CN101234139B - Proprietary Chinese medicine for curing common cold and preparation thereof - Google Patents
Proprietary Chinese medicine for curing common cold and preparation thereof Download PDFInfo
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- CN101234139B CN101234139B CN2008100265280A CN200810026528A CN101234139B CN 101234139 B CN101234139 B CN 101234139B CN 2008100265280 A CN2008100265280 A CN 2008100265280A CN 200810026528 A CN200810026528 A CN 200810026528A CN 101234139 B CN101234139 B CN 101234139B
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Abstract
The invention provides a Chinese patent medicine for treating common cold, the raw materials of the medicine with the weight proportions are as follows: 12.4-37.4 percent of bupleurum, 11.2-33.6 percent of Scutellaria baicalensis Georgi, 15.0-44.8 percent of southernwood, 11.2-33.6 percent of chrysanthemum indicum L. and 0.2-0.6 percent of gypsum. The formula is used for treating symptoms of common cold, fever, headache, cough, nasal mucus and swollen sore throat and so on. At the same time, the invention also provides a preparation method for the cold medicine.
Description
Technical field
The present invention relates to a kind of prescription and manufacture method of Chinese patent medicine, particularly a kind of Chinese patent medicine for the treatment of flu and preparation method thereof.
Background technology
At present, the medicine that is used for the treatment of flu on the China market just has kind more than 200, wherein in the majority with Western medicine and Chinese and Western synthetic drug, Western medicine such as Sino-U.S. SmithKline, new contac etc., are raised gram tablet of antelope horn for common cold etc. at Chinese patent medicine such as bavin pornographic movie, the yellow electuary of bavin, and most of Western medicine can only temporarily alleviate disease, cure the symptoms, not the disease, and often only effective to some disease, the easily recurrence of treatment back can not be played basic therapeutical effect to most of patient; And treat the Chinese patent medicine of this type of disease, exist take effect slow, take defective such as inconvenience.
Therefore, provide a kind of instant effect, taking convenience, side effect little, the Chinese patent medicine formula and the manufacture method that are used for the treatment of flu are real in necessary.
Summary of the invention
The object of the present invention is to provide a kind of instant effect, taking convenience, side effect little, the Chinese patent medicine formula and the manufacture method that are used for the treatment of flu, the effect that it can play relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing is used for the treatment of diseases such as flu, heating, headache, cough, nasal obstruction watery nasal discharge, laryngopharynx swelling and pain.
The invention provides a kind of Chinese patent medicine for the treatment of flu, the percentage by weight of each raw material is:
Radix Bupleuri 12.4-37.4%
Radix Scutellariae 11.2-33.6%
Herba Artemisiae Annuae 15.0-44.8%
Flos Chrysanthemi Indici 11.2-33.6%
Gypsum Fibrosum 0.2-0.6%.
The present invention also provides the preparation method of coldrex, adopts raw material Radix Bupleuri, Radix Scutellariae, Herba Artemisiae Annuae, Flos Chrysanthemi Indici and Gypsum Fibrosum to make, and said method comprising the steps of:
(1) from corresponding raw material, extracts corresponding extract respectively: Oleum Bupleuri, Radix Bupleuri extract, Radix Scutellariae extract, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, Flos Chrysanthemi Indici extract and Gypsum Fibrosum powder;
(2) take by weighing the Radix Bupleuri extract and the Flos Chrysanthemi Indici extract of recipe quantity, add an amount of filler, behind the abundant mixing of heated and stirred, add Oleum Bupleuri, Radix Scutellariae extract, Gypsum Fibrosum powder, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, emulsifying agent and antiseptic, after stirring, be pressed into the soft capsule finished product.
Described filler is PEG400, Macrogol 600, vegetable oil, liquid paraffin, starch or dextrin; Described emulsifying agent is tween or span; Described antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sodium benzoate, potassium sorbate, and wherein, described emulsifier concentration is 0.05%-0.2%, and described concentration of preservatives is 0.03%～0.05%.
Wherein, further may further comprise the steps in the step (1):
(11) produce Oleum Bupleuri: the material Radix Bupleuri of getting it filled is ground into coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.43g/cm
3Under the condition of 30～40 ℃ of extracting pressure 20～30MPa, extraction temperature through twice parsing, resolve I pressure 10～15MPa, resolve 45～65 ℃ of I temperature, resolve II pressure 5～15MPa, resolve 45～65 ℃ of II temperature, extracting 3～5 hours and getting extract is Oleum Bupleuri;
(12) produce Radix Bupleuri extract: get (11) Radix Bupleuri coarse powder after deoiling, 95% soak with ethanol that adds 10 times of weight is after 2 hours, 60～70 ℃ of temperature are carried 0.5 hour, filter, the concentration that medicinal residues add 6 times of amounts again is 80% soak with ethanol after 1 hour, and 60～70 ℃ of temperature are carried 0.5 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is 1.05～1.10 (60～70 ℃), adding water stirs, leave standstill, layering, getting supernatant concentration to relative density is 1.05～1.10 (60～70 ℃), add the alcohol dissolving and adjust determining alcohol to 60%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.15～1.18 (80 ℃), be Radix Bupleuri extract;
(13) produce Radix Scutellariae extract: baikal skullcap root decoction pieces with the water extraction of 80～100 ℃ of 10 times of weight 2 times, each 1 hour, is filtered, medicinal liquid merges, and suitably concentrates, and adds hydrochloric acid and makes pH value reach 1～2,80 ℃ of insulations 1 hour, the baicalin cohesion is separated out, leave standstill, layering, filter, precipitate is extremely neutral with hot water wash, drying, get pale yellow powder, be Radix Scutellariae extract;
(14) produce Herba Artemisiae Annuae oil: the Herba Artemisiae Annuae pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.2g/cm
3Under the condition of 30～50 ℃ of extracting pressure 15～25MPa, extraction temperature through twice parsing: resolve I pressure 10～15MPa, resolve 50～70 ℃ of I temperature, resolve II pressure 5～10Mpa, resolve 40～60 ℃ of II temperature, extracting 2～4 hours and getting extract is Herba Artemisiae Annuae oil;
(15) produce the Herba Dendranthematis indici caul-fat: the Flos Chrysanthemi Indici pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.26g/cm
3Under the condition of 35～45 ℃ of extracting pressure 10～25Mpa, extraction temperature through twice parsing: resolve I pressure 5～10MPa, resolve the I temperature: 40～50 ℃, resolve II pressure 5～10MPa, resolve 40～60 ℃ of II temperature, extracting 2～5 hours and getting extract is the Herba Dendranthematis indici caul-fat;
(16) produce Flos Chrysanthemi Indici extract: get (15) Flos Chrysanthemi Indici coarse powder after deoiling, 95% soak with ethanol 2 hours that adds 10 times of weight, heating extraction 0.5 hour, filter, medicinal residues add 80% soak with ethanol 1 hour of 6 times of weight again, 0.5 half an hour of heating extraction, filter, merging filtrate, reclaim ethanol, being concentrated into relative density is the extractum of 1.10～1.20 (60～80 ℃), and extractum adds the boiling water of 6 times of weight, heated and stirred becomes the muddy liquid of homogeneous, the salt that adds former extractum weight 10% stirs, and leaves standstill layering, filter, filtrate is concentrated into the thick paste shape, adds the dissolve with ethanol of 2 times of former extractum weight, filters, it is 1.15～1.18 (80 ℃) thick paste that filtrate is concentrated into relative density, promptly gets Flos Chrysanthemi Indici extract;
(17) produce Gypsum Fibrosum powder: carry out micronizing after getting the roguing of Gypsum Fibrosum medical material, promptly get Gypsum Fibrosum powder.
Compared with prior art, prescription of the present invention is to reach at " bavin pornographic movie " on the basis of " bavin yellow electuary " prescription to have increased Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Gypsum Fibrosum, adjusts compatibility and after clinical practice checking effectively and get, form by Radix Bupleuri, Radix Scutellariae, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Gypsum Fibrosum five tastes medical material, have relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, the effect of heat-clearing and toxic substances removing is used for cold, fever, headache, cough, nasal obstruction watery nasal discharge, diseases such as laryngopharynx swelling and pain, be the good recipe of treatment cold, fever, suitable especially to viral influenza, hyperpyrexia person.
On manufacture method, adopt the supercritical carbon dioxide extraction technology to get indescribably with bupleurum Chinese, Herba Artemisiae Annuae, Flos Chrysanthemi Indici five equilibrium that supercritical process extracts, and medicinal residues are carried out water is carried or alcohol extraction, and Radix Scutellariae is extracted refining being fit in the prescription, Gypsum Fibrosum is carried out micronizing, finally make soft capsule.In the Chinese medicine extract with supercritical carbon dioxide extraction, its chemical constituent or content of effective are considerably beyond the extract with the common process method.
The specific embodiment
The invention provides a kind of Chinese patent medicine for the treatment of flu, the percentage by weight of each raw material is:
Radix Bupleuri 12.4-37.4%
Radix Scutellariae 11.2-33.6%
Herba Artemisiae Annuae 15.0-44.8%
Flos Chrysanthemi Indici 11.2-33.6%
Gypsum Fibrosum 0.2-0.6%.
The below physical and chemical performance and the pharmacological action of each component of summary:
Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurumscorzonerifolium Willd..Have reconciling superficies and interior, the effect of soothing the liver yang invigorating is used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect is used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae annuae Artemisia annua L..Have clearing away summer-heat, remove and steam, the effect of preventing the attack (or recurrence) of malaria is used for the pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Flos Chrysanthemi Indici is the dry capitulum of feverfew Herba Dendranthematis indici Chrysanthemum indicum L..Effect with heat-clearing and toxic substances removing is used for the furuncle carbuncle, conjunctival congestion and swelling pain, and it is dizzy to have a headache.
Gypsum Fibrosum is Sulfates mineral anhydrite family, the main hydrous calcium sulfate (CaSO42H2O) that contains.Have clearing away heat-fire, the effect that relieving restlessness is quenched the thirst is used for fever caused by exogenous pathogenic factors, hyperpyrexia excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
This prescription is made up of Radix Bupleuri, Radix Scutellariae, Flos Chrysanthemi Indici, Herba Artemisiae Annuae, Gypsum Fibrosum five tastes medical material, has relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, and the effect of heat-clearing and toxic substances removing is used for cold, fever, headache, cough, nasal obstruction watery nasal discharge, diseases such as laryngopharynx swelling and pain, suitable especially to viral influenza, hyperpyrexia person, be the good recipe of treatment cold, fever.The traditional Chinese medical science is thought lung governing qi, and department breathes, and closes fur outward, for body is defended outer barrier.The invasion and attack of the heresy of wind heat, attacking the lung first, lung are defended and are held back, and defending sun can not be warm, aversion to wind then, heresy of wind heat and healthy energy friendship are striven, and then see fever of the body, and calorific potential are more very.All YANG-meridians meeting into the head, the exterior tightened by exogenous pathogens is then seen headache.Nose is the breath road, and throat is the door of lung, wind-heat invading the lung, and abnormal rising of lung-QI, then cough is coughed up phlegm, and expectorant is sticking or yellow, parched throat or red swelling and pain of throat, nasal obstruction, stream turbid nasal discharge.More very, it is violent then may to cause pharyngalgia as calorific potential, and very then accumulation of heat suppurates.Thirst with desire to drink, tongue tip side of red, the little Huang of thin white fur of tongue, floating and rapid pulse have been resembling of heat.So control suitable dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing.Radix Bupleuri acrid in the mouth hardship in the side, feeble QI is cold, fragrant catharsis, can separate pathogenic factor in the exterior outward, the clear interior-heat of holding concurrently is to be monarch drug, the Radix Scutellariae bitter cold is gone into lung meridian, the excess-heat of the kind lung heat clearing fire and the part of the body cavity above the diaphragm housing the heart and lungs, help the Radix Bupleuri heat clearing away, and Radix Bupleuri and Radix Scutellariae mutually 5 gone into few positive gallbladder meridian again and the heat of the few positive gallbladder meridian of removing summer-heat, and Herba Artemisiae Annuae lightly floats, hot fragrant saturating loosing, help Radix Bupleuri to evacuate pathogenic factor in the exterior, nature and flavor bitter cold, the interior-heat clearly thoroughly of holding concurrently, the two is ministerial drug altogether, Flos Chrysanthemi Indici hardship, suffering, be slightly cold, the power of clearing away heat-fire, relieving sore throat and pain is stronger, Gypsum Fibrosum suffering, sweet, Great Cold, the power of clearing away heat and promoting production of body fluid very, principal drug assistance heat-clearing and toxic substances removing sore-throat relieving.Be adjuvant drug altogether.All medicines are harmonious, and are total to the long memorial wind, relieving exterior syndrome, the merit of heat-clearing and toxic substances removing, and so then exopathogen must be separated, and interior-heat gets clearly, and all disease knowing are removed.
The present invention also provides the preparation method of the Chinese patent medicine of this treatment flu, adopts raw material Radix Bupleuri, Radix Scutellariae, Herba Artemisiae Annuae, Flos Chrysanthemi Indici and Gypsum Fibrosum to make, and said method comprising the steps of:
(1) from corresponding raw material, extracts corresponding extract respectively: Oleum Bupleuri, Radix Bupleuri extract, Radix Scutellariae extract, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, Flos Chrysanthemi Indici extract and Gypsum Fibrosum powder;
(2) take by weighing the Radix Bupleuri extract and the Flos Chrysanthemi Indici extract of recipe quantity, add an amount of filler, behind the abundant mixing of heated and stirred (40～60 ℃), add Oleum Bupleuri, Radix Scutellariae extract, Gypsum Fibrosum powder, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, emulsifying agent and antiseptic, after stirring, be pressed into the soft capsule finished product.
Described filler is PEG400, Macrogol 600, vegetable oil, liquid paraffin, starch or dextrin; Described emulsifying agent is tween or span; Described antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sodium benzoate, potassium sorbate, and wherein, described emulsifier concentration is 0.05%-0.2%, and described concentration of preservatives is 0.03%～0.05%.
Wherein, step (1) further may further comprise the steps:
(11) produce Oleum Bupleuri: the material Radix Bupleuri of getting it filled is ground into coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.43g/cm
3, under the condition of 30～40 ℃ of pressure 20～30MPa, temperature, extract, then, through twice parsing, resolve I pressure 10～15MPa, resolve 45～65 ℃ of I temperature, resolve II pressure 5～15MPa, resolve 45～65 ℃ of II temperature, extracting 3～5 hours and getting extract is Oleum Bupleuri;
(12) produce Radix Bupleuri extract: get (11) Radix Bupleuri coarse powder after deoiling, 95% soak with ethanol that adds 10 times of weight is after 2 hours, 60～70 ℃ of temperature are carried 0.5 hour, filter, the concentration that medicinal residues add 6 times of amounts again is 80% soak with ethanol after 1 hour, and 60～70 ℃ of temperature are carried 0.5 hour, filter, merging filtrate reclaims ethanol, and being concentrated into relative density is 1.05～1.10 (60～70 ℃), adding water stirs, leave standstill, layering, getting supernatant concentration to relative density is 1.05～1.10 (60～70 ℃), add the alcohol dissolving and adjust determining alcohol to 60%, leave standstill, get the thick paste that supernatant concentration to relative density is 1.15～1.18 (80 ℃), be Radix Bupleuri extract;
(13) produce Radix Scutellariae extract: baikal skullcap root decoction pieces with the water extraction of 80～100 ℃ of 10 times of weight 2 times, each 1 hour, is filtered, medicinal liquid merges, and suitably concentrates, and adds hydrochloric acid and makes pH value reach 1～2,80 ℃ of insulations 1 hour, the baicalin cohesion is separated out, leave standstill, layering, filter, precipitate is extremely neutral with hot water wash, drying, get pale yellow powder, be Radix Scutellariae extract;
(14) produce Herba Artemisiae Annuae oil: the Herba Artemisiae Annuae pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.2g/cm
3Under the condition of 30～50 ℃ of pressure 15～25MPa, temperature, extract, then, through twice parsing: resolve I pressure 10～15MPa, resolve 50～70 ℃ of I temperature, resolve II pressure 5～10Mpa, resolve 40～60 ℃ of II temperature, extracting 2～4 hours and getting extract is Herba Artemisiae Annuae oil;
(15) produce the Herba Dendranthematis indici caul-fat: the Flos Chrysanthemi Indici pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.26g/cm
3Under the condition of 35～45 ℃ of extracting pressure 10～25Mpa, extraction temperature through twice parsing: resolve I pressure 5～10MPa, resolve the I temperature: 40～50 ℃, resolve II pressure 5～10MPa, resolve 40～60 ℃ of II temperature, extracting 2～5 hours and getting extract is the Herba Dendranthematis indici caul-fat;
(16) produce Flos Chrysanthemi Indici extract: get (15) Flos Chrysanthemi Indici coarse powder after deoiling, 95% soak with ethanol 2 hours that adds 10 times of weight, heating extraction 0.5 hour, filter, medicinal residues add 80% soak with ethanol 1 hour of 6 times of weight again, 0.5 half an hour of heating extraction, filter, merging filtrate, reclaim ethanol, being concentrated into relative density is the extractum of 1.10～1.20 (60～80 ℃), and extractum adds the boiling water of 6 times of weight, heated and stirred becomes the muddy liquid of homogeneous, the salt that adds former extractum weight 10% stirs, and leaves standstill layering, filter, filtrate is concentrated into the thick paste shape, adds the dissolve with ethanol of 2 times of former extractum weight, filters, it is 1.15～1.18 (80 ℃) thick paste that filtrate is concentrated into relative density, promptly gets Flos Chrysanthemi Indici extract;
(17) produce Gypsum Fibrosum powder: adopt Baily pulverizing mill BFM-6 type machine to carry out micronizing after getting the roguing of Gypsum Fibrosum medical material, promptly get the Gypsum Fibrosum powder that is ultra tiny powdery.
By above-mentioned experimental technique and following each the formulation coldrex of the present invention provide is provided:
Embodiment 1
In the present embodiment, the percentage by weight of each raw material of coldrex is:
Radix Bupleuri 24.9%
Radix Scutellariae 22.4%
Herba Artemisiae Annuae 29.9%
Flos Chrysanthemi Indici 22.4%
Gypsum Fibrosum 0.4%.
Embodiment 2
In the present embodiment, the percentage by weight of each raw material of coldrex is:
Radix Bupleuri 37.4%
Radix Scutellariae 33.6%
Herba Artemisiae Annuae 16.0%
Flos Chrysanthemi Indici 12.4%
Gypsum Fibrosum 0.6%.
Embodiment 3
In the present embodiment, the percentage by weight of each raw material of coldrex is:
Radix Bupleuri 12.4%
Radix Scutellariae 11.2%
Herba Artemisiae Annuae 42.6%
Flos Chrysanthemi Indici 33.6%
Gypsum Fibrosum 0.2%.
Prescription of the present invention is to reach at " bavin pornographic movie " on the basis of " bavin yellow electuary " prescription to have increased Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Gypsum Fibrosum, adjust compatibility and, form, have relieving the exterior syndrome with drugs of pungent in flavor and cool in nature by Radix Bupleuri, Radix Scutellariae, Herba Artemisiae Annuae, Flos Chrysanthemi Indici, Gypsum Fibrosum five tastes medical material through the effective back and definite of clinical practice checking, the effect of heat-clearing and toxic substances removing, be used for affection due to external wind and heat, headache, cough, the nasal obstruction watery nasal discharge, diseases such as laryngopharynx swelling and pain are the good recipes of treatment cold, fever, and are suitable especially to viral influenza, hyperpyrexia person.
On manufacture method, adopt the supercritical carbon dioxide extraction technology to get indescribably with bupleurum Chinese, Herba Artemisiae Annuae, Flos Chrysanthemi Indici five equilibrium that supercritical process extracts, and medicinal residues are carried out water is carried or alcohol extraction, and Radix Scutellariae is extracted refining being fit in the prescription, Gypsum Fibrosum is carried out micronizing, finally make soft capsule.In the Chinese medicine extract with supercritical carbon dioxide extraction, its chemical constituent or content of effective are considerably beyond the extract with the common process method.Be appreciated that prescription of the present invention can be made into the dosage form of choosing any one kind of them in capsule, granule, tablet, oral liquid and the spray.
Claims (7)
1. Chinese patent medicine for the treatment of flu, it is characterized in that: the percentage by weight of each extracts of bulk drugs is:
The preparation method of the Chinese patent medicine of described treatment flu may further comprise the steps:
(1) from corresponding crude drug, extracts corresponding extract respectively: Oleum Bupleuri, Radix Bupleuri extract, Radix Scutellariae extract, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, Flos Chrysanthemi Indici extract and Gypsum Fibrosum powder;
Wherein, produce Oleum Bupleuri: the material Radix Bupleuri of getting it filled is ground into coarse powder, through supercritical carbon dioxide extraction, and through one parsing at least and the extract Oleum Bupleuri;
Produce Radix Bupleuri extract: get the Radix Bupleuri coarse powder after above-mentioned the deoiling, behind alcohol bubble at least once, temperature is carried, and filters, and filtrate concentrates, and adds water and stirs, and leaves standstill, and gets supernatant concentration, through the alcohol bubble, leaves standstill again, gets supernatant concentration and becomes thick paste, promptly gets Radix Bupleuri extract;
Produce Radix Scutellariae extract: get baikal skullcap root decoction pieces, carry through water, filter, concentrate, add acid the baicalin cohesion is separated out, more after filtration, drying promptly gets Radix Scutellariae extract;
Produce Herba Artemisiae Annuae oil: get the Herba Artemisiae Annuae pulverizing medicinal materials and become coarse powder, through supercritical carbon dioxide extraction, and through one parsing at least and the extract Herba Artemisiae Annuae oil;
Produce the Herba Dendranthematis indici caul-fat: get the Flos Chrysanthemi Indici pulverizing medicinal materials and become coarse powder, through supercritical carbon dioxide extraction, and through one parsing at least and extract Herba Dendranthematis indici caul-fat;
Produce Flos Chrysanthemi Indici extract: the Flos Chrysanthemi Indici coarse powder after above-mentioned the deoiling of learning from else's experience, carry through at least once alcohol bubble, temperature, filter, filtrate concentrates, add water and stir, leave standstill, get supernatant concentration, steep through alcohol again, leave standstill, get the supernatant reconcentration and become thick paste, promptly get Flos Chrysanthemi Indici extract;
Produce Gypsum Fibrosum powder: carry out micronizing after getting the roguing of Gypsum Fibrosum medical material, promptly get Gypsum Fibrosum powder;
(2) take by weighing the Radix Bupleuri extract and the Flos Chrysanthemi Indici extract of recipe quantity, add an amount of filler, behind the abundant mixing of heated and stirred, add Oleum Bupleuri, Radix Scutellariae extract, Gypsum Fibrosum powder, Herba Artemisiae Annuae oil, Herba Dendranthematis indici caul-fat, emulsifying agent and antiseptic, after stirring, make the finished product of the dosage form of choosing any one kind of them in capsule, granule and the tablet.
2. the Chinese patent medicine of treatment flu as claimed in claim 1, it is characterized in that: the percentage by weight of each extracts of bulk drugs is:
3. the Chinese patent medicine of treatment flu as claimed in claim 1, it is characterized in that: the percentage by weight of each extracts of bulk drugs is:
4. the Chinese patent medicine of treatment flu as claimed in claim 1, it is characterized in that: the percentage by weight of each extracts of bulk drugs is:
5. the Chinese patent medicine of treatment flu as claimed in claim 1, it is characterized in that: described step (1) may further comprise the steps:
(11) produce Oleum Bupleuri: the material Radix Bupleuri of getting it filled is ground into coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.43g/cm
3, under the condition of 30～40 ℃ of pressure 20～30MPa, temperature, extract, then, through twice parsing, resolve I pressure 10～15MPa, resolve 45～65 ℃ of I temperature, resolve II pressure 5～15MPa, resolve 45～65 ℃ of II temperature, extracting 3～5 hours and getting extract is Oleum Bupleuri;
(12) produce Radix Bupleuri extract: get (11) Radix Bupleuri coarse powder after deoiling, add 95% an amount of soak with ethanol after 2 hours, 60～70 ℃ of temperature are carried 0.5 hour, filter, it is 80% soak with ethanol after 1 hour that medicinal residues add an amount of concentration again, and 60～70 ℃ of temperature are carried 0.5 hour, filter, merging filtrate reclaims ethanol, and being concentrated into 60～70 ℃ of following relative densities is 1.05～1.10, adding water stirs, leave standstill, layering, getting supernatant concentration to 60～70 a ℃ following relative density is 1.05～1.10, add the alcohol dissolving and adjust determining alcohol to 60%, leave standstill, get supernatant concentration to 80 ℃ following relative density and be 1.15～1.18 thick paste, be Radix Bupleuri extract;
(13) produce Radix Scutellariae extract: baikal skullcap root decoction pieces with an amount of 80～100 ℃ water extraction 2 times, each 1 hour, is filtered, medicinal liquid merges, and suitably concentrates, and adds hydrochloric acid and makes pH value reach 1～2,80 ℃ of insulations 1 hour, the baicalin cohesion is separated out, leave standstill, layering, filter, precipitate is extremely neutral with hot water wash, drying, get pale yellow powder, be Radix Scutellariae extract;
(14) produce Herba Artemisiae Annuae oil: the Herba Artemisiae Annuae pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.2g/cm
3Under the condition of 30～50 ℃ of pressure 15～25MPa, temperature, extract, then, through twice parsing: resolve I pressure 10～15MPa, resolve 50～70 ℃ of I temperature, resolve II pressure 5～10Mpa, resolve 40～60 ℃ of II temperature, extracting 2～4 hours and getting extract is Herba Artemisiae Annuae oil;
(15) produce the Herba Dendranthematis indici caul-fat: the Flos Chrysanthemi Indici pulverizing medicinal materials becomes coarse powder, places the supercritical carbon dioxide extraction device, and bulk density is 0.26g/cm
3Under the condition of 35～45 ℃ of extracting pressure 10～25Mpa, extraction temperature through twice parsing: resolve I pressure 5～10MPa, resolve the I temperature: 40～50 ℃, resolve II pressure 5～10MPa, resolve 40～60 ℃ of II temperature, extracting 2～5 hours and getting extract is the Herba Dendranthematis indici caul-fat;
(16) produce Flos Chrysanthemi Indici extract: get (15) Flos Chrysanthemi Indici coarse powder after deoiling, add 95% an amount of soak with ethanol 2 hours, heating extraction 0.5 hour, filter, medicinal residues add 80% an amount of soak with ethanol 1 hour again, 0.5 half an hour of heating extraction, filter, merging filtrate, reclaim ethanol, relative density is 1.10～1.20 extractum when being concentrated into 60～80 ℃, and extractum adds an amount of boiling water, heated and stirred becomes the muddy liquid of homogeneous, the salt that adds former extractum weight 10% stirs, and leaves standstill layering, filter, filtrate is concentrated into the thick paste shape, adds the adequate amount of ethanol dissolving, filters, it is 1.15～1.18 thick pastes that filtrate is concentrated into 80 ℃ of following relative densities, promptly gets Flos Chrysanthemi Indici extract;
(17) produce Gypsum Fibrosum powder: carry out micronizing after getting the roguing of Gypsum Fibrosum medical material, promptly get Gypsum Fibrosum powder.
6. the Chinese patent medicine of treatment flu as claimed in claim 5, it is characterized in that: described filler is PEG400, Macrogol 600, vegetable oil, liquid paraffin, starch or dextrin; Described emulsifying agent is tween or span; Described antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sodium benzoate, potassium sorbate.
7. the Chinese patent medicine of treatment flu as claimed in claim 5, it is characterized in that: described emulsifier concentration is 0.05%-0.2%, described concentration of preservatives is 0.03%～0.05%.
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| 冯毅凡等.柴芩菊感冒软胶囊质量标准研究.中国新药杂志.2005,14(10),第1193-1196页. * |
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