JPS61502466A - マイコプラズマのような微生物による病気に対するワクチン、その調整および活性因子としての微生物膜 - Google Patents
マイコプラズマのような微生物による病気に対するワクチン、その調整および活性因子としての微生物膜Info
- Publication number
- JPS61502466A JPS61502466A JP60502608A JP50260885A JPS61502466A JP S61502466 A JPS61502466 A JP S61502466A JP 60502608 A JP60502608 A JP 60502608A JP 50260885 A JP50260885 A JP 50260885A JP S61502466 A JPS61502466 A JP S61502466A
- Authority
- JP
- Japan
- Prior art keywords
- mycoplasma
- membrane
- microorganism
- vaccine
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title claims description 50
- 241000204031 Mycoplasma Species 0.000 title claims description 43
- 239000012528 membrane Substances 0.000 title claims description 39
- 244000005700 microbiome Species 0.000 title claims description 27
- 201000010099 disease Diseases 0.000 title claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 18
- 230000000813 microbial effect Effects 0.000 title description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
- 241000282887 Suidae Species 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 13
- 229920000936 Agarose Polymers 0.000 claims description 10
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 206010035664 Pneumonia Diseases 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000002255 vaccination Methods 0.000 claims description 7
- 210000000170 cell membrane Anatomy 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000002054 inoculum Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 230000003698 anagen phase Effects 0.000 claims description 3
- 238000003306 harvesting Methods 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 238000009738 saturating Methods 0.000 claims description 2
- 230000007717 exclusion Effects 0.000 claims 2
- 241001463392 Anoplophora macularia Species 0.000 claims 1
- 229920000832 Cutin Polymers 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 description 12
- 208000015181 infectious disease Diseases 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 239000000872 buffer Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 230000007170 pathology Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 230000003902 lesion Effects 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 238000009395 breeding Methods 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 210000003022 colostrum Anatomy 0.000 description 2
- 235000021277 colostrum Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009313 farming Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 208000012153 swine disease Diseases 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 241000203024 Acholeplasma Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241000196742 Mycoplasma equigenitalium Species 0.000 description 1
- 241000204022 Mycoplasma gallisepticum Species 0.000 description 1
- 241000202938 Mycoplasma hyorhinis Species 0.000 description 1
- 241001148555 Mycoplasma meleagridis Species 0.000 description 1
- 241000202936 Mycoplasma mycoides Species 0.000 description 1
- 241000202935 Mycoplasma mycoides subsp. mycoides Species 0.000 description 1
- 241000204003 Mycoplasmatales Species 0.000 description 1
- 241000337007 Oceania Species 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- CJPQIRJHIZUAQP-MRXNPFEDSA-N benalaxyl-M Chemical compound CC=1C=CC=C(C)C=1N([C@H](C)C(=O)OC)C(=O)CC1=CC=CC=C1 CJPQIRJHIZUAQP-MRXNPFEDSA-N 0.000 description 1
- -1 beta-propio Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000006538 friis medium Substances 0.000 description 1
- 235000013882 gravy Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000012017 passive hemagglutination assay Methods 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- WNRDTCFXPXEVMO-UHFFFAOYSA-M sodium;2-ethoxybenzoate Chemical compound [Na+].CCOC1=CC=CC=C1C([O-])=O WNRDTCFXPXEVMO-UHFFFAOYSA-M 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- HQOJMTATBXYHNR-UHFFFAOYSA-M thallium(I) acetate Chemical compound [Tl+].CC([O-])=O HQOJMTATBXYHNR-UHFFFAOYSA-M 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8409422A FR2565825B1 (fr) | 1984-06-15 | 1984-06-15 | Vaccin contre les maladies dues a des microorganismes tels que des mycoplasmes, sa preparation et membranes de microorganismes en tant que principe actif |
| FR84/09422 | 1984-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61502466A true JPS61502466A (ja) | 1986-10-30 |
Family
ID=9305083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60502608A Pending JPS61502466A (ja) | 1984-06-15 | 1985-06-14 | マイコプラズマのような微生物による病気に対するワクチン、その調整および活性因子としての微生物膜 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0185042B1 (enExample) |
| JP (1) | JPS61502466A (enExample) |
| DE (1) | DE3574109D1 (enExample) |
| DK (1) | DK162509C (enExample) |
| FR (1) | FR2565825B1 (enExample) |
| WO (1) | WO1986000019A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63258427A (ja) * | 1987-03-26 | 1988-10-25 | エム エル テクノロジー ベンチヤーズ エルピー | マイコプラズマ肺炎用ワクチン |
| JP2009541448A (ja) * | 2006-06-29 | 2009-11-26 | メナリニ インターナショナル オペレーションズ ルクセンブルグ ソシエテ アノニマ | 抗イデオタイプ抗体である抗ｃａ−１２５及びアルミニウム誘導体を含有する医薬組成物 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU622855B2 (en) * | 1986-07-25 | 1992-04-30 | Synergen, Inc. | Polypeptides useful in diagnosis of mycoplasma infections in swine and recombinant-dna methods for manufacturing same |
| US5225324A (en) * | 1987-04-24 | 1993-07-06 | Bioscience International, Inc. | Diagnostics for mycobacteria in public health, medical, and veterinary practice |
| GB8709803D0 (en) * | 1987-04-24 | 1987-05-28 | Mcfadden J J | Treatment of crohn's disease &c |
| US4985243A (en) * | 1988-01-20 | 1991-01-15 | Ml Technology Ventures, L.P. | Composition and method for protecting against diseases caused by microorganisms |
| US4873937A (en) * | 1988-01-28 | 1989-10-17 | Nordson Corporation | Method and apparatus for spraying powder into a continuous tow |
| DE3809796A1 (de) * | 1988-03-23 | 1989-10-05 | Wolfgang Prof Dr Med Bredt | Verfahren zum reinigen eines 168 kd-proteins von mycoplasma pneumoniae |
| ATE134705T1 (de) * | 1988-06-29 | 1996-03-15 | Ml Technology Ventures | Rekombinantes hyopneumoniae antigen und dessen verwendung |
| DE69027112T2 (de) * | 1989-01-23 | 1997-01-09 | Auspharm International Ltd 4Th | Impfstoffzusammensetzung |
| US5338543A (en) * | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| USRE39494E1 (en) * | 1992-02-27 | 2007-02-27 | Intervet Inc. | Inactivated mycoplasma hyopneumoniae and uses therefor |
| US7943352B2 (en) * | 2006-03-29 | 2011-05-17 | Bacoustics, Llc | Apparatus and methods for vaccine development using ultrasound technology |
| ME01000B (me) | 2007-11-06 | 2012-10-20 | Zoetis Services Llc | Živa vakcina avirulentne mycoplasma hyopneumoniae sa adjuvansom |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5540568B2 (enExample) * | 1972-10-05 | 1980-10-18 |
-
1984
- 1984-06-15 FR FR8409422A patent/FR2565825B1/fr not_active Expired - Lifetime
-
1985
- 1985-06-14 WO PCT/FR1985/000152 patent/WO1986000019A1/fr not_active Ceased
- 1985-06-14 JP JP60502608A patent/JPS61502466A/ja active Pending
- 1985-06-14 DE DE8585902582T patent/DE3574109D1/de not_active Expired
- 1985-06-14 EP EP19850902582 patent/EP0185042B1/fr not_active Expired
-
1986
- 1986-02-14 DK DK071686A patent/DK162509C/da not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63258427A (ja) * | 1987-03-26 | 1988-10-25 | エム エル テクノロジー ベンチヤーズ エルピー | マイコプラズマ肺炎用ワクチン |
| JP2009541448A (ja) * | 2006-06-29 | 2009-11-26 | メナリニ インターナショナル オペレーションズ ルクセンブルグ ソシエテ アノニマ | 抗イデオタイプ抗体である抗ｃａ−１２５及びアルミニウム誘導体を含有する医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0185042A1 (enExample) | 1986-06-25 |
| DK162509C (da) | 1992-03-30 |
| DK162509B (da) | 1991-11-11 |
| FR2565825B1 (fr) | 1990-07-13 |
| DK71686D0 (da) | 1986-02-14 |
| DK71686A (da) | 1986-02-14 |
| FR2565825A1 (fr) | 1985-12-20 |
| DE3574109D1 (en) | 1989-12-14 |
| WO1986000019A1 (fr) | 1986-01-03 |
| EP0185042B1 (fr) | 1989-11-08 |
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