JPS5925323A - プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 - Google Patents

プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤

Info

Publication number
JPS5925323A
JPS5925323A JP58035200A JP3520083A JPS5925323A JP S5925323 A JPS5925323 A JP S5925323A JP 58035200 A JP58035200 A JP 58035200A JP 3520083 A JP3520083 A JP 3520083A JP S5925323 A JPS5925323 A JP S5925323A
Authority
JP
Japan
Prior art keywords
therapeutic agent
diseases involving
depression
brain neurotransmitters
involving brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58035200A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0369890B2 (Direct
Inventor
ハンス−クリストフ・クルテイウス
ハインリツヒ−ゲオルグ・ミユルドナ−
ア−ロイス・ニ−ダ−ビ−ゼル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of JPS5925323A publication Critical patent/JPS5925323A/ja
Publication of JPH0369890B2 publication Critical patent/JPH0369890B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP58035200A 1982-03-03 1983-03-02 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 Granted JPS5925323A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH130082 1982-03-03
CH1300/82 1982-03-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2052418A Division JPH02262517A (ja) 1982-03-03 1990-03-02 プテリン誘導体からなる精神疾患症状の治療剤
JP4257964A Division JPH05194229A (ja) 1982-03-03 1992-09-28 プテリン誘導体からなる精神疾患症状の治療剤

Publications (2)

Publication Number Publication Date
JPS5925323A true JPS5925323A (ja) 1984-02-09
JPH0369890B2 JPH0369890B2 (Direct) 1991-11-05

Family

ID=4207209

Family Applications (3)

Application Number Title Priority Date Filing Date
JP58035200A Granted JPS5925323A (ja) 1982-03-03 1983-03-02 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤
JP2052418A Pending JPH02262517A (ja) 1982-03-03 1990-03-02 プテリン誘導体からなる精神疾患症状の治療剤
JP4257964A Pending JPH05194229A (ja) 1982-03-03 1992-09-28 プテリン誘導体からなる精神疾患症状の治療剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2052418A Pending JPH02262517A (ja) 1982-03-03 1990-03-02 プテリン誘導体からなる精神疾患症状の治療剤
JP4257964A Pending JPH05194229A (ja) 1982-03-03 1992-09-28 プテリン誘導体からなる精神疾患症状の治療剤

Country Status (2)

Country Link
US (2) US4758571A (Direct)
JP (3) JPS5925323A (Direct)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262517A (ja) * 1982-03-03 1990-10-25 Kanegafuchi Chem Ind Co Ltd プテリン誘導体からなる精神疾患症状の治療剤
WO1996003989A1 (en) * 1994-08-05 1996-02-15 Suntory Limited Remedy for spinocerebellar degeneration
JPH10338637A (ja) * 1996-08-30 1998-12-22 Yoshiharu Kanayama Ｎｏｓの機能低下が寄与する疾患の予防または治療剤
WO1999043324A1 (en) * 1998-02-27 1999-09-02 Suntory Limited Preventives or remedies for drug-induced renal disturbance
WO1999043325A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Remedes preventifs ou therapeutiques contre les maladies associees a une anomalie fonctionnelle vasculaire en relation avec la resistance a l'insuline
WO2007119367A1 (ja) * 2006-03-20 2007-10-25 Kaneka Corporation ビオプテリンを含む組成物及びその使用方法
JP2008504295A (ja) * 2004-06-25 2008-02-14 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 注意欠陥多動性障害及び高フェニルアラニン血症の治療のための方法及び組成物
US7820667B2 (en) 1996-08-30 2010-10-26 Daiichi Sankyo Company, Limited Methods of treating hypertension
WO2011132435A1 (ja) 2010-04-22 2011-10-27 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
JP2012523570A (ja) * 2009-04-09 2012-10-04 ベイラー リサーチ インスティテュート ファブリー病のマーカー及び治療薬としてのテトラヒドロビオプテリンの使用
JP2019535836A (ja) * 2016-11-29 2019-12-12 センサ ファーマシューティカルズ インコーポレイテッドＣｅｎｓａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． セピプテリン及びその塩の多形
US11752154B2 (en) 2017-09-01 2023-09-12 Ptc Therapeutics Mp, Inc. Pharmaceutical compositions comprising sepiapterin and uses thereof

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318926B1 (en) * 1987-11-30 1995-05-03 Kabushiki Kaisha Vitamin Kenkyusyo Intermediates for synthesizing 5,6,7,8-tetrahydro-L-erythro-biopterin and its derivatives
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5534514A (en) * 1992-10-27 1996-07-09 San Diego State University Anti-neoplastic compositions and methods for application thereof
US6506378B1 (en) 1998-12-16 2003-01-14 Arch Development Corporation Vesicular monoamine transporter gene therapy in Parkinson's disease
US6319905B1 (en) * 1998-12-29 2001-11-20 Cell Genesys, Inc. Method of controlling L-Dopa production and of treating dopamine deficiency
US20060110325A1 (en) * 2003-02-21 2006-05-25 Hinz Martin C Serotonin and catecholamine segment optimization technology
US20030181509A1 (en) * 2002-03-21 2003-09-25 Hinz Martin C. Serotonin and catecholamine system segment optimization technology
US20090311795A1 (en) * 2002-03-21 2009-12-17 Hinz Martin C Bilateral control of functions traditionally regulated by only serotonin or only dopamine
US20070293571A1 (en) * 2006-06-08 2007-12-20 Hinz Martin C Adminstration of dopa precursors with sources of dopa to effectuate optimal catecholamine neurotransmitter outcomes
US6830281B2 (en) * 2002-09-20 2004-12-14 Lawrence Andrew Hoffman Power tonneau cover actuator
DE10260263A1 (de) * 2002-12-20 2004-07-15 Biocrates Life Sciences Gmbh Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen
EP1603448A4 (en) * 2003-02-21 2007-12-05 Martin C Hinz SEROTONIN AND CATECHOLAMINE SYSTEM SEGMENT OPTIMIZATION TECHNOLOGY
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
CA2545584C (en) 2003-11-17 2012-10-23 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of metabolic disorders
JP2007536210A (ja) 2003-11-17 2007-12-13 メルック・エプロバ・アクチエンゲゼルシヤフト （６ｒ）−ｌ−エリスロ−テトラヒドロビオプテリンジヒドロクロライドの結晶形
US7576073B2 (en) * 2004-05-28 2009-08-18 UNIVERSITé LAVAL Combined therapy for the treatment of parkinson's disease
AU2005306686B2 (en) 2004-11-17 2011-06-02 Biomarin Pharmaceutical Inc. Stable tablet formulation of tetrahydrobiopterin
US20100130500A1 (en) * 2004-12-08 2010-05-27 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
US8877802B2 (en) * 2005-07-28 2014-11-04 Duke Univerity Antiparkinsonian action of phenylisopropylamines
AU2006321942A1 (en) * 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
US8017348B1 (en) 2005-12-12 2011-09-13 Elan Pharma International Limited Assay for Parkinson's Disease therapeutics
US20090317825A1 (en) * 2005-12-12 2009-12-24 Elan Pharma International Limited Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
DK2139485T3 (da) 2007-04-11 2013-01-21 Biomarin Pharm Inc Fremgangsmåder til admistration af tetrahydrobiopterin, associerede sammensætninger, og fremgangsmåder til måling
MX2010006025A (es) * 2008-01-03 2010-06-30 Biomarin Pharm Inc Analogo de pterina para tratar afeccion sensible a bh4.
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
EP3548487A4 (en) 2016-11-29 2020-04-29 Censa Pharmaceuticals Inc. POLYMORPHE SHAPE OF SEPIAPTERIN
RS65874B1 (sr) 2018-05-30 2024-09-30 Ptc Therapeutics Mp Inc Primena sepiapterina bez hrane za upotrebu u postupku za povećanje izloženosti plazme sepiapterinu
CA3102105A1 (en) 2018-05-30 2019-12-05 Ptc Therapeutics Mp, Inc. Compositions and methods for increasing tetrahydrobiopterin plasma exposure

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925323A (ja) * 1982-03-03 1984-02-09 鐘淵化学工業株式会社 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤
JPS61277618A (ja) * 1985-06-04 1986-12-08 Suntory Ltd 自閉症治療剤
JPH0692302B2 (ja) * 1986-09-02 1994-11-16 鐘淵化学工業株式会社 神経病治療剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DIE PARKINSON-KRANKHEIT=1980 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02262517A (ja) * 1982-03-03 1990-10-25 Kanegafuchi Chem Ind Co Ltd プテリン誘導体からなる精神疾患症状の治療剤
JPH05194229A (ja) * 1982-03-03 1993-08-03 Kanegafuchi Chem Ind Co Ltd プテリン誘導体からなる精神疾患症状の治療剤
WO1996003989A1 (en) * 1994-08-05 1996-02-15 Suntory Limited Remedy for spinocerebellar degeneration
JPH10338637A (ja) * 1996-08-30 1998-12-22 Yoshiharu Kanayama Ｎｏｓの機能低下が寄与する疾患の予防または治療剤
US7820667B2 (en) 1996-08-30 2010-10-26 Daiichi Sankyo Company, Limited Methods of treating hypertension
WO1999043325A1 (fr) * 1998-02-27 1999-09-02 Suntory Limited Remedes preventifs ou therapeutiques contre les maladies associees a une anomalie fonctionnelle vasculaire en relation avec la resistance a l'insuline
US6288067B1 (en) 1998-02-27 2001-09-11 Suntory Limited Prophylactic or therapeutic agents for drug-induced renal injury
US6410535B1 (en) 1998-02-27 2002-06-25 Suntory Limited Prophylactic or therapeutic agents for diseases having vascular dysfunction associated with insulin resistance
WO1999043324A1 (en) * 1998-02-27 1999-09-02 Suntory Limited Preventives or remedies for drug-induced renal disturbance
JP2008504295A (ja) * 2004-06-25 2008-02-14 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 注意欠陥多動性障害及び高フェニルアラニン血症の治療のための方法及び組成物
WO2007119367A1 (ja) * 2006-03-20 2007-10-25 Kaneka Corporation ビオプテリンを含む組成物及びその使用方法
JP2012523570A (ja) * 2009-04-09 2012-10-04 ベイラー リサーチ インスティテュート ファブリー病のマーカー及び治療薬としてのテトラヒドロビオプテリンの使用
WO2011132435A1 (ja) 2010-04-22 2011-10-27 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
JP5066756B2 (ja) * 2010-04-22 2012-11-07 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
US11173158B2 (en) 2010-04-22 2021-11-16 Ptc Therapeutics Mp, Inc. Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same
JP2019535836A (ja) * 2016-11-29 2019-12-12 センサ ファーマシューティカルズ インコーポレイテッドＣｅｎｓａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． セピプテリン及びその塩の多形
JP2023002532A (ja) * 2016-11-29 2023-01-10 ピーティーシー セラピューティクス エムピー，インコーポレイテッド セピプテリン及びその塩の多形
US11773097B2 (en) 2016-11-29 2023-10-03 Ptc Therapeutics Mp, Inc. Polymorphs of sepiapterin and salts thereof
US12269829B2 (en) 2016-11-29 2025-04-08 Ptc Therapeutics Mp, Inc. Polymorphs of sepiapterin and salts thereof
US11752154B2 (en) 2017-09-01 2023-09-12 Ptc Therapeutics Mp, Inc. Pharmaceutical compositions comprising sepiapterin and uses thereof
US12213982B2 (en) 2017-09-01 2025-02-04 Ptc Therapeutics Mp, Inc. Pharmaceutical compositions comprising sepiapterin and uses thereof

Also Published As

Publication number Publication date
US4758571A (en) 1988-07-19
JPH05194229A (ja) 1993-08-03
JPH02262517A (ja) 1990-10-25
JPH0369890B2 (Direct) 1991-11-05
US4774244A (en) 1988-09-27

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