JPS58172537A - 光散乱測定装置 - Google Patents
光散乱測定装置Info
- Publication number
- JPS58172537A JPS58172537A JP5586282A JP5586282A JPS58172537A JP S58172537 A JPS58172537 A JP S58172537A JP 5586282 A JP5586282 A JP 5586282A JP 5586282 A JP5586282 A JP 5586282A JP S58172537 A JPS58172537 A JP S58172537A
- Authority
- JP
- Japan
- Prior art keywords
- light scattering
- antigen
- measurement
- reaction
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000149 argon plasma sintering Methods 0.000 title claims abstract description 40
- 238000006243 chemical reaction Methods 0.000 claims abstract description 54
- 238000005259 measurement Methods 0.000 claims abstract description 30
- 230000023555 blood coagulation Effects 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000000427 antigen Substances 0.000 claims abstract description 14
- 102000036639 antigens Human genes 0.000 claims abstract description 14
- 108091007433 antigens Proteins 0.000 claims abstract description 14
- 238000012360 testing method Methods 0.000 claims description 33
- 230000008859 change Effects 0.000 claims description 15
- 238000001556 precipitation Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 5
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract description 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract description 4
- 239000003114 blood coagulation factor Substances 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 4
- 229940019700 blood coagulation factors Drugs 0.000 abstract description 2
- 230000001900 immune effect Effects 0.000 abstract description 2
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 13
- 230000015271 coagulation Effects 0.000 description 11
- 238000005345 coagulation Methods 0.000 description 11
- 238000010586 diagram Methods 0.000 description 10
- 239000012895 dilution Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 108010073385 Fibrin Proteins 0.000 description 4
- 102000009123 Fibrin Human genes 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 108010049003 Fibrinogen Proteins 0.000 description 4
- 102000008946 Fibrinogen Human genes 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 239000004816 latex Substances 0.000 description 4
- 229920000126 latex Polymers 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000002123 temporal effect Effects 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 229940012952 fibrinogen Drugs 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108010000499 Thromboplastin Proteins 0.000 description 2
- 102000002262 Thromboplastin Human genes 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000012113 quantitative test Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 206010005133 Bleeding tendencies Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 108010058861 Fibrin Fibrinogen Degradation Products Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 101710123661 Venom allergen 5 Proteins 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000000208 fibrin degradation product Substances 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5586282A JPS58172537A (ja) | 1982-04-04 | 1982-04-04 | 光散乱測定装置 |
| US06/481,961 US4766083A (en) | 1982-04-04 | 1983-04-04 | Method for the photometric determination of biological agglutination |
| AT83103297T ATE58245T1 (de) | 1982-04-04 | 1983-04-05 | Verfahren zur photometrischen bestimmung biologischer agglutinaten. |
| EP83103297A EP0091636B1 (en) | 1982-04-04 | 1983-04-05 | Method for the photometric determination of biological agglutination |
| DE8383103297T DE3381979D1 (de) | 1982-04-04 | 1983-04-05 | Verfahren zur photometrischen bestimmung biologischer agglutinaten. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5586282A JPS58172537A (ja) | 1982-04-04 | 1982-04-04 | 光散乱測定装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58172537A true JPS58172537A (ja) | 1983-10-11 |
| JPH0311423B2 JPH0311423B2 (enrdf_load_stackoverflow) | 1991-02-15 |
Family
ID=13010866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5586282A Granted JPS58172537A (ja) | 1982-04-04 | 1982-04-04 | 光散乱測定装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58172537A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01503566A (ja) * | 1987-06-11 | 1989-11-30 | オリオン・コーポレィション・リミテッド | 生物検定を行なうためのキュベットおよび装置 |
| US6251615B1 (en) | 1998-02-20 | 2001-06-26 | Cell Analytics, Inc. | Cell analysis methods |
| WO2011068049A1 (ja) | 2009-12-04 | 2011-06-09 | 株式会社日立ハイテクノロジーズ | 血液凝固分析装置 |
| WO2012157206A1 (ja) * | 2011-05-13 | 2012-11-22 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP2017537873A (ja) * | 2014-08-19 | 2017-12-21 | リアプリックス エイピーエス | 遠心分離機および血液サンプルを遠心分離する方法 |
| CN110006795A (zh) * | 2019-04-30 | 2019-07-12 | 华北电力大学（保定） | 颗粒检测装置、方法及fpga |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5014466B2 (ja) | 2010-06-04 | 2012-08-29 | 徹 小幡 | ゲル粒子測定装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5193286A (enrdf_load_stackoverflow) * | 1975-02-13 | 1976-08-16 | ||
| JPS54140240A (en) * | 1978-04-24 | 1979-10-31 | Mitsubishi Electric Corp | Sheath heater sealing method |
| JPS576361A (en) * | 1980-06-12 | 1982-01-13 | Joko:Kk | Method for deciding peak in dynamic measurement of immune nephelometric device |
-
1982
- 1982-04-04 JP JP5586282A patent/JPS58172537A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5193286A (enrdf_load_stackoverflow) * | 1975-02-13 | 1976-08-16 | ||
| JPS54140240A (en) * | 1978-04-24 | 1979-10-31 | Mitsubishi Electric Corp | Sheath heater sealing method |
| JPS576361A (en) * | 1980-06-12 | 1982-01-13 | Joko:Kk | Method for deciding peak in dynamic measurement of immune nephelometric device |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01503566A (ja) * | 1987-06-11 | 1989-11-30 | オリオン・コーポレィション・リミテッド | 生物検定を行なうためのキュベットおよび装置 |
| US6251615B1 (en) | 1998-02-20 | 2001-06-26 | Cell Analytics, Inc. | Cell analysis methods |
| WO2011068049A1 (ja) | 2009-12-04 | 2011-06-09 | 株式会社日立ハイテクノロジーズ | 血液凝固分析装置 |
| JP5667989B2 (ja) * | 2009-12-04 | 2015-02-12 | 株式会社日立ハイテクノロジーズ | 血液凝固分析装置 |
| US9395298B2 (en) | 2009-12-04 | 2016-07-19 | Hitachi High-Technologies Corporation | Blood coagulation analyzer |
| WO2012157206A1 (ja) * | 2011-05-13 | 2012-11-22 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| US9645160B2 (en) | 2011-05-13 | 2017-05-09 | Hitachi High-Technologies Corporation | Automatic analysis device |
| JP2017537873A (ja) * | 2014-08-19 | 2017-12-21 | リアプリックス エイピーエス | 遠心分離機および血液サンプルを遠心分離する方法 |
| CN110006795A (zh) * | 2019-04-30 | 2019-07-12 | 华北电力大学（保定） | 颗粒检测装置、方法及fpga |
| CN110006795B (zh) * | 2019-04-30 | 2024-02-13 | 华北电力大学（保定） | 颗粒检测装置、方法及fpga |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0311423B2 (enrdf_load_stackoverflow) | 1991-02-15 |
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