JPS6188872A - 高濃度連続培養方法及び装置 - Google Patents
高濃度連続培養方法及び装置Info
- Publication number
- JPS6188872A JPS6188872A JP59211747A JP21174784A JPS6188872A JP S6188872 A JPS6188872 A JP S6188872A JP 59211747 A JP59211747 A JP 59211747A JP 21174784 A JP21174784 A JP 21174784A JP S6188872 A JPS6188872 A JP S6188872A
- Authority
- JP
- Japan
- Prior art keywords
- culture
- filtration
- membrane
- tank
- circulation circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title description 7
- 238000001914 filtration Methods 0.000 claims abstract description 53
- 239000012528 membrane Substances 0.000 claims abstract description 47
- 239000001963 growth medium Substances 0.000 claims abstract description 13
- 230000002441 reversible effect Effects 0.000 claims abstract description 12
- 230000002503 metabolic effect Effects 0.000 claims abstract description 7
- 239000002207 metabolite Substances 0.000 claims description 29
- 230000001580 bacterial effect Effects 0.000 claims description 27
- 238000012258 culturing Methods 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000012136 culture method Methods 0.000 claims description 5
- 239000012737 fresh medium Substances 0.000 claims description 4
- 238000011027 product recovery Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 19
- 239000002609 medium Substances 0.000 abstract description 14
- 235000015097 nutrients Nutrition 0.000 abstract description 10
- 239000000047 product Substances 0.000 abstract description 6
- 238000011001 backwashing Methods 0.000 abstract description 2
- 239000000706 filtrate Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 13
- 230000012010 growth Effects 0.000 description 10
- 230000007423 decrease Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000012466 permeate Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 229940072107 ascorbate Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 241001148470 aerobic bacillus Species 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000034655 secondary growth Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59211747A JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59211747A JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6188872A true JPS6188872A (ja) | 1986-05-07 |
| JPS6363193B2 JPS6363193B2 (enrdf_load_stackoverflow) | 1988-12-06 |
Family
ID=16610912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59211747A Granted JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6188872A (enrdf_load_stackoverflow) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989012676A1 (en) * | 1988-06-21 | 1989-12-28 | Kopf Henry B | Culture device and method |
| JPH0242992A (ja) * | 1988-08-03 | 1990-02-13 | Tanabe Seiyaku Co Ltd | 生体触媒を用いる反応方法およびその反応装置 |
| WO1990002171A1 (en) * | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
| WO1992013940A1 (en) * | 1991-02-12 | 1992-08-20 | Synbiotics Corporation | Hollow fiber cell propagation |
| US6048727A (en) * | 1986-11-26 | 2000-04-11 | Kopf; Henry B. | Apparatus and method for mass transfer involving biological/pharmaceutical media |
| US6388355B2 (en) | 1998-06-29 | 2002-05-14 | Mitsubishi Denki Kabushiki Kaisha | Motor for an electric power steering assembly |
| JP2003521877A (ja) * | 1999-02-05 | 2003-07-22 | プロテイン サイエンシーズ コーポレイション | 高密度の細胞を産生および使用するための装置および方法およびそこからの産物 |
| JP2005261342A (ja) * | 2004-03-19 | 2005-09-29 | Yanmar Co Ltd | プランクトン培養システム |
| JP2016530893A (ja) * | 2013-09-16 | 2016-10-06 | ジェンザイム・コーポレーション | 細胞培養物を処理する方法およびシステム |
| JP2018521683A (ja) * | 2015-08-07 | 2018-08-09 | ローディア オペレーションズ | 発酵によるバニリンの改良された製造 |
| CN113634125A (zh) * | 2021-10-18 | 2021-11-12 | 深圳市路阳农业科技有限公司 | 一种碱性微生物培养液浓缩过滤装置 |
-
1984
- 1984-10-09 JP JP59211747A patent/JPS6188872A/ja active Granted
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022742A (en) * | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
| US6048727A (en) * | 1986-11-26 | 2000-04-11 | Kopf; Henry B. | Apparatus and method for mass transfer involving biological/pharmaceutical media |
| WO1989012676A1 (en) * | 1988-06-21 | 1989-12-28 | Kopf Henry B | Culture device and method |
| JPH0242992A (ja) * | 1988-08-03 | 1990-02-13 | Tanabe Seiyaku Co Ltd | 生体触媒を用いる反応方法およびその反応装置 |
| WO1990002171A1 (en) * | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
| WO1992013940A1 (en) * | 1991-02-12 | 1992-08-20 | Synbiotics Corporation | Hollow fiber cell propagation |
| US6388355B2 (en) | 1998-06-29 | 2002-05-14 | Mitsubishi Denki Kabushiki Kaisha | Motor for an electric power steering assembly |
| JP2003521877A (ja) * | 1999-02-05 | 2003-07-22 | プロテイン サイエンシーズ コーポレイション | 高密度の細胞を産生および使用するための装置および方法およびそこからの産物 |
| JP2005261342A (ja) * | 2004-03-19 | 2005-09-29 | Yanmar Co Ltd | プランクトン培養システム |
| JP2016530893A (ja) * | 2013-09-16 | 2016-10-06 | ジェンザイム・コーポレーション | 細胞培養物を処理する方法およびシステム |
| JP2020124204A (ja) * | 2013-09-16 | 2020-08-20 | ジェンザイム・コーポレーション | 細胞培養物を処理する方法およびシステム |
| JP2022050549A (ja) * | 2013-09-16 | 2022-03-30 | ジェンザイム・コーポレーション | 細胞培養物を処理する方法およびシステム |
| JP2023058588A (ja) * | 2013-09-16 | 2023-04-25 | ジェンザイム・コーポレーション | 細胞培養物を処理する方法およびシステム |
| JP2018521683A (ja) * | 2015-08-07 | 2018-08-09 | ローディア オペレーションズ | 発酵によるバニリンの改良された製造 |
| US11060118B2 (en) | 2015-08-07 | 2021-07-13 | Rhodia Operations | Production of vanillin by fermentation |
| CN113634125A (zh) * | 2021-10-18 | 2021-11-12 | 深圳市路阳农业科技有限公司 | 一种碱性微生物培养液浓缩过滤装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6363193B2 (enrdf_load_stackoverflow) | 1988-12-06 |
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