JPS60208982A - アセチルコリンエステラーゼ抑制特性を有するヒソスチグミン誘導体およびその製造方法 - Google Patents

アセチルコリンエステラーゼ抑制特性を有するヒソスチグミン誘導体およびその製造方法

Info

Publication number
JPS60208982A
JPS60208982A JP60038994A JP3899485A JPS60208982A JP S60208982 A JPS60208982 A JP S60208982A JP 60038994 A JP60038994 A JP 60038994A JP 3899485 A JP3899485 A JP 3899485A JP S60208982 A JPS60208982 A JP S60208982A
Authority
JP
Japan
Prior art keywords
hysostigmine
derivative
spectrum
hinstigmine
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60038994A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0354952B2 (enExample
Inventor
マリオ・ブルフアーニ
クラウデイロ・カステラーノ
マウリチオ・マルタ
アルベルト・オリベリオ
フラミニア・パボーヌ
マツシモ・ポンポーニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consiglio Nazionale delle Richerche CNR
Original Assignee
Consiglio Nazionale delle Richerche CNR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale delle Richerche CNR filed Critical Consiglio Nazionale delle Richerche CNR
Publication of JPS60208982A publication Critical patent/JPS60208982A/ja
Publication of JPH0354952B2 publication Critical patent/JPH0354952B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
JP60038994A 1984-03-01 1985-03-01 アセチルコリンエステラーゼ抑制特性を有するヒソスチグミン誘導体およびその製造方法 Granted JPS60208982A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT47780/84A IT1199076B (it) 1984-03-01 1984-03-01 Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
IT47780A/84 1984-03-01

Publications (2)

Publication Number Publication Date
JPS60208982A true JPS60208982A (ja) 1985-10-21
JPH0354952B2 JPH0354952B2 (enExample) 1991-08-21

Family

ID=11262469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60038994A Granted JPS60208982A (ja) 1984-03-01 1985-03-01 アセチルコリンエステラーゼ抑制特性を有するヒソスチグミン誘導体およびその製造方法

Country Status (6)

Country Link
US (1) US4831155A (enExample)
EP (2) EP0154864B1 (enExample)
JP (1) JPS60208982A (enExample)
AT (1) ATE54917T1 (enExample)
DE (1) DE3578789D1 (enExample)
IT (1) IT1199076B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323881A (ja) * 1986-07-16 1988-02-01 ヘキスト−ルセル・フア−マシユウテイカルズ・インコ−ポレイテツド １，２，３，３ａ，８，８ａ−ヘキサヒドロ−３ａ，８（および１，３ａ，８）−ジ（およびトリ）メチルピロロ〔２，３−ｂ〕インド−ルおよびそれらの製造法
JPS6425777A (en) * 1987-04-03 1989-01-27 Mediolanum Farmaceut Srl Organic salt of physostigmine
JPH03153688A (ja) * 1989-09-28 1991-07-01 Hoechst Roussel Pharmaceut Inc フイソスチグミンに関連した４―および６―カルバメートおよびそれらの製法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US5306825A (en) * 1984-03-01 1994-04-26 Consiglio Nazionale Delle Ricerche Physostigmine derivatives with acetylcholinesterase inhibition properties, and the relative production process
US5187165A (en) * 1987-05-15 1993-02-16 Hoechst-Roussel Pharmaceuticals Inc. Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles
AT400331B (de) * 1987-05-15 1995-12-27 Hoechst Roussel Pharma 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo (2,3-b)indole, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5077289A (en) * 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5177101A (en) * 1989-11-30 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US4983616A (en) * 1990-02-01 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
US5428043A (en) * 1990-02-08 1995-06-27 Pfizer Inc. Tricyclic-cyclic amines as novel cholinesterase inhibitors
TW197442B (enExample) * 1990-02-08 1993-01-01 Pfizer
AU634654B2 (en) * 1990-05-11 1993-02-25 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments
US5216017A (en) * 1990-05-11 1993-06-01 Hoechst-Roussel Pharmaceuticals Incorporated Pyrrolo[2,3-b]indole-ketones and analogs
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments
IT1243917B (it) * 1990-11-20 1994-06-28 Mediolanum Farmaceutici Spa Derivati della fisostigmina
IT1246050B (it) * 1990-12-21 1994-11-07 Mediolanum Farmaceutici Spa Impiego dell'eptastigmina nella terapia dell'ictus cerebrale.
IT1251166B (it) * 1991-08-09 1995-05-04 Chiesi Farma Spa Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono
JP3708957B2 (ja) * 1991-09-26 2005-10-19 アメリカ合衆国 （−）−エゼロリン、（−）−ｎ１−ノルエゼロリンおよび（−）−ｎ１−ベンジルノルエゼロリンの置換フェンゼリンおよびフェニルカルバミン酸塩：特異的アセチルコリンエステラーゼ阻害薬としての使用
US5206260A (en) * 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
GB9205670D0 (en) * 1992-03-16 1992-04-29 Indena Spa New derivatives of physostigmine,their use and pharmaceutical formulations containing them
US5302721A (en) * 1992-07-21 1994-04-12 Hoechst-Roussel Pharmaceuticals Incorporated Method of preparation of physostigmine carbamate derivatives from eseretholes
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
IT1276928B1 (it) * 1995-10-13 1997-11-03 Angelini Ricerche Spa Processo migliorato per produrre eptastigmina e nuovo intermedio utile allo scopo
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
CA2304505A1 (en) * 1997-09-24 1999-04-01 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
US6495700B1 (en) 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog
WO2005072713A2 (en) 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909530A (en) * 1958-09-26 1959-10-20 Grace W R & Co Physostigmine derivatives
CH467777A (de) * 1965-06-17 1969-01-31 Sandoz Ag Verfahren zur Herstellung neuer Indol-Derivate
IT1109003B (it) * 1977-09-20 1985-12-16 Univ Firenze Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
US4278679A (en) * 1980-05-01 1981-07-14 Chromalloy American Corporation Combination of two or more drugs in a single dosage form wherein one of the drugs is a physostigmine compound
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323881A (ja) * 1986-07-16 1988-02-01 ヘキスト−ルセル・フア−マシユウテイカルズ・インコ−ポレイテツド １，２，３，３ａ，８，８ａ−ヘキサヒドロ−３ａ，８（および１，３ａ，８）−ジ（およびトリ）メチルピロロ〔２，３−ｂ〕インド−ルおよびそれらの製造法
JPS6425777A (en) * 1987-04-03 1989-01-27 Mediolanum Farmaceut Srl Organic salt of physostigmine
JPH03153688A (ja) * 1989-09-28 1991-07-01 Hoechst Roussel Pharmaceut Inc フイソスチグミンに関連した４―および６―カルバメートおよびそれらの製法

Also Published As

Publication number Publication date
EP0354594A3 (en) 1990-05-09
US4831155A (en) 1989-05-16
IT8447780A1 (it) 1985-09-01
EP0154864A1 (en) 1985-09-18
EP0354594A2 (en) 1990-02-14
EP0154864B1 (en) 1990-07-25
IT1199076B (it) 1988-12-30
IT8447780A0 (it) 1984-03-01
ATE54917T1 (de) 1990-08-15
DE3578789D1 (de) 1990-08-30
JPH0354952B2 (enExample) 1991-08-21

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