JPS60184074A - 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体 - Google Patents

上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体

Info

Publication number
JPS60184074A
JPS60184074A JP60022821A JP2282185A JPS60184074A JP S60184074 A JPS60184074 A JP S60184074A JP 60022821 A JP60022821 A JP 60022821A JP 2282185 A JP2282185 A JP 2282185A JP S60184074 A JPS60184074 A JP S60184074A
Authority
JP
Japan
Prior art keywords
sulfamoylbenzo
furan
alkyl
aryl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60022821A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0588228B2 (enExample
Inventor
ケネス　エル．シエパード
サミユエル　エル．グラハム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS60184074A publication Critical patent/JPS60184074A/ja
Publication of JPH0588228B2 publication Critical patent/JPH0588228B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
JP60022821A 1984-02-09 1985-02-09 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体 Granted JPS60184074A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/578,463 US4544667A (en) 1984-02-09 1984-02-09 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure
US578463 2000-05-25

Publications (2)

Publication Number Publication Date
JPS60184074A true JPS60184074A (ja) 1985-09-19
JPH0588228B2 JPH0588228B2 (enExample) 1993-12-21

Family

ID=24312989

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60022821A Granted JPS60184074A (ja) 1984-02-09 1985-02-09 上昇した眼内圧の治療用の２‐スルフアモイルベンゾ〔ｂ〕フラン誘導体

Country Status (4)

Country Link
US (1) US4544667A (enExample)
EP (1) EP0152340B1 (enExample)
JP (1) JPS60184074A (enExample)
DE (1) DE3570076D1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163671A (ja) * 1984-09-05 1986-04-01 Shionogi & Co Ltd ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤
EP0189690B1 (en) * 1984-12-12 1989-03-01 Merck & Co. Inc. Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
JPS62155269A (ja) * 1984-12-29 1987-07-10 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
EP0271273A3 (en) * 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
US4914111A (en) * 1987-03-23 1990-04-03 Merck & Co., Inc. 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents
EP0309028A3 (en) * 1987-09-16 1990-06-27 Merck & Co. Inc. Substituted thieno(2,3-b)furan-2-sulfonamides as antiglaucoma agents
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5519040A (en) * 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
CN105085450A (zh) * 2015-09-14 2015-11-25 中国药科大学 苯并呋喃类衍生物、其制备方法及其治疗作用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391627A (en) * 1980-07-25 1983-07-05 E. I. Du Pont De Nemours And Company Herbicidal benzothiophene and benzofuran sulfonamides
AR241136A1 (es) * 1981-07-13 1991-11-29 Merck E Co Inc Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
US4416890A (en) * 1981-07-13 1983-11-22 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
BR8204028A (pt) * 1981-07-16 1983-07-05 Du Pont Composto herbicida composicao adequada e processo para controlar o crescimento de vegetacao indesejada
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
EP0152340A1 (en) 1985-08-21
EP0152340B1 (en) 1989-05-10
DE3570076D1 (en) 1989-06-15
JPH0588228B2 (enExample) 1993-12-21
US4544667A (en) 1985-10-01

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