210000001672 ovary Anatomy 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 description 14
- 238000000034 method Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000004593 Epoxy Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 2
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 2
- 229960003656 ricinoleic acid Drugs 0.000 description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 2
- 235000009518 sodium iodide Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- RWZSLAVGSFOKCN-UHFFFAOYSA-N 11-methyloctadeca-10,12-dienoic acid Chemical compound CCCCCC=CC(C)=CCCCCCCCCC(O)=O RWZSLAVGSFOKCN-UHFFFAOYSA-N 0.000 description 1
- JHWIEAWILPSRMU-UHFFFAOYSA-N 2-methyl-3-pyrimidin-4-ylpropanoic acid Chemical compound OC(=O)C(C)CC1=CC=NC=N1 JHWIEAWILPSRMU-UHFFFAOYSA-N 0.000 description 1
- SZNVIDWMWMWUCY-UHFFFAOYSA-N 8-(5-hexylfuran-2-yl)octanoic acid Chemical compound CCCCCCC1=CC=C(CCCCCCCC(O)=O)O1 SZNVIDWMWMWUCY-UHFFFAOYSA-N 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- LULAYUGMBFYYEX-UHFFFAOYSA-N metachloroperbenzoic acid Natural products OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 1
- DIPHDXIHMQRKSX-UHFFFAOYSA-N methyl 12-oxooctadec-9-enoate Chemical compound CCCCCCC(=O)CC=CCCCCCCCC(=O)OC DIPHDXIHMQRKSX-UHFFFAOYSA-N 0.000 description 1
- ZZSFTHVENQKCDJ-UHFFFAOYSA-N methyl 8-(5-hexylfuran-2-yl)octanoate Chemical compound CCCCCCC1=CC=C(CCCCCCCC(=O)OC)O1 ZZSFTHVENQKCDJ-UHFFFAOYSA-N 0.000 description 1
- ZKGJOTNOOSGNIW-UHFFFAOYSA-N methyl 8-[3-(2-oxooctyl)oxiran-2-yl]octanoate Chemical compound CCCCCCC(=O)CC1OC1CCCCCCCC(=O)OC ZKGJOTNOOSGNIW-UHFFFAOYSA-N 0.000 description 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Furan Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60292860A JPS62153218A (ja) | 1985-12-27 | 1985-12-27 | 制癌剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60292860A JPS62153218A (ja) | 1985-12-27 | 1985-12-27 | 制癌剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62153218A true JPS62153218A (ja) | 1987-07-08 |
| JPH0544927B2 JPH0544927B2 (enrdf_load_html_response) | 1993-07-07 |
Family
ID=17787307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60292860A Granted JPS62153218A (ja) | 1985-12-27 | 1985-12-27 | 制癌剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62153218A (enrdf_load_html_response) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067929A1 (de) * | 2001-02-23 | 2002-09-06 | Sirs-Lab Gmbh | Furanfettsauren zur steigerung der effizienz der zytotstatika-therapie und/oder bestrahlungstherapie |
| US10399953B2 (en) * | 2015-09-14 | 2019-09-03 | The Regents Of The University Of California | Preparation of furan fatty acids from 5-(chloromethyl)furfural |
-
1985
- 1985-12-27 JP JP60292860A patent/JPS62153218A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067929A1 (de) * | 2001-02-23 | 2002-09-06 | Sirs-Lab Gmbh | Furanfettsauren zur steigerung der effizienz der zytotstatika-therapie und/oder bestrahlungstherapie |
| US10399953B2 (en) * | 2015-09-14 | 2019-09-03 | The Regents Of The University Of California | Preparation of furan fatty acids from 5-(chloromethyl)furfural |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0544927B2 (enrdf_load_html_response) | 1993-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4216224A (en) | Methods and compositions for treating psoriasis with retinoyl compounds | |
| US5786383A (en) | Pharmaceutical preparation | |
| JPS62230722A (ja) | 肥満および／または関連状態の治療剤 | |
| Lijinsky et al. | Lung tumors in rats treated with N-nitrosoheptamethyleneimine and N-nitrosooctamethyleneimine | |
| NL8204126A (nl) | Werkwijze voor het bereiden van een farmaceutisch preparaat met locaal-anesthetische werking dat een dialylamino-2',6'acetoxylidide en/of een farmaceutisch aanvaardbaar zout daarvan bevat, alsmede de onder toepassing van deze werkwijze verkregen gevormde farmaceutische preparaten en werkwijze voor het bereiden van dialkylamino-2',6'acetoxylididen en de farmaceutisch aanvaardbare zouten daarvan. | |
| CN113788772B (zh) | 含氨基硫脲的没食子酸类衍生物及合成方法与用途 | |
| JPS5869812A (ja) | 血糖降下剤 | |
| US4386077A (en) | Pharmaceutical composition for oral administration containing cytidine diphosphocholine | |
| JPH05503077A (ja) | 抗腫瘍剤としてのイルージンアナログ | |
| US4914105A (en) | Anti-cancer compositions for delivering 5-fluorouracil | |
| JPS60190742A (ja) | フエニルメチルフエノキシ化合物その製造法および医薬組成物 | |
| JPS62153218A (ja) | 制癌剤 | |
| JPS6140268A (ja) | イミダゾリン、その付加塩及びその製造方法並びにイミダゾリン又はその付加塩を有効成分とする医薬 | |
| JPS60105637A (ja) | ル−ペロ−ルとその誘導体 | |
| SU865127A3 (ru) | Способ получени спирооксазолидиндионов | |
| US3143469A (en) | Anti-cholesterol nicotinic acid nu-oxide | |
| JPS59212499A (ja) | 抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体 | |
| CA1274547A (en) | Gem-dihalo and tetrahalo-1,12-diamino-4, 9-diaza-dodecanes | |
| US3829581A (en) | Aliphatic polycyclic amidoximes as influenza antiviral agents | |
| JPS6270335A (ja) | ２環性アリルエ−テル誘導体、その製法および用途 | |
| CN111499623B (zh) | 一类非核苷抗肿瘤药物的噻唑酮脲衍生物及其药物用途 | |
| JPH0222252A (ja) | ５―ヒドロキシトリプタミン―１ａ―受容体結合化合物 | |
| US3073740A (en) | Method of reducing cholesterol levels with tri- (dialkylaminoalkyl) phosphates | |
| Fissekis et al. | N-Pantoyl-(substituted) amines, pantothenic acid analogues | |
| JPS62500453A (ja) | ピロチン誘導体の使用 |