JPS5843993A - １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法 - Google Patents

１−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Info

Publication number
JPS5843993A
JPS5843993A JP56142045A JP14204581A JPS5843993A JP S5843993 A JPS5843993 A JP S5843993A JP 56142045 A JP56142045 A JP 56142045A JP 14204581 A JP14204581 A JP 14204581A JP S5843993 A JPS5843993 A JP S5843993A
Authority
JP
Japan
Prior art keywords
uracil
arabinofuranosyl
halogenovinyl
phosphoric acid
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56142045A
Other languages
English (en)
Japanese (ja)
Other versions
JPS637559B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Shinji Sakata
紳二 坂田
Haruhiko Machida
治彦 町田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15306105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5843993(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP56142045A priority Critical patent/JPS5843993A/ja
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to DE8282108163T priority patent/DE3262887D1/de
Priority to KR8203969A priority patent/KR890000762B1/ko
Priority to EP82108163A priority patent/EP0074101B1/en
Priority to US06/414,824 priority patent/US4542210A/en
Priority to AT82108163T priority patent/ATE12503T1/de
Priority to AU87996/82A priority patent/AU552353B2/en
Priority to GB08225547A priority patent/GB2108964B/en
Priority to ES515573A priority patent/ES8308570A1/es
Priority to CA000411003A priority patent/CA1204107A/en
Publication of JPS5843993A publication Critical patent/JPS5843993A/ja
Priority to SG817/87A priority patent/SG81787G/en
Priority to MY826/87A priority patent/MY8700826A/xx
Publication of JPS637559B2 publication Critical patent/JPS637559B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
JP56142045A 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法 Granted JPS5843993A (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
DE8282108163T DE3262887D1 (en) 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof
KR8203969A KR890000762B1 (ko) 1981-09-09 1982-09-03 1-β-D-아라비노프라노실-(E)-5-(2-할로게노비닐)우라실-5'-인산의 제조방법
EP82108163A EP0074101B1 (en) 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof
US06/414,824 US4542210A (en) 1981-09-09 1982-09-03 1-β-D-Arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil-5'-phosphate, preparation thereof and use thereof
AT82108163T ATE12503T1 (de) 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2halogensubstituiertes vinyl) uracil-5-phosphate; ihre herstellung und verwendung.
AU87996/82A AU552353B2 (en) 1981-09-09 1982-09-03 1-beta-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)- uracil-5:-phosphate
GB08225547A GB2108964B (en) 1981-09-09 1982-09-08 1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl)uracil-5'-phosphates
CA000411003A CA1204107A (en) 1981-09-09 1982-09-08 1-.beta.-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL) URACIL-5'-PHOSPHATE, PREPARATION THEREOF AND USE THEREOF
ES515573A ES8308570A1 (es) 1981-09-09 1982-09-08 Un procedimiento para producir 5'-fosfato de 1, beta d-arabino-furanosil-(e)-5-(2-halogenovinil) uracilo.
SG817/87A SG81787G (en) 1981-09-09 1987-10-09 1-b-d-arabinofuranosyl-(e)-5-(2-halogenovinyl) uracil-5'-phosphate, preparation thereof and use thereof
MY826/87A MY8700826A (en) 1981-09-09 1987-12-30 1-b-d-arabinofuranosyl-(e)-5-(2-halo-genovinyl) uracil-5'-phosphate preparation thereof and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56142045A JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP18570082A Division JPS5877817A (ja) 1982-10-21 1982-10-21 抗ウイルス剤

Publications (2)

Publication Number Publication Date
JPS5843993A true JPS5843993A (ja) 1983-03-14
JPS637559B2 JPS637559B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-02-17

Family

ID=15306105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56142045A Granted JPS5843993A (ja) 1981-09-09 1981-09-09 １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Country Status (12)

Country Link
US (1) US4542210A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0074101B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5843993A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890000762B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE12503T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU552353B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1204107A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3262887D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8308570A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2108964B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8700826A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG81787G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007210963A (ja) * 2006-02-10 2007-08-23 Arigen Inc ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
DE3377647D1 (de) * 1982-09-17 1988-09-15 Glaxo Group Ltd 5-halovinyl-2'-deoxyuridine derivatives
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
DE3570441D1 (en) * 1985-01-24 1989-06-29 Neopharmed Spa Acylated derivatives of cytidine-diphosphate-choline, process for their preparation and their therapeutic use
GB8912972D0 (en) * 1989-06-06 1989-07-26 Wellcome Found Therapeutic nucleosides
US5446031A (en) * 1991-04-24 1995-08-29 Yamasa Shuyu Kabushiki Kaisha 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives
CA2085994A1 (en) * 1991-04-24 1992-10-25 Shinji Sakata 1-beta-d-arabinofuranosyl-(e)-5- (2-halogenovinyl) uracil derivatives
DE69840216D1 (de) * 1997-08-08 2008-12-24 Celmed Oncology Usa Inc Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
US6339151B1 (en) 1998-01-23 2002-01-15 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
JP2003525866A (ja) 1999-07-22 2003-09-02 ニューバイオティックス インコーポレイテッド 治療抵抗性腫瘍を処置するための方法
CA2441350A1 (en) * 2001-01-19 2002-07-25 Newbiotics, Inc. Methods to treat autoimmune and inflammatory conditions
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE684554A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-07-27 1967-01-03
US3382232A (en) * 1965-08-26 1968-05-07 Takeda Chemical Industries Ltd Method for the production of 5'-ribonucleotide
FR5616M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1966-07-29 1968-01-15
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
JPS5714598A (en) * 1980-06-30 1982-01-25 Yamasa Shoyu Co Ltd 5-substituted-1-beta-d-arabinofuranosyluracil derivative and its preparation
US4383990A (en) * 1980-10-01 1983-05-17 Beecham Group Limited Antiviral agents, their preparation and use
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007210963A (ja) * 2006-02-10 2007-08-23 Arigen Inc ピリミジンヌクレオシド誘導体及びその塩
WO2008099492A1 (ja) * 2007-02-15 2008-08-21 Arigen Pharmaceuticals, Inc. ピリミジンヌクレオシド誘導体及びその塩
US8076302B2 (en) 2007-02-15 2011-12-13 Arigen Pharmaceuticals, Inc. Pyrimidine nucleoside derivatives and salts thereof

Also Published As

Publication number Publication date
ES515573A0 (es) 1983-09-16
JPS637559B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-02-17
US4542210A (en) 1985-09-17
GB2108964A (en) 1983-05-25
KR840001589A (ko) 1984-05-07
MY8700826A (en) 1987-12-31
AU8799682A (en) 1983-03-17
CA1204107A (en) 1986-05-06
EP0074101A1 (en) 1983-03-16
EP0074101B1 (en) 1985-04-03
ATE12503T1 (de) 1985-04-15
SG81787G (en) 1988-04-15
ES8308570A1 (es) 1983-09-16
KR890000762B1 (ko) 1989-04-05
GB2108964B (en) 1985-04-11
AU552353B2 (en) 1986-05-29
DE3262887D1 (en) 1985-05-09

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