JPH03161414A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic, containing lysophosphatidylglycerol as an active ingredient, having excellent humectant performance and improving effects on skin roughening and excellent in feeling of use with low irritancy. CONSTITUTION:A cosmetic obtained by blending lysophosphatidylglycerol as a partial hydrolyzate of the so-called transferred lecithin containing phophatidylglycerol as a chief ingredient or produced by transferring a lyso type phospholipid to glycerol in an amount of 0.1-10wt.%, preferably 0.5-5wt.% in a milky lotion, toilet water, cream, pack, essence, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to cosmetics containing lysophosphatidylglycerol as a highly hydrophilic emulsifier that has excellent moisturizing properties and an effect on improving rough skin.

[Conventional technology] Conventionally, egg yolk lecithin, which is a natural phospholipid compound,
Soybean lecithin or its fractionated extracts and hydrogenated products are used in cosmetics. They function as emulsifiers, preservatives, dispersants, liposome preparation agents, etc.
It was used because it was expected to cause less skin irritation than synthetic surfactants. However, these natural phospholipids are components of biological membranes, and although they are less irritating to the skin and have excellent biocompatibility, they have inferior emulsifying properties and poor solubility in water compared to chemically synthesized products. There were disadvantages such as poor quality and easy deterioration and off-odor generation during long-term storage. Furthermore, there was still room for improvement in various functions such as moisturizing properties and foaming properties.

Various modified lecithins have been developed to compensate for the drawbacks of these lecithins. For example, a water-based transparent cosmetic was produced using lyso-type phosphatidylinositol, which has improved lecithin solubilization performance (Japanese Patent Application Laid-Open No. 183207/1983), and lyso-type phosphatidylcholine also has excellent properties for skin and hair. Disclosed that
No. 243009).

On the other hand, in addition to these lyso-type phospholipids, there are phospholipid derivatives modified using D-type phospholipid-degrading enzymes, among which phosphatidylglycerol (so-called , metastatic lecithin), HLB value (hydrophilic lipophilic ba
It has high expectations for its high solubility and dispersibility. These metastatic lecithins are
By using soybean lecithin, egg yolk lecithin, etc. as starting materials, and using the transfer action of enzymes to replace the hydrophilic phospholipid part with a component (glycerol) that has good hydration properties, it is possible to create natural It is an extremely safe natural material that has been converted into a composition whose main ingredient is phosphatidylglycerol. In addition, its high HLB value,
Because the main component is an anionic surfactant, it is a surfactant with different characteristics from conventional lecithins (so-called phospholipids), and its surfactant and emulsifying effects are used in a wide range of foods and cosmetics. It is known that it is used in industrial products such as (Japanese Patent Application Laid-Open No. 63-245684).

When this phosphatidylglycerol contains a polyunsaturated fatty acid group having two or more double bonds, oxidative stability,
Skin blood flow increase rate (JP-A-64-75409), heat retention (JP-A-64-75409, JP-A-1-17591)
It is known that it can be used as a cosmetic because it is good in terms of No. 5).

[Problems to be Solved by the Invention] The use of phosphatidylglycerol in cosmetics was known from the three prior patents mentioned above. As a cosmetic, it is natural that it is desirable to have a high skin moisture retention property, a long-lasting effect, and a high emulsifying ability, but phosphatidylglycerol is insufficient in this respect.

Phospholipids such as soybean lecithin, egg yolk lecithin, and fractionated lecithin other than phosphatidylglycerol, so-called natural moisturizers such as organic acids, amino acids, and bebutides, and chemically synthesized products such as 1.3-butanediol.
Propylene glycol is also often used as a humectant.

However, although these have excellent heat absorbing properties, they have the disadvantage that their moisturizing ability decreases under low humidity and that the amount of moisturizing is limited for a short period of time. I was never satisfied with these points either.

In order to solve the above-mentioned problems, the present inventors searched for a cosmetic material with better performance, and found that lysophosphatidylglycerol (referred to as LPG) could meet this purpose. It was completed.

[Means for Solving the Problems] The cosmetic according to the wood invention uses LPG as an effective precept.

[Function] LPG can be produced as a partial hydrolyzate of so-called transferred lecithin containing phosphatidylglycerol as a main component, or by transferring lyso-type phospholipids to glycerol.

That is, it can be produced by allowing phospholibase A2 or lipase to act on so-called transferred lecithin containing phosphatidylglycerol to release one molecule of fatty acid in phosphatidylglycerol. Alternatively, it can be produced by using lysophosphatidylcholine or sophosphatidylethanolamine as a phosphatidyl group donor and ester bonding these to glycerol, which is an acceptor for transfer reaction.

The LPG obtained in this way has excellent surfactant ability and antibacterial activity, and is a material that can be widely used in foods, cosmetics, and industrial products by taking advantage of these functions.

Raw materials for LPG production include natural lecithins such as soybean lecithin, egg yolk lecithin, corn lecithin, rapeseed lecithin, and sunflower lecithin, as well as their fractionated concentrates, partial hydrolysates, and hydrogenated products. Chemically synthesized products can be used. By allowing phosphadylation enzyme (PL-D) and fatty acid ester hydrolase (PL-A2, Reverse, etc.) to act on these raw material phospholipids in the presence of an activator such as Ca' or an organic solvent, A lyso-transferred lecithin containing the desired LPG can be produced.

For the purpose of moisturizing properties and improving skin roughness, this LPG can be added in 0.1 to 10% by weight, preferably 0.5 to 5%, to milk products, lotions, creams, packs, essences, etc. to achieve the desired effect. effect can be obtained.

The effect of LPG on improving rough skin is much higher than that of, for example, phosphatidylglycerol, and it has long-lasting moisturizing performance. Furthermore, as a natural material, it is less irritating to the skin and is a cosmetic that is easy to use.

It is thought that LPG's remarkable preservation (star performance) and skin roughness improvement effect depend to a large extent on the hydration of three hydroxyl groups and one phosphoric acid group in the molecule. It is thought that the balance with the groups and the molecular three-dimensional structure of LPG are closely related to the water retention ability and the feeling of use, but the clear mechanism of effect expression is unknown.

[Example] The present invention will be explained below using specific examples.

[Test Method] The cosmetic composition according to the present invention and the comparative cosmetic composition were applied to the inner forearms of 10 female panelists every day for two weeks.

The following day after the two-week application was completed, a test was conducted using the following method.

(1) After washing the test subject's application area with warm water at 37°C, resting in a room with a temperature of 20°C and a humidity of 50% for 30 minutes, the water content of the stratum corneum was measured using a conductance meter (manufactured by IBS, IB
-355).

(2) After resting for 30 minutes under the same conditions as (l),
Create a skin replica and examine the skin surface morphology using a 3D Skin Scanner
(manufactured by Ichimaru Falcos) was used for image analysis.

Example l A milky lotion having the following composition was prepared according to a conventional method.

Composition (milk, night) Comparison product Invention product 1 (wt%) (wt%) Stearic acid 1.0
1.0 to henic acid 0.5
0.5 Ryudo paraffin 3.0
3.0 Octyltodecyl myristate 0
．． 6 0.6 beef tallow 1.2
1.2 Glyceryl monostearate 1.5
1.5POE (25) Monostearate
2.3 2.3 Glycerin
0.25 0.25 xanthan gum
0.2 0.2LPG-30
-3.0LP
G-80 Ethylbaraben 0.1
0.1 Methylparaben 0.2
0.2 Fragrance 0.3 0.3 Purified ice Milk (III2) with the same composition as on the left above was analyzed for stratum corneum water content and skin surface morphology according to the test method above.

The test results for the stratum corneum water content are shown in Table 1 below.

As is clear from Table 1, it was found that the moisture content of the stratum corneum was increased by the addition of LPG, and it was found that the cosmetic composition of the present invention has excellent maintenance properties.

Furthermore, the results of the skin surface morphology analysis are shown in Table 2 below.

The rough state of the second surface skin means that the skin grooves and skin mounds do not exist in a regular network pattern and are non-uniform. That is, it is thought that the greater the variation in the distance between the skin grooves and the skin ridges, the more severe the rough skin condition is, but as is clear from Table 2, it was found that the rough skin condition was improved by the addition of lysophosphatidylglycerol.

As described above, it was found that products 1 and 2 of the present invention containing lysophosphatidylglycerol had superior heat retention performance and skin roughness improving effect compared to comparative products containing no lysophosphatidylglycerol.

For each of the following Examples, cosmetics having the respective compositions were prepared according to conventional methods, and their maintenance performance and rough skin improvement effects were verified.

Example 2 Composition (lotion) (wt%) ethanol 6,0 glycerin
2.01-3 Ptylene gellicol
20 Methylparaben 0.
2LPG-301
．． 0 Perfume purified water 0.2 Example 3 with total as 100 Composition (Lotion) Ethanol POE (24) Hydrogenated castor oil 1-3 Butylene glycol Methylparaben LPG-80 Perfume purified ice (wt%) 8.0 1. 0 2.0 02 30 0.2 Example 4 where all numbers are 100 Composition (Cream) Squalane vaseline stearate cetanol jojoba 7 piles (% by weight) 10.0 6,0 4,0 2.0 20 d1-α- Tocopherol poε(20) Behenyl ether glyceryl monostearate Glycerin I-3 Butylene glycol Potassium hydroxide Methyl rose hemp tyll paraben LPG-30 Flavor purified ice 0.2 2.0 4,0 3.0 2.0 0,2 02 0I 1.0 0.2 Example 5 with all numbers set at 100 Composition (cream) Liquid paraffin squalane vaseline Beeswax Cetano stearate (wt%) 60 15.0 9.0 4.0 05 2.0 POE (20) Sorbitan Monostearate Glyceryl Monostearate 1-3 Butylene Glycol 2 Example 6 Composition (Emulsion) Cetyl stearate Vaseline Squalane POE (10) Cetyl ether sorbitan monostearate Glycerin 1-3 Butylene glycol (% by weight) 2.0 1.0 40 60 0.6 1.5 2 .0 60 Carboxyvinyl Polymer Potassium Hydroxide Methylparaben Butylparaben LPG-30 Perfume Purified Water 0.2 0.2 0.2 0.1! ．． 0 0.2 Example 7 with total as 100 Composition (milk) (wt%) Stearic acid 1.0 Behenic acid
0.5 squalane
60 Vaseline
2, OPOE (201 Zorbitan Monostearate 2,5 Glyceryl Monostearate
1.5 Jojoba oil 4
．． 01-3 Butylene glycol 3.0 Xanthan gum 6.2 Methylparaben 0.2 Butyl paraben LPG-80 Fragrance purified ice 0.1 3,0 0.2 Example 8 with the total as 100 Composition (pack) Ethanol polyvinyl alcohol POE (5) POP Glycol (35) 13 Butylene Gelicol Methylparaben LPG-3 0 Perfume Purified Water (wt%) 10.0 15.0 1.0 6.0 0.2 3.0 0.2 The whole is 100 Example 9 Composition (Paste pack) Ethanol polyvinyl alcohol (% by weight) 12.0 14.0 POE (30) POP glycol (35) Titanium oxide 1-3 butylene glyco. -Methylparaben LPG-80 Perfume ice making l. 0 4,0 4.0 0.2 3.0 0.2 Example 10 where the total is 100 Composition (Essence) Ethanol POE (50) Hydrogenated castor oil carboxyvinyl borimer glycerin 1-3 butylene glycol methyl paraben LPG-30 Flavored purified ice (wt%) 8,0 0.5 0.5 l0.0 10 0 0.2 3.0 0.2 Example 11 where the whole is 100 Essence Ethanol POE (60) Hardened castor Oil Carboxy Vinyl Polymer Sodium Ascorbate Glycerin 1-3 Butylene Glycol Methyl Paraben LPG-80 Perfume Purified Water (wt%) 6.0 1.0 0.3 l0 5.0 10.0 0.2 3.0 (1. 2 The cosmetics of the present invention obtained in Examples 2 to 11, where the total score is 100, all exhibited excellent effects on improving rough skin and heat retention performance.

[Effects of the Invention] As explained above, since the cosmetic of the present invention contains LPG as an active ingredient, it is a hypoallergenic cosmetic that has excellent heat retention performance and an effect on improving rough skin, and is comfortable to use. It has effects such as being able to manufacture.

Claims (1)

[Claims] A cosmetic characterized by containing lysophosphatidylglycerol as an active ingredient.