JPS6041679B2 - 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法 - Google Patents

新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法

Info

Publication number
JPS6041679B2
JPS6041679B2 JP53023552A JP2355278A JPS6041679B2 JP S6041679 B2 JPS6041679 B2 JP S6041679B2 JP 53023552 A JP53023552 A JP 53023552A JP 2355278 A JP2355278 A JP 2355278A JP S6041679 B2 JPS6041679 B2 JP S6041679B2
Authority
JP
Japan
Prior art keywords
horteimycin
culture
hortimycin
kgl
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53023552A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54117478A (en
Inventor
清吾 高沢
公勝 白幡
征二 佐藤
恵一 高橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP53023552A priority Critical patent/JPS6041679B2/ja
Priority to GB7906517A priority patent/GB2018246B/en
Priority to FR7905359A priority patent/FR2418795A1/fr
Priority to DE2908150A priority patent/DE2908150C2/de
Priority to CA322,681A priority patent/CA1129796A/en
Priority to US06/017,276 priority patent/US4241182A/en
Publication of JPS54117478A publication Critical patent/JPS54117478A/ja
Priority to US06/120,116 priority patent/US4623722A/en
Publication of JPS6041679B2 publication Critical patent/JPS6041679B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/867—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
JP53023552A 1978-03-03 1978-03-03 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法 Expired JPS6041679B2 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP53023552A JPS6041679B2 (ja) 1978-03-03 1978-03-03 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法
GB7906517A GB2018246B (en) 1978-03-03 1979-02-23 Fortimicin factors kg kg and kg 3 and processes for production therof
FR7905359A FR2418795A1 (fr) 1978-03-03 1979-03-01 Facteurs de fortimycine kg1, kg2 et kg3 et procedes pour leur production
DE2908150A DE2908150C2 (de) 1978-03-03 1979-03-02 Fortimicin KG↓1↓, KG↓2↓ und KG↓3↓ Verfahren zu ihrerHerstellung und pharmazeutische Zubereitung
CA322,681A CA1129796A (en) 1978-03-03 1979-03-02 Fortimicin factors kg.sub.1, kg.sub.2 and kg.sub.3 and processes for production thereof
US06/017,276 US4241182A (en) 1978-03-03 1979-03-05 Fortimicin factors KG1, KG2 and KG3 and processes for production thereof
US06/120,116 US4623722A (en) 1978-03-03 1980-02-11 Fortimicin factor KG3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53023552A JPS6041679B2 (ja) 1978-03-03 1978-03-03 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法

Publications (2)

Publication Number Publication Date
JPS54117478A JPS54117478A (en) 1979-09-12
JPS6041679B2 true JPS6041679B2 (ja) 1985-09-18

Family

ID=12113645

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53023552A Expired JPS6041679B2 (ja) 1978-03-03 1978-03-03 新抗生物質ホ−テイマイシンｋｇ↓１，ｋｇ↓２およびｋｇ↓３ならびにそれらの製造法

Country Status (6)

Country Link
US (2) US4241182A (cg-RX-API-DMAC7.html)
JP (1) JPS6041679B2 (cg-RX-API-DMAC7.html)
CA (1) CA1129796A (cg-RX-API-DMAC7.html)
DE (1) DE2908150C2 (cg-RX-API-DMAC7.html)
FR (1) FR2418795A1 (cg-RX-API-DMAC7.html)
GB (1) GB2018246B (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338307A (en) * 1980-11-10 1982-07-06 Abbott Laboratories 2'-N-Des-β-lysyl antibiotic AX-127B-1 and 4-N-acyl and alkyl derivatives thereof
US4338309A (en) * 1980-11-10 1982-07-06 Abbott Laboratories 4',5'-Dihydro-antibiotic AX-127B-1; 2'-N-des-β-lysyl-4',5'-dihydro-antibiotic AX-127B-1; and 4-N-derivatives thereof
US4338308A (en) * 1980-11-10 1982-07-06 Abbott Laboratories 4-N-β-Lysyl-2'-N-des-β-lysyl antibiotic AX-127B-1 and the pharmaceutically acceptable salts thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5145675B2 (cg-RX-API-DMAC7.html) * 1973-07-23 1976-12-04
US3931400A (en) * 1973-04-17 1976-01-06 Abbott Laboratories Fortimicin B and process for production thereof
US3991183A (en) * 1975-05-01 1976-11-09 Pfizer Inc. Antibiotic produced by a species of micromonospora
JPS5218888A (en) * 1975-08-01 1977-02-12 Kyowa Hakko Kogyo Co Ltd Preparation of fortimicin c
US4091032A (en) * 1976-09-23 1978-05-23 Abbott Laboratories 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A
US4124756A (en) * 1976-12-27 1978-11-07 Abbott Laboratories 3-DE-O-Methylfortimicins
JPS53141244A (en) 1977-05-11 1978-12-08 Kyowa Hakko Kogyo Co Ltd Novel hortemycin derivatives
JPS5466679A (en) 1977-11-07 1979-05-29 Kyowa Hakko Kogyo Co Ltd Novel antibiotic substance fortimicin kf and fortimicin kg, and their preparation
US4187299A (en) 1977-12-21 1980-02-05 Abbott Laboratories Fortimicin E

Also Published As

Publication number Publication date
DE2908150A1 (de) 1979-09-06
DE2908150C2 (de) 1982-04-01
GB2018246A (en) 1979-10-17
FR2418795A1 (fr) 1979-09-28
CA1129796A (en) 1982-08-17
US4623722A (en) 1986-11-18
JPS54117478A (en) 1979-09-12
GB2018246B (en) 1982-08-11
FR2418795B1 (cg-RX-API-DMAC7.html) 1982-03-19
US4241182A (en) 1980-12-23

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