JPS6025421B2 - 排卵抑制剤およびその製造方法 - Google Patents

排卵抑制剤およびその製造方法

Info

Publication number
JPS6025421B2
JPS6025421B2 JP51130356A JP13035676A JPS6025421B2 JP S6025421 B2 JPS6025421 B2 JP S6025421B2 JP 51130356 A JP51130356 A JP 51130356A JP 13035676 A JP13035676 A JP 13035676A JP S6025421 B2 JPS6025421 B2 JP S6025421B2
Authority
JP
Japan
Prior art keywords
methoxy
ethyl
acetamide
mixture
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP51130356A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5257169A (en
Inventor
マイケル・イー・フラーグ
ジエームス・エー・クレメンズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/720,311 external-priority patent/US4087444A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5257169A publication Critical patent/JPS5257169A/ja
Publication of JPS6025421B2 publication Critical patent/JPS6025421B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C207/00—Compounds containing nitroso groups bound to a carbon skeleton
    • C07C207/04—Compounds containing nitroso groups bound to a carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP51130356A 1975-10-29 1976-10-28 排卵抑制剤およびその製造方法 Expired JPS6025421B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62689075A 1975-10-29 1975-10-29
US626890 1975-10-29
US05/720,311 US4087444A (en) 1976-09-08 1976-09-08 Amides as ovulation inhibitors
US720311 1985-04-04

Publications (2)

Publication Number Publication Date
JPS5257169A JPS5257169A (en) 1977-05-11
JPS6025421B2 true JPS6025421B2 (ja) 1985-06-18

Family

ID=27090276

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51130356A Expired JPS6025421B2 (ja) 1975-10-29 1976-10-28 排卵抑制剤およびその製造方法

Country Status (9)

Country Link
JP (1) JPS6025421B2 (enExample)
CA (1) CA1072087A (enExample)
CH (1) CH602638A5 (enExample)
DE (1) DE2645865A1 (enExample)
FR (1) FR2329274A1 (enExample)
GB (1) GB1562825A (enExample)
IE (1) IE43725B1 (enExample)
IL (1) IL50536A (enExample)
NL (1) NL7611971A (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85189A (en) * 1987-02-02 1992-06-21 Lilly Co Eli Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
CN1047936C (zh) * 1987-02-02 2000-01-05 伊莱利利公司 制备含烷基褪黑激素的药物组合物的方法
AU2310895A (en) * 1994-04-07 1995-10-30 Cemaf Novel spiro{indole-pyrrolidine} derivatives as melatoninergic agonists, method for preparing same and use thereofas a drug
EP1049472A4 (en) * 1997-10-28 2002-04-03 Merck & Co Inc GONADOTROPIN RELEASING HORMON ANTAGONISTS
CA2308454A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US8053462B2 (en) 2004-03-08 2011-11-08 Masanori Somei Indole derivative and application thereof
JP3964417B2 (ja) 2004-09-27 2007-08-22 国立大学法人金沢大学 インドール誘導体を有効成分とするα２受容体遮断剤及び血管拡張剤
AU2015276941B2 (en) * 2014-06-19 2018-07-19 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof

Also Published As

Publication number Publication date
CA1072087A (en) 1980-02-19
IE43725L (en) 1977-04-29
CH602638A5 (enExample) 1978-07-31
IL50536A0 (en) 1976-11-30
IL50536A (en) 1980-03-31
NL7611971A (nl) 1977-05-03
FR2329274B1 (enExample) 1978-12-22
FR2329274A1 (fr) 1977-05-27
IE43725B1 (en) 1981-05-06
DE2645865C2 (enExample) 1988-07-07
JPS5257169A (en) 1977-05-11
DE2645865A1 (de) 1977-05-12
GB1562825A (en) 1980-03-19

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