JPS61131746A - 凍結乾燥製剤用止栓 - Google Patents
凍結乾燥製剤用止栓Info
- Publication number
- JPS61131746A JPS61131746A JP59253050A JP25305084A JPS61131746A JP S61131746 A JPS61131746 A JP S61131746A JP 59253050 A JP59253050 A JP 59253050A JP 25305084 A JP25305084 A JP 25305084A JP S61131746 A JPS61131746 A JP S61131746A
- Authority
- JP
- Japan
- Prior art keywords
- stopper
- weight
- rubber
- polymer block
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims description 11
- 238000004108 freeze drying Methods 0.000 title description 4
- 229920000642 polymer Polymers 0.000 claims description 23
- 229920001971 elastomer Polymers 0.000 claims description 15
- 239000005060 rubber Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 229920005672 polyolefin resin Polymers 0.000 claims description 5
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 4
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 3
- 229920003244 diene elastomer Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 description 16
- 239000000047 product Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 238000000465 moulding Methods 0.000 description 9
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 8
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229920001400 block copolymer Polymers 0.000 description 5
- 238000007906 compression Methods 0.000 description 5
- 230000006835 compression Effects 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000004073 vulcanization Methods 0.000 description 4
- 239000004636 vulcanized rubber Substances 0.000 description 4
- -1 zenten-1 Chemical compound 0.000 description 4
- 230000032798 delamination Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000013557 residual solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000011256 inorganic filler Substances 0.000 description 2
- 229910003475 inorganic filler Inorganic materials 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920002857 polybutadiene Polymers 0.000 description 2
- 239000002952 polymeric resin Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000004711 α-olefin Substances 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229920006038 crystalline resin Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229920001384 propylene homopolymer Polymers 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
Landscapes
- Closures For Containers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59253050A JPS61131746A (ja) | 1984-11-30 | 1984-11-30 | 凍結乾燥製剤用止栓 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59253050A JPS61131746A (ja) | 1984-11-30 | 1984-11-30 | 凍結乾燥製剤用止栓 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61131746A true JPS61131746A (ja) | 1986-06-19 |
| JPH033493B2 JPH033493B2 (enrdf_load_stackoverflow) | 1991-01-18 |
Family
ID=17245782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59253050A Granted JPS61131746A (ja) | 1984-11-30 | 1984-11-30 | 凍結乾燥製剤用止栓 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61131746A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01193352A (ja) * | 1988-01-28 | 1989-08-03 | Mitsubishi Petrochem Co Ltd | 熱可塑性エラストマー組成物 |
| EP0415653A3 (en) * | 1989-08-31 | 1991-04-17 | H.G. Wallace Limited | Intravascular placement apparatus |
| EP0999146A2 (en) | 1998-11-04 | 2000-05-10 | Taisei Plas Co., Ltd. | Pierceable stopper and method of producing the same |
| CN102256584A (zh) * | 2009-03-13 | 2011-11-23 | 安隆化成株式会社 | 医疗容器塞子用弹性体组成物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5759536A (en) * | 1980-09-27 | 1982-04-09 | Terumo Corp | Rubber gasket for vacuum blood sampling tube |
| JPS5858057A (ja) * | 1981-10-02 | 1983-04-06 | テルモ株式会社 | 医療容器用栓体 |
| JPS5928965A (ja) * | 1982-08-11 | 1984-02-15 | テルモ株式会社 | 医療容器用栓体 |
| JPS5967933A (ja) * | 1982-10-08 | 1984-04-17 | テルモ株式会社 | 減圧採血管 |
-
1984
- 1984-11-30 JP JP59253050A patent/JPS61131746A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5759536A (en) * | 1980-09-27 | 1982-04-09 | Terumo Corp | Rubber gasket for vacuum blood sampling tube |
| JPS5858057A (ja) * | 1981-10-02 | 1983-04-06 | テルモ株式会社 | 医療容器用栓体 |
| JPS5928965A (ja) * | 1982-08-11 | 1984-02-15 | テルモ株式会社 | 医療容器用栓体 |
| JPS5967933A (ja) * | 1982-10-08 | 1984-04-17 | テルモ株式会社 | 減圧採血管 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01193352A (ja) * | 1988-01-28 | 1989-08-03 | Mitsubishi Petrochem Co Ltd | 熱可塑性エラストマー組成物 |
| EP0415653A3 (en) * | 1989-08-31 | 1991-04-17 | H.G. Wallace Limited | Intravascular placement apparatus |
| US5122120A (en) * | 1989-08-31 | 1992-06-16 | H G Wallace Ltd. | Intravascular placement apparatus |
| EP0999146A2 (en) | 1998-11-04 | 2000-05-10 | Taisei Plas Co., Ltd. | Pierceable stopper and method of producing the same |
| US6607685B2 (en) | 1998-11-04 | 2003-08-19 | Taisei Plas Co., Ltd. | Method of producing pierceable stopper |
| CN102256584A (zh) * | 2009-03-13 | 2011-11-23 | 安隆化成株式会社 | 医疗容器塞子用弹性体组成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH033493B2 (enrdf_load_stackoverflow) | 1991-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |