JPS61183207A - Solubilized water-based clear cosmetic - Google Patents

Abstract

PURPOSE:To produce the titled composition giving mild and pleasant feeling to the skin, and having excellent applicability, storage stability and appearance, by solubilizing an oily substance uniformly in water in transparent state with a specific mono-O-acyl-3-glycerylphosphorylinositol. CONSTITUTION:The objective solubilized water-based transparent cosmetic acting mildly to the skin an hair, giving excellent feeling to the skin, having excellent applicability, storage stability and appearance 9clarity and transpar ency), is produced by using (A) a solubilizing agent consisting of one or more compounds selected from 1 (or 2)-palmitoyl-3-glycerylphosphorylinositol and 1 (or 2)-stearoyl-e-glycerylphosphorylinositol of formula I-formula IV and (B) an oily substance, as main components. the amount of the component A is 0.001-5wt%, preferably 0.01-1wt%, and that of the component B is 0.0001-1wt%, preferably 0.001-0.3wt% based on the whole cosmetic prepara tion.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention provides a method for transparently and uniformly solubilizing oily substances in water by using specific mono-0-acyl-8-glycerylphosphorylinositol described below as a solubilizing agent. , relates to a transparent aqueous liquid cosmetic.

More specifically, the present invention relates to a solubilized water-based transparent cosmetic that has a mild effect on skin and hair, gives a good feel, is excellent in usability and storage stability, and has a good appearance (clear and transparent).

(Prior art) Conventionally, synthetic surfactants have been used as solubilizers in solubilized transparent cosmetics such as Rosilon, but synthetic surfactants have the disadvantage of easily causing skin irritation. .

On the other hand, lecithins such as egg yolk lecithin and soybean lecithin are known as natural emulsifiers that are mild to the skin. It has drawbacks such as becoming cloudy and easily deteriorating in quality and changing odor during long-term storage. Therefore, lecithins cannot transparently solubilize oily substances in water, and cannot produce solubilized water-based transparent cosmetics as described below.

(Problems to be Solved by the Invention) As a result of intensive research to develop a phospholipid-based solubilizer that improves the drawbacks of the prior art, the present inventors found that Inositol does not irritate the skin, is stable, dissolves transparently in water, solubilizes oil-based substances transparently in water, acts mildly on the skin, gives a good feeling, and is easy to use.
The present invention was completed based on the discovery that it is possible to easily produce a solubilized water-based transparent cosmetic with good storage stability and appearance.

The object of the present invention is to provide a solubilized water-based transparent product that has a mild effect on the skin and hair, gives a good feeling, is excellent in usability and storage stability, and has a good appearance (clear, transparent). Our goal is to provide cosmetics.

Another object of the present invention is to provide a novel solubilizing agent useful for solubilized aqueous transparent cosmetics.

(Means for Solving the Problems) The above-mentioned object consists of a solubilizing agent, an oily substance, and water as the main components, and as a solubilizing agent, 1-palmitoyl-3-glycerylphosphorylinositol, 2-palmitoyl -3-glycerylphosphorylinositol, ■-
Mono-acyl-8 selected from the group consisting of stearoyl-8-glycerylphosphorylinositol, 2-stearoyl-8-glycerylphosphorylinositol
- With a solubilized water-based transparent cosmetic containing at least one of glycerylphosphorylinositol,
achieved.

The specific mono-0-acyl-8-glycerylphosphorylinositol in the present invention is a known compound and is represented by the following structural formulas (1) to (4).

(1) 1-Palmitoyl-3-glycerylphosphorylinositol H2C--0-C-(CH2)14 CH8(2)
2-Palmitoyl-3-glycerylphosphorylinositol (3) 1-stearoyl-8-glycerylphosphorylinositol H2C-〇-C-(CH2)16CH8-C-OH (4) 2-stearoyl-8-glycerylphosphorylinositol H2C-0HQ H-C-〇-C-(CH2)16cH8 The above-mentioned specific 7-no〇-acyl,-8-glycerylphosphorylinositol can be obtained, for example, by using phosphtidylinositol as a raw material, snake venom phosphoryl/so-7, or pig pancreas extract enzyme. It is obtained by treating with pancreatin and fractionating by high performance liquid chromatography.

The above-mentioned specific mono-0-acyl-8-glycerylphosphorylinositol is safe for the human body, and its skin irritation was evaluated according to the Dralze method described later, and both the animal skin irritation score and the human skin irritation score were 0 (zero), confirming that it is non-irritating.

[Draize, J.H., As5ociation
of Food and Drug official
of the United 5tates,'
Appraisal of the 5afiety of
Chemicals in Foods, Dru
gsand Cosmetics', 46 (1
969).

Texas, 5tate Department of
Health, Au5tin, ] In the present invention, the above-mentioned specific mono-0-acyl-8-glycerylphosphorylinositol is used singly or in combination as a solubilizing agent.

The usage amount (compounding amount) is from 0.001 to 0.001 based on the total weight of the prescription ingredients in the cosmetic (composition weight).
5% by weight, preferably 0.01-1% by weight. 0.
When the amount is less than 0.001% by weight, the solubilization of the oily substance tends to deteriorate, and when it is more than 5% by weight, the solubility in the system decreases and it tends to become cloudy.

The oily substances used in the present invention refer to oily substances in a broad sense, including oil-soluble fragrances extracted from natural animals and plants, synthetic oil-soluble fragrances, and oil-soluble vitamins (e.g., vitamin A, vitamin D, vitamin E, vitamin F, vitamins in the vitamin group, pyridoxine caprilate, pyridoxine cybalmitate, dl-α-tocopherol acetate, d nicotinic acid
vitamin derivatives such as l-α-tocopherol, ascorbyl civalmitate, ascorbyl monopalmitate, ascorbyl monostearate, etc.), oil-soluble hormones (e.g., estradiol, ethinylestradiol, estrone, diethylstilbestrol, etc.), oil-soluble Pigments (e.g., Sudan ■, tetrabromofluorescein, dibromefluorescein, fluorescein, quinizarin green SS, etc.), oil-soluble ultraviolet absorbers (e.g., oxybenzone, 2,5-diisopropyl methyl cinnamate, etc.), animal and vegetable oils (e.g., avocado oil, olive oil, almond oil, palm oil, etc.), higher aliphatic hydrocarbons (e.g., liquid paraffin, squalane, etc.), higher fatty acids (e.g., isostearic acid, oleic acid, etc.)
, higher alcohols (eg, isostearyl alcohol, ophthaldodecanol, etc.), ester oils (eg, isopropyl myristate, octyldodecyl myristate, etc.), and the like. These oily substances may be used singly or in combination. The blending amount is 0.0001-1% by weight, preferably 0.001-0.8% by weight, based on the total weight of the prescription ingredients. 0.00
If the amount is less than 1% by weight, the unique characteristic effects of the oily substance will be reduced, and if it is more than 1% by weight, it tends to be difficult to solubilize.

The amount of water in the present invention is 50 to 99.9% by weight, preferably 60 to 96% by weight, based on the total weight of the prescription ingredients.

In the solubilized aqueous transparent cosmetic composition of the present invention, the inclusion of alcohol is not an essential requirement.

Also, by adding and mixing an appropriate amount of alcohol, a refreshing feeling can be imparted and the drying speed can be improved. The amount of alcohol blended is at most 80% by weight, preferably 5 to 20% by weight.

Further, when the solubilized aqueous transparent cosmetic composition of the present invention is a two-layer conditioner lotion or the like, required known pigments are further added and blended. The amount of pigment added is at most 10% by weight.
, preferably 0.5 to 5% by weight. Examples of pigments include kaolin, mica, sericite, talc, yellow iron oxide, red iron oxide, and the like.

In addition, the solubilized aqueous transparent cosmetic of the present invention may further contain known additive ingredients such as a known humectant, a skin or hair nutrient, a water-soluble pigment, an ultraviolet absorber, and an astringent, if necessary. may be blended.

The solubilized water-based transparent cosmetics of the present invention include, for example, skin conditioning lotion, wiping lotion, softening lotion, Akio-Net Treatment Mend lotion, aftershave lotion, II-type conditioning lotion, cleansing lotion, It is useful as a hair tonic, etc.

Examples will be described below.

The parts shown in the examples mean parts by weight. The characteristics (appearance, feel during use, etc.) of the transparent cosmetics shown in Examples were examined by eight specialized inspectors. The appearance was determined visually, and the tactile effects of the sample compositions were examined, such as the feel when applied to the skin (light feeling, wet feeling, sticky feeling), and the finish after application.

Example 1 (Skin conditioning lotion) (1) Prescription ■ 1-palmitoyl-3-glycerylphosphorylinositol 0.2 parts ■ Fragrance (lavender oil) 0.05 parts ■ Methyl paraoxybenzoate 0.1 part ■ Purified water 9
9.65 parts (2) Manufacturing method The above component (2) is mixed and dissolved in a portion of component (2), and component (2) is dispersed and dissolved therein. Next, a mixed and dissolved solution of component (2) was added to the remainder of component (2) and mixed uniformly to obtain a skin conditioning lotion of the present invention.

This skin lotion had a transparent appearance. This skin lotion is easy to apply and has a smooth finish after application, and
It had a good moist feel.

Comparative Example 1 Except for not using 1-palmitoyl-3-glycerylphosphorylinositol and using 99.85 parts of water,
A comparative skin lotion was prepared in the same manner as in Example 1. As a result, the appearance of the obtained skin lotion was noticeably cloudy and
The perfume particles were floating, the finish after application was not smooth, and it was not possible to give a moist feeling to the skin.

Comparative Example 2 A comparative skin lotion was prepared in the same manner as in Example 1, except that phosphatidylinositol was used instead of 1-palmitoyl-3-glycerylphosphorylinositol. As a result, the appearance of the obtained skin conditioning lotion was cloudy, the finish after application was not smooth and sticky, and it was not possible to impart a moist feeling to the skin.

Comparative Example 8 Example 1 except that egg yolk lecithin was used instead of 1-palmitoyl-3-glycerylphosphorylinositol.
A comparative skin conditioning lotion was prepared in the same manner as above. As a result, the appearance of the skin conditioning lotion obtained was cloudy, the finish after application was not smooth, and it was not possible to impart a moist feeling to the skin. Furthermore, after being left at room temperature for 6 months, the product changed odor and produced a strange odor.

Example 2 (wiping lotion) A wipe-off lotion was prepared according to the formulation based on Table 1. The properties of each of the obtained wipe-off lotions are shown in Table 2.
-The amount of glycerylphosphorylinositol is o, o
A clear wipe-off lotion with a good feel was obtained at oi ~5% by weight (preferably 0.01-1% by weight).

Example 8 (soft lotion) A softening lotion was prepared according to the formulation based on Table 8.

Table 4 shows the properties of the obtained softening lotion. As is clear from this result, the amount of oily substance blended is o, oooi
-1% by weight (preferably 0.01-0.8% by weight) of a clear softening lotion giving a good feel was obtained.

Table 8 (Parts) Table 4 Example 4 (Acne Treatment Lotion) (1) Prescription ■ Ethanol 20 parts ■ Estradiol 0.001 part ■ 1.8-
Butylene glycol 5.0 parts ■ Blue No. 1
0.0001 part ■ Purified water
74.9 parts (2) Manufacturing method The acne treatment lotion of the present invention was prepared by mixing and dissolving component (1) with the above-mentioned component (1), and adding a mixture and dissolving solution of components (1) to (2) to component (2). This acne treatment lotion had a pale blue transparent appearance. And 1. When used, this Acne Treatment Locilon blended well with the skin, had a smooth finish, had a good refreshing feel, and had a good moisturizing effect.

Example 5 (aftershave silane) (1) Prescription ■ Ethanol 80 parts ■ Fragrance (clary sage oil) 0.05 parts ■ Isopropylmethylphenol o, oi parts ■ Vitamin A O, 05 parts ■ 2-palmitoyl-3-glycerylphosphoryl Inositol
0.15 parts■ 2-stearoyl-8-glycerylphosphorylinositol 0.15i■
Polyethylene glycol 200 2.0 parts ■ Purified water 67.59 parts (2) Manufacturing method Mix and dissolve ingredients ■ to ■ in the above ingredient ■, and mix and dissolve ingredients ■, ■ edict, and ■ in component ■. In addition, an aftershave rosylon of the present invention was prepared. When used after shaving, this aftershave lotion
The finish was smooth, had a refreshing, light feel, and was good in that it suppressed itching and damage.

Example 6 (double-layer conditioning treatment) (1
) Prescription■ Ethyl alcohol 10 parts■ Fragrance (hyacinth absolute) 0.1 part■
Zinc sulfate 0.8 parts ■ Zinc white 1.0 parts ■ Red iron
0. Part O1 ■ Talc
1.0 parts■ Sodium carbonate
0.2 parts [phase] Purified water
87.19 parts (2) Manufacturing method Mix and dissolve components (1), (2), and (2) in a part of the [phase] of the above components, and add to this aqueous solution a mixture of components (1) to (2) that have been mixed in advance by drawing and crushing. Disperse uniformly while stirring. Next, a solution of component (■) is gradually added to the remainder of the [phase] of the component while stirring, and then a solution of component (■) in component (■) is uniformly mixed to create the two-layered structure of the present invention. A mold conditioner was prepared.

As a result of investigating the uniform miscibility of this two-layer conditioner guest lotion when shaken, the powder layer and water layer, which had been separated, were mixed together after the required number of shaking four times, and the powder was uniformly mixed in the water. A suspension solution was produced in which the suspension was dispersed in From these results, it was found that this two-layer conditioning lotion can easily be shaken to form a uniformly suspended two-layer conditioning lotion, and can be maintained stably for an appropriate period of time, making it extremely easy to use. admitted. After 1 hour of standing, the product had a beautiful appearance with a clear separation into two layers: a transparent colorless water layer and a pale red powder layer.

presented. ``This two-layer conditioning lotion did not have a sticky feeling when used, had a good feel, smoothness, and refreshing feeling, and had a good finish after application.

Example 7 (Hair Tonic) (1) Prescription■ Ethanol 80 parts■
1-Palmitoyl-3-glycerylphosphorylinositol 0.8 parts ■ Estradiol 0.001 parts ■ Fragrance (clary sage oil) 0.1 parts ■ D-bantothenyl alcohol 0.1 parts ■ Purified water
69 parts (2) Manufacturing method Components (1) to (2) were mixed and dissolved in the above component (1), and a mixture of component (2) and (2) was added thereto to prepare a hair tonic of the present invention. This hair tonic had a transparent appearance. In addition, when this hair tonic was used while massaging the head, it left the scalp and hair smooth and had good moisturizing and hair-nourishing effects.

Procedural amendment (voluntary) September 4, 1985 Patent Application No. 24005 of 1985 2, Name of the invention Solubilized water-based transparent cosmetics 8, Relationship with the case of the person making the amendment Patent applicant address Tokyo 584 Sumida 5-17-4, Sumida-ku
Kanebo Co., Ltd. Patent Department, 1-5-90 Tomobuchi-cho, Bejima-ku, Osaka Telephone: (06) 921-1251 4. Number of inventions increased by amendment None 6. Contents of amendment (1) Memorandum A, No. 5 "1(20-0H0 H-0-0-0-(OH2)+40HIl(3) 1
-stearoyl-8-glycerylphosphorylinositol H2O-0-0-(OH2)+60. ET8E(-0-
0H (4) 2-stearoyl-8-glycerylphosphorylinositol (3) 1-stearoyl-8-glycerylphosphorylinositol H2O-0-0-(OHg) to OHa (4) 2-
Stearoyl-8-glycerylphosphorylinositol

Claims (3)

[Claims] (1) The main constituent components are a solubilizer, an oily substance, and water, and the solubilizers include 1-palmitoyl-3-glycerylphosphorylinositol, 2-palmitoyl-
At least one mono-O-acyl-3-glycerylphosphorylinositol selected from the group consisting of 3-glycerylphosphorylinositol, 1-stearoyl-3-glycerylphosphorylinositol, and 2-stearoyl-3-glycerylphosphorylinositol is blended. A solubilized water-based transparent cosmetic. (2) Claim (1), wherein at least one of the mono-O-acyl-3-glycerylphosphorylinositols is blended in an amount of 0.001 to 5% by weight based on the total weight of the prescription ingredients. The solubilized aqueous transparent cosmetic described above. (3) The solubilized water-based transparent cosmetic according to claim (1), wherein the oily substance is blended in an amount of 0.0001 to 1% by weight based on the total weight of the prescription ingredients.