JPS6016934A - 抗腫瘍剤 - Google Patents
抗腫瘍剤Info
- Publication number
- JPS6016934A JPS6016934A JP58122985A JP12298583A JPS6016934A JP S6016934 A JPS6016934 A JP S6016934A JP 58122985 A JP58122985 A JP 58122985A JP 12298583 A JP12298583 A JP 12298583A JP S6016934 A JPS6016934 A JP S6016934A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- carnosine
- agent
- acid
- antineoplastic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- 108010087806 Carnosine Proteins 0.000 claims abstract description 44
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- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 44
- 229940044199 carnosine Drugs 0.000 claims description 18
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims description 17
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- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract description 10
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 235000020185 raw untreated milk Nutrition 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 230000028527 righting reflex Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019385 spermaceti wax Nutrition 0.000 description 1
- 201000002471 spleen cancer Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 208000013066 thyroid gland cancer Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000037455 tumor specific immune response Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58122985A JPS6016934A (ja) | 1983-07-06 | 1983-07-06 | 抗腫瘍剤 |
| DE3424781A DE3424781C2 (de) | 1983-07-06 | 1984-07-05 | Verwendung von L-Carnosin zur Tumorbehandlung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58122985A JPS6016934A (ja) | 1983-07-06 | 1983-07-06 | 抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6016934A true JPS6016934A (ja) | 1985-01-28 |
| JPH0312045B2 JPH0312045B2 (en, 2012) | 1991-02-19 |
Family
ID=14849438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58122985A Granted JPS6016934A (ja) | 1983-07-06 | 1983-07-06 | 抗腫瘍剤 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS6016934A (en, 2012) |
| DE (1) | DE3424781C2 (en, 2012) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988000048A1 (en) * | 1986-07-03 | 1988-01-14 | Zeria Pharmaceutical Co., Ltd. | Drug for prophylaxis and treatment of hepatopathy |
| JPH02221230A (ja) * | 1989-02-23 | 1990-09-04 | Kinuko Nagai | 骨粗鬆症予防剤 |
| JP2005120007A (ja) * | 2003-10-16 | 2005-05-12 | Tokyoto Igaku Kenkyu Kiko | 血管新生阻害剤、血管新生を伴う疾患の治療剤または予防剤 |
| JP2005532269A (ja) * | 2002-02-28 | 2005-10-27 | ヴラディミール エフゲニエヴィッチ ネボルシン | 細胞分化の誘発方法 |
| JP2012219080A (ja) * | 2011-04-12 | 2012-11-12 | Anbas:Kk | 経口投与により腫瘍の発生又は増殖を抑止する組成物 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61186322A (ja) * | 1985-02-13 | 1986-08-20 | Nippon Univ | 免疾調節剤 |
| AU638681B2 (en) * | 1988-09-28 | 1993-07-08 | Commonwealth Scientific And Industrial Research Organisation | Compound and method for the retardation of collagen cross-linking |
| EP0436611A4 (en) * | 1988-09-28 | 1992-03-11 | Peptide Technology Ltd | Compound and method for the retardation of collagen cross-linking |
| AUPM463794A0 (en) * | 1994-03-22 | 1994-04-14 | Commonwealth Scientific And Industrial Research Organisation | Inhibition of growth of cancer cells by carnosine |
| US5965596A (en) | 1997-08-12 | 1999-10-12 | Harris; Roger | Methods and compositions for increasing the anaerobic working capacity in tissue |
| US7504376B2 (en) | 1996-08-12 | 2009-03-17 | Natural Alternatives International | Methods and compositions for increasing the anaerobic working capacity in tissues |
| WO1998006278A1 (en) * | 1996-08-12 | 1998-02-19 | Harris, Roger | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US20040057974A1 (en) * | 2002-08-06 | 2004-03-25 | Naina Sachdev | Antiwrinkle composition and age reversal complex |
| EP1761272B1 (en) | 2004-06-08 | 2013-04-24 | Flamma S.P.A. | Compositions containing d-carnosine |
| CA2621365C (en) | 2005-05-23 | 2012-09-04 | Natural Alternatives International | Compositions and methods for the sustained release of beta-alanine |
| JP2010539015A (ja) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としての、ＩＬ−１レセプターペプチド単独またはＤ−Ａｌａ−Ｇｌｎ−オクタデシルエステルとの組合せの使用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50114453U (en, 2012) * | 1974-03-03 | 1975-09-18 |
-
1983
- 1983-07-06 JP JP58122985A patent/JPS6016934A/ja active Granted
-
1984
- 1984-07-05 DE DE3424781A patent/DE3424781C2/de not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50114453U (en, 2012) * | 1974-03-03 | 1975-09-18 |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988000048A1 (en) * | 1986-07-03 | 1988-01-14 | Zeria Pharmaceutical Co., Ltd. | Drug for prophylaxis and treatment of hepatopathy |
| JPH02221230A (ja) * | 1989-02-23 | 1990-09-04 | Kinuko Nagai | 骨粗鬆症予防剤 |
| JP2005532269A (ja) * | 2002-02-28 | 2005-10-27 | ヴラディミール エフゲニエヴィッチ ネボルシン | 細胞分化の誘発方法 |
| US7759313B2 (en) | 2002-02-28 | 2010-07-20 | Obschetstvo S Ogranichennoi Otvetstvennostiyu “Pharmenterprises” | Induction method for cell differentiation |
| JP2005120007A (ja) * | 2003-10-16 | 2005-05-12 | Tokyoto Igaku Kenkyu Kiko | 血管新生阻害剤、血管新生を伴う疾患の治療剤または予防剤 |
| JP2012219080A (ja) * | 2011-04-12 | 2012-11-12 | Anbas:Kk | 経口投与により腫瘍の発生又は増殖を抑止する組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3424781A1 (de) | 1985-01-17 |
| JPH0312045B2 (en, 2012) | 1991-02-19 |
| DE3424781C2 (de) | 1987-04-30 |
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