JPS58214333A - 粒状物 - Google Patents
粒状物Info
- Publication number
- JPS58214333A JPS58214333A JP9572082A JP9572082A JPS58214333A JP S58214333 A JPS58214333 A JP S58214333A JP 9572082 A JP9572082 A JP 9572082A JP 9572082 A JP9572082 A JP 9572082A JP S58214333 A JPS58214333 A JP S58214333A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- low
- powder
- particle size
- melting point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 34
- 239000008187 granular material Substances 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 238000010309 melting process Methods 0.000 claims abstract description 5
- 238000002844 melting Methods 0.000 claims description 31
- 230000008018 melting Effects 0.000 claims description 27
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 27
- 239000002245 particle Substances 0.000 abstract description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 7
- 229960003511 macrogol Drugs 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000004503 fine granule Substances 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 description 17
- 230000003179 granulation Effects 0.000 description 17
- 239000002904 solvent Substances 0.000 description 7
- 108010019160 Pancreatin Proteins 0.000 description 6
- 229940055695 pancreatin Drugs 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 238000007908 dry granulation Methods 0.000 description 2
- 239000002702 enteric coating Substances 0.000 description 2
- 238000009505 enteric coating Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- -1 paraffin Chemical class 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 238000003677 abuse test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- ZCZLQYAECBEUBH-UHFFFAOYSA-L calcium;octadec-9-enoate Chemical compound [Ca+2].CCCCCCCCC=CCCCCCCCC([O-])=O.CCCCCCCCC=CCCCCCCCC([O-])=O ZCZLQYAECBEUBH-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940075894 denatured ethanol Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- MCCIMQKMMBVWHO-UHFFFAOYSA-N octadecanoic acid;titanium Chemical compound [Ti].CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O MCCIMQKMMBVWHO-UHFFFAOYSA-N 0.000 description 1
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IRYJRGCIQBGHIV-UHFFFAOYSA-N trimethadione Chemical compound CN1C(=O)OC(C)(C)C1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 229960004453 trimethadione Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Glanulating (AREA)
- Fats And Perfumes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9572082A JPS58214333A (ja) | 1982-06-04 | 1982-06-04 | 粒状物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9572082A JPS58214333A (ja) | 1982-06-04 | 1982-06-04 | 粒状物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58214333A true JPS58214333A (ja) | 1983-12-13 |
| JPH0413019B2 JPH0413019B2 (enrdf_load_stackoverflow) | 1992-03-06 |
Family
ID=14145309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9572082A Granted JPS58214333A (ja) | 1982-06-04 | 1982-06-04 | 粒状物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58214333A (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62181214A (ja) * | 1986-02-06 | 1987-08-08 | Dai Ichi Seiyaku Co Ltd | 徐放性粒状物の製造法 |
| EP0455391A3 (en) * | 1990-04-28 | 1991-12-18 | Takeda Chemical Industries, Ltd. | Granulated preparations and method of producing the same |
| EP0508653A1 (en) | 1991-04-08 | 1992-10-14 | Tanabe Seiyaku Co., Ltd. | Sustained-release pharmaceutical preparation and process for preparing the same |
| WO1997003656A1 (fr) * | 1995-07-21 | 1997-02-06 | Daiichi Pharmaceutical Co., Ltd. | Preparation granulaire et son procede de production |
| JP2004277431A (ja) * | 1995-07-21 | 2004-10-07 | Dai Ichi Seiyaku Co Ltd | 粒状製剤及びその製造法 |
| WO2005039538A1 (ja) * | 2003-10-29 | 2005-05-06 | Shionogi & Co., Ltd. | 不快味を改善した被覆製剤の製造方法 |
| JP2006102558A (ja) * | 2004-09-30 | 2006-04-20 | Pauretsuku:Kk | 粒子のコーティング方法 |
| JP2007513920A (ja) * | 2003-12-09 | 2007-05-31 | ザンボン グループ エス．ピー．エー． | ガバペンチン含有医薬製剤 |
| JP2007284423A (ja) * | 2006-03-24 | 2007-11-01 | Daiichi Sankyo Healthcare Co Ltd | 医薬用製剤およびその製造方法 |
| JP2008528675A (ja) * | 2005-02-03 | 2008-07-31 | ニコメド ファーマ エイエス | カルシウム含有化合物を含む組成物の溶融造粒 |
| JP2013018769A (ja) * | 2011-06-14 | 2013-01-31 | Taisho Pharmaceutical Co Ltd | 生薬含有固形製剤 |
| JP2013163698A (ja) * | 2006-03-24 | 2013-08-22 | Daiichi Sankyo Healthcare Co Ltd | 医薬用製剤およびその製造方法 |
| JP2014043439A (ja) * | 2012-08-03 | 2014-03-13 | Taisho Pharmaceutical Co Ltd | 固形製剤 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4834780A (enrdf_load_stackoverflow) * | 1971-08-31 | 1973-05-22 | ||
| JPS5420571A (en) * | 1977-07-13 | 1979-02-16 | Daimaru Shiki Kk | Device of automatically cutting pasteboard |
-
1982
- 1982-06-04 JP JP9572082A patent/JPS58214333A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4834780A (enrdf_load_stackoverflow) * | 1971-08-31 | 1973-05-22 | ||
| JPS5420571A (en) * | 1977-07-13 | 1979-02-16 | Daimaru Shiki Kk | Device of automatically cutting pasteboard |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62181214A (ja) * | 1986-02-06 | 1987-08-08 | Dai Ichi Seiyaku Co Ltd | 徐放性粒状物の製造法 |
| EP0455391A3 (en) * | 1990-04-28 | 1991-12-18 | Takeda Chemical Industries, Ltd. | Granulated preparations and method of producing the same |
| US5443846A (en) * | 1990-04-28 | 1995-08-22 | Takeda Chemical Industries, Ltd. | Granulated preparations and method of producing the same |
| EP0508653A1 (en) | 1991-04-08 | 1992-10-14 | Tanabe Seiyaku Co., Ltd. | Sustained-release pharmaceutical preparation and process for preparing the same |
| WO1997003656A1 (fr) * | 1995-07-21 | 1997-02-06 | Daiichi Pharmaceutical Co., Ltd. | Preparation granulaire et son procede de production |
| US6217910B1 (en) | 1995-07-21 | 2001-04-17 | Daiichi Pharmaceutical Co., Ltd. | Granular preparation and producing process thereof |
| JP2004277431A (ja) * | 1995-07-21 | 2004-10-07 | Dai Ichi Seiyaku Co Ltd | 粒状製剤及びその製造法 |
| JPWO2005039538A1 (ja) * | 2003-10-29 | 2007-11-22 | 塩野義製薬株式会社 | 不快味を改善した被覆製剤の製造方法 |
| WO2005039538A1 (ja) * | 2003-10-29 | 2005-05-06 | Shionogi & Co., Ltd. | 不快味を改善した被覆製剤の製造方法 |
| JP2007513920A (ja) * | 2003-12-09 | 2007-05-31 | ザンボン グループ エス．ピー．エー． | ガバペンチン含有医薬製剤 |
| JP2006102558A (ja) * | 2004-09-30 | 2006-04-20 | Pauretsuku:Kk | 粒子のコーティング方法 |
| JP2008528675A (ja) * | 2005-02-03 | 2008-07-31 | ニコメド ファーマ エイエス | カルシウム含有化合物を含む組成物の溶融造粒 |
| JP2007284423A (ja) * | 2006-03-24 | 2007-11-01 | Daiichi Sankyo Healthcare Co Ltd | 医薬用製剤およびその製造方法 |
| JP2013163698A (ja) * | 2006-03-24 | 2013-08-22 | Daiichi Sankyo Healthcare Co Ltd | 医薬用製剤およびその製造方法 |
| JP2013018769A (ja) * | 2011-06-14 | 2013-01-31 | Taisho Pharmaceutical Co Ltd | 生薬含有固形製剤 |
| JP2014043439A (ja) * | 2012-08-03 | 2014-03-13 | Taisho Pharmaceutical Co Ltd | 固形製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0413019B2 (enrdf_load_stackoverflow) | 1992-03-06 |
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