JPS58135820A - 放射化モノクロン抗体及びそれを有効成分とする造影剤 - Google Patents

放射化モノクロン抗体及びそれを有効成分とする造影剤

Info

Publication number
JPS58135820A
JPS58135820A JP57188921A JP18892182A JPS58135820A JP S58135820 A JPS58135820 A JP S58135820A JP 57188921 A JP57188921 A JP 57188921A JP 18892182 A JP18892182 A JP 18892182A JP S58135820 A JPS58135820 A JP S58135820A
Authority
JP
Japan
Prior art keywords
monoclonal antibody
tumor
antibody
radionuclide
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57188921A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0564130B2 (fr
Inventor
ト−マス・ヘンリ−・アダムス
ガリ−・サミエル・デイヴイツド
サミエル・エリオツト・ハルパ−ン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
University of California
Original Assignee
Hybritech Inc
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc, University of California filed Critical Hybritech Inc
Publication of JPS58135820A publication Critical patent/JPS58135820A/ja
Publication of JPH0564130B2 publication Critical patent/JPH0564130B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1066—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP57188921A 1981-10-27 1982-10-26 放射化モノクロン抗体及びそれを有効成分とする造影剤 Granted JPS58135820A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31528681A 1981-10-27 1981-10-27
US315286 1989-02-24

Publications (2)

Publication Number Publication Date
JPS58135820A true JPS58135820A (ja) 1983-08-12
JPH0564130B2 JPH0564130B2 (fr) 1993-09-14

Family

ID=23223718

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57188921A Granted JPS58135820A (ja) 1981-10-27 1982-10-26 放射化モノクロン抗体及びそれを有効成分とする造影剤

Country Status (18)

Country Link
JP (1) JPS58135820A (fr)
AT (1) AT392004B (fr)
BE (1) BE894829A (fr)
CA (1) CA1202892A (fr)
CH (1) CH653040A5 (fr)
DE (1) DE3239410A1 (fr)
DK (1) DK164682C (fr)
ES (2) ES516797A0 (fr)
FI (1) FI82379C (fr)
FR (1) FR2515046B1 (fr)
GB (1) GB2109407B (fr)
IL (1) IL67068A0 (fr)
IT (1) IT1153857B (fr)
LU (1) LU84441A1 (fr)
NL (1) NL8204108A (fr)
NO (1) NO169947C (fr)
SE (1) SE8206073L (fr)
ZA (1) ZA827806B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214261A (ja) * 1984-04-10 1985-10-26 Takeda Chem Ind Ltd ヒト癌胎児性抗原反応性モノクローナル抗体の製造法
JP2008195715A (ja) * 1995-05-16 2008-08-28 Purdue Res Found 腫瘍画像化法および組成物

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
CA1225930A (fr) * 1982-06-07 1987-08-25 Otto A. Gansow Anticorps monoclonaux conjugues avec des chelates metalliques
US4741900A (en) * 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB2140030A (en) * 1983-04-08 1984-11-21 Kureha Chemical Ind Co Ltd Monoclonal antibody to human urinary bladder cancer
GB2139645A (en) * 1983-04-08 1984-11-14 Kureha Chemical Ind Co Ltd Antibody to human prostrate cancer
JPS59199636A (ja) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk 放射性診断剤
US4677058A (en) * 1983-05-19 1987-06-30 Karl Tryggvason Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JPS60201260A (ja) * 1984-03-27 1985-10-11 Yamasa Shoyu Co Ltd 心疾患診断薬
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
CA1260827A (fr) * 1984-08-31 1989-09-26 Richard C. Siegel Complexes anticorps - ions metalliques
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4986256A (en) * 1985-02-28 1991-01-22 The United States Of America As Represented By The Department Of Health And Human Services Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4830847A (en) * 1985-06-28 1989-05-16 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
CA1340014C (fr) * 1986-10-27 1998-08-25 Bryan Michael Longenecker Anticorps monoclonaux marqueurs de carcinomes; leur elicitation avec l'antigene asialo-gmi
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5177192A (en) * 1987-04-02 1993-01-05 Centocor, Incorporated Method for labeling antibodies with a metal ion
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US4838274A (en) * 1987-09-18 1989-06-13 Air Products And Chemicals, Inc. Perfluoro-crown ethers in fluorine magnetic resonance imaging
US5217704A (en) * 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5648471A (en) * 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
US4867962A (en) * 1988-02-26 1989-09-19 Neorx Corporation Functionally specific antibodies
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
EP0955066A3 (fr) * 1992-07-31 2002-08-28 Australian Nuclear Science And Technology Organisation Complexes métalliques d' agents chélateurs de type acide aminocarboxylique contenant le groupe hydroxyaryl
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5695119A (en) * 1979-10-29 1981-08-01 University Patents Inc Method and composition for detecting human cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323546A (en) * 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4272503A (en) * 1978-05-25 1981-06-09 New England Nuclear Corporation Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
AU556548B2 (en) * 1980-03-03 1986-11-06 Milton David Goldenberg Tumor localization and therapy with labeled antibodies and antibody fragments specific to tumor-associated markers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5695119A (en) * 1979-10-29 1981-08-01 University Patents Inc Method and composition for detecting human cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214261A (ja) * 1984-04-10 1985-10-26 Takeda Chem Ind Ltd ヒト癌胎児性抗原反応性モノクローナル抗体の製造法
JP2008195715A (ja) * 1995-05-16 2008-08-28 Purdue Res Found 腫瘍画像化法および組成物

Also Published As

Publication number Publication date
SE8206073D0 (sv) 1982-10-26
FI82379B (fi) 1990-11-30
FI823633L (fi) 1983-04-28
LU84441A1 (fr) 1983-06-13
DE3239410A1 (de) 1983-05-19
AT392004B (de) 1991-01-10
DK164682B (da) 1992-08-03
ES8505482A1 (es) 1985-05-16
DK474182A (da) 1983-04-28
CH653040A5 (de) 1985-12-13
NO169947B (no) 1992-05-18
ATA391682A (de) 1990-07-15
FR2515046B1 (fr) 1985-11-29
BE894829A (fr) 1983-02-14
ES8404857A1 (es) 1984-05-16
FR2515046A1 (fr) 1983-04-29
IT8223932A0 (it) 1982-10-26
GB2109407B (en) 1985-12-18
CA1202892A (fr) 1986-04-08
ES529310A0 (es) 1985-05-16
NL8204108A (nl) 1983-05-16
DE3239410C2 (fr) 1991-12-19
JPH0564130B2 (fr) 1993-09-14
FI82379C (fi) 1991-03-11
IT1153857B (it) 1987-01-21
NO169947C (no) 1992-08-26
NO823530L (no) 1983-04-28
DK164682C (da) 1992-12-21
FI823633A0 (fi) 1982-10-25
GB2109407A (en) 1983-06-02
ES516797A0 (es) 1984-05-16
IL67068A0 (en) 1983-02-23
ZA827806B (en) 1983-08-31
SE8206073L (sv) 1983-04-28

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