JPS6089412A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic useful as a skin cosmetic such as nutritive cream, hand cream, milky lotion, toilet lotion, etc. or a scalp cosmetic, effective for treating chaps, cracks in the skin, or scalp, improving chapped skin, containing a mucopolysaccharide and a brown dyestuff of an extract of crude sugar. CONSTITUTION:A cosmetic containing both a mucopolysaccharide and a substantially pure brown dyestuff extracted from crude sugar. Hyaluronic acid, chondroitin 4-sulfate, and chondroitin 6-sulfate may be preferably cited as the mucopolysaccharide and its amount added is 0.001-5.0wt% preferably 0.05- 3.0wt% based on the total amount of cosmetic. The brown dyestuff extracted from crude sugar, for example, is obtained by dissolving crude sugar in water, treating the solution with an adsorbent, washing the adsorbent with water to remove a sugar component, so that only sugar dyestuff is adsorbed on it. The sugar dyestuff is released by the use of an alcohol, and the eluate is evaporated to dryness under reduced pressure. An amount of the dyestuff added is preferably 0.001-1.0wt%.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel cosmetic that has significantly improved effects on improving rough skin.

The stratum corneum of the skin maintains an appropriate amount of water through water supply from the body and water absorption from the outside, and generally has a water content of 10
~20% amount is said to be optimal. When this amount is less than 10%, the skin becomes dry, so-called rough skin, and in extreme cases, cracks may occur. To solve this problem, cosmetics containing moisturizing agents such as sodium lactate, glycerin, sodium pyrrolidone carboxylate, and propylene glycol have been used.

However, these moisturizers have a physicochemical effect on the surface of the skin and function to supply moisture to the stratum corneum, and this effect is temporary and greatly influenced by environmental conditions. In addition, although it performs its function under high humidity, under low humidity, moisture absorption from the skin increases (as a result, a large amount of moisture is absorbed from the surface of the skin). It also has the disadvantage that it may cause rough skin to deteriorate rather than improve it.

On the other hand, other than the above-mentioned moisturizers, cosmetics containing mucopolysaccharides, raw sugar extracts, etc. have been proposed as having effects such as preventing rough skin, imparting flexibility to the skin, and whitening the skin. In this case, the effect could not be confirmed.

In view of these circumstances, the present inventors conducted extensive research to obtain cosmetics with excellent effects on improving rough skin, and as a result, they discovered that mucopolysaccharide and a substantially pure brown pigment extracted from raw sugar. We have discovered that by blending them together, the objective described in 1 can be achieved, and the effect of improving rough skin increases synergistically compared to when each is used alone.Based on this knowledge, we have completed the present invention. It's arrived.

Specifically, the present invention provides a cosmetic material containing mucopolysaccharide and a substantially pure brown pigment extracted from raw sugar.

Hereinafter, the structure of the present invention will not be described in detail.S0 Mucopolysaccharides used in the present invention include hyaluronic acid, chondroitin tetrasulfur r'llt, and :I7y.

Itin 6 sulfate, dermatan sulfate, chondroitin 4.6
Examples include disulfuric acid, dermatan 4.6 disulfuric acid, keratan sulfate, heparan sulfate, and the like. Among these, hyaluronic acid, chondroitin, Qt acid, and chondroidin hexasulfate are feminine.

The blending amount of mucopolysaccharide is 0.0 in the total amount of the skin cosmetic of the present invention.
If it exceeds 0.01 to 5.0% by weight (hereinafter not simply referred to as %), the solubility becomes poor, the viscosity of the system increases too much, and the system becomes gel-like, which is not preferable.

The properties of the substantially pure brown pigment (hereinafter referred to as sugar pigment a) extracted from raw sugar used in the present invention are already described.

(1) A brown hygroscopic powder with a slightly burnt odor and a slightly bitter taste.

C) Soluble in water bone alcohol, insoluble in benzene-chloroform, ether-hexane, petroleum ether.

(3) 1% aqueous solution shows pl+7.5.

(4) Infrared absorption spectrum = 1 v l1ax (NuJol) cm: 3300.1
590.1020.720(5) Maximum ultraviolet absorption λ■aχ(1120)n■: 272.320(6) 5%
Adding 2-3 drops of the aqueous solution to a boiling Fehling test e 5 cc produces a red precipitate. Even if a ferric chloride test solution is added to a 5% aqueous solution, the result is negative.

No precipitation occurs even when gelatin test solution is added to 5% water + 8 solutions.

(7) Thin layer chromatography When 10 cm of one main island is dissolved in 1 cc of water and tested according to the Japanese Pharmacopoeia General Test Method Section 26 Thin Layer Chromatography method under the following conditions, a single red color with an Rr value of about 0.6 was obtained. Acknowledge the spot.

Amount of sample attached: 10. ．． 2 Support: Nijirica gel 60Fz54 (manufactured by Merck & Co., thickness: 0.25mm) Developing solvent: Chloroform/methanol/water (05:3)
5:10) Lower layer development distance n1: 10 cm Detection: 5 at 105°C after spraying r'-anisaldehyde reagent
According to the elemental analysis (heated for 8 minutes), the constituent elements are nitrogen, oxygen,
Contains carbon and hydrogen.

The above sugar pigment is extracted, for example, as follows.

(1) Raw sugar, or brown sugar, is dissolved in water and treated with an adsorbent. As an adsorbent, a porous cross-linked polystyrene resin adsorbent with a large reticular structure, such as Amberlite XAD, is used.
-1 and D-2 to X (manufactured by Rohm and Haas)
, Selvachrome XAD-Type 2 (manufactured by Selva), etc. are preferably used. Particularly preferred is Selvachrome XAD
- Type 2. This resin is obtained, for example, by suspension polymerization of styrene and divinylbenzene, and its surface is nonpolar. It is generally preferred to use a large amount of adsorbent.

(2) The adsorbent is washed with water to remove the sugar content, leaving only the sugar pigment absorbed.

(3) Desorption of the sugar dye from the adsorbent is preferably carried out using hydrous alcohol with an alcohol concentration of 20% or more. Specifically, for example, most of the sugar dye is eluted with about 20-30% ethanol, and then completely eluted with 95% ethanol.

(4) Evaporate the eluent to dryness under reduced pressure.

Sugar pigments can be extracted by the operations (1) to (4) above. In addition, in the operation (3) above, approximately 9
Elution may be performed using 5% or more alcohol, or the yield will be slightly lower. Moreover, instead of the above operation (4), purification may be performed by recrystallizing from the eluent.

Furthermore, if sugar remains in the eluent,
) is removed separately after the operation. The yield of sugar pigment obtained from brown sugar in this way is approximately 0 of the weight L1 of brown sugar.
．． 05-0.3%. Apart from the above extraction method, sugar pigments can also be obtained by cooling or digesting brown sugar with a lower alcohol such as methanol or ethanol, filtering, and then evaporating to dryness. However, the yield is significantly lower than that of methods using adsorbents.

The extracted sugar pigment appears to be a substantially pure single component based on the thin layer chromatography data mentioned above and does not contain sugar. Therefore, when formulating cosmetics, it can be incorporated into the base completely independently of the sugar content.

The blending amount is 0.0001 to 3.0% by weight, preferably 0.001 to 1.0% by weight.

If it is less than 0.0001% by weight, sufficient effects cannot be expected;
If it is blended in an amount of 3.0% by weight or more, problems such as loss of stability of the system will occur, which is not preferable.

In addition to the above-mentioned essential ingredients, the cosmetics of the present invention usually contain surfactants, oils, humectants, ultraviolet absorbers, alcohols, chelating agents, P11 regulators, preservatives, thickeners, pigments, fragrances, etc. Ingredients used in cosmetics can be blended as appropriate. Of course, these must be within a range that does not impair the effects of the present invention.

The cosmetics of the present invention have an excellent effect on improving rough skin, and can be used as nutritional creams, hand creams, body creams, milky lotions, etc.
It is used not only for skin cosmetics such as lotions and packs, but also for hair cosmetics, especially for the scalp, and is used to treat cracks in winter, chapped skin, rough skin, skin after shaving, rough hands, and scalp damaged by dyed or permed hair. Suitable for cleaning etc.

Next, the effect of the cosmetics of the present invention on improving rough skin will be explained with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

Rough skin improvement effect test method 0 test method th) 14 A woman aged 20 to 40 who has rough skin in winter.The period of time was 2 weeks during winter, and the cosmetics of Comparative Example 1 was applied to one cheek and the other. The cosmetics of Example 1, Comparative Example 2, or 3 of each group were applied to the cheeks of each group at least twice a day, once in the morning and once in the evening.

(Measurement and judgment method) Measurement and judgment were carried out by the following method on the day after the two-week application was completed.

■ TWL E which shows the amount of water insensibly lost from the skin
rvo Mad, Inc.).

The larger the value of this judgment TWL value, the more rough the skin is.

■By collecting skin samples using silicone resin and observing them under a stereomicroscope, we investigated the surface morphology of the skin, which is closely related to the appearance of the skin.

Book judgment It has become.

Comparative Examples 1 to 3 and Example 1 (Production method) ■■■ and ■ are dissolved in [phase]. Separately 70°
Example 1
I got the cream. Comparative Examples 1 to 3 were also produced in the same manner as Example 1. The results are not shown in Table 1. Note that the numbers in the table represent the number of subjects judged for that item.

(Results) 1 As is clear from Table 1, the cosmetic of the present invention has a superior effect on improving rough skin compared to a cosmetic containing sugar pigment and chondroidis/tetrasulfuric acid alone. It was proven that they act synergistically.

Example 2 Lotion ■ Glycerin 3.0 ■ Propylene glycol 4.0 ■ Ethanol 8.0 0 Polyoxyethylene (20 mol) 0.5 Oleyl alcohol ■ Sugar pigment 0.001 ■ Hyaluronic acid 0.001 ■ Co/Droichi / Toru-6 sulfuric acid 0.05 ■Medylbaraben 0.1 ■Citric acid 0.001 [Phase] Sodium citrate 0.1 0Fragrance 0.05 0Ion exchange water 84.197 (Production method) ■■■■■ Add ■■ and [phase] and dissolve at room temperature (Part A). Add ■■■■ and ■ to ■ and dissolve at room temperature (Part B). A lotion was obtained by adding Part B to Part A.

Left Example 3 Scalp Treatment ■Liquid Paraffin 15.0 ■Vaseline 2.0 ■Cetanol 2.0 ■Polyethylene Glycol 1500 7.0 ■Stearic Acid 2.5 ■I'0E (G) Sorbitan Monostearate 1.0
■ Glyceryl More Stearate 1.0 ■ Caustic potash
1.0 ■Shiyuga Ichipigment 0.1 [Phase] Chondroichi/6 Sulfuric Acid 0.001 ■Quinoline Yellow Appropriate amount ■Brilliant blue Appropriate amount [Phase] Fragrance 0.5 ■Iono-exchanged water 67.8 0 Ethylparaben 0.05 ( Manufacturing method) Heat and dissolve ■■■ [phase] ■ and @ in ■ and keep at 70°C (Part A). Mix other ingredients, heat and melt and keep at 70°C (Part B). Part B was added to Part A, mixed by stirring, and then emulsified using a homomixer. After emulsification, cool to 30°C without stirring to make a milky lotion Example 4 Emulsion ■ Stearic acid 2.5 ■ Cedyl alcohol 1.5 ■ Vaseline 5.0 ■ Liquid paraffin 10.0 ■ Polyoxyethylene (10 Mol) 2.0 monooleic acid ester ■Polyethylene glycol 3.0 ■Triethanolamine 1.0 ■Shyuga pigment 0.5 0Fragrance 0.5 0Medylbaraben 0.05 (Production method) [Phase]■■■ Add and heat to dissolve at 7°C.
(Part A). Mix other ingredients, heat and dissolve for 70 minutes.
Keep at °C (Part B). Pre-emulsification was carried out by adding 13 parts to Part A, and the mixture was uniformly emulsified using a homomixer. After emulsification, the mixture was cooled to 30° C. while stirring to obtain a milky lotion.

Example 5 Back vinyl acetate resin! Mulsion 15.0 Polyvinyl alcohol 109O A Liebura 5.0 Glycerin 5.0 Dita oxide/8.0 Kaori 7 7.0 Sodium hexametaphosphate 0.05 Ethyl alcohol 5,0 43, +5 Ion exchange water Fang M catty S. Fragrance 0.3 Ethyl roseoxybenzoate 0.2 (Production method) Wet polyvinyl alcohol with a portion of ethyl alcohol, add it to ion-exchanged water in which titanium oxide, limestone/and sodium hexametaphosphate are dispersed. , 70°C
Heat to and stir to uniformly disperse.

To this, add glycerin, vinyl acetate resin emulsion 9, fragrance dissolved in the remainder of ethyl alcohol, ethyl roseoxybenzoate, and olive oil, stir well to make a uniform paste), and further dissolve in some ion-exchanged water. A bag was obtained by gradually adding sugar pigment and hyaluronic acid.

The cosmetics of Examples 2 to 5 thus obtained were all excellent in improving effects on rough skin.

Applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] A cosmetic product characterized by containing mucopolysaccharide and a substantially pure brown pigment extracted from raw sugar.