JP2752231B2 - Solubilized transparent cosmetic - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a solubilized transparent cosmetic, and more specifically,
By incorporating a specific monoacyl-type phospholipid, a specific alkylglycoside, an oily substance and water in combination, the appearance is transparent, the stability over time is excellent, and the sensory properties are excellent (that is, it is good for the skin when applied and used). A solubilized transparent cosmetic material that gives a feel to the skin while giving a feel and has a moist and smooth finish with no sticky feeling).

[Problems to be Solved by Conventional Techniques and Inventions] In recent years, many studies on solubilization have been made. As a result, solubilizers and solubilization techniques have advanced, and very stable solubilized products have been used in many fields.

These solubilizers can be classified into nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

However, these commonly used solubilizers generally have the disadvantage of easily causing irritation to the skin and hair. Even non-ionic surfactants, which are said to have the least irritation, have problems such as poor skin familiarity due to having a polyoxyethylene chain which is a synthetic substance.

Against this background, monoacyl-type phospholipids and alkylglycosides, which are nonionic surfactants having no polyoxyethylene chain and the like, which are naturally occurring substances, have recently attracted attention.

JP-A-61-112007 and JP-A-61-176511 disclose cosmetics containing monoacyl-type phospholipids as transparent cosmetics. However, monoacyl-type phospholipids have low solubility in solvents such as water and alcohols, and solubilized transparent cosmetics containing the same alone have a problem in stability over time under low-temperature conditions. That is, if the cosmetic is stored for a long time at a low temperature, there are problems such that the cosmetic becomes cloudy or precipitates.

JP-A-59-130210 discloses a mild cleaning composition, JP-A-64-25709 discloses a clean room skin cosmetic, and JP-A-01-203036 discloses an emulsion composition and an emulsion composition. There are disclosed cosmetics each containing an alkyl glycoside as a product. However, with these compositions, it is difficult to obtain a solubilized transparent cosmetic which is excellent in all of the appearance characteristics (transparency), aging stability and sensory characteristics, which are the objects of the present invention. Was.

Further, as described above, the solubilizing type transparent cosmetic using only the alkyl glycoside as the solubilizing agent generally has poor solubilizing ability, and particularly when a polar substance such as an ester oil is used as an oily substance, the temperature is low. When stored under conditions (5 ° C. or lower) or high-temperature conditions (40 ° C. or higher), a precipitate is formed or the solution tends to be turbid, and there is a problem in stability over time. Further, further improvement was required in terms of appearance characteristics (transparency), sensory characteristics, and the like.

An object of the present invention is to obtain a solubilized transparent cosmetic having good aging stability and excellent sensory characteristics.

[Means for Solving the Problems] The present invention relates to the following general formula (I) or (II) (In the above formula, R1 is Or X is At least one of monoacyl phospholipids represented by
The following general formula (III): G _n -R ₂ (III) (wherein, R ₂ is an alkyl group or alkenyl group having 8 to 22 carbon atoms, and G is a residue derived from a reducing sugar having 5 to 6 carbon atoms) , N is 1
Represents an integer of from 5 to 5. A solubilized transparent cosmetic comprising at least one of the alkyl glycosides represented by the formula (1), an oily substance and water.

 Hereinafter, the configuration of the present invention will be described in detail.

The compounds represented by the general formulas (I) and (II) in the present invention, that is, mono-O-acyl-3-glyceryl phosphorylcholine, mono-O-acyl-3-glyceryl phosphorylethanolamine, mono-O- Acyl-3-glyceryl phosphoryl inositol includes, for example, 1-palmitoyl-3-glyceryl phosphorylcholine, 1-stearoyl-3-glyceryl phosphorylcholine, 1-palmitoyl-3-glyceryl phosphorylethanolamine, 1
-Stearoyl-3-glycerylphosphorylethanolamine, 1-palmitoyl-3-glycerylphosphorylinositol, 1-stearoyl-3-glycerylphosphorylinositol, 2-palmitoyl-3-glycerylphosphorylcholine, 2-stearoyl-3-glycerylphosphorylcholine, 2- Palmitoyl-3-glycerylphosphorylethanolamine, 2-stearoyl-3-glycerylphosphorylethanolamine, 2-palmitoyl-3-glycerylphosphorylinositol, 2-stearoyl-3
-Glyceryl phosphoryl inositol and the like.

The compounds represented by the above-mentioned general formulas (I) and (II) are treated with, for example, pancreatin, a pancreatic pancreatic enzyme, using phosphatidylcholine, phosphatidylethanolamine obtained from egg yolk or phosphatidylinositol obtained from soybean as a raw material. Obtained by high performance liquid chromatography. Alternatively, it can be obtained by chemical synthesis.

The monoacyl-type phospholipids represented by formulas (I) and (II) in the solubilized transparent cosmetic of the present invention are used alone or in combination of two or more as solubilizers. The compounding amount is preferably 0.001 to 5.0% by weight, particularly preferably 0.01 to 1.0% by weight, based on the total amount of the composition.
It is. If the amount is less than 0.001% by weight, the solubilization of the oily substance tends to be poor. If the amount is more than 5.0% by weight, the solubility in the system tends to decrease, and the oily substance tends to become cloudy, which is not preferable.

Examples of the alkyl glycoside represented by the general formula (III) in the present invention include residues 1 to 5 derived from a reducing sugar having 5 to 6 carbon atoms and having an alkyl or alkenyl group having 8 to 22 carbon atoms at a terminal. It is composed of individual pieces.

As a raw material of G, glucose, galactose, xylose, fructose, mannose, lyxose, apbinose, etc. are used for monosaccharides, and maltose,
Xylopiose, isomaltose, lactose, sucrose, raffinose and the like. Among these, preferred raw materials are glucose, fructose, maltose and sucrose in terms of availability and low cost.
In the case of an alkyl glycoside composed of two or more residues, the sugar chain binding mode is 1-2, 1-3, 1-4, 1-6.
Bonds, furthermore α-, β-pyranoside or furanoside bonds and any mixtures thereof are possible. Accordingly, for example, decyl-β-D-glucoside, tetradecyl-α-D-fructoside, dodecyl-β-D-maltoside, octadecyl-α-D-scroside and the like can be mentioned.

In the present invention, the alkyl glycoside represented by the general formula (III) is used alone or in combination of two or more as a solubilizing agent. The compounding amount is preferably 0.01 to 5.0% by weight, particularly preferably 0.1 to 1.0% by weight, based on the total amount of the composition. If it is less than 0.01% by weight, the solubilization of the oily substance tends to be poor, and if it is more than 5.0% by weight, the feel at the time of use tends to be poor, which is not preferable.

The oily substance used in the present invention means an oily substance in a broad sense, and includes oil-soluble flavors (eg, bergamot oil) extracted from natural animals and plants, synthetic oil-soluble flavors, and oil-soluble vitamins (eg, vitamin A, vitamin D). , Vitamin E, Vitamin F,
Vitamins of the vitamin K group, pyridoxine dicaprylate,
Vitamin derivatives such as pyridoxine dipalmitate, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, ascorbyl dipalmitate, ascorbyl monopalmitate and ascorbyl monostearate),
Oil-soluble hormones (eg, estradiol, ethinylestradiol, estrone, diethylstilbestrol, etc.), oil-soluble pigments (eg, sudan III, tetrabromofluorescein, dibromofluorescein, fluorescein, quinizarin green SS, etc.), oil-soluble UV absorbers (eg, oxybenzone, 2,5-diisopropyl methyl cinnamate, etc.), animal and vegetable oils (eg, avocado oil, olive oil, almond oil, palm oil, etc.), higher aliphatic hydrocarbons (eg, liquid paraffin) , Squalane, petrolatum, ceresin, etc.), higher fatty acids (for example,
Lauric acid, myristic acid, isostearic acid, oleic acid, etc., higher alcohols (for example, laryl alcohol, cetyl alcohol, isostearyl alcohol,
Octyldodecanol, etc.), and ester oils (eg, butyl stearate, hexyl laurate, diisopropyl adipate, isopropyl myristate, octyl dodecyl myristate, etc.).

These oily substances are used alone or in combination of two or more. The amount is based on the total amount of the composition,
Preferably 0.0001 to 1.0% by weight, particularly preferably 0.001 to 1.0%
0.3% by weight. When the amount is less than 0.0001% by weight, the characteristic effect of the oily substance is reduced, and when the amount exceeds 1.0% by weight, the solubilization tends to be difficult, which is not preferable.

As the water in the present invention, purified water such as ion-exchanged water is generally used, and its compounding amount is preferably 50 to 99.0% by weight, particularly preferably 60 to 90% by weight, based on the total amount of the composition.
% By weight.

In the solubilized transparent cosmetic of the present invention, by adding and mixing an appropriate amount of an alcohol in addition to the above essential components, a refreshing feeling can be given and the drying speed can be improved. In this case, the amount of the alcohol is preferably 50% by weight or less, particularly preferably 5 to 30% by weight.

When the solubilized transparent cosmetic of the present invention is a two-layer conditioning lotion or the like, known known pigments can be further added and blended. The amount of the pigment is preferably 10
% Or less, particularly preferably 0.5 to 5% by weight. Examples of the pigment at that time include kaolin, mica, red iron oxide, sericite, talc, zinc oxide, yellow iron oxide, red iron oxide and the like.

The solubilized transparent cosmetic of the present invention may further contain a known moisturizer, a nutrient for the skin or hair, a water-soluble pigment, an ultraviolet absorber, an absorbent, and a water-soluble natural polymer, if necessary. A casein soda, pectin, xanthan gum, karaya gum, locust bean gum, carrageenan, etc., a clouding agent (acrylic styrene copolymer dispersion, etc.), a pearly luster imparting agent (fish scale foil, etc.) and the like may be added.

Examples of the cosmetics of the present invention include skin lotion, wiping lotion, soft lotion, acne treatment lotion, aftershave lotion, cleansing lotion, and hair tonic.

[Examples] Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples. The compounding amount is represented by% by weight. Test methods for appearance characteristics (transparency), aging stability, and sensory characteristics in the examples are as follows.

(1) Appearance characteristics (transparency) The test composition was allowed to stand in a thermostat at 30 ° C for 6 months, and the wavelength was 450 nm.
The transmittance of light having a wavelength of was measured. In addition, when the value is 80% or more, it is transparent even with the naked eye.

(2) Stability over time The sample composition was left in a thermostat at 45 ° C. and 0 ° C. for a maximum of 6 months, and its turbidity, precipitation, and the like were visually inspected.

(3) Sensory characteristics The feeling (freshness, moistness, stickiness, smoothness) at the time of use of the coating and the finish after the coating were examined by three professional inspectors and comprehensively evaluated.

Examples 1 to 5 and Comparative Examples 1 to 2 Toners for skin conditioner Components 1 to 3 in the composition listed in the upper row of Table 1 are mixed and dissolved (solution 1), and components 4 to 8 are separately mixed and dissolved (solution) 2) Mix solution 2 with solution 1 to prepare a skin lotion
The various tests were performed. The results are shown in the lower part of Table 1.

As can be seen from Table 1, the skin lotion of the present invention containing both the monoacyl-type phospholipid and the alkyl glycoside has high transparency and chronological stability despite containing isopropyl myristate which is a polar substance. Excellent. On the other hand, the skin lotions of Comparative Example 1 and Comparative Example 2 lacking either the monoacyl-type phospholipid or the alkyl glycoside had poor transparency and stability over time, and caused cloudiness and oil floating. In addition, the skin lotion of the present invention was superior to the comparative example also in sensory characteristics.

Examples 6 to 9, Comparative Examples 3 to 4 After-shave lotion Components 1 to 6 in the composition shown in the upper row of Table 2 were mixed and dissolved (solution 1), and components 7 and 8 were separately mixed and dissolved (solution 2).
The solution 2 was mixed with the solution 1 to prepare an aftershave lotion, and the above-described tests were performed. The results are shown in the lower part of Table 2.

As can be seen from Table 2, the aftershave lotion of the present invention containing both the monoacyl-type phospholipid and the alkyl chlicoside was excellent in all of transparency, aging stability and sensory characteristics. On the other hand, the after-shave lotions of Comparative Examples 3 and 4 lacking either the monoacyl type phospholipid or the alkyl glycoside cause precipitation, turbidity, and oil floating. Thus, there was a problem in their transparency and stability over time.

Example 10 Double-layer conditioning lotion (composition) (% by weight) 1. Ethanol 10.0 2. Fragrance (bergamot oil) 0.1 3. Zinc sulfate 0.3 4. Zinc oxide 1.0 5. Bengala 0.01 6. Talc 1.0 7. Octadecyl-α -D- scroside 0.05 8. 8. Dodecyl-β-D-maltoside 0.1 9. 2-palmitoyl-3-glyceryl phosphorylethanolamine 0.1 10. Sodium carbonate 0.2 11. Purified water 87.14 Part of component 11 in the above composition Components 3, 7, 8 and 9 are mixed and dissolved, and components 4 to 6 are mixed and stirred in advance in this aqueous solution.
And uniformly dispersed with stirring. Next, a solution obtained by dissolving the component 10 in the remainder of the component 11 was gradually added with stirring, and a solution obtained by dissolving the component 2 in the component 1 was uniformly mixed to prepare a two-layer conditioning lotion of the present invention. Various tests were performed.

As a result of examining the uniform miscibility of the two-layer conditioning lotion during shaking, the separated powder layer and water layer were mixed together with the required number of shaking times of four, and the powder was uniformly dispersed in water. This produced a suspension dispersed in. from this result,
It was recognized that the two-layer conditioning lotion was easily formed into a uniformly suspended two-layer conditioning lotion by shaking, could be stably maintained for an appropriate time, and was extremely easy to use. After one hour of standing, a beautiful appearance was clearly separated into two layers, a transparent colorless aqueous layer and a pale red powder layer.

This two-layer conditioning lotion gave an extremely excellent cosmetic having no sticky feeling at the time of use and a good feel after application.

The two-layer conditioning lotion prepared using other alkyl glycosides in place of dodecyl-β-D-maltoside and octadecyl-α-D-scroside in Example 10 also showed almost the same behavior as in Example 10. .

[Effects of the Invention] The present invention provides a transparent appearance, good day-to-day stability, and a good feel to the skin when used by application by including a specific monoacyl-type phospholipid and a specific alkyl glycoside. It is possible to provide an excellent and useful solubilizing transparent cosmetic which has a familiar skin, a moist and smooth finish and no stickiness.

──────────────────────────────────────────────────続 き Continuation of the front page (58) Field surveyed (Int. Cl. ⁶ , DB name) A61K 7/00-7/50 C11D 1/00-19/00

Claims (1)

(57) [Claims] (1) The following general formula (I) or (II) (In the above formula, R ₁ is Or X is At least one of monoacyl phospholipids represented by
Following general formula _{(III) G n -R 2 ......} (III) ( wherein, R ₂ is an alkyl or alkenyl group having 8 to 22 carbon atoms, G is derived from a reducing sugar having a carbon number of 5 to 6 residues , N is 1
Represents an integer of from 5 to 5. A solubilized transparent cosmetic comprising at least one alkylglycoside represented by the formula (1), an oily substance and water.