JPS6188872A - Method and apparatus for continuous cultivation at high concentration - Google Patents

Method and apparatus for continuous cultivation at high concentration

Info

Publication number
JPS6188872A
JPS6188872A JP21174784A JP21174784A JPS6188872A JP S6188872 A JPS6188872 A JP S6188872A JP 21174784 A JP21174784 A JP 21174784A JP 21174784 A JP21174784 A JP 21174784A JP S6188872 A JPS6188872 A JP S6188872A
Authority
JP
Japan
Prior art keywords
filtration
culture
case
metabolic product
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP21174784A
Other languages
Japanese (ja)
Other versions
JPS6363193B2 (en
Inventor
Eitaro Kumazawa
Kisao Satou
Yoshitomo Minamide
Shinichi Takato
Kazuo Imon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Snow Brand Milk Products Co Ltd
Original Assignee
Snow Brand Milk Products Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snow Brand Milk Products Co Ltd filed Critical Snow Brand Milk Products Co Ltd
Priority to JP21174784A priority Critical patent/JPS6363193B2/ja
Publication of JPS6188872A publication Critical patent/JPS6188872A/en
Publication of JPS6363193B2 publication Critical patent/JPS6363193B2/ja
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To enable the culture of microbial cells in high concentration, by supplying the culture medium to the second filtration membrane in the case of normal flow direction in the circulation circuit, and supplying to the first filtration membrane in the case of reverse flow and continuing the cultivation while removing the metabolic products from the medium.
CONSTITUTION: A seed microorganism is inoculated in the culture tank 10, the cultivation is started, and when the concentration of the metabolic product reaches a specific level, the operation of membranes is started. In the case of the normal flow operation shown by the solid arrow, the cell liquid extracted from the culture tank 10 with the pump 37 is passed in the order of the first and the second filtration chambers 11, 12. The first filtration chamber 11 is operated under higher pressure, and the filtrate containing the metabolic product is introduced into the filtration chamber 27, the metabolic product is removed by the RO membrane, and the nutrient component having low molecular weight is returned to the medium supply tank 29. When the system is turned to the reverse-flow operation shown by the dotted arrow by the simultaneous change-over of the three-way solenoid valves 19, 20, 21, 23 and 32, the first filtration chamber is subjected to the back-washing, and is supplied with low-molecular nutrient component.
COPYRIGHT: (C)1986,JPO&Japio
JP21174784A 1984-10-09 1984-10-09 Expired JPS6363193B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21174784A JPS6363193B2 (en) 1984-10-09 1984-10-09

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21174784A JPS6363193B2 (en) 1984-10-09 1984-10-09

Publications (2)

Publication Number Publication Date
JPS6188872A true JPS6188872A (en) 1986-05-07
JPS6363193B2 JPS6363193B2 (en) 1988-12-06

Family

ID=16610912

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21174784A Expired JPS6363193B2 (en) 1984-10-09 1984-10-09

Country Status (1)

Country Link
JP (1) JPS6363193B2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269444A2 (en) * 1986-11-26 1988-06-01 Henry B. Kopf Apparatus and method for mass transfer involving biological/pharmaceutical media
EP0336974A1 (en) * 1987-10-01 1989-10-18 Sumitomo Electric Industries, Ltd. Cell propagation apparatus
WO1989012676A1 (en) * 1988-06-21 1989-12-28 Kopf Henry B Culture device and method
JPH0242992A (en) * 1988-08-03 1990-02-13 Tanabe Seiyaku Co Ltd Reaction using biocatalyst and device for said reaction
WO1990002171A1 (en) * 1988-08-31 1990-03-08 Cellco Advanced Bioreactors, Inc. In vitro cell culture reactor
WO1992013940A1 (en) * 1991-02-12 1992-08-20 Synbiotics Corporation Hollow fiber cell propagation
US6388355B2 (en) 1998-06-29 2002-05-14 Mitsubishi Denki Kabushiki Kaisha Motor for an electric power steering assembly
JP2003521877A (en) * 1999-02-05 2003-07-22 プロテイン サイエンシーズ コーポレイション Apparatus and methods for producing and using high density cells and products therefrom
JP2005261342A (en) * 2004-03-19 2005-09-29 Yanmar Co Ltd Plankton culture system
JP2016530893A (en) * 2013-09-16 2016-10-06 ジェンザイム・コーポレーション Method and system for processing cell culture
JP2018521683A (en) * 2015-08-07 2018-08-09 ローディア オペレーションズ Improved production of vanillin by fermentation.
CN113634125A (en) * 2021-10-18 2021-11-12 深圳市路阳农业科技有限公司 Alkaline microorganism culture solution concentration and filtration device

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269444A2 (en) * 1986-11-26 1988-06-01 Henry B. Kopf Apparatus and method for mass transfer involving biological/pharmaceutical media
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US6048727A (en) * 1986-11-26 2000-04-11 Kopf; Henry B. Apparatus and method for mass transfer involving biological/pharmaceutical media
EP0336974A1 (en) * 1987-10-01 1989-10-18 Sumitomo Electric Industries, Ltd. Cell propagation apparatus
WO1989012676A1 (en) * 1988-06-21 1989-12-28 Kopf Henry B Culture device and method
JPH0242992A (en) * 1988-08-03 1990-02-13 Tanabe Seiyaku Co Ltd Reaction using biocatalyst and device for said reaction
WO1990002171A1 (en) * 1988-08-31 1990-03-08 Cellco Advanced Bioreactors, Inc. In vitro cell culture reactor
WO1992013940A1 (en) * 1991-02-12 1992-08-20 Synbiotics Corporation Hollow fiber cell propagation
US6388355B2 (en) 1998-06-29 2002-05-14 Mitsubishi Denki Kabushiki Kaisha Motor for an electric power steering assembly
JP2003521877A (en) * 1999-02-05 2003-07-22 プロテイン サイエンシーズ コーポレイション Apparatus and methods for producing and using high density cells and products therefrom
JP2005261342A (en) * 2004-03-19 2005-09-29 Yanmar Co Ltd Plankton culture system
JP2016530893A (en) * 2013-09-16 2016-10-06 ジェンザイム・コーポレーション Method and system for processing cell culture
JP2020124204A (en) * 2013-09-16 2020-08-20 ジェンザイム・コーポレーション Method and system for processing cell culture
JP2018521683A (en) * 2015-08-07 2018-08-09 ローディア オペレーションズ Improved production of vanillin by fermentation.
US11060118B2 (en) 2015-08-07 2021-07-13 Rhodia Operations Production of vanillin by fermentation
CN113634125A (en) * 2021-10-18 2021-11-12 深圳市路阳农业科技有限公司 Alkaline microorganism culture solution concentration and filtration device

Also Published As

Publication number Publication date
JPS6363193B2 (en) 1988-12-06

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