JPS61210030A - 抗腫瘍剤 - Google Patents
抗腫瘍剤Info
- Publication number
- JPS61210030A JPS61210030A JP4989485A JP4989485A JPS61210030A JP S61210030 A JPS61210030 A JP S61210030A JP 4989485 A JP4989485 A JP 4989485A JP 4989485 A JP4989485 A JP 4989485A JP S61210030 A JPS61210030 A JP S61210030A
- Authority
- JP
- Japan
- Prior art keywords
- tocotrienol
- active ingredient
- antitumor agent
- deodorized
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 title claims abstract description 7
- 229930003802 tocotrienol Natural products 0.000 claims abstract description 12
- 239000011731 tocotrienol Substances 0.000 claims abstract description 12
- 235000019148 tocotrienols Nutrition 0.000 claims abstract description 12
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 3
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims description 6
- 229940068778 tocotrienols Drugs 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 abstract description 6
- 239000003925 fat Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 238000002347 injection Methods 0.000 abstract description 3
- 239000007924 injection Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 244000043261 Hevea brasiliensis Species 0.000 abstract description 2
- 239000011230 binding agent Substances 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 abstract description 2
- 239000002270 dispersing agent Substances 0.000 abstract description 2
- 239000000839 emulsion Substances 0.000 abstract description 2
- 239000004816 latex Substances 0.000 abstract description 2
- 229920000126 latex Polymers 0.000 abstract description 2
- 239000003094 microcapsule Substances 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 239000003755 preservative agent Substances 0.000 abstract description 2
- 239000000725 suspension Substances 0.000 abstract description 2
- 241000905957 Channa melasoma Species 0.000 abstract 1
- 239000004606 Fillers/Extenders Substances 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 6
- 239000008158 vegetable oil Substances 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- 229940064063 alpha tocotrienol Drugs 0.000 description 4
- RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 description 4
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 description 4
- 235000019145 α-tocotrienol Nutrition 0.000 description 4
- 239000011730 α-tocotrienol Substances 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 235000019871 vegetable fat Nutrition 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- GXJLQJFVFMCVHG-QXMHVHEDSA-N 2-methylpropyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C)C GXJLQJFVFMCVHG-QXMHVHEDSA-N 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920003211 cis-1,4-polyisoprene Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4989485A JPS61210030A (ja) | 1985-03-13 | 1985-03-13 | 抗腫瘍剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4989485A JPS61210030A (ja) | 1985-03-13 | 1985-03-13 | 抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61210030A true JPS61210030A (ja) | 1986-09-18 |
| JPS6222966B2 JPS6222966B2 (enExample) | 1987-05-20 |
Family
ID=12843732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4989485A Granted JPS61210030A (ja) | 1985-03-13 | 1985-03-13 | 抗腫瘍剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61210030A (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0242030A (ja) * | 1987-08-25 | 1990-02-13 | Nisshin Flour Milling Co Ltd | イソプレノイド誘導体とそれを含有する抗潰瘍剤 |
| US5015661A (en) * | 1988-08-09 | 1991-05-14 | Hoffmann-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
| US5132310A (en) * | 1988-08-09 | 1992-07-21 | Hoffmann-La Roche Inc. | Pharmacologically active chromanes |
| US5260294A (en) * | 1988-08-09 | 1993-11-09 | Hoffman-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
| EP2143793A4 (en) * | 2007-03-27 | 2010-06-30 | Bridgestone Corp | GENES OF ENZYMES INVOLVED IN THE VITAMIN E-BIOSYNTHESIS IN THE RUBBER TREE |
-
1985
- 1985-03-13 JP JP4989485A patent/JPS61210030A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0242030A (ja) * | 1987-08-25 | 1990-02-13 | Nisshin Flour Milling Co Ltd | イソプレノイド誘導体とそれを含有する抗潰瘍剤 |
| US5015661A (en) * | 1988-08-09 | 1991-05-14 | Hoffmann-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
| US5132310A (en) * | 1988-08-09 | 1992-07-21 | Hoffmann-La Roche Inc. | Pharmacologically active chromanes |
| US5260294A (en) * | 1988-08-09 | 1993-11-09 | Hoffman-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
| EP2143793A4 (en) * | 2007-03-27 | 2010-06-30 | Bridgestone Corp | GENES OF ENZYMES INVOLVED IN THE VITAMIN E-BIOSYNTHESIS IN THE RUBBER TREE |
| US8372616B2 (en) | 2007-03-27 | 2013-02-12 | Bridgestone Corporation | Homogentisic acid geranylgeranyl transerase polypeptide |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6222966B2 (enExample) | 1987-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |