CN105943557A - Anti-rheumatic-arthritis emulsifiable paste composition and preparation method thereof - Google Patents
Anti-rheumatic-arthritis emulsifiable paste composition and preparation method thereof Download PDFInfo
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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Abstract
The invention relates to an anti-rheumatic-arthritis emulsifiable paste composition, and also relates to a preparation method of the anti-rheumatic-arthritis emulsifiable paste composition. The composition contains camel oil, menthol, seabuckthorn oil, an emulsifying agent, an emollient, a humectant, a preservative, a thickening agent, essence and the like. The anti-rheumatic-arthritis emulsifiable paste has the advantages that the paste color is light yellow and glossy; the texture is fine; no irritation is generated on the skin; the release effect is achieved in the aspects of antiinflammation, swelling subsidence, pain ease, wind dispelling, dampness eliminating and the like; the auxiliary treatment function is realized in the aspects of swelling subsidence, pain ease, inflammation diminishing, allergy resistance, wind dispelling and dampness eliminating; good moistening and moisture preserving efficacy are achieved.
Description
[technical field]
The invention belongs to functional food technical field.More particularly it relates to an wind resistance
Wet arthritis antiperspirant cream compositions, further relates to the preparation side of described rheumatism arthritis antiperspirant cream compositions
Method.
[background technology]
Lac Cameli is all the time as traditional food good merchantable brand and the medical cosmetic of the arid-desert areas people
Product, have the good reputation of " desert gold ".As far back as nineteen eighty-two, Lac Cameli is because its biological value is at machine
Important function in terms of body disease resistance mechanisms, among the people is considered as the food with medical care effect it
Product.The most also there is the research of many medical health care functions to Lac Cameli and achieve new progress.
Research shows, Lac Cameli and is easily disappeared by human body in the nutritional labeling of health rich in multiple beneficial
Change and absorb.In addition to containing to other similar nutritional labelings in poultry Ruzhongs, Lac Cameli contain lysozyme,
Content and the structure of the protective proteins such as peroxidase, lactoferrin and immunoglobulin are superior to
Other raise breast, therefore have the effects such as higher sterilization, antiallergic, immunity.Multinomial zoopery is equal
Confirm, Lac Cameli have hemopoietic, invigorate blood circulation, tranquillizing and allaying excitement, enhancing function of liver and spleen, improve pancreatic function,
The liver and the kidney tonifying, lung heat clearing are relieved summer heat, yin nourishing, detoxify, remove the effect such as slough.Also study table
Bright, Kazak traditional zymotic Lac Cameli Carrageenan induced mice foot swelling and cotton balls cause granuloma shape
Cheng Jun has significant inhibitory action and then plays removing slough, antiinflammatory and immunoregulation effect.
In Mongolia, Arabic and some surrounding countries, already among the people Lac Cameli is used for wound disinfection, stops
The external of antiinflammatory and arthritis ache bitterly is smeared, and has obtained good effect.
Record according to Compendium of Material Medica, camel oil have cure mainly insensitive impediment literary excellence, malignant boil poison is swollen, muscle stiff
The effect such as hard.Camel oil is mainly derived from Lac Cameli fat, the fatty and hunchbacked abdominal cavity fat of hump, wherein
Lac Cameli fat is to be heated 30min at temperature 65 DEG C by Lac Cameli, then be centrifugally separating to obtain, hump
Fat and camel abdominal cavity fat are to be dissolved purification with camel abdominal cavity two parts fat through decocting in water by hump to obtain
's.Research finds, Lac Cameli Oil globule particle diameter relatively little Yi is absorbed by the skin, there have skin to be stronger
Permeability, and there is quickening skin metabolism, strengthen the function such as cell viability.Lac Cameli fat
Rich in vitamin C, additionally contain the unsaturated fatty acid of a large amount of needed by human body, ferrum and vitamin
B, Lac Cameli fat can effectively be removed free radical after penetrating into skin, have sterilization antiinflammatory, regulates and exempt from
The effects such as epidemic disease, thus play the pivotal role of conditioning skin.Therefore Lac Cameli becomes natural cosmetics
Primary raw material source.In Egyptian and some countries and regions, the Middle East, the sky with Lac Cameli as raw material
So cosmetics occupy a tiny space in cosmetics industry always, but do not have in other countries
Obtain the enough attention of cosmetic industry personage.Along with the diversification of live element, cosmetics city
Development situation and consumer psychology, natural pollution-free, multifunctional cosmetics is made into for product of improving looks
The Main Trends of The Development of product.Therefore, effect product utilizing Lac Cameli to develop more renewal has emphatically
The meaning wanted.
[summary of the invention]
[solving the technical problem that]
It is an object of the invention to provide a kind of rheumatism arthritis antiperspirant cream compositions.
It is a further object to provide the preparation of described rheumatism arthritis antiperspirant cream compositions
Method.
[technical scheme]
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of rheumatism arthritis antiperspirant cream compositions.
Described rheumatism arthritis antiperspirant cream compositions is by 20～30 weight portion camels oil, 0～1.0 weight
Part menthol, 0.1～1.0 weight portion Oleum Hippophaes, 6～9 parts by weight Emulsifier, 3～8 weight portion skin moistening
Agent, 5～15 weight portion wetting agents, 0.06～0.15 weight portion preservative, 0.1～0.3 weight portion thickening
Agent, 0.1～0.3 weight portion essence be supplemented to 100 parts by weight of deionized water composition.
A preferred embodiment of the invention, described hunchbacked oil is by Lac Cameli fat, hump fat
With camel abdominal cavity fat according to weight ratio 1:0.1～0.2:0.01～0.05 composition.
According to the another kind of preferred implementation of the present invention, described emulsifying agent is one or more choosings
Emulsifying agent from glyceryl monostearate, Tween 80 or Cithrol 4ML.
According to the another kind of preferred implementation of the present invention, described wetting agent is one or more choosings
Moisturizing from glycerol, propylene glycol, hyaluronic acid, vaseline, 16/octadecanol or vitamin E
Agent.
According to the another kind of preferred implementation of the present invention, described emollient is one or more choosings
Emollient from polydimethylsiloxane, squalane, isopropyl palmitate or isopropyl myristate.
According to the another kind of preferred implementation of the present invention, described thickening agent is one or more choosings
Thickening agent from carbomer, xanthan gum or Cera Flava.
According to the another kind of preferred implementation of the present invention, described preservative is one or more choosings
From methyl hydroxybenzoate, propylparaben, methyl isoxazolines ketone or the preservative of dihydroxymethyl glycolylurea.
According to the another kind of preferred implementation of the present invention, described essence is Geranium Essential or smokes
Clothing grass quintessence oil.
The invention still further relates to the preparation method of described rheumatism arthritis antiperspirant cream compositions.
The step of this preparation method is as follows:
A, prepare oil mixture:
By 20～30 weight portion camels oil, 0～1.0 weight portion menthols, 0.1～1.0 weight portion Oleum Hippophaes,
3.8～5.5 parts by weight Emulsifier, 3～8 weight portion emollient, 1.8～4.6 weight portion wetting agent with
0.06～0.15 weight portion preservative mixing, stirs to these raw materials the most molten at temperature 75～80 DEG C
Solve；
B, prepare aqueous mixture
By 3-10 weight portion wetting agent, 2.2-3.5 parts by weight Emulsifier and be supplemented to 100 weight portions
Deionized water mixing, stir at temperature 75～80 DEG C to these raw materials and all dissolve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 15～25r/min continue stirring 2～5 minutes, then
Homogenizing 4～6min under conditions of homogenizing speed 8000～12000r/min with temperature 60～70 DEG C,
To a kind of mixture；
D, charging
The mixture obtained in step C continues stirring 5～10min, then its temperature is reduced to
45～50 DEG C, add 0.2-0.4 weight portion wetting agent, 0.1～0.3 parts by weight of thickening agent and 0.1～0.3
Weight portion essence, is uniformly mixed, and its temperature is down to room temperature, obtains described rheumatism and closes
The scorching antiperspirant cream compositions of joint.
The present invention is described in more detail below.
The present inventor, according to the feature of camel oil, with Lac Cameli tool anti-inflammatory analgetic effect as Research foundation, grinds
Make a kind of containing natural camel oil component there is expelling wind and removing dampness, rheumatism emulsifiable paste that antiinflammatory relieves the pain produces
Product.Research finds, Lac Cameli fat is in addition to These characteristics, and its contained unsaturated fatty acid is most
The most oxidized for long-chain fatty acid (palmitoleic acid), become sour, fishy smell material is heavier, and its fusing point
At about 48 DEG C higher than other breasts, at room temperature solidifying shape all in semisolid, greasy feeling is very strong,
Hydrophilic is poor, is difficult to be directly used in external and smears.Therefore, the present inventor is making wind resistance
During wet arthritis antiperspirant cream compositions, with the addition of effective emulsifier component and increased by high speed homogenization
Its stability, and add skin moistening wetting agent and promote that it is preferably absorbed by the skin, add other skin smoothing
Composition, neutralizes its greasy feeling, thus reaches for assisting some pain such as treatment rheumatic arthritis scorching
Disease.The present inventor develops for camel functional oil while providing new approaches, is also arthritis
And rheumatoid patient treatment provides new treatment guidelines.
The present invention relates to a kind of rheumatism arthritis antiperspirant cream compositions.
Described rheumatism arthritis antiperspirant cream compositions is by 20～30 weight portion camels oil, 0～1.0 weight
Part menthol, 0.1～1.0 weight portion Oleum Hippophaes, 6～9 parts by weight Emulsifier, 3～8 weight portion skin moistening
Agent, 5～15 weight portion wetting agents, 0.06～0.15 weight portion preservative, 0.1～0.3 weight portion thickening
Agent, 0.1～0.3 weight portion essence be supplemented to 100 parts by weight of deionized water composition.
According to the present invention, described hunchbacked oil be by Lac Cameli fat, hump fat with camel abdominal cavity fat according to weight
Than 1:0.1～0.2:0.01～0.05 composition.
Camel oil is containing abundant nature nutrient, highly insatiable hunger fatty acid and abundant vitamin E, camel oil
Oil globule particle diameter is minimum, and permeability is strong, is easily absorbed by the skin, wherein rich in immunity substance
Matter can promote that human body vis medicatrix naturae and metabolism are accelerated, and promotes new cell regeneration, and relieve the pain anti-inflammation.
Camel oil causes some skins such as rheumatism, scald, eczema after having been found to immunocompromised wind
Skin disease has therapeutical effect.
The Lac Cameli fat that the present invention uses is under agitation isolated block butter oil, tool from Lac Cameli
Body method is as follows:
Lac Cameli is performing centrifugal separation at temperature 32-38 DEG C obtain dilute butter, and (in water, oil O/W type is newborn
Liquid), through temperature 80-85 DEG C high temperature 15s, it is cooled to temperature 2-5 DEG C after sterilizing to assign
To 12-16h, make butterfat drop sufficient crystallising ripening, then be placed in agitator in temperature 7-13 DEG C
Under the conditions of be stirred vigorously 50min, destroy the Oil globule coagulation and emulsifying being dispersed in butter, formed
Butter grain.From liquid phase buttermilk, butter grain is separated again, through repeatedly washing, refine molded prepared oil
Mid-water type (w/o type) sticky emulsion, i.e. Lac Cameli fat.
The hump fat that the present invention uses is as follows with the camel abdominal cavity concrete extracting method of fat:
Healthy adult camel, after butchering, gathers the subcutaneous fat of fresh, clean and intact hump respectively
Fat and camel abdominal cavity fat, and these fatty tissuees do not have bone, onal, internal organs, thyroid,
Adrenal gland, lymph node, trachea, thick blood vessel, heavy clear, squeezing material and other analog, Yi Jiying
As far as possible without muscular tissue and blood vessel.These fatty tissuees carry out following process respectively: rubbing
After feed intake in the decocting in water tank with agitating function, decocting in water 6h, obtain thick Adeps Cameli.In tank quiet
Put profit layering, lower layer of water put, add 10%NaOH solution stirring by weight and neutralize,
Being pH is 7.Neutralize the complete 5 times amount water that add in tank and be heated to temperature 55～65 DEG C, stir
Mixing 40min, then stratification is drained the oil.Identical method is used to repeat washing twice, and will
After water is allowed to dry only, whisk while be sequentially added into powdered active carbon, active hargil, kieselguhr
(weight ratio 5:5:1), heats 0.5～1.0h at temperature 60～70 DEG C, adds tophan box while hot,
Centrifugal, finally respectively obtain refined hump subcutaneous fat and camel abdominal cavity fat, their color is
It is bordering on water white oily, and without specific peculiar smell.
In the present invention, when other component is in described content range, if camel oil content is less than
20 weight portions, then the emulsifiable paste moistening effect prepared is bad；If camel oil content is higher than 30 weight portions,
The most greasy being unfavorable for of emulsifiable paste then prepared absorbs；Therefore, camel oil content is that 20～30 weight portions are
Reasonably, preferably 24～28 weight portions, more preferably 25～26 weight portion.
Menthol (Oleum menthae) is used for assisting neutralization camel oil fishy smell, and Oleum menthae has the special of Herba Menthae
Fragrance, relieveing pain and refreshing, can optionally stimulate the Cold receptor of human body skin or mucosa, produce
Sense of cold reflection and creeping chill.External can with anti-inflammatory analgetic, antipruritic, blood circulation promoting, alleviate edema
Deng, can reach the skinfeel of salubrious comfortable non-greasy in the present invention.
In the present invention, when other component is in described content range, if menthol content is high
In 1.0 weight portions, then skinfeel is the coolest；Therefore, menthol content be 0～1.0 weight portions be reasonable
's.
The menthol that the present invention uses is product sold in the market, such as public by Shanghai snow bear
Department is with trade name " menthol " product sold.
Oleum Hippophae is used for changing mastic color, and assists camel oil to reach preferably to absorb treatment merit
Effect.Fructus Hippophae rich in nutritive value, medical value is also fine, and " Chinese medicine big dictionary " records Fructus Hippophae
In oil, total flavones has promoting blood circulation to remove blood stasis, the chest stuffiness relieving that reduces phlegm, the effect of heat clearing away and internal heat reducing, and Oleum Hippophae also has
The magical effect promoting tissue regeneration and epithelial tissue to heal, boiling hot for treating with among the people clinically
Wound, burn, cold injury and traumatic injury all have good effect.
In the present invention, when other component is in described content range, if Oleum Hippophae content is little
In 0.1 weight portion, then DeGrain and mastic color are the lightest；If Oleum Hippophae content is higher than
1.0 weight portions, cost is high and can not highlight effect that camel is oily；Therefore, Oleum Hippophae content is
0.1～1.0 weight portions are appropriate, preferably 0.2～0.8 weight portion, more preferably 0.4～0.6
Weight portion.
The Oleum Hippophae that the present invention uses is product sold in the market, such as, thought by Spain's moral
Wound company is with trade name " Oleum Hippophae " product sold.
In the present invention, the basic role in oil mixture of the described emulsifying agent is to reduce breast
Liquid interfacial surface tension makes the potential energy of dispersion decline, and is that paste stability increases, unsuitable moisture
Separate out.
The emulsifying agent that the present invention uses is that one or more are selected from glyceryl monostearate, Tween 80
Or the emulsifying agent of Cithrol 4ML.
Described glyceryl monostearate, Tween 80 or Cithrol 4ML emulsifying
Agent is all product sold in the market, such as by standing grain major company of Britain with trade name " stearic acid
Monoglyceride " sell glyceryl monostearate, by Shanghai Reagent Company with trade name Tween-80
Sell Tween 80, by Hai'an petro-chemical corporation with trade name " Cithrol 4ML "
The Cithrol 4ML sold.
In the present invention, when other component is in described content range, if emulsifier content is little
In 6 weight portions, then mastic is unstable, and water oil is easily separated；If emulsifier content is higher than 9 weight
Part, then cost is the most uneconomical；Therefore, emulsifier content be 6～9 weight portions be suitable, excellent
Selection of land is 6.8～8.2 weight portions, more preferably 7.2～7.8 weight portion.
In the present invention, the basic role of described emollient is to increase the greasy property of mastic.
The present invention use emollient be one or more be selected from polydimethylsiloxane, squalane,
Isopropyl palmitate or the emollient of isopropyl myristate.
Described polydimethylsiloxane, squalane, isopropyl palmitate or isopropyl myristate
Emollient is all product sold in the market, such as by Dow corning company with trade name
Polydimethylsiloxane that " dimethyl siloxane " is sold, by Nof Corp. with trade name " angle
Shark alkane " sell squalane, by International Specialty Products company of the U.S. with trade name " isopropyl palmitate "
Sell isopropyl palmitate, by standing grain major company of Britain with trade name " isopropyl myristate " sell
The isopropyl myristate sold.
In the present invention, when other component is in described content range, if emollient levels is little
In 3 weight portions, then mastic assimilation effect is not optimal；If emollient levels is higher than 8 weight portions,
Then mastic is greasy airtight, and cost is high；Therefore, emollient levels be 3～8 weight portions be suitable,
Preferably 3.8～7.2 weight portions, more preferably 4.2～6.8 weight portion.
In the present invention, the basic role in oil mixture of the described wetting agent is to contribute to
Skin absorption moisture and prevent skin internal moisture scatter and disappear.
The present invention use wetting agent be one or more be selected from glycerol, propylene glycol, hyaluronic acid,
The wetting agent of vaseline, 16/octadecanol or vitamin E.
Described glycerol, propylene glycol, hyaluronic acid, vaseline, 16/octadecanol or vitamin E
Wetting agent is all product sold in the market, such as by Shandong Fu Ruida company with trade name
Hyaluronic acid that " hyaluronic acid " is sold, by Kening Co., Ltd of Thailand with trade name " 16/octadecanol "
16/the octadecanol sold, the propylene glycol sold with trade name " propylene glycol " by LG-DOW company.
In the present invention, when other component is in described content range, if content of humectant is little
In 5 weight portions, then moistening effect is inconspicuous；If content of humectant is higher than 15 weight portions, then
The most greasy breathability of mastic is bad；Therefore, content of humectant be 5～15 weight portions be rational,
Preferably 7～12 weight portions, more preferably 8～10 weight portion.
In the present invention, the basic role of described preservative is to make product to microbiologically stabilised and have
Enough shelf lifes.
The present invention use preservative be one or more be selected from methyl hydroxybenzoate, propylparaben,
Methyl isoxazolines ketone, the preservative of dihydroxymethyl glycolylurea.
Described methyl hydroxybenzoate, propylparaben, methyl isoxazolines ketone, dihydroxymethyl glycolylurea are prevented
Rotten agent is all product sold in the market, such as by Zhejiang Sheng Xiao company with trade name " Ni Bo
Tortoise beetle ester " sell methyl hydroxybenzoate, by Jiangsu health and happiness company with trade name " methyl isoxazolines ketone "
Sell methyl isoxazolines ketone, by Yancheng Rui Jie company with trade name " dihydroxymethyl glycolylurea " sell
Dihydroxymethyl glycolylurea.
In the present invention, when other component is in described content range, if antiseptic content is little
In 0.06 weight portion, then antiseptic effect is inconspicuous；If antiseptic content is higher than 0.15 weight portion,
Then skin there is side effect；Therefore, antiseptic content be 0.06～0.15 weight portion be feasible,
Preferably 0.08～0.12 weight portion.
In the present invention, the basic role of described thickening agent is that making mastic is paste liquid.
The thickening agent that the present invention uses is that one or more are selected from the increasing of carbomer, xanthan gum or Cera Flava
Thick dose.
Described carbomer, xanthan gum or Cera Flava thickening agent is all product sold in the market,
The carbomer such as sold with trade name " carbomer 540 " by Shanghai Reagent Company.
In the present invention, when other component is in described content range, if amount of thickener is little
In 0.1 weight portion, then the emulsifiable paste can not prepare paste than relatively dilute；If amount of thickener is higher than
0.3 weight portion, then mastic the thickest painting Zhan Bukai, quality is uneven；Therefore, amount of thickener
Be 0.1～0.3 weight portion be feasible.
The essence that the present invention uses is Geranium Essential or Herba Lysimachiae foenum-graeci quintessence oil.They are all existing markets
Upper product sold, such as, sold with trade name " Geranium Essential " by Shanghai Ke Dao cosmetics company
The Geranium Essential sold, sold with trade name " Herba Lysimachiae foenum-graeci quintessence oil " by Shanghai Ke Dao cosmetics company
Herba Lysimachiae foenum-graeci quintessence oil.
The essence consumption used in the present invention is 0.1～0.3 weight portion, it is obvious that essence consumption
Too much or very few be all disadvantageous.
The invention still further relates to the preparation method of described rheumatism arthritis antiperspirant cream compositions.
The step of this preparation method is as follows:
A, prepare oil mixture:
By 20～30 weight portion camels oil, 0～1.0 weight portion menthols, 0.1～1.0 weight portion Oleum Hippophaes,
3.8～5.5 parts by weight Emulsifier, 3～8 weight portion emollient, 1.8～4.6 weight portion wetting agent with
0.06～0.15 weight portion preservative mixing, stirs to these raw materials the most molten at temperature 75～80 DEG C
Solve；
B, prepare aqueous mixture
By 3～10 weight portion wetting agents, 2.2～3.5 parts by weight Emulsifier be supplemented to 100 weight portions
Deionized water mixing, stir at temperature 75～80 DEG C to these raw materials and all dissolve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 15～25r/min continue stirring 2～5 minutes, then
Homogenizing 4～6min under conditions of homogenizing speed 8000～12000r/min with temperature 60～70 DEG C,
To a kind of mixture；
D, charging
The mixture obtained in step C continues stirring 5～10min, then its temperature is reduced to
45～50 DEG C, add 0.2-0.4 weight portion wetting agent, 0.1～0.3 parts by weight of thickening agent and 0.1～0.3
Weight portion essence, is uniformly mixed, and its temperature is down to room temperature, obtains described rheumatism and closes
The scorching antiperspirant cream compositions of joint.
Relevant camel oil, menthol, Oleum Hippophae, emulsifying agent, emollient, wetting agent, preservative,
Wetting agent, thickening agent and the situation of essence, already described above, do not repeat them here.
The equipment used when the present invention prepares rheumatism arthritis antiperspirant cream compositions is all this technology neck
Normally used, the equipment sold in the market in territory.
The present invention resisting rheumatoid arthritis emulsifiable paste containing natural camel oil to antiinflammatory, subside a swelling, ease pain, dispel
Wind dehumidifying etc. has mitigation, and Repercusion analgesia, antiinflammatory antiallergic, expelling wind and removing dampness are had auxiliary treatment merit
Can, and there is the most moist moisture-keeping efficacy.Resisting rheumatoid arthritis cream formulation of the present invention uniqueness,
Moist moistening effect is obvious, the salubrious non-greasy of skinfeel, and has light speckle wrinkle removing bright color simultaneously
Good result, delay skin aging.Resisting rheumatoid arthritis emulsifiable paste process for making of the present invention is steady
Yellowish glossy, the exquisite quality of fixed, mastic color, non-stimulated to skin, reach to moisten the good of skin and complexion improving
Good effect.
[beneficial effect]
The invention has the beneficial effects as follows: the present invention is containing the resisting rheumatoid arthritis emulsifiable paste pair of natural camel oil
Antiinflammatory, subside a swelling, ease pain, expelling wind and removing dampness etc. has mitigation, to Repercusion analgesia, antiinflammatory antiallergic,
Expelling wind and removing dampness has auxiliary treatment function, and has the most moist moisture-keeping efficacy.Rheumatism of the present invention
Property arthritis cream formulation is unique, obvious, the salubrious non-greasy of skinfeel that moistens moistening effect, and simultaneously
There is the good result of light speckle wrinkle removing bright color, delay skin aging.Antirheumatic of the present invention closes
The scorching emulsifiable paste process for making of joint is stable, yellowish glossy, the exquisite quality of mastic color, to skin without
Stimulate, reach to moisten the good effects of skin and complexion improving.
[accompanying drawing explanation]
Fig. 1 be the Wistar rat toes swelling rate using resisting rheumatoid arthritis emulsifiable paste of the present invention with
The variation diagram of time；
Fig. 2 is the Wistar rat body weight variation tendency using resisting rheumatoid arthritis emulsifiable paste of the present invention
Figure；
Fig. 3 is the Wistar rat arthritis scoring knot using resisting rheumatoid arthritis emulsifiable paste of the present invention
Fruit figure.
[detailed description of the invention]
The present invention is will be better understood that by following embodiment.
Embodiment 1: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 24 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
According to weight ratio 1:0.10:0.02 composition camel oil, 0.8 weight portion menthol, 0.4 weight portion sand
Spine oil, 4.8 weight portion glyceryl monostearate emulsifying agents, 4.2 weight portion polydimethylsiloxane,
Squalane, isopropyl palmitate and isopropyl myristate (weight ratio 2:1:2:1) emollient, 3.4
Parts by weight of glycerin wetting agent and the mixing of 0.08 weight portion methyl hydroxybenzoate preservative, temperature 75 DEG C
Lower stirring is all dissolved to these raw materials；
B, prepare aqueous mixture
By 10.0 parts by weight of glycerin wetting agents, 2.2 weight portion glyceryl monostearate emulsifying agent and benefits
It is charged to the deionized water mixing of 100 weight portions, stirs to these raw materials the most molten at temperature 75 DEG C
Solve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 15r/min continue stirring 3 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 4min under conditions of homogenizing speed 8000r/min with temperature 68 DEG C, obtains a kind of mixed
Compound；
D, charging
The mixture obtained in step C continues stirring 5min, then its temperature is reduced to 45 DEG C,
Add 0.2 parts by weight of glycerin wetting agent, 0.10 weight portion carbomer thickening agent and 0.1 weight portion
Geranium Essential essence, is uniformly mixed, and its temperature is down to room temperature, obtains described wind resistance
Wet arthritis antiperspirant cream compositions.
Embodiment 2: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 28 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
According to weight ratio 1:0.18:0.01 composition camel oil, 0 weight portion menthol, 0.6 weight portion sand
Spine oil, 3.8 weight portion Tween 80 emulsifying agents, 6.8 weight portion polydimethylsiloxane, squalane,
Isopropyl palmitate and isopropyl myristate (weight ratio 2:2:1:1) emollient, 1.8 weight portions
Propylene glycol wetting agent and the mixing of 0.06 weight portion propylparaben preservative, stir at temperature 78 DEG C
Mix to these raw materials and all dissolve；
B, prepare aqueous mixture
By 7.2 parts by weight of propylene glycol wetting agents, 2.5 weight portion Tween 80 emulsifying agents and be supplemented to 100
The deionized water mixing of weight portion, stirs at temperature 80 DEG C to these raw materials and all dissolves；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 20r/min continue stirring 2 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 6min under conditions of homogenizing speed 10000r/min with temperature 62 DEG C, obtains one
Mixture；
D, charging
The mixture obtained in step C continues stirring 6min, then its temperature is reduced to 48 DEG C,
Add 0.24 parts by weight of propylene glycol wetting agent, 0.30 weight portion xanthan gum thickening agent and 0.2 weight
Part Herba Lysimachiae foenum-graeci quintessence oil essence, is uniformly mixed, its temperature is down to room temperature, obtains described resisting
Rheumatic arthritis antiperspirant cream compositions.
Embodiment 3: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 20 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
According to weight ratio 1:0.14:0.04 composition camel oil, 0.4 weight portion menthol, 0.1 weight portion sand
Spine oil, 5.5 weight portion Cithrol 4ML emulsifying agents, 3 weight portion poly dimethyls
Siloxanes, squalane, isopropyl palmitate and isopropyl myristate (weight ratio 2:1.5:1:2)
Emollient, 2.4 weight portion hyaluronic acid wetting agents and 0.15 weight portion methyl isoxazolines ketone preservative
Mixing, stirs at temperature 80 DEG C to these raw materials and all dissolves；
B, prepare aqueous mixture
By 3.0 weight portion hyaluronic acid wetting agents, 2.8 weight portion Cithrol 4MLs
Emulsifying agent mixes with the deionized water being supplemented to 100 weight portions, stirs to these at temperature 78 DEG C
Raw material all dissolves；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 25r/min continue stirring 5 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 5min under conditions of homogenizing speed 12000r/min with temperature 60 C, obtains one
Mixture；
D, charging
The mixture obtained in step C continues stirring 8min, then its temperature is reduced to 50 DEG C,
Add 0.4 weight portion hyaluronic acid wetting agent, 0.14 weight portion Cera Flava thickening agent and 0.3 weight
Part Geranium Essential essence, is uniformly mixed, its temperature is down to room temperature, obtains described resisting
Rheumatic arthritis antiperspirant cream compositions.
Embodiment 4: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 30 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
According to weight ratio 1:0.12:0.05 composition camel oil, 1.0 weight portion menthols, 1.0 weight portions sand
Spine oil, 4.4 weight portion glyceryl monostearate emulsifying agents, 8 weight portion polydimethylsiloxane, angle
Shark alkane, isopropyl palmitate and isopropyl myristate (weight ratio 2:2:0:0) emollient, 4.6
Weight portion vaseline wetting agent and the mixing of 0.10 weight portion dihydroxymethyl glycolylurea preservative, in temperature
Stir at 75 DEG C to these raw materials and all dissolve；
B, prepare aqueous mixture
By 4.4 weight portion vaseline wetting agents, 3.5 weight portion glyceryl monostearate emulsifying agent and benefits
It is charged to the deionized water mixing of 100 weight portions, stirs to these raw materials the most molten at temperature 75 DEG C
Solve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 15r/min continue stirring 4 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 4min under conditions of homogenizing speed 8000r/min with temperature 70 C, obtains a kind of mixed
Compound；
D, charging
The mixture obtained in step C continues stirring 10min, then its temperature is reduced to 45 DEG C,
Add 0.28 weight portion vaseline wetting agent, 0.26 weight portion carbomer thickening agent and 0.1 weight
Part Geranium Essential and Herba Lysimachiae foenum-graeci quintessence oil mixture (weight ratio 1:1) essence, be uniformly mixed,
Its temperature is down to room temperature, obtains described rheumatism arthritis antiperspirant cream compositions.
Embodiment 5: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 25 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
Camel oil, 1.0 weight portion menthols, 0.2 weight portion according to weight ratio 1:0.16:0.03 composition
Oleum Hippophae, 4.8 weight portion glyceryl monostearate emulsifying agents, 3.8 weight portion polydimethylsiloxane,
Squalane, isopropyl palmitate and isopropyl myristate (weight ratio 2:0:1:2) emollient, 2.9
Weight portion 16/octadecanol wetting agent and the mixing of 0.12 weight portion methyl isoxazolines ketone preservative,
Stir at temperature 78 DEG C to these raw materials and all dissolve；
B, prepare aqueous mixture
By 5.8 weight portion 16/octadecanol wetting agents, 3.0 weight portion PEG400 list Laurels
Acid esters emulsifying agent mixes with the deionized water being supplemented to 100 weight portions, stir at temperature 80 DEG C to
These raw materials all dissolve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 20r/min continue stirring 3 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 5min under conditions of homogenizing speed 10000r/min with temperature 66 DEG C, obtains one
Mixture；
D, charging
The mixture obtained in step C continues stirring 8min, then its temperature is reduced to 48 DEG C,
Adding 0.36 weight portion 16/octadecanol wetting agent, 0.18 weight portion carbomer thickening agent and 0.2
Weight portion Geranium Essential and Herba Lysimachiae foenum-graeci quintessence oil mixture (weight ratio 2:1) essence, stirring mixing
Uniformly, its temperature is down to room temperature, obtains described rheumatism arthritis antiperspirant cream compositions.
Embodiment 6: prepare rheumatism arthritis antiperspirant cream compositions of the present invention
The enforcement step of this embodiment is as follows:
A, prepare oil mixture:
By this specification, 26 weight portions are described the Lac Cameli fat of extraction, hump fat is pressed with camel abdominal cavity fat
According to weight ratio 1:0.20:0.03 composition camel oil, 0.2 weight portion menthol, 0.8 weight portion sand
Spine oil, 5.2 weight portion glyceryl monostearate emulsifying agents, 7.2 weight portion polydimethylsiloxane,
Squalane, isopropyl palmitate and isopropyl myristate (weight ratio 1:1:2:1) emollient, 4.0
Part by weight of vitamin E wetting agent and the mixing of 0.13 weight portion methyl hydroxybenzoate preservative, in temperature
Stir at 80 DEG C to these raw materials and all dissolve；
B, prepare aqueous mixture
By 8.6 part by weight of vitamin E wetting agents, 3.2 weight portion glyceryl monostearate emulsifying agents
Mix with the deionized water being supplemented to 100 weight portions, stir to these raw materials complete at temperature 78 DEG C
Portion dissolves；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured into and obtains in step A
To oil mixture in, under low whipping speed 25r/min continue stirring 4 minutes, be then used by
By Shanghai Frock Fluid Machinery Manufacture Co., Ltd. with trade name FLUKO Fu Luke sell equal
Matter machine is homogenizing 6min under conditions of homogenizing speed 12000r/min with temperature 64 DEG C, obtains one
Mixture；
D, charging
The mixture obtained in step C continues stirring 6min, then its temperature is reduced to 50 DEG C,
Add 0.32 part by weight of vitamin E wetting agent, 0.22 weight portion xanthan gum thickening agent and 0.3 weight
Amount part Geranium Essential and Herba Lysimachiae foenum-graeci quintessence oil mixture (weight ratio 1:2) essence, stirring mixing is all
Even, its temperature is down to room temperature, obtains described rheumatism arthritis antiperspirant cream compositions.
The present invention has also carried out following test example, so that rheumatism arthritis emulsifiable paste of the present invention to be described
The beneficial effect of compositions.
Test example 1: the rheumatism both effectiveness test of arthritis antiperspirant cream compositions of the present invention
For checking natural camel oil mixture, there is the auxiliary treatment rheumatism such as anti-inflammatory analgetic, expelling wind and removing dampness
Effect, use it for suffering from the ankle of rheumatism Wistar rat, smear twice every day, often
Secondary lasting 15 minutes, to ensure that it, not by mouse lick off, is adhered to 100 days, observe it and make diligent
Effect.Matched group is that the rat suffering from rheumatic arthritis does not carries out any treatment, and treatment group also includes being coated with
Smearing Flos Carthami line of oils and smear ibuprofen group, the result obtained is listed in accompanying drawing 1-3.
By accompanying drawing 1-3 it can be seen that when 20 days rat modeling be successful on the whole and suffer from arthritis, open
Begin smear Experimental agents carry out contrast treatment, all have certain effect, by accompanying drawing 1 it can be seen that
After smearing rheumatism arthritis antiperspirant cream compositions of the present invention, rat toes swelling phenomenon is controlled
System, and gradually tend towards stability.By accompanying drawing 2 it will be seen that led owing to rat is ill when 20 days
Cause body weight to increase hardly, after smearing rheumatism arthritis antiperspirant cream compositions of the present invention, it will be apparent that
See that body weight is recovered again to increase, it is seen that rheumatism arthritis antiperspirant cream compositions of the present invention is to Fengshi Guanjie
Scorching disease has certain alleviation and therapeutic efficiency.
Test example 2: physical and chemical index is checked
This test example has carried out following several tests:
1, character detection
Rheumatism arthritis antiperspirant cream compositions of the present invention is faint yellow, and viscosity is suitable, and hardness is suitable,
Mastic is fine and smooth uniformly, stretchability is good, and with rear refrigerant comfortable non-greasy, good stability, abnormal smells from the patient are clear
Simple the most and elegant.
2, caloric test
Rheumatism arthritis antiperspirant cream compositions of the present invention is sealed and is loaded in transparence cosmetic bottle, in temperature
Spend cold preservation one week in 4 DEG C of refrigerators, do not observe lamination.24h in 55 DEG C of calorstats of temperature,
Rheumatism arthritis antiperspirant cream compositions of the present invention does not occurs being layered the phenomenons such as emulsifying is spoiled.
3, centrifugal test
Rheumatism arthritis antiperspirant cream compositions of the present invention is packaged in tool plug test tube, at rotating speed
Under 3000r/min, centrifugal 20min, does not finds lamination.
4, stability test
Being placed in bottle for cosmetics by rheumatism arthritis antiperspirant cream compositions of the present invention, room temperature stands to be investigated
6 months, without lamination, with after feel unchanged, abnormal smells from the patient is unchanged.
5, irritant experiment, anaphylaxis experiment
Test white mice back is cut off hair, the rheumatism arthritis of the present invention embodiment 3 prepared
Antiperspirant cream compositions is applied in respectively cuts plucked position, is meanwhile also coated with not cutting off a mao position
Smear identical antiperspirant cream compositions, as a means of comparing.Cutting plucked position and do not having after smearing 30min
Cut off mao position and zest and the anaphylaxiss such as rubescent, dermexanthesis, foaming phenomena the most do not occur.
Four kinds of rheumatism joints prepared by 1g above-described embodiment 2-5 are smeared respectively in volunteer's gesture and facial expression
Scorching antiperspirant cream compositions, does not observes the phenomenons such as rubescent, dermexanthesis, foaming after smearing 30min.
Test example 3: skinfeel is tested
Feel that evaluating rheumatism arthritis antiperspirant cream compositions of the present invention is smearing below with on probation
Effect after 30min.Use public-opinion poll point system, choose 30 age bracket 20-60 year people
For object on probation, they are arbitrarily divided into five groups, respectively the present invention prepared by embodiment 1-5 are resisted
Rheumatic arthritis antiperspirant cream compositions is applied at become silted up with it blue or green pain or dry and cracked decortication.
Application process is within one day, to be coated with 3 times, each 5-10 minute, processes one month time.
Moisture retention standards of grading: after using this emulsifiable paste, skin beauty water profit is the most tight
Salubrious property standards of grading: after using this emulsifiable paste, the refrigerant non-greasy of skinfeel
Analgesic standards of grading: after using this emulsifiable paste, pain alleviates, swelling phenomenon is alleviated
Blood stasis dispelling standards of grading: after using this emulsifiable paste, blood is smooth, blue or green phenomenon of becoming silted up gradually is alleviated
Anti-inflammatory standards of grading: after using this emulsifiable paste, inflammation fades away, and skin gradually recovers strong
Health
Promote wound healing standards of grading: after using this emulsifiable paste, wound gradually heals
Every using effect total score is 5 points；5 are divided into best result, represent very well, feel quite pleased；4
It is divided into preferably；3 are divided into and can accept；Less than 3 points is bad, it is impossible to accept.The following is every
Average mark, the results are shown in Table 1 for it.
Table 1: skinfeel result of the test
The result of table 1 clearly illustrates, after using this emulsifiable paste, skin becomes water profit clearly, and rheumatism is drawn
The phenomenons such as the arthralgia that rises, swelling, silt are blue or green have had improvement, and the various problems of skin all obtain
Good improvement.
In sum, the cream made by the present invention, goodlooking, viscosity is suitable, green health,
Mastic is fine and smooth uniformly, stretchability is good, and with rear the most comfortable, good stability, abnormal smells from the patient are pure and fresh simple and elegant,
There are good pain relieving blood stasis dispelling, anti-inflammation detumescence, promotion wound healing, activate the effects such as new cell regeneration.
Claims (9)
1. a rheumatism arthritis antiperspirant cream compositions, it is characterised in that described rheumatism closes
The scorching antiperspirant cream compositions of joint by 20～30 weight portion camels oil, 0～1.0 weight portion menthols, 0.1～1.0
Weight portion Oleum Hippophae, 6～9 parts by weight Emulsifier, 3～8 weight portion emollient, 5～15 weight portions
Wetting agent, 0.06～0.15 weight portion preservative, 0.1～0.3 parts by weight of thickening agent, 0.1～0.3 weight
Amount part essence forms with being supplemented to 100 parts by weight of deionized water.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
In described hunchbacked oil be by Lac Cameli fat, hump fat with camel abdominal cavity fat according to weight ratio 1:0.1～0.2:
0.01～0.05 composition.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
It is that one or more are selected from glyceryl monostearate, Tween 80 or poly-second in described emulsifying agent
The emulsifying agent of glycol 400 monolaurate.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
In described wetting agent be one or more be selected from glycerol, propylene glycol, hyaluronic acid, vaseline,
16/octadecanol or the wetting agent of vitamin E.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
It is that one or more are selected from polydimethylsiloxane, squalane, Palmic acid in described emollient
Isopropyl ester or the emollient of isopropyl myristate.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
It is that one or more are selected from the thickening agent of carbomer, xanthan gum or Cera Flava in described thickening agent.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
It is that one or more are selected from methyl hydroxybenzoate, propylparaben, methyl in described preservative different
Oxazoline ketone or the preservative of dihydroxymethyl glycolylurea.
Rheumatism arthritis antiperspirant cream compositions the most according to claim 1, its feature exists
It is Geranium Essential or Herba Lysimachiae foenum-graeci quintessence oil in described essence.
9. according to rheumatism arthritis emulsifiable paste described in claim any one of claim 1-8
The preparation method of compositions, it is characterised in that the step of the method is as follows:
A, prepare oil mixture:
By 20～30 weight portion camels oil, 0～1.0 weight portion menthols, 0.1～1.0 weight portion Fructus Hippophaes
Oil, 3.8～5.5 parts by weight Emulsifier, 3～8 weight portion emollient, 1.8～4.6 weight portion moisturizings
Agent mixes with 0.06～0.15 weight portion preservative, stirs to these former at temperature 75～80 DEG C
Material all dissolves；
B, prepare aqueous mixture
By 3-10 weight portion wetting agent, 2.2-3.5 parts by weight Emulsifier and be supplemented to 100 weight
Part deionized water mixing, stir at temperature 75～80 DEG C to these raw materials and all dissolve；
C, mixing
Under conditions of stirring, the aqueous mixture obtained in step B is poured in step A
In the oil mixture obtained, under low whipping speed 15～25r/min, continue stirring 2～5 minutes,
Then homogenizing under conditions of homogenizing speed 8000～12000r/min with temperature 60～70 DEG C
4～6min, obtain a kind of mixture；
D, charging
The mixture obtained in step C continues stirring 5～10min, then its temperature is reduced to
45～50 DEG C, add 0.2～0.4 weight portion wetting agent, 0.1～0.3 parts by weight of thickening agent with
0.1～0.3 weight portion essence, is uniformly mixed, and its temperature is down to room temperature, obtains described
Rheumatism arthritis antiperspirant cream compositions.
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| CN201610544481.1A CN105943557B (en) | 2016-07-08 | 2016-07-08 | Anti-rheumatic arthritis cream composition and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107028771A (en) * | 2017-03-16 | 2017-08-11 | 中山大学惠州研究院 | A kind of moisturizing plaster preparation of non-woven fabrics and preparation method thereof |
| CN108379212A (en) * | 2018-06-04 | 2018-08-10 | 内蒙古骆驼研究院 | Newborn moisturizing cream of a kind of camel with senile-resistant efficacy and preparation method thereof |
| CN113855780A (en) * | 2021-10-28 | 2021-12-31 | 上海月月舒妇女用品有限公司 | Essential oil for activating collaterals, relaxing tendons, relieving pain and relieving and preparation method thereof |
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| CN1870972A (en) * | 2003-09-08 | 2006-11-29 | 列夫－巴尔有限公司 | Cosmetic composition comprising camel milk or components thereof |
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| CN1870972A (en) * | 2003-09-08 | 2006-11-29 | 列夫－巴尔有限公司 | Cosmetic composition comprising camel milk or components thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107028771A (en) * | 2017-03-16 | 2017-08-11 | 中山大学惠州研究院 | A kind of moisturizing plaster preparation of non-woven fabrics and preparation method thereof |
| CN108379212A (en) * | 2018-06-04 | 2018-08-10 | 内蒙古骆驼研究院 | Newborn moisturizing cream of a kind of camel with senile-resistant efficacy and preparation method thereof |
| CN113855780A (en) * | 2021-10-28 | 2021-12-31 | 上海月月舒妇女用品有限公司 | Essential oil for activating collaterals, relaxing tendons, relieving pain and relieving and preparation method thereof |
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|---|---|
| CN105943557B (en) | 2020-02-14 |
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