JPS60132964A - チアミンジスルフイドの付加化合物及びその製法 - Google Patents
チアミンジスルフイドの付加化合物及びその製法Info
- Publication number
- JPS60132964A JPS60132964A JP24087583A JP24087583A JPS60132964A JP S60132964 A JPS60132964 A JP S60132964A JP 24087583 A JP24087583 A JP 24087583A JP 24087583 A JP24087583 A JP 24087583A JP S60132964 A JPS60132964 A JP S60132964A
- Authority
- JP
- Japan
- Prior art keywords
- thiamine disulfide
- addition compound
- thiamine
- higher fatty
- disulfide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GFEGEDUIIYDMOX-BMJUYKDLSA-N n-[(4-amino-2-methylpyrimidin-5-yl)methyl]-n-[(z)-3-[[(z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Chemical compound C=1N=C(C)N=C(N)C=1CN(C=O)C(\C)=C(CCO)/SSC(/CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N GFEGEDUIIYDMOX-BMJUYKDLSA-N 0.000 title claims abstract description 33
- 229960001385 thiamine disulfide Drugs 0.000 title claims abstract description 33
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 17
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 16
- 239000000194 fatty acid Substances 0.000 claims abstract description 16
- 229930195729 fatty acid Natural products 0.000 claims abstract description 16
- 239000002904 solvent Substances 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229960003495 thiamine Drugs 0.000 abstract description 12
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 abstract description 12
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 abstract description 11
- 235000019157 thiamine Nutrition 0.000 abstract description 11
- 239000011721 thiamine Substances 0.000 abstract description 11
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract description 6
- 235000019658 bitter taste Nutrition 0.000 abstract description 6
- 239000008187 granular material Substances 0.000 abstract description 5
- 239000002552 dosage form Substances 0.000 abstract description 4
- 239000000843 powder Substances 0.000 abstract description 3
- 238000003860 storage Methods 0.000 abstract description 2
- 229930003451 Vitamin B1 Natural products 0.000 abstract 1
- 239000004503 fine granule Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011691 vitamin B1 Substances 0.000 abstract 1
- 235000010374 vitamin B1 Nutrition 0.000 abstract 1
- 239000013078 crystal Substances 0.000 description 11
- 238000002844 melting Methods 0.000 description 11
- 230000008018 melting Effects 0.000 description 10
- 235000021355 Stearic acid Nutrition 0.000 description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical compound CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 2
- RQFLGKYCYMMRMC-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O RQFLGKYCYMMRMC-UHFFFAOYSA-N 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 150000003544 thiamines Chemical class 0.000 description 2
- GTQXMAIXVFLYKF-UHFFFAOYSA-N thiochrome Chemical compound CC1=NC=C2CN3C(C)=C(CCO)SC3=NC2=N1 GTQXMAIXVFLYKF-UHFFFAOYSA-N 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229940038384 octadecane Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- YLLIGHVCTUPGEH-UHFFFAOYSA-M potassium;ethanol;hydroxide Chemical compound [OH-].[K+].CCO YLLIGHVCTUPGEH-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24087583A JPS60132964A (ja) | 1983-12-22 | 1983-12-22 | チアミンジスルフイドの付加化合物及びその製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24087583A JPS60132964A (ja) | 1983-12-22 | 1983-12-22 | チアミンジスルフイドの付加化合物及びその製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60132964A true JPS60132964A (ja) | 1985-07-16 |
| JPS627190B2 JPS627190B2 (enrdf_load_html_response) | 1987-02-16 |
Family
ID=17065991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24087583A Granted JPS60132964A (ja) | 1983-12-22 | 1983-12-22 | チアミンジスルフイドの付加化合物及びその製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60132964A (enrdf_load_html_response) |
-
1983
- 1983-12-22 JP JP24087583A patent/JPS60132964A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS627190B2 (enrdf_load_html_response) | 1987-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU224212B1 (hu) | 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]benzil]tiazolidin-2,4-dion-maleát és ezt tartalmazó gyógyszerkészítmények | |
| KR880002087B1 (ko) | 항균성 나프티리딘 또는 퀴놀린 화합물의 염 및 그의 제조방법 | |
| KR20140123081A (ko) | 아미노산과 카르복실산을 포함한 게르마늄의 착체 및 이를 제조하는 방법 | |
| US20090156648A1 (en) | Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA) | |
| US6077542A (en) | Solid substances comprising valproic acid and sodium valproate | |
| EP3774751B1 (en) | Co-crystals | |
| JPS5925377A (ja) | メトロニダゾ−ルとｎ，ｎ−ジメチルグリシンとのエステルおよびその酸付加湿 | |
| US4067974A (en) | Stabilized solid form choline salicylate compositions | |
| JPS61158922A (ja) | フイブリンからの不溶性フイブリンの形成阻止剤 | |
| JPS60132964A (ja) | チアミンジスルフイドの付加化合物及びその製法 | |
| US3709991A (en) | Hypolipidemic method | |
| JP2018111718A (ja) | オピオイド作動薬としてのα−６−ＭＰＥＧ６−Ｏ−ヒドロキシコドンの固体塩およびその使用 | |
| JP4015954B2 (ja) | トシル酸スプラタスト結晶 | |
| US3506761A (en) | Combinations of aluminum-coordinating therapeutic adjuvants and aluminum chelates and process for making and using the same | |
| US7956218B2 (en) | Organic salts of β-alanine | |
| CN108250116B (zh) | 一种福多司坦晶型及其制备方法 | |
| EP3572069A1 (en) | Increasing solubility and bioavailability of enzalutamide | |
| US3274055A (en) | Acid addition salts of morpholine ethanol | |
| US3422191A (en) | Compositions and methods for tranquilization employing salts of n-morpholine ethanol | |
| JPH07509239A (ja) | Ｎ▲ｇ▼−モノメチル−ｌ−アルギニン塩酸塩誘導体および敗血性ショックの治療におけるこれらの使用 | |
| JPS61100572A (ja) | １，３‐ビス（１ｈ‐１，２‐４‐トリアゾール‐１‐イル）‐２‐フルオロ‐２‐（２，４‐ジフルオロフエニル）プロパン、該化合物を含有する抗菌組成物、ならびに該化合物および該組成物の製造方法 | |
| US2931838A (en) | 2-methyl-2-hydroxy-4-(2, 2, 2-trichloro-1-hydroxyethoxy)-pentane and its production | |
| JPH04202131A (ja) | 長期間安定な経口用医薬製剤 | |
| JPS61143345A (ja) | メナジオンコリン重亜硫酸付加物及びその製法 | |
| AU2017217728A1 (en) | Crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts |