JPS59179094A - トリアゾ−ルデオキシリボヌクレオシドの製造法 - Google Patents
トリアゾ−ルデオキシリボヌクレオシドの製造法Info
- Publication number
- JPS59179094A JPS59179094A JP5575083A JP5575083A JPS59179094A JP S59179094 A JPS59179094 A JP S59179094A JP 5575083 A JP5575083 A JP 5575083A JP 5575083 A JP5575083 A JP 5575083A JP S59179094 A JPS59179094 A JP S59179094A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- acid
- enzyme
- triazole
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005549 deoxyribonucleoside Substances 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 150000003852 triazoles Chemical class 0.000 claims description 9
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- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 6
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 6
- SJCDBQHCQSIZHN-UHFFFAOYSA-N 1,2-dihydrotriazole-3-carboxamide Chemical compound NC(=O)N1NNC=C1 SJCDBQHCQSIZHN-UHFFFAOYSA-N 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 abstract description 55
- 239000000126 substance Substances 0.000 abstract description 17
- 150000001875 compounds Chemical class 0.000 abstract description 10
- 241000450599 DNA viruses Species 0.000 abstract description 3
- 230000000840 anti-viral effect Effects 0.000 abstract description 3
- 241001493065 dsRNA viruses Species 0.000 abstract description 3
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 abstract 2
- 239000002777 nucleoside Substances 0.000 abstract 1
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- 238000000034 method Methods 0.000 description 24
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- 238000011282 treatment Methods 0.000 description 17
- 239000002253 acid Substances 0.000 description 16
- -1 1-triazolyl compound Chemical class 0.000 description 12
- 238000006911 enzymatic reaction Methods 0.000 description 11
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
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- 229940048102 triphosphoric acid Drugs 0.000 description 5
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- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
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- 229920002472 Starch Polymers 0.000 description 3
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- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
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- 125000003729 nucleotide group Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 229940085991 phosphate ion Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- OQRXBXNATIHDQO-UHFFFAOYSA-N 6-chloropyridine-3,4-diamine Chemical compound NC1=CN=C(Cl)C=C1N OQRXBXNATIHDQO-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
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- 102100036286 Purine nucleoside phosphorylase Human genes 0.000 description 2
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- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 2
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
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Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5575083A JPS59179094A (ja) | 1983-03-30 | 1983-03-30 | トリアゾ−ルデオキシリボヌクレオシドの製造法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5575083A JPS59179094A (ja) | 1983-03-30 | 1983-03-30 | トリアゾ−ルデオキシリボヌクレオシドの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS59179094A true JPS59179094A (ja) | 1984-10-11 |
JPH0335915B2 JPH0335915B2 (enrdf_load_stackoverflow) | 1991-05-29 |
Family
ID=13007526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5575083A Granted JPS59179094A (ja) | 1983-03-30 | 1983-03-30 | トリアゾ−ルデオキシリボヌクレオシドの製造法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS59179094A (enrdf_load_stackoverflow) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63317093A (ja) * | 1987-06-19 | 1988-12-26 | Ajinomoto Co Inc | 2’−デオキシリバビリンの製造方法 |
JP2007001098A (ja) * | 2005-06-23 | 2007-01-11 | Pentel Corp | クリップ取り付け構造 |
-
1983
- 1983-03-30 JP JP5575083A patent/JPS59179094A/ja active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63317093A (ja) * | 1987-06-19 | 1988-12-26 | Ajinomoto Co Inc | 2’−デオキシリバビリンの製造方法 |
JP2007001098A (ja) * | 2005-06-23 | 2007-01-11 | Pentel Corp | クリップ取り付け構造 |
Also Published As
Publication number | Publication date |
---|---|
JPH0335915B2 (enrdf_load_stackoverflow) | 1991-05-29 |