JPS59222416A - 高血圧症及び心筋梗塞治療用の製薬学的製品 - Google Patents
高血圧症及び心筋梗塞治療用の製薬学的製品Info
- Publication number
- JPS59222416A JPS59222416A JP59100328A JP10032884A JPS59222416A JP S59222416 A JPS59222416 A JP S59222416A JP 59100328 A JP59100328 A JP 59100328A JP 10032884 A JP10032884 A JP 10032884A JP S59222416 A JPS59222416 A JP S59222416A
- Authority
- JP
- Japan
- Prior art keywords
- product
- group
- pharmaceutical product
- observed
- animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000010125 myocardial infarction Diseases 0.000 title claims description 10
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 9
- 229940127557 pharmaceutical product Drugs 0.000 title claims description 9
- 206010020772 Hypertension Diseases 0.000 title claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229910002012 Aerosil® Inorganic materials 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000004332 silver Substances 0.000 claims description 2
- 229910052709 silver Inorganic materials 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 description 31
- 210000004027 cell Anatomy 0.000 description 26
- 238000002474 experimental method Methods 0.000 description 20
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 15
- 241000700159 Rattus Species 0.000 description 14
- 206010028851 Necrosis Diseases 0.000 description 13
- 230000017074 necrotic cell death Effects 0.000 description 12
- 206010014950 Eosinophilia Diseases 0.000 description 11
- 230000004872 arterial blood pressure Effects 0.000 description 10
- 229960001597 nifedipine Drugs 0.000 description 10
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 230000002107 myocardial effect Effects 0.000 description 9
- 206010062575 Muscle contracture Diseases 0.000 description 8
- 208000006111 contracture Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 231100000241 scar Toxicity 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000008595 infiltration Effects 0.000 description 6
- 238000001764 infiltration Methods 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 230000036772 blood pressure Effects 0.000 description 5
- 210000002808 connective tissue Anatomy 0.000 description 5
- 210000002889 endothelial cell Anatomy 0.000 description 5
- 210000004165 myocardium Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000004531 blood pressure lowering effect Effects 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001713 cholinergic effect Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 231100000053 low toxicity Toxicity 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001338 necrotic effect Effects 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 230000009772 tissue formation Effects 0.000 description 3
- 102000015427 Angiotensins Human genes 0.000 description 2
- 108010064733 Angiotensins Proteins 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- 206010007556 Cardiac failure acute Diseases 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- CMUNUTVVOOHQPW-LURJTMIESA-N L-proline betaine Chemical compound C[N+]1(C)CCC[C@H]1C([O-])=O CMUNUTVVOOHQPW-LURJTMIESA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- 206010040741 Sinus bradycardia Diseases 0.000 description 2
- 230000007059 acute toxicity Effects 0.000 description 2
- 231100000403 acute toxicity Toxicity 0.000 description 2
- 230000001800 adrenalinergic effect Effects 0.000 description 2
- 239000003416 antiarrhythmic agent Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003205 diastolic effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 229940095990 inderal Drugs 0.000 description 2
- 230000000053 inderal effect Effects 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 2
- 230000030214 innervation Effects 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 210000000663 muscle cell Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- CMUNUTVVOOHQPW-ZCFIWIBFSA-N stachydrine Natural products C[N+]1(C)CCC[C@@H]1C([O-])=O CMUNUTVVOOHQPW-ZCFIWIBFSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001186 vagus nerve Anatomy 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- CEMAWMOMDPGJMB-CYBMUJFWSA-N (2r)-1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-CYBMUJFWSA-N 0.000 description 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- VYLJAYXZTOTZRR-BTPDVQIOSA-N CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C Chemical compound CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C VYLJAYXZTOTZRR-BTPDVQIOSA-N 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 102100023195 Nephrin Human genes 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000008601 Polycythemia Diseases 0.000 description 1
- 241001474791 Proboscis Species 0.000 description 1
- 101100517377 Rattus norvegicus Ntm gene Proteins 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HRBMESHSNKKVBJ-OLKYXYMISA-N [(1r,4r,5r,7s)-8-benzyl-7-[[4-(dimethylamino)phenyl]carbamoyl]-8-azabicyclo[3.2.1]octan-4-yl] n-ethylcarbamate Chemical class N1([C@@H]2C[C@@H]([C@H]1CC[C@H]2OC(=O)NCC)C(=O)NC=1C=CC(=CC=1)N(C)C)CC1=CC=CC=C1 HRBMESHSNKKVBJ-OLKYXYMISA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000674 adrenergic antagonist Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229950009941 chloralose Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000008473 connective tissue growth Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000004882 diastolic arterial blood pressure Effects 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 229960003072 epinephrine hydrochloride Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 230000033687 granuloma formation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- VYLJAYXZTOTZRR-UHFFFAOYSA-N hopane-6alpha,7beta,22-triol Natural products C12CCC3C4(C)CCCC(C)(C)C4C(O)C(O)C3(C)C1(C)CCC1C2(C)CCC1C(C)(O)C VYLJAYXZTOTZRR-UHFFFAOYSA-N 0.000 description 1
- ATADHKWKHYVBTJ-UHFFFAOYSA-N hydron;4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;chloride Chemical compound Cl.CNCC(O)C1=CC=C(O)C(O)=C1 ATADHKWKHYVBTJ-UHFFFAOYSA-N 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical group COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 208000037891 myocardial injury Diseases 0.000 description 1
- 108010027531 nephrin Proteins 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000003767 neural control Effects 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000035485 pulse pressure Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 230000004873 systolic arterial blood pressure Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU3593392 | 1983-05-18 | ||
| SU3593392 | 1983-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS59222416A true JPS59222416A (ja) | 1984-12-14 |
Family
ID=21064187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59100328A Pending JPS59222416A (ja) | 1983-05-18 | 1984-05-18 | 高血圧症及び心筋梗塞治療用の製薬学的製品 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4568689A (enExample) |
| JP (1) | JPS59222416A (enExample) |
| CA (1) | CA1229553A (enExample) |
| DE (1) | DE3418651A1 (enExample) |
| FR (1) | FR2548899B1 (enExample) |
| GB (1) | GB2142533B (enExample) |
| IT (1) | IT1196109B (enExample) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2319278C2 (de) * | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmazeutisches Mittel |
| US3974176A (en) * | 1973-08-16 | 1976-08-10 | Byk-Gulden Lomberg Chemische Fabrik Gmbh | Halogen pyrazoles derivatives, a method for producing these halogen pyrazole derivatives and medicaments containing them |
| LU71847A1 (enExample) * | 1975-02-14 | 1977-01-05 | ||
| SU747855A1 (ru) * | 1978-04-12 | 1980-07-15 | Ташкентский Ордена Трудового Красного Знамени Медицинский Институт | 3-Пиразолилметиловый эфир пропионовой кислоты, обладающий противовоспалительной активностью |
| GB2073740A (en) * | 1980-03-03 | 1981-10-21 | Wellcome Found | Pyrazolidinones |
-
1984
- 1984-05-07 CA CA000453725A patent/CA1229553A/en not_active Expired
- 1984-05-15 GB GB08412342A patent/GB2142533B/en not_active Expired
- 1984-05-16 IT IT20949/84A patent/IT1196109B/it active
- 1984-05-16 US US06/610,634 patent/US4568689A/en not_active Expired - Fee Related
- 1984-05-18 FR FR8407799A patent/FR2548899B1/fr not_active Expired
- 1984-05-18 JP JP59100328A patent/JPS59222416A/ja active Pending
- 1984-05-18 DE DE19843418651 patent/DE3418651A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3418651A1 (de) | 1984-11-22 |
| DE3418651C2 (enExample) | 1987-11-05 |
| GB2142533B (en) | 1987-03-04 |
| IT1196109B (it) | 1988-11-10 |
| CA1229553A (en) | 1987-11-24 |
| GB8412342D0 (en) | 1984-06-20 |
| US4568689A (en) | 1986-02-04 |
| IT8420949A0 (it) | 1984-05-16 |
| FR2548899B1 (fr) | 1989-01-06 |
| IT8420949A1 (it) | 1985-11-16 |
| FR2548899A1 (fr) | 1985-01-18 |
| GB2142533A (en) | 1985-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Prys-Roberts et al. | Efficacy and safety of doxazosin for perioperative management of patients with pheochromocytoma | |
| Kurien et al. | The role of free fatty acids in the production of ventricular arrhythmias after acute coronary artery occlusion | |
| Jacobs et al. | Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade | |
| US3773939A (en) | N-arallyl-n'-aralkyl piperazine pharmaceutical compositions | |
| US2937118A (en) | Aminopyridine compositions | |
| JPS60188323A (ja) | 心筋虚血治療用医薬組成物 | |
| JPS6169722A (ja) | 医薬用組成物 | |
| Bawaskar et al. | Cardiovascular manifestations of severe scorpion sting in India (review of 34 children) | |
| JPH02121922A (ja) | Ace阻害剤の使用 | |
| Miller et al. | The action of procaine amide in cardiac arrhythmias | |
| Oram et al. | Digitalis as a cause of paroxysmal atrial tachycardia with atrioventricular block | |
| Awan et al. | Therapeutic application of prazosin in chronic refractory congestive heart failure: tolerance and “tachyphylaxis” in perspective | |
| JPS59222416A (ja) | 高血圧症及び心筋梗塞治療用の製薬学的製品 | |
| Yeung et al. | Comparison of labetalol, clonidine and diazoxide intravenously administered in severe hypertension | |
| Nielsen et al. | Analgetic Treatment in Acute Myocardial Infarction: A Controlled Clinical Comparison of Morphine, Nicomorphine and Pethidine | |
| WOLFF et al. | Analgesic Treatment in Acute Myocardial Infarction: A Double‐blind Comparison of Ketobemidone+ the Spasmolytic A29 (Ketogan®) and Morphine | |
| RU2245147C2 (ru) | Применение ингибитора вазопептидазы для лечения стенокардии | |
| CA1330947C (en) | Treatment of cardiac arrhythmias | |
| RU2181286C2 (ru) | Кардиотоническое и гипертензивное средство, длительно повышающее давление, и лекарственные формы на его основе | |
| McKinnon et al. | Angiotensinamide in the treatment of probable anaphylaxis to succinylated gelatin (Gelofusine) | |
| RU2155608C2 (ru) | Способ комплексной интенсивной терапии ожоговых больных с сочетанным применением стресс-протекторных, адаптогенных препаратов и внутривенного лазерного облучения крови | |
| DE68912159T2 (de) | Dioxoquinazolinderivat enthaltendes Antihypertensivum. | |
| HK1044279A1 (en) | Aminotetralin derivative for the therapy of cardiovascular diseases | |
| Hunt et al. | Myocardial damage following inadvertent administration of adrenaline | |
| JP2889374B2 (ja) | ソマトスタチン活性ポリペプチドを活性成分とする医薬組成物 |