KR101440533B1 - A composition comprising herbal extracts for cleaning nasal cavity - Google Patents

Abstract

The present invention relates to a composition comprising herbal extracts such as licorice, sanguisorba root, green tea, Ulmus macrocarpa, Platycodon glandiflorum, and Astragalus membranaceus for cleaning nasal cavity. The composition has effects of remarkably suppressing the sinusitis symptoms such as yellowish nasal discharge and nasal congestion and the rhinitis symptoms such as clear nasal discharge and sneezing, and has high in-vivo stability by consisting herbal extracts extracted from edible herbal medicines, thereby can be practically used as a composition for cleaning the nasal cavity.

Description

[0001] The present invention relates to a composition containing herbal extracts for cleaning nasal cavity,

The present invention relates to a nasal washing liquid composition containing herbal extracts, and more particularly, to a nasal washing liquid composition containing herbal extracts of licorice, jelly, green tea, yukee, gakyung and yanggi.

Modern society, where urbanization is proceeding at a rapid pace, is changing into an environment where various diseases are likely to occur through respiration such as nose due to air pollution or environmental pollution. In addition, atmospheric suspended substances such as house dust mites, pollen, floating pollen, fungus, and various dusts are gradually increasing along with urbanization. If the foreign substances are accumulated in the nasal mucosa as the atmospheric suspended solids are introduced into the nostril, allergic rhinitis, atrophic rhinitis, sinusitis and the like are frequently generated.

Allergic rhinitis is characterized by sudden, continuous sneezing, a large amount of clear nasal discharge, blocked nose, and at the same time a heavy head and tears. When you get up in the morning in the morning and your body is temporarily cooled, you may have symptoms like the ones mentioned before, and then it gets better in a few hours. It is often confused with a cold, which is different from a cold, often accompanied by asthma or urticaria.

Atrophic rhinitis is a chronic disease in which the nasal mucosa or bony quality of the nose is reduced. It is also known as odor nausea, and the mucous membrane in the nose is contracted and the nasal cavity becomes empty. Strictly speaking, there is a stinking or not stinking atrophic rhinitis. The odor is called smell, and the cause of it is not clear. However, the cause of the stinking is not clear, but the constitutional characteristic, endocrine disorder, vitamin deficiency, bacterial infection, Immune diseases, genetic factors, etc., and it is believed that several factors overlap. This is especially the case for many diseases in women, usually puberty, but it may appear in children, nasal mucosal atrophy, scab formation, and odor are the three major symptoms, and occasionally nasal obstruction, Headache, etc. may occur. Odor differs depending on the amount of scab, but it tends to get worse during menstruation. The patient himself can not recognize odor because he has a sense of smell, but others can smell even at a considerable distance from the patient. The scab is darkish green, which causes necrosis, and even if you remove the scab, you feel necrotic. If the atrophic rhinitis progresses further, it causes complications such as atrophic pharyngitis and atrophic laryngitis, which also causes mucosal atrophy and scabs, and causes symptoms such as dryness, itching, coughing and hoarseness. The fundamental principle of treatment is to clear the nostrils and restore the function of the mucous membranes.

In this way, nasal congestion caused by various rhinitis or sinusitis can cause chronic oxygen deficiency. If you have rhinitis or sinusitis, children or adolescents often complain of chronic fatigue and learning disabilities. This also causes many disruptions to many workers as a result of reduced work efficiency.

If both sides have rhinitis, they prescribe anti-allergic drugs, antihistamines, antibiotics and anti-inflammatory drugs. However, antihistamines do not have a high therapeutic effect and may cause drowsiness. Topical steroids in the nose also eliminate symptoms at the time of use, but if used for a long period of time, they may cause sinusitis. Can not be done. Antibiotics and anti-inflammatory drugs also only help alleviate the symptoms of sunburn. In cases of intensive nasal obstruction, laser surgery is performed, but the risk of recurrence is high.

Jiyu (楡 楡) is an oryme ( Sanguisorba officinalis L.). It is also called the watermelon grass, because if you smell the leaves while rubbing the leaves, you can feel the smell of ou and watermelon. Jiyu is excellent in hemostatic effect and is used as a therapeutic agent for intestinal hemorrhage, uterine hemorrhage, hemorrhagic hemorrhage, and hematemesis, and is also used for promoting digestion. It also has antibacterial and anti-inflammatory properties and is also used as an anti-inflammatory agent. The major components of the oil are gallic acid and derivatives of ellagic acid, saponins such as angus sorbin and pterin, flavonoids such as camphorol and quercetin, ascorbic acid and the like, pomolic acid glycosides.

Licorice is called ural licorice and curly licorice. It grows in Russia (Siberia), Iran, Afghanistan, Pakistan, China (Gansuk province, Shin Kangseong), Mongolia and grows in Korea. European licorice is distributed in Southern Europe, Central Asia and China. As a variant of European licorice, there are Russian licorice, Persian licorice, and Iran licorice, but not medicinal. In Korea and Japan, roots and stem parts of licorice ( Glycyrrhiza uralensis Fischer), European licorice ( Glycyrrhiza glabra L.) or other plants are peeled or peeled. In China, dried roots of licorice ( Glycyrrhiza uralensis Fischer: licorice), licorice ( Glycyrrhiza glabra L) and licorice ( Glycyrrhiza inflata Batal: 果 甘草) are used. Licorice has a unique odor, sweet taste, harmonizes the toxicity of all medicines, and has the effect of showing good efficacy. In addition to this, licorice regulates the heat and fraud of the book, makes good communication of all blood vessels, and strengthens muscles and bones. Pharmacological action is effective in detoxification, hepatitis, urticaria, dermatitis, eczema. Jinhae, genomes, muscle relaxation, diuretic, anti-inflammatory action and inhibits peptic ulcer. The active ingredients of licorice include glycyrrhizin, glabraic acid, liquiritin which is a flavanone glycoside, neuriculitin, rhamnolcuritin, chalcones glycoside isocyanuric acid, And dozens of other flavonoids and coumarins such as hernia, umbelliferone, malic acid, benzoic acid, ferulic acid, and saccharides.

Green tea is produced by processing the leaves of Camellia sinensis . The active ingredients are flavonoid, saponin, caffeine, tannin, theanine, siccenol, vitamin C, vitamin B1, B2, niacin, pentotenic acid, inositol, . Green tea has an antioxidant effect, prevents the formation of blood clots and lowers cholesterol and blood sugar. It also has the effect of preventing tooth decay and inhibiting excessive acidity.

It is also referred to as milky skin, epidermis, and feathers, and refers to the root shell of the elm ( Ulmus macrocarpa Hance). This medicine has a little smell, a little taste, and the property is flat without any bias. The urinary bladder is urine discomfort, feeling urination pain, urine is mixed with blood and is used when swollen. It is used in the contents of boil, gauntlet, om, It has been reported that pharmacological action is used as a cancer treatment agent in the private sector.

Gakgyeong is a medicinal product made by removing roots or juniors of Platycodon grandiflorum A. De Candolle, which is a little bit odorous, has a very good taste, and has a fairly flat quality. Gyungyung works on the lungs to treat symptoms with a lot of seawater and sputum, uncomfortable breathing, clearing the lungs, releasing the stiff chest, releasing cold air in the stomach, stopping the cough and removing the wall. I do not see my urine, I have generalized edema, and even when the amount of urine is small. Sore throat, cold cough, sputum, nasal congestion, asthma, bronchial inflammation, pleurisy, headache, chills and tonsillitis. A pharmacological action was reported, such as a gadam action, a hypoglycemic action, and a cholesterol-lowering action. Saponin is mainly used as an active ingredient of purine ginseng, and saponin ingested into the body may be degraded by platycodigenin, polygalactic acid, and platycannic acid. In addition, there are abundant stenol derivatives and tterpenoids such as betulin, coumarin, inulin, and platycodine.

Astragalus membranaceus BUNGE uses roots as herbs. In animal experiments, central nervous system excitement and diuretic activity were also remarkable. When a large amount of powder was administered to rats, it inhibited the development of nephritis, delayed the onset of proteinuria and cholesterol, . This medicine is mild and mild. The efficacy is easily fatigued, weak in strength, low in vomiting, weak in pulse, and exhibiting remarkable efficacy in people who sweat a lot, and has been widely used as substitute for ginseng since ancient times. It is also widely used for uterine drainage, gastrointestinal tract, gastrointestinal tract, esophagus, and uterine bleeding. It also increases physical strength and increases the tension of whole body muscles. Therefore, it belongs to a drug commonly used in oriental medicine. However, it can not be used when the fever is severe. The active ingredients include folic acid, glucuronic acid, choline, betaine, dihydroxy, dimethoxy-isoflavane, And amino acids such as amino-butanoic acid, saccharides, alkaloids, and betaine are abundant.

Jujube is the fruit of a jujube, also called jujube or wood grain. It is used for cookies, medicinal use, and as jujube, jujube tea, jujube vinegar, and jujube porridge. Honey juice as a processed product is popular in China, Japan and Europe. In one room, it is used as diuretic, tonic, and emollient. Examples of the active ingredient of jujube include fructose, sucrose, glucose, rhamnose and organic acids such as succinic acid, malic acid, wine acid, succinic acid and glycolic acid. Examples of inorganic salts include potassium, iron, cobalt, . In addition, it is rich in proteins, amino acids, ascorbic acid, cadecine, flavonoids and the like.

Puerariae Radix (葛根) are South Korea, Japan, using the roots, remove the jupi of kudzu (Pueraria lobata (Willd.) Ohwi ) and Chinese kudzu (Pueraria lobata (Willd.) Ohwi) and Pueraria thomsonii Benth .: powder root) is used. There is no smell, and the mildew is sweet and spicy. Changgeun sweat, fever fever, high fever, cure headache and stop the thirst. It is used for digestion, headache, anemia, dysentery, abdominal pain, dryness, cold, vomiting and bleeding of wife. It blooms raw roots and sucks and drinks. The fruit of the 칡 is called the gag, and it is effective in the diarrhea. The 칡 flower which is a 칡 flower has a unique sweetness, and it releases the digestion and strengthens the intestines. 칡 powder is called galmium to stop the thirst, to see the feces and to see the children, fever is sick and the end is burning. Diabetes, dysentery, colitis, and malignant tumors. Examples of the active ingredient of Pueraria are isodextrin compounds such as daidzein, daidzin, puerarin, fuerarin xyloside, luteolin, biocanin A, and the like.

Peppermint oil is a pale yellow liquid which is obtained by drying the stem and leaves of mint, which is a perennial herb of Lamiaceae, and separating the essential oil contained in it from the steam distillation. When the essential oil is cooled to 4 ° C or lower It is also known as de-balun oil because it is refined by removing white crystals (thin pepper) which is composed mainly of free menthol. There are many kinds of mints that are used as raw materials, but they are often called different names depending on the raw species. The oriental species (M. arvensis) has a high menthol content in refined oil and refers to it when referring to peppermint oil. The essential oil of Peppermint, a Western species, is called peppermint oil and is rich in aroma and good quality. Other spearmint oil from spearmint produced in North America and Europe, and penny royal oil from Spain's Penny Royal mint. Peppermint oil is widely used in soft drinks, toothpaste, fragrance of confectionery, medicines and the like.

Accordingly, the inventors of the present invention have found that the herbal medicine extracts of licorice, jiri oil, green tea, yuengpei, gakyung, and hwanggi have excellent nasal washing effect and have high improvement effects such as sinusitis or allergic rhinitis, .

On the other hand, conventionally used nasal washing solutions include saline for spraying used for the purpose of prevention or improvement of allergic rhinitis and sinusitis. However, it has only a temporary symptom improvement but does not have a long-term therapeutic effect.

The present inventors have invented a nasal washing liquid (Korean Patent Laid-Open Publication No. 2000-0031276) containing a herbal medicine extract containing chief oil as a main component, but the herbal medicine extract disclosed in the present invention is a herbal medicine extract disclosed in Korean Patent Publication No. 2000-0031276 It is confirmed that the nasal wash effect is better than the crude drug extract.

Korean Patent No. 614679 discloses a mucosal cleansing composition for use in a nasal wash containing an extract of Korean mistletoe as an active ingredient. In Korean Patent No. 735541, a nasal washing solution containing extracts of Shin, But the constituent components of the nasal wash liquid are different from those of the present invention. Korean Patent Laid-Open Publication No. 2005-0000229 discloses a composition for treating rhinitis including an elm (elm) extract, but the prior art has a different technical structure from the present invention which is related to a nasal wash liquid .

Korean Registered Patent No. 614679 (registered as a cleaning composition for promoting mucosal immunity containing Korean mistletoe extract as an active ingredient, registered on August 14, 2006) Korean Registered Patent No. 735541 (nasal detergent composition and preparation method thereof, registered on June 28, 2007) Korean Patent Laid-Open No. 2000-0031276 (Method for producing a cleaning liquid for washing the nose, disclosed in Jun. 6, 2000) Korean Patent Publication No. 2005-0000229 (composition for treating rhinitis, published on Jan. 03, 2005)

It is an object of the present invention to provide a nasal washing liquid composition containing herbal extracts, and in particular, to provide a nasal washing liquid composition containing herbal extracts of licorice, jelly, green tea, yuukee,

The present invention relates to a nasal washing liquid composition containing herbal extracts of licorice, jelly, green tea, yuukee, gyeongyang, and yanggi.

Preferably, the herbal medicine extract is a mixture of 400 to 700 parts by weight of ground oil, 5 to 50 parts by weight of green tea, 5 to 50 parts by weight of rhizome, 5 to 50 parts by weight of germanium and 5 to 50 parts by weight of sulfur based on 100 parts by weight of licorice And may be a hot-water extract of the herbal medicine.

In the herbal medicine extract, at least one kind of herbal medicine selected from the group consisting of 20 to 100 parts by weight of jujube and 5 to 50 parts by weight of Puerariae may be added based on 100 parts by weight of licorice.

The herbal medicine extract of the present invention may be an extract containing 1 to 5% by weight of the total extract as an active ingredient.

In addition, 0.5 to 2 parts by weight of peppermint oil may be added based on 100 parts by weight of the herbal medicine extract.

The herbal medicine extract may contain an extract prepared by mixing the licorice extract with a crude oil and extracting the mixture at 75 to 85 ° C for 0.5 to 4 days.

According to another aspect of the present invention,

(Step 1) 6000 to 10000 parts by weight of water is added to 100 parts by weight of licorice, boiling to 90 to 110 ° C, and the water is kneaded so that the content of water is 3000 to 5000 parts by weight;

(Step 2) The solid extract is removed from the solubilized extract to prepare a licorice extract;

(Step 3) 300-900 parts by weight of a fat-like oil is mixed with the licorice extract of the above two processes, and the mixture is extracted at 75 to 85 ° C for 0.5 to 4 days, and the solid content is removed to prepare a licorice extract and a crude oil extract.

(Step 4) 5 to 50 parts by weight of green tea, 5 to 50 parts by weight of rape root, 5 to 50 parts by weight of radix root and 5 to 50 parts by weight of radial root are mixed with 100 to 1000 parts by weight of water, By weight and boiling at 90 to 110 캜, so that the water content is 300 to 500 parts by weight;

(Step 5) The solid content is removed from the solubilized extract of the above 4 steps to prepare green tea, yugunpyu, gyeonggyeong and hwanggi extracts. And

(Step 6): preparing a herbal medicine extract by mixing the licorice extracts of the above three processes with the green tea of the above-mentioned five processes, yuguni, gyeonggyeong, and yanggi extract;

And a method for preparing the nasal wash composition.

Hereinafter, the present invention will be described in detail.

In the first step, 20 to 100 parts by weight of jujube may be added to 100 parts by weight of licorice.

In the above-mentioned three steps, when the extract of licorice and juniper oil is mixed with the licorice extract, the complex polysaccharide extracted from licorice reacts with the juniper oil to obtain an aging effect. Thus, when extracting the juniper oil with water, This is because the extraction of the effective component of the polyhedrons increases.

In addition, in the above-mentioned three steps, the extracting temperature is preferably 75 to 85 ° C. in the preparation of the extract of licorice and juniper oil. When the extraction temperature exceeds 85 ° C., the active ingredient of the oil is volatilized and the nasal washing effect is not good. Further, when the extraction temperature is lower than 75 캜, extraction of the active ingredient is not performed well.

In the above step 4, 5 to 50 parts by weight of the molasses may be added to the mixture of green tea, yugun pei, gyeongyang, and yulgye based on 100 parts by weight of licorice.

0.5 to 2 parts by weight of peppermint oil may be added based on 100 parts by weight of the herbal medicine extract of step 6 above. In the above step 6, the peppermint oil mixed with the herbal medicine extract is obtained by dissolving peppermint leaves and branches. The peppermint oil can be prepared and sold by a conventional method. The peppermint oil is slowly lowered by 2 [deg.] C from 35 [ It is preferable to use the one containing 2 to 4% by weight of the whole.

In the step 6, the licorice extract and the extract of green tea, green tea, yuukee, gyeongyang and yanggi extracts may be mixed in a weight ratio of 1: 0.05 ~ 0.2, preferably 1: 0.08-0.15, more preferably 1: 0.1 It is preferable to mix them in a weight ratio.

The herbal medicine extract may be diluted in purified water at 1 to 10 times (weight basis) and used as a nasal wash liquid. The nasal wash solution is administered to the nostrils of the nose one to five times a day at a rate of 5 to 50 ml per day, and the nasal cavity can be cleaned by flowing through the nasal cavity to the opposite nostrils. As the nasal wash liquid, additives included in a conventional washing liquid may be used. For example, a pH adjusting agent, an ion balance adjusting agent, an antiseptic agent, an alcohol, etc. may be added. As the ion balance regulator, sodium chloride or potassium chloride may be used, and as the alcohol, preferably ethanol may be used.

The present invention relates to a nasal washing liquid composition containing herbal extracts of licorice, jelly, green tea, yuukee, gyeongyang, and yanggi. The composition is excellent in the symptoms of sinusitis such as nasal runny nose flow, nasal congestion, clear rhinorrhea and nasal symptoms such as sneezing, and is composed of herbal medicine extracts extracted from edible herbal medicine. , And can be usefully used as a composition for non-hardening.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow chart showing a process for producing a herbal medicine extract of the present invention. FIG.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the intention is to provide an exhaustive, complete, and complete disclosure of the principles of the invention to those skilled in the art.

≪ Example 1: Preparation of crude drug extract >

Each herbal medicine was prepared under the conditions shown in Table 1 below, and herbal medicine extracts were prepared by the following method. First, licorice (roots) and 8 kg of distilled water were mixed and heated to 100 ° C., and solids were removed until the amount of water became 4 kg to prepare 4 kg of licorice extract. Jujube (juice) was mixed with juice as needed. Next, the licorice extracts were mixed with ground oil and reacted at 80 ° C for 24 hours (in which water was evaporated to 15%). Then, the solids were removed and licorice extract and oilseed oil extract were prepared. Further, 800 g of distilled water was added to the mixture, and then the mixture was heated to 100 ° C. until the amount of water reached 400 g, and the solid content was removed to obtain 400 g of green tea, yugenmei, . In addition, if necessary, a mixture of green tea, yugunpyu, gyeongyang, and hwanggi was added to the mixture. Then, the herbal medicine extracts were prepared by mixing the licorice extracts with the extracts of green tea, yuukee, gakyung, and yanggi extracts. To the nasal wash solution, if necessary, peppermint oil (containing 3 wt% menthol) was added. On the other hand, the extract added with the peppermint oil increased the volume of the extract compared to other extracts. To compare the effect of the extract, the amount of the peppermint oil added was reduced by distillation to remove the moisture, and then the peppermint oil was added. The solid content of herbal medicine extracts prepared at this time was 2 to 4 wt%.

Condition Weight (g) licorice Jujube Oil green tea Yugunpi Gakyung Hwanggi Changwon peppermint oil Gross weight Example 1-1 100 0 690 30 25 25 30 0 0 900 Examples 1-2 100 100 450 50 50 50 50 50 0 900 Example 1-3 100 20 640 20 40 25 25 30 0 900 Examples 1-4 100 0 740 10 10 10 15 15 0 900 Examples 1-5 100 0 690 50 5 50 5 0 0 900 Examples 1-6 100 0 690 5 50 5 50 0 0 900 Examples 1-7 100 50 600 15 25 20 20 20 50 900

< Comparative Example  1. Preparation of herbal extracts to be compared ①>

The herbal medicine extracts were prepared in the same manner as in Example 1, except that the herbal medicine extracts were obtained under the conditions shown in Table 2 below. At this time, in Comparative Examples 1-2 to 1-5, only one to three kinds of herbal medicines were included in green tea, yugunghi, gyeonggyeong and hwanggi, respectively. In addition, the extract of Comparative Example 1-6 was prepared only to the licorice extract and the oil-in-water extract, and the extracts of green tea, yuguanpyeo, gyeonggyeong and yanggi were not mixed (instead, the same amount of water was added) After the reaction was carried out at 80 ° C for 24 hours, the extracts of green tea, yugun pei, gyeonggyeong and yanggi were mixed.

Condition Weight (g) licorice Oil green tea Yugunpi Gakyung Hwanggi Gross weight Comparative Example 1-1 100 300 125 125 125 125 900 Comparative Example 1-2 100 640 0 80 0 80 900 Comparative Example 1-3 100 640 50 0 50 60 900 Comparative Example 1-4 100 740 0 60 0 0 900 Comparative Example 1-5 100 740 0 0 60 0 900 Comparative Example 1-6 100 800 0 0 0 0 900 Comparative Example 1-7 100 0 200 200 200 200 900

< Comparative Example  2. Production of herbal extracts to be compared ②>

38 g of licorice, 38 g of Saururus chinensis and 676 g of coconut oil were mixed and then mixed with 8 kg of water. The mixture was heated to 100 캜, and solids were removed until the amount of water became 4 kg, thereby preparing licorice, Thereafter, the licorice, Saururus chinensis and extracts of papavergrass were reacted at 80 DEG C for 24 hours. Further, 800 g of water was mixed with 800 g of water, 23 g of ginseng, 17 g of scarlet, 17 g of green tea, 19 g of green tea, 14 g of omelet, 14 g of omelet, ginger, Rosemary, mint, green tea, omija, ginger, and yukigae were prepared. Thereafter, the extracts of licorice, Saururus chinensis, and the extracts of Shinwoo, Shinsei, Sucemy, mint, green tea, omija, ginger and yukigae were mixed (900 g of herbal medicine was used in total). The extracts disclosed in Korean Patent Publication No. 2000-0031276 and herbal medicine ingredients A similar herbal extract was prepared.

<Experimental Example 1> Confirmation of the therapeutic effect of herbal medicine extract on sinusitis or allergic rhinitis>

For each of the extracts of Example 1, Comparative Example 1, and Comparative Example 2, 7 patients were enrolled in a 20 mL syringe three times daily (morning, at 2 pm, before bedtime) 10 ml of herbal extracts of Example 1, Comparative Example 1 and Comparative Example 2 were injected into one nostril and flowed through the opposite nostril through the nasal cavity. Then, the nasal cavity was cleaned through the opposite nostril by the same method Respectively. After 10 days of such nasal washing, the degree of improvement of sinusitis or allergic rhinitis was checked on the basis of 'Sinusitis or allergic rhinitis symptom index' in each patient. The patients with sinusitis or rhinitis were diagnosed with sinusitis or allergic rhinitis at the hospitals from January 1, 2010 to December 31, 2012. The patients were all male and female, Respectively.

Condition Symptom index of sinusitis or allergic rhinitis Example 1-1 3.4 Examples 1-2 3.5 Example 1-3 3.5 Examples 1-4 3.6 Examples 1-5 3.4 Examples 1-6 3.6 Examples 1-7 4.4 Comparative Example 1-1 2.0 Comparative Example 1-2 1.6 Comparative Example 1-3 1.8 Comparative Example 1-4 1.4 Comparative Example 1-5 1.5 Comparative Example 1-6 1.6 Comparative Example 1-7 1.5 Comparative Example 2 2.5 Control group (unused) 1.0 * Sinusitis or allergic rhinitis symptoms index *
1 point: runny nose, sneezing, severe nasal congestion, no change before treatment
2 points: Reduce runny nose, sneezing and nasal congestion by 20% compared to before use
3 points: Reduce runny nose, sneezing and nasal congestion by 50% compared to before use
4 points: Runny nose, sneezing and nasal congestion are reduced by 80% compared to before use
5 points: Runny nose flow, sneezing and nasal obstruction completely disappeared before use

Referring to the results of Table 3 above, the extract of Example 1 showed higher nasal cleansing effect than the extract of Comparative Example 1, and thus the improvement effect of sinusitis or allergic rhinitis was higher. In addition, the extracts containing licorice, licorice, mint, green tea, yuukee, gyeonggyeong, and hwanggi were more effective than extracts containing licorice, powdery mildew or peppermint oil. On the other hand, the extract of Comparative Example 2 is similar to the herbal medicine extract disclosed in Korean Patent Laid-Open Publication No. 2000-0031276 filed by the present inventor and the herbal medicine extract of Example 1 has the nasal washing effect of the extract of Comparative Example 2 Nasal wash effect.

On the other hand, an extract was prepared in the same manner as in Example 1-7, except that the crude oil was added, boiled at 100 ° C for 3 hours, and then reacted at 80 ° C for the remaining 21 hours to prepare a herbal extract The amount was adjusted according to the amount of evaporation in the same manner as the extract of Example 1-7). The extract showed that the suppressive effect of sinusitis or allergic rhinitis was reduced by only about 50% in the runny nose, sneezing and nasal clogging compared to before use .

<Experimental Example 2> Confirmation of anti-inflammatory effect of nasal washing solution containing herbal extracts>

Nasal inflammation was measured in patients with swollen nasal passages. The patients were selected among patients with rhinitis who had swollen nasal passages from January 1, 2010 to December 31, 2012 at a bilateral hospital. Seven patients were inflated with swollen nasal passages in each experimental group, and their heads were leaned three times a day (before morning, at 2 pm, and at night before bed), using a 20 ml syringe to compare Example 1, Comparative Example 1 and Comparative Example 10 ml of the herbal extract of Example 2 was injected into one nostril and flowed through the opposite nostril through the nasal cavity. Then, the nasal cavity was washed through the opposite nostril by the same method. On the 10th day, the internal nares of both nasal cavities of the same depth were measured in a lateral direction using a digital inner micrometer (TESA, Swiss) The rate of change was calculated. The rate of change in nasal edema was calculated by the following formula. Here, A is the inner diameter value of the nasal cavity just before administration of herbal medicine extract, and B is the value after 10 days of administration of the extract. The rate of change in nasal edema is shown in Table 4, and the larger the rate of change in nasal edema, the smaller the size of edema.

Change rate (%) = (B-A) / A x 100

Condition Rate of change in nasal edema (%) Example 1-1 17.6 Examples 1-2 19.5 Example 1-3 20.4 Examples 1-4 19.7 Examples 1-5 18.6 Examples 1-6 17.8 Examples 1-7 22.3 Comparative Example 1-1 10.6 Comparative Example 1-2 8.9 Comparative Example 1-3 9.6 Comparative Example 1-4 7.7 Comparative Example 1-5 7.4 Comparative Example 1-6 7.5 Comparative Example 1-7 7.5 Comparative Example 2 11.6

Referring to Table 4, it was confirmed that the herbal medicine extract of Example 1 of the present invention had the highest rate of nasal edema change and had the best effect of suppressing edema in the nasal cavity. The herbal medicine extract of Comparative Example 2 (similar to the herbal medicine extract disclosed in Korean Patent Publication No. 2000-0031276) was also found to have a lower rate of nasal edema change due to nasal washing than the herbal medicine extract of Example 1.

On the other hand, an extract was prepared in the same manner as in Example 1-7, except that the crude oil was added, boiled at 100 ° C for 3 hours, and then reacted at 80 ° C for the remaining 21 hours to prepare a herbal extract The amount of the extract was adjusted to be the same as that of the extract of Example 1-7) and the rate of change of the nasal edema was only 14.5%. Thus, extraction of the oil at 75 to 85 ° C is more effective for nasal treatment .

Claims (7)

Liquorice extract, liquorice extract, green tea, green tea, yugun peel, royal jelly, and hwanggi. The method according to claim 1,
The crude herbal medicine extract is prepared by mixing 400 to 700 parts by weight of ground oil, 5 to 50 parts by weight of green tea, 5 to 50 parts by weight of rape root, 5 to 50 parts by weight of radish root and 5 to 50 parts by weight of radish root, Wherein the composition is an extract. 3. The method according to claim 1 or 2,
Wherein the herbal medicine extract comprises at least one kind of herbal medicine selected from the group consisting of 20 to 100 parts by weight of jujube and 5 to 50 parts by weight of Puerariae, based on 100 parts by weight of licorice. 3. The method according to claim 1 or 2,
Wherein the herbal medicine extract is an extract containing 1 to 5% by weight of a solid content of the whole extract as an active ingredient. 3. The method according to claim 1 or 2,
Wherein 0.5 to 2 parts by weight of peppermint oil is added based on 100 parts by weight of the herbal medicine extract. 3. The method according to claim 1 or 2,
Wherein the herbal medicine extract comprises an extract prepared by mixing the licorice extract with a coenzyme and extracting the extract at 75 to 85 ° C for 0.5 to 4 days. (Step 1) 6000 to 10000 parts by weight of water is added to 100 parts by weight of licorice, boiling to 90 to 110 ° C, and the water is kneaded so that the content of water is 3000 to 5000 parts by weight;
(Step 2) The solid extract is removed from the solubilized extract to prepare a licorice extract;
(Step 3) 300-900 parts by weight of a fat-like oil is mixed with the licorice extract of the above two processes, and the mixture is extracted at 75 to 85 ° C for 0.5 to 4 days, and the solid content is removed to prepare a licorice extract and a crude oil extract.
(Step 4) 5 to 50 parts by weight of green tea, 5 to 50 parts by weight of rape root, 5 to 50 parts by weight of radix root and 5 to 50 parts by weight of radial root are mixed with 100 to 1000 parts by weight of water, By weight and boiling at 90 to 110 캜, so that the water content is 300 to 500 parts by weight;
(Step 5) The solid content is removed from the solubilized extract of the above 4 steps to prepare green tea, yugunpyu, gyeonggyeong and hwanggi extracts; And
(Step 6): preparing a herbal medicine extract by mixing the licorice extracts of the above three processes with the green tea of the above-mentioned five processes, yuguni, gyeonggyeong, and yanggi extract;
Wherein the nasal wash liquid composition is prepared by a method comprising the steps of:

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