JPS59175493A - マイトマイシン誘導体 - Google Patents

マイトマイシン誘導体

Info

Publication number
JPS59175493A
JPS59175493A JP5018683A JP5018683A JPS59175493A JP S59175493 A JPS59175493 A JP S59175493A JP 5018683 A JP5018683 A JP 5018683A JP 5018683 A JP5018683 A JP 5018683A JP S59175493 A JPS59175493 A JP S59175493A
Authority
JP
Japan
Prior art keywords
mitomycin
methyl
carbon atoms
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5018683A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0358349B2 (enrdf_load_stackoverflow
Inventor
Kazumichi Kono
河野　一通
Yutaka Saito
裕 斎藤
Joji Goto
譲治 後藤
Kimikatsu Shirahata
白幡　公勝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP5018683A priority Critical patent/JPS59175493A/ja
Priority to DE1983307423 priority patent/DE116208T1/de
Priority to EP19830307423 priority patent/EP0116208B1/en
Priority to DE8383307423T priority patent/DE3376114D1/de
Publication of JPS59175493A publication Critical patent/JPS59175493A/ja
Publication of JPH0358349B2 publication Critical patent/JPH0358349B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5018683A 1982-12-07 1983-03-25 マイトマイシン誘導体 Granted JPS59175493A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP5018683A JPS59175493A (ja) 1983-03-25 1983-03-25 マイトマイシン誘導体
DE1983307423 DE116208T1 (de) 1982-12-07 1983-12-06 Mitomycin-analoge.
EP19830307423 EP0116208B1 (en) 1982-12-07 1983-12-06 Mitomycin analogues
DE8383307423T DE3376114D1 (en) 1982-12-07 1983-12-06 Mitomycin analogues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5018683A JPS59175493A (ja) 1983-03-25 1983-03-25 マイトマイシン誘導体

Publications (2)

Publication Number Publication Date
JPS59175493A true JPS59175493A (ja) 1984-10-04
JPH0358349B2 JPH0358349B2 (enrdf_load_stackoverflow) 1991-09-05

Family

ID=12852145

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5018683A Granted JPS59175493A (ja) 1982-12-07 1983-03-25 マイトマイシン誘導体

Country Status (1)

Country Link
JP (1) JPS59175493A (enrdf_load_stackoverflow)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59205382A (ja) * 1983-04-11 1984-11-20 ブリストル―マイヤーズ　スクイブ　カンパニー アミノ２硫化物
JPS61112078A (ja) * 1984-09-04 1986-05-30 ブリストル―マイアーズ　スクイブ　コムパニー 置換７−オキソマイトサン
US4691024A (en) * 1984-06-01 1987-09-01 Kyowa Hakko Kogyo Kabushiki Kaisha New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
WO1988001622A1 (en) * 1986-08-29 1988-03-10 Kyowa Hakko Kogyo Kabusiki Kaisha Mitomycin derivatives
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility
US4863935A (en) * 1986-12-13 1989-09-05 Kyowa Hakko Kogyo K.K. Mitomycin compounds having useful anti-tumor activity
JPH0745503B1 (enrdf_load_stackoverflow) * 1986-08-29 1995-05-17 Kyowa Hakko Kogyo Kk
EP2060272A2 (en) 2002-05-15 2009-05-20 Endocyte, Inc. Vitamin-mitomycin conjugates
US7875612B2 (en) 2001-04-24 2011-01-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
US9662402B2 (en) 2012-10-16 2017-05-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US10738086B2 (en) 2007-06-25 2020-08-11 Endocyte Inc. Conjugates containing hydrophilic spacer linkers

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59205382A (ja) * 1983-04-11 1984-11-20 ブリストル―マイヤーズ　スクイブ　カンパニー アミノ２硫化物
US4691024A (en) * 1984-06-01 1987-09-01 Kyowa Hakko Kogyo Kabushiki Kaisha New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
JPS61112078A (ja) * 1984-09-04 1986-05-30 ブリストル―マイアーズ　スクイブ　コムパニー 置換７−オキソマイトサン
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility
WO1988001622A1 (en) * 1986-08-29 1988-03-10 Kyowa Hakko Kogyo Kabusiki Kaisha Mitomycin derivatives
JPH0745503B1 (enrdf_load_stackoverflow) * 1986-08-29 1995-05-17 Kyowa Hakko Kogyo Kk
US4863935A (en) * 1986-12-13 1989-09-05 Kyowa Hakko Kogyo K.K. Mitomycin compounds having useful anti-tumor activity
US8470822B2 (en) 2001-04-24 2013-06-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
US7875612B2 (en) 2001-04-24 2011-01-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
EP2060272A2 (en) 2002-05-15 2009-05-20 Endocyte, Inc. Vitamin-mitomycin conjugates
US7910594B2 (en) 2002-05-15 2011-03-22 Endocyte, Inc. Vitamin-mitomycin conjugates
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US9090563B2 (en) 2004-07-23 2015-07-28 Endocyte, Inc. Bivalent linkers and conjugates thereof
US10647676B2 (en) 2004-07-23 2020-05-12 Endocyte, Inc. Bivalent linkers and conjugates thereof
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10500204B2 (en) 2007-06-25 2019-12-10 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10738086B2 (en) 2007-06-25 2020-08-11 Endocyte Inc. Conjugates containing hydrophilic spacer linkers
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
US9745341B2 (en) 2007-10-25 2017-08-29 Endocyte, Inc. Tubulysins and processes for preparing
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US10765756B2 (en) 2012-02-24 2020-09-08 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US11344623B2 (en) 2012-02-24 2022-05-31 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US9662402B2 (en) 2012-10-16 2017-05-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using

Also Published As

Publication number Publication date
JPH0358349B2 (enrdf_load_stackoverflow) 1991-09-05

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