JPS60181022A - Anti-inflammatory and analgesic composition for mucosa - Google Patents

Abstract

PURPOSE:An anti-inflammatory and analgesic composition for mucosa useful as a preventive and a remedy for gastric ulcer pain, pharynx pain, tonsil pain, etc., alleviating rapidly and extremely musoca ache and mucocitis, containing three components of dried root of Glycyrrhiza uralensis, dried root of Hibiscus manihot LINNAEUS and dried fruit of Crataegus cuneata. CONSTITUTION:An anti-inflammatory and analgesic composition for the mucosa containing dried root of Glycyrrhiza uralensis, dried root of Hibiscus manihot LINNAEUS and dried fruit of Crataegus cuneata of crude drugs of Chinese herbal remedy as active ingredients. These active ingredients are usually used as an extract or an fluidextract. Namely, in case of dried root of Glycyrrhiza uralensis, an extract extracted with a strongly polar organic solvent, especially a fluidextract extracted with water and ethanol, is used. In case of dried root of Hibiscus manihot LINNAEUS, an extract extracted with water is preferable. In case of dried fruit of Crataegus cuneata, an extract extracted with <=55 deg.C water is preferable. By using the three components, mucosa ache and mucocitis can be rapidly and excellently alleviated. Moreover, safety is established as Chinese herbal remedy.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to an anti-inflammatory and analgesic composition for mucous membranes using herbal herbal medicines.

[Prior art]

Many people complain of mucous membrane pain, especially sore throats caused by colds and tonsillitis, and it is said that this tendency has become particularly strong in recent years.

By the way, mucous membrane pain and inflammation such as sore throat and tonsillitis are
It has become effective (curable) with antibiotics such as tetracytalin, penicillin, and cephalosporin.

However, on the other hand, in the case of colds caused by viruses, antibiotics do not necessarily work effectively and the sore throat often persists for a long time. Those who continue using the drug often develop bacterial cross-resistance and other serious side effects.

Therefore, attempts have been made to alleviate mucosal cancers such as sore throats and mucosal inflammations such as tonsillitis, and to avoid long-term use of antibiotics. As part of such an attempt, ampoules of aqueous licorice extract have been sold for the treatment of initial or mild sore throats, and are attracting attention. However, the reality is that in many cases it is difficult to recognize the effects of licorice alone in terms of immediate effect and effectiveness.

[Disclosure of the invention]

Under these circumstances, the Society of Inventors has conducted various studies and has found that mucosal pain and mucosal inflammation can be rapidly and significantly alleviated by using licorice in combination with the three flavors of Aspergillus orientalis and Sanshuzi. I discovered that.

The present invention has been completed based on this knowledge, and relates to an anti-inflammatory and analgesic composition for mucous membranes, which contains the three flavors of Aspergillus orientalis, Porphyra spp., and Licorice as active ingredients.

The yellow hollyhock used in the present invention is of the Malvaceae family (Fam-41
y Malvaceae) plant, the plant
llibis-cus manihot LINNAE
US, ) roots are dried.

In addition, Yamaseko is a member of the Rosaceae family (Family Rosaceae).
ae) plant, hawthorn (Crataegus cun)
eater) fruit or its dried product.

The grass is a member of the Fabaceae family (order Fasales, Le5minosae).
Candela (Glycyrrhiga ural)
Glycyr ensis), other colayers [e.g. Glycyr
rhiza glabra) is dried.

These active ingredients are usually used as their extracts or liquid extracts.

Preferred examples of the extract or liquid extract of Aspergillus orientalis include those extracted with water. For water extraction,
Extraction may be performed by heating if necessary.

Preferable examples of the extract or liquid extract of Phytophthora japonica include those extracted using water (at a temperature of 55° C. or less), those obtained by squeezing the raw fruit, and extracting the juice using a mixer, juicer, etc.

As the licorice extract or liquid extract, an extract eluted with water, a strong polar organic solvent, or a mixed solvent thereof, particularly a liquid extract extracted with water and ethanol is used.

The composition ratio of each component is usually licorice: Huangshuoi: Yamasako = t:
O,S~540.5~10 (weight ratio).

In the anti-inflammatory/analgesic composition for mucous membranes of the present invention,
In addition to these three herbal medicines, other herbal medicines such as Huangren, Huangbai, Nantenmi, Nantenha, Colombo, etc. may be added as required, and chemical drugs with antibacterial activity may be added.

The active ingredients of the anti-inflammatory and analgesic composition for mucous membranes of the present invention are all Chinese herbal medicines that have been used since ancient times, and their safety has already been established.

In the present invention, examples of mucous membranes include the oral cavity wall and the gastrointestinal wall, and since the composition of the present invention has an anti-inflammatory and analgesic effect on the mucous organs, it can be used to treat gastric ulcers, sore throats, tonsillitis, etc. It is used as a prophylactic/therapeutic agent, a symptom reliever, etc.

Therefore, the anti-inflammatory and analgesic composition for mucous membranes of the present invention,
It is used as an anti-inflammatory and painkiller, and as a so-called health supplement.

The anti-inflammatory and analgesic composition for mucous membranes of the present invention is preferably mixed with pharmaceutical additives such as pharmaceutically acceptable carriers, excipients, and diluents to form syrups, drinks, troches, and the like. Ru. It may also be mixed with starch syrup or the like to form a so-called health supplement.

The blending amount of each active ingredient is about 0.02 to 60% by weight, preferably about 0.41 to 50% by weight, in pharmaceutical additives such as carriers, excipients, and diluents.

When the anti-inflammatory/analgesic composition for mucous membranes of the present invention is used as an anti-inflammatory/analgesic, it is usually administered orally to mammals including humans. The dosage may be any amount that relieves sore throat by exerting anti-inflammatory and analgesic effects, and may vary depending on the animal to be administered, symptoms, dosage form, etc., but in general, in the case of oral preparations, each lθ to 1000 mg of crude drug powder is used. degree, preferably 50 to 500 mg. In addition, the amount of the extract is equivalent to the above-mentioned amount in terms of herbal medicine. The frequency of administration can be appropriately selected within the range of 1 to 3 times a day.

The effectiveness of the anti-inflammatory and analgesic composition for mucous membranes using herbal herbal medicines of the present invention will be demonstrated below by giving examples and experimental examples.

Example 1 (water syrup) Malt starch syrup 80g Maltose 15g Fructose 5g The following crude drug composition was blended into the above starch syrup base.

Licorice water extract 0.5g Huangshu Fasui Extract Ig Yamasako raw juice 2g Example 2 (1' linking agent) Honey 2g Glucose 3g Water 95g The following crude drug composition was blended into the above drink base.

Licorice ethanol extract 0.4g Huangshu water extract 10g (1g of herbal medicine) Sanshazi watery extract 5g (2g of herbal medicine) Comparative example 1 In Example 1, 0 glucose was used instead of the licorice water extract.
．． A starch syrup using 5 g was obtained.

Comparative Example 2 A drink was obtained using 5 g of 5% glucose solution in place of the Aqueduct extract in Example 2.

Experimental Example Examples 1 and 2 were given to 20 people who complained of sore throat due to colds.
The formulations or foods of Comparative Examples 1 and 2 were administered, and the symptoms were examined two days later. The results are shown in the following table.

The above examples clearly prove that the basic car is effective.

Claims (1)

[Scope of Claims] +11 An anti-inflammatory and analgesic composition for mucous membranes, which contains Kegusa oleracea, Aspergillus spp. (2) The anti-inflammatory and analgesic composition for mucous membranes according to claim 11, wherein the licorice is in the form of water or a strong polar organic solvent extract. (3) Anti-inflammatory treatment for mucous membranes according to claim 111 or (2), wherein Astragalus is in the form of a water extract.
Analgesic composition. (4) Claim No. +1), (2) or
3) The composition having anti-inflammatory and analgesic properties for mucous membranes as described in section 3).