JPS6087224A - Emulsion-type dermatic drug for external use - Google Patents

Abstract

PURPOSE:To obtain the titled external drug, by extracting the crude drug such as TOKI (root of Angelica acutiloba), BYAKUSHI (root of Angelica duhurica) and SHIKON (root of Lithospermum erythrorhizon) with a specific organic solvent to obtain an oil phase containing viscous extract, esparately extracting the above crude durg with ethanol to obtain an aqueous phase containing powdery extract, and mixing and emulsifying the oily phase and the aqueous phase. CONSTITUTION:One or more crude drugs selected from TOKI, BYAKUSHI and SHIKON are extracted with an organic solvent having low polarity (e.g. benzene, n- hexane, chloroform, etc.) and the obtained viscous extract is used as a component of an oily phase. Separately, the crude drugs are extracted with a 50-80% ethanol and the obtained powdery extract is used as a component of an aqueous phase. The oily phase is mixed and emulsified with the aqueous phase to obtain the objective emulsion- type dermatic drug for external use. The ethanol fraction extract of the above three kinds of crude drugs contains a component effective to keep the moisture of the skin and give the moistness to the skin. EFFECT:Compared with the simple ethanol extraction of the crude drug, the use of the extraction residue with the organic solvent having low polarity is advantageous, and the extraction efficiency can be improved.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a skin external preparation that retains its medicinal effects,
The present invention relates to a novel emulsified skin preparation for external use that has improved applicability and absorption to the skin and can also provide a skin moisture retaining function.

Since ancient times, Danggui has been widely used in Chinese medicine as a tonic, sedative, and emetic, eight positives as an analgesic, hemostasis, purulent, and purifying agent, and purple root as a detoxifying and antipyretic agent. When using Ton et al., the usual method was to extract it with hot water using the method described above, and then take the extracted liquid internally. However, in China, there are several cases where 8-zheng, dang-gu, etc. were extracted with oil and fat and used as an ointment.

On the other hand, in Japan, there is also something called shiun-yang, which is made by extracting purple root and HII with oil and using it as an ointment.

However, since these known ointments are also extracted with fats and oils, research by the present inventors revealed that 11% of the extracted ingredients are
Although there are components that have antibacterial and anti-inflammatory properties, it has been discovered that there are no components that have aftereffects such as skin moisture retaining and moisturizing effects.

On the other hand, since the above-mentioned euphonic therapy was mainly applied internally, the reality is that there has been little research into the effectiveness of its ingredients externally (especially on the skin). Ta.

Therefore, the present inventors investigated in detail the efficacy of the above-mentioned three types of crude drugs against this skin debris, and found that 50-8
It was discovered that components that retain moisture and moisturize the skin are present in a fractionated extract using 0% ethanol.

Furthermore, in order to further demonstrate the efficacy as an external skin preparation, the three herbal medicines mentioned above were extracted with an organic solvent that has little compatibility with water, and the above 50-80% ethanol fraction was extracted into the oil phase. The present invention has been completed by the knowledge that a topical preparation for skin dregs can be obtained by incorporating the extracts into the aqueous phase and emulsifying them.

The present invention is based on one or two selected types of present invention, eight positive, and purple roots.
An oil phase containing a viscous extract obtained by extracting different types of herbal medicines with a low polarity organic solvent, and
The present invention relates to an emulsified skin shavings external preparation prepared by emulsifying an aqueous phase containing a powdered extract obtained by extraction with 0% ethanol.

In the present invention, the viscous extract contained in the oil phase is prepared by the following method. That is, first, any K11g1 to 2a or more is selected depending on the purpose from five types of herbal medicines: Dangki, 8-sei, and Shikon, and this is used, for example, benzene, which has almost no compatibility with water.

Digestion extraction treatment in a single or mixed solvent of a low polar organic solvent (n-hexane, chloroform, ether, etc.),
The filtered filtrate is obtained by concentrating to dryness by an appropriate method. It is dissolved in ethers, esters, and hydrocarbons used as the oil phase during normal emulsification, and used as the oil phase of the nt-emulsion.

Further, the method for preparing the powdered extract contained in the aqueous phase is as follows. When the three herbal medicines are extracted with 50-80% ethanol at room temperature or by digestion, and the oral fluid is concentrated, a product containing ingredients that retain moisture and moisturize the skin can be obtained. However, from a cost perspective, it is better to extract jILfi from herbal medicines with 50 to 8ON ethanol, but it is better to extract the jILfi after extraction with the organic solvent with low polarity. l! E1! It is more advantageous to use t7, and in order to further improve the extraction efficiency of t7, it is more practical to follow the following alternative method. That is, the main drug is a low polar organic fI! After filtration, the remaining fIi is sufficiently re-extracted with water or hot water. Thereafter, the Cl solution is am+ed to an extent convenient for operation. Next, add alcohol to this and adjust kJ11 so that the alcohol concentration is 50 to 80%. Then, unbathable substances (this substance has almost no water retention ability) will precipitate, so when liquid a is collected and concentrated to dryness, a liquid containing the same components as above is obtained. .

In order to evaluate the water retention function of the extract obtained as described above, the present inventors used exfoliated horns of human feet and performed the following methods 1) and 2). I checked the effect. The results are shown in Tables 1, 2 and 2.

1) Sample 2 using extract A, water soluble, 75% KtOH insoluble part (precipitate) B, water and 75% EtOH soluble part O0 urine cumulative (vs.f!@) p, water (Control) Method C: A corner 5t-1 pressed into a tablet with a thickness of 0.5 amm s and a diameter of 1α was placed in a 5% water bath solution of the above A%B%C and D for 50 minutes! ! Crush it, then drain the excess liquid with tissue A.
+++ Try wiping with A-9. This was left at a constant temperature and humidity of 20°C and 93%, and after 5 days, the moisture remaining (retention) in the stratum corneum ID 011g:
Jtt was measured. n-5゜2) Measurement using cream containing extract #: a
, n-hexane extracted extract' (cream b containing 2 wt% of H, water soluble, cream containing 5 wt% of 75% EtOE insoluble portion (precipitate) 6-cream C0 containing 5 wt% of water and 75% EtOH soluble portion* Cream containing both components (1, A and C (7wt) (product of the present invention) Method O: The same method as in 1) was conducted.n=5゜Table-1 Moisture Retention (Extracted) (n = 5 average value) Table 2 Moisture retention f (cream) (n = 5 average value) As the results in Tables 1 and 2 show, Hakusei, Toki, Shikon water and 751Et
It can be seen that the OI (soluble extracted part) has a clear skin moisture retention effect. Also, in Cream d (product of the present invention) in Table 2, no decrease in the moisture retention effect was observed.
It becomes possible to provide an excellent external preparation for the skin by taking into account the expected effects of Chinese herbal ointments. still.

Just to be sure, we compared the wound healing effects (healing forces, healing days) of commercially available Shiun Gypsum and Cream d of the present invention using rabbits, and found that it had an effect equal to or better than that of Shiun Gypsum. It was.

The emulsified skin preparation obtained by the present invention further has the following advantages and characteristics.

(1) Conventional Chinese herbal ointments are hard and difficult to apply in an appropriate amount, making it difficult to apply them evenly to the skin surface, but emulsification eliminates this drawback.

(21 Chinese medicine soft if extracts with oil at 4 temperatures promotes the oxidation of the oil and fat, but an increase in POV and other factors that have a negative effect on the skin was observed, but this problem has been resolved this time.

(3) By emulsifying, it is possible to use less mulberry than in the case of soft mulberry, which does not absorb the medicinal ingredients well.

9- Examples of the present invention are shown below. The blending ratio in the prescription is n-t''n parts by weight.

Example 1 Mix 100 t of cream and 100 f of s8, and add 1 part of hexane.
Digest twice at t and concentrate the 7'C filtrate to dryness.
Let it be extract 1. Next, the filtered residue was washed with 1.5 tons of hot water for 2 hours.
Extract twice, concentrate the obtained Ω solution appropriately, and add alcohol to adjust the TS content to 80%. Next, the precipitate is mixed, and the 0 liquid is concentrated to dryness to obtain Extract 2.

These extracts 1% extract 2 were blended into the following cream formulation and emulsified.

! l! Example 2 Emulsion Increase Toki, 8 Sei, and Shikon by 709 and mix.

The mixture was digested twice with 1 t of ether, and the filtered Q solution was concentrated to dryness to obtain Extract 1. Next, extract the remaining attenuate twice with 1.5 t of hot water, concentrate the Q solution appropriately, add alcohol,
Adjust the concentration to 70%. This was passed through the mouth, and the 0 solution was concentrated to dryness to obtain Extract 2. Each of these extracts 1 and 2 was distributed into the emulsion formulation shown below and emulsified.

Claims (1)

[Scope of Claims] 1) A viscous extract obtained by extracting one or more selected herbal medicines, such as @ki, 8sei, and purple root, with a low polarity organic solvent. The oil phase and the herbal medicine containing 50 to 80%
An emulsified skin preparation prepared by mixing and emulsifying an aqueous phase containing a powdered extract obtained by extraction with X ethanol. 2) Select a less polar organic solvent such as benzene, n-hexane, chloroform, ether, etc. or the emulsified skin preparation for external use according to claim 1, which is a mixture of two or more. 3) Powdered extraction dI! ! IJ is obtained by re-extracting the extraction residue obtained by extracting mulberry with a low polar organic solvent with 50 to 80% ethanol, as described in claim 1). emulsified skin preparation for external use.