JPS6363193B2 - - Google Patents
Info
- Publication number
- JPS6363193B2 JPS6363193B2 JP21174784A JP21174784A JPS6363193B2 JP S6363193 B2 JPS6363193 B2 JP S6363193B2 JP 21174784 A JP21174784 A JP 21174784A JP 21174784 A JP21174784 A JP 21174784A JP S6363193 B2 JPS6363193 B2 JP S6363193B2
- Authority
- JP
- Japan
- Prior art keywords
- culture
- membrane
- filtration
- tank
- metabolites
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001914 filtration Methods 0.000 claims description 51
- 239000012528 membrane Substances 0.000 claims description 47
- 239000002207 metabolite Substances 0.000 claims description 29
- 230000001580 bacterial effect Effects 0.000 claims description 26
- 239000001963 growth medium Substances 0.000 claims description 10
- 230000002441 reversible effect Effects 0.000 claims description 10
- 238000012258 culturing Methods 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 238000012136 culture method Methods 0.000 claims description 4
- 239000012737 fresh medium Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 description 17
- 241000894006 Bacteria Species 0.000 description 11
- 239000002609 medium Substances 0.000 description 10
- 230000012010 growth Effects 0.000 description 9
- 239000012466 permeate Substances 0.000 description 8
- 235000015097 nutrients Nutrition 0.000 description 7
- 230000007423 decrease Effects 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 238000011001 backwashing Methods 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000034655 secondary growth Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- 241001148470 aerobic bacillus Species 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59211747A JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59211747A JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6188872A JPS6188872A (ja) | 1986-05-07 |
| JPS6363193B2 true JPS6363193B2 (enrdf_load_stackoverflow) | 1988-12-06 |
Family
ID=16610912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59211747A Granted JPS6188872A (ja) | 1984-10-09 | 1984-10-09 | 高濃度連続培養方法及び装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6188872A (enrdf_load_stackoverflow) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022742A (en) * | 1986-11-26 | 2000-02-08 | Kopf; Henry B. | Culture device and method |
| US4885087A (en) * | 1986-11-26 | 1989-12-05 | Kopf Henry B | Apparatus for mass transfer involving biological/pharmaceutical media |
| JP2520155B2 (ja) * | 1988-08-03 | 1996-07-31 | 田辺製薬株式会社 | 生体触媒を用いる反応方法およびその反応装置 |
| WO1990002171A1 (en) * | 1988-08-31 | 1990-03-08 | Cellco Advanced Bioreactors, Inc. | In vitro cell culture reactor |
| US5656421A (en) * | 1990-02-15 | 1997-08-12 | Unisyn Technologies, Inc. | Multi-bioreactor hollow fiber cell propagation system and method |
| JP2000224822A (ja) | 1998-06-29 | 2000-08-11 | Mitsubishi Electric Corp | 電動パワーステアリング装置用モータ |
| US8026096B1 (en) * | 1998-10-08 | 2011-09-27 | Protein Sciences Corporation | In vivo active erythropoietin produced in insect cells |
| JP2005261342A (ja) * | 2004-03-19 | 2005-09-29 | Yanmar Co Ltd | プランクトン培養システム |
| BR122021001466B1 (pt) * | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| CN107849590A (zh) * | 2015-08-07 | 2018-03-27 | 罗地亚经营管理公司 | 通过发酵改进的香兰素的生产 |
| CN113634125A (zh) * | 2021-10-18 | 2021-11-12 | 深圳市路阳农业科技有限公司 | 一种碱性微生物培养液浓缩过滤装置 |
-
1984
- 1984-10-09 JP JP59211747A patent/JPS6188872A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6188872A (ja) | 1986-05-07 |
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