JPS6013758A - トリプトフアンの精製法 - Google Patents
トリプトフアンの精製法Info
- Publication number
- JPS6013758A JPS6013758A JP12143483A JP12143483A JPS6013758A JP S6013758 A JPS6013758 A JP S6013758A JP 12143483 A JP12143483 A JP 12143483A JP 12143483 A JP12143483 A JP 12143483A JP S6013758 A JPS6013758 A JP S6013758A
- Authority
- JP
- Japan
- Prior art keywords
- acetic acid
- tryptophan
- crystal
- aqueous solution
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title claims abstract description 27
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 238000000746 purification Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 99
- 239000013078 crystal Substances 0.000 claims abstract description 40
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 238000005406 washing Methods 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 239000012535 impurity Substances 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 6
- 238000004040 coloring Methods 0.000 abstract description 4
- 239000002002 slurry Substances 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 3
- 235000020776 essential amino acid Nutrition 0.000 abstract description 2
- 239000003797 essential amino acid Substances 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 229960004799 tryptophan Drugs 0.000 description 19
- 238000002425 crystallisation Methods 0.000 description 10
- 230000008025 crystallization Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 238000002834 transmittance Methods 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006911 enzymatic reaction Methods 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000003729 cation exchange resin Substances 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003456 ion exchange resin Substances 0.000 description 2
- 229920003303 ion-exchange polymer Polymers 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Indole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12143483A JPS6013758A (ja) | 1983-07-04 | 1983-07-04 | トリプトフアンの精製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12143483A JPS6013758A (ja) | 1983-07-04 | 1983-07-04 | トリプトフアンの精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6013758A true JPS6013758A (ja) | 1985-01-24 |
| JPH0352455B2 JPH0352455B2 (enrdf_load_stackoverflow) | 1991-08-12 |
Family
ID=14811038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12143483A Granted JPS6013758A (ja) | 1983-07-04 | 1983-07-04 | トリプトフアンの精製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6013758A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4778808A (en) * | 1985-03-15 | 1988-10-18 | Ajinomoto Co., Inc. | Feed additive containing tryptophan |
| JPH0331258A (ja) * | 1989-06-27 | 1991-02-12 | Mitsui Toatsu Chem Inc | トリプトファンの精製方法 |
| JPH05185142A (ja) * | 1992-01-10 | 1993-07-27 | Nakayama Steel Works Ltd | 線材コイル角張り修正装置 |
| EP0908523A3 (en) * | 1997-10-07 | 1999-05-19 | Mitsubishi Chemical Corporation | Process for producing high-purity erythritol crystal |
-
1983
- 1983-07-04 JP JP12143483A patent/JPS6013758A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4778808A (en) * | 1985-03-15 | 1988-10-18 | Ajinomoto Co., Inc. | Feed additive containing tryptophan |
| JPH0331258A (ja) * | 1989-06-27 | 1991-02-12 | Mitsui Toatsu Chem Inc | トリプトファンの精製方法 |
| US5057615A (en) * | 1989-06-27 | 1991-10-15 | Mitsui Toatsu Chamicals, Inc. | Process for purifying tryptophan |
| JPH05185142A (ja) * | 1992-01-10 | 1993-07-27 | Nakayama Steel Works Ltd | 線材コイル角張り修正装置 |
| EP0908523A3 (en) * | 1997-10-07 | 1999-05-19 | Mitsubishi Chemical Corporation | Process for producing high-purity erythritol crystal |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0352455B2 (enrdf_load_stackoverflow) | 1991-08-12 |
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