JPS58130119A - 塩化水酸化アルミニウム水和物錯体及びその製造法 - Google Patents
塩化水酸化アルミニウム水和物錯体及びその製造法Info
- Publication number
- JPS58130119A JPS58130119A JP57213240A JP21324082A JPS58130119A JP S58130119 A JPS58130119 A JP S58130119A JP 57213240 A JP57213240 A JP 57213240A JP 21324082 A JP21324082 A JP 21324082A JP S58130119 A JPS58130119 A JP S58130119A
- Authority
- JP
- Japan
- Prior art keywords
- content
- phosphate
- aluminum
- water
- aluminum hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- -1 Aluminum hydroxide chloride hydrate Chemical compound 0.000 title description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 13
- YCNOUTVVAYPXHG-UHFFFAOYSA-K trichloroalumane dihydrate Chemical compound O.O.[Cl-].[Al+3].[Cl-].[Cl-] YCNOUTVVAYPXHG-UHFFFAOYSA-K 0.000 claims description 12
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 229910001868 water Inorganic materials 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 18
- 229910019142 PO4 Inorganic materials 0.000 description 15
- 235000021317 phosphate Nutrition 0.000 description 15
- 239000010452 phosphate Substances 0.000 description 14
- 229910052801 chlorine Inorganic materials 0.000 description 12
- 239000002253 acid Substances 0.000 description 11
- 239000000460 chlorine Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 7
- 229940024545 aluminum hydroxide Drugs 0.000 description 7
- 239000002775 capsule Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 4
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 4
- PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 229910052740 iodine Inorganic materials 0.000 description 4
- 239000011630 iodine Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229940085991 phosphate ion Drugs 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 208000009911 Urinary Calculi Diseases 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 208000008281 urolithiasis Diseases 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- BYFGZMCJNACEKR-UHFFFAOYSA-N aluminium(i) oxide Chemical compound [Al]O[Al] BYFGZMCJNACEKR-UHFFFAOYSA-N 0.000 description 2
- 229940118662 aluminum carbonate Drugs 0.000 description 2
- 229940069428 antacid Drugs 0.000 description 2
- 239000003159 antacid agent Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- CAYKLJBSARHIDI-UHFFFAOYSA-K trichloroalumane;hydrate Chemical compound O.Cl[Al](Cl)Cl CAYKLJBSARHIDI-UHFFFAOYSA-K 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000013824 Acidemia Diseases 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 235000011293 Brassica napus Nutrition 0.000 description 1
- 240000008100 Brassica rapa Species 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- DTRYYPKLEYYJTH-UHFFFAOYSA-N I.OP(O)(O)=O Chemical compound I.OP(O)(O)=O DTRYYPKLEYYJTH-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
- 101100536300 Pasteurella multocida (strain Pm70) talB gene Proteins 0.000 description 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- BHCDGYGRFCWAMH-UHFFFAOYSA-N [I].OP(O)(O)=O Chemical compound [I].OP(O)(O)=O BHCDGYGRFCWAMH-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical compound O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-M lysinate Chemical compound NCCCCC(N)C([O-])=O KDXKERNSBIXSRK-UHFFFAOYSA-M 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002694 phosphate binding agent Substances 0.000 description 1
- 102200088128 rs3213422 Human genes 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F7/00—Compounds of aluminium
- C01F7/48—Halides, with or without other cations besides aluminium
- C01F7/56—Chlorides
- C01F7/57—Basic aluminium chlorides, e.g. polyaluminium chlorides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Geology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE31478697 | 1981-12-03 | ||
| DE3147869A DE3147869A1 (de) | 1981-12-03 | 1981-12-03 | Aluminiumchloridhydroxidhydrat-komplex als arzneimittel zur phosphatbindung und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS58130119A true JPS58130119A (ja) | 1983-08-03 |
Family
ID=6147802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57213240A Pending JPS58130119A (ja) | 1981-12-03 | 1982-12-03 | 塩化水酸化アルミニウム水和物錯体及びその製造法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS58130119A (enrdf_load_stackoverflow) |
| DE (1) | DE3147869A1 (enrdf_load_stackoverflow) |
| ES (1) | ES517891A0 (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01131023A (ja) * | 1987-11-16 | 1989-05-23 | Tomita Seiyaku Kk | 経口用リン酸イオン吸着剤 |
| JPH062580B2 (ja) * | 1988-11-14 | 1994-01-12 | 富田製薬株式会社 | ベーマイト状水酸化アルミニウム、その製造法及びそれを有効成分とする経口用リン酸イオン吸着剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1048280B (it) * | 1974-03-28 | 1980-11-20 | Snam Progetti | Processo per la produzione di cuoroidrossidi di alluminio |
-
1981
- 1981-12-03 DE DE3147869A patent/DE3147869A1/de active Granted
-
1982
- 1982-12-02 ES ES517891A patent/ES517891A0/es active Granted
- 1982-12-03 JP JP57213240A patent/JPS58130119A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3147869C2 (enrdf_load_stackoverflow) | 1989-09-14 |
| ES8402234A1 (es) | 1984-01-16 |
| DE3147869A1 (de) | 1983-06-16 |
| ES517891A0 (es) | 1984-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI82682B (fi) | Foerfarande foer framstaellning av ett anti-inflammatoriskt och analgetiskt verksamt resinat av en substituerad karboxylsyra. | |
| US4885281A (en) | Sucralfate suspension | |
| KR100997504B1 (ko) | 인산염 결합제로서의 혼합 또는 황산화된 금속 화합물 | |
| US4199560A (en) | Solid oral pharmaceutical product with increased efficacy and predetermined steady state of solubility | |
| JP2907299B2 (ja) | 胃酸を結合する薬学的製剤 | |
| JPH06502431A (ja) | 消化管治療のための製品及び方法 | |
| US10300020B2 (en) | Formulation and manufacturing process for calcium acetate capsules | |
| US20100260852A1 (en) | Laxative agent | |
| JPH05155776A (ja) | 高リン血症治療剤 | |
| JPS58130119A (ja) | 塩化水酸化アルミニウム水和物錯体及びその製造法 | |
| US4067974A (en) | Stabilized solid form choline salicylate compositions | |
| HUT59656A (en) | Process for producing s/+/-phenyl-alkanoic acids and alpha-amino-acids containing complexes and pharmaceutical compositions containing them as active components | |
| RU2130310C1 (ru) | Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для внутреннего применения | |
| FI60851C (fi) | Foerfarande foer framstaellning av foer urinstensbehandling laempligt aluminiumpolyhydroxisulfat-hydrat | |
| EP0143576A1 (en) | An antacid composition and a process for the preparation thereof | |
| KR870002160B1 (ko) | 변성 점토의 제조방법 | |
| FI56770C (fi) | Foerfarande foer framstaellning av ett terapeutiskt anvaendbart stabilt fast kolinsalicylatkomplex | |
| US4889725A (en) | Means to promote the neutralization reaction between particulate calcium carbonate and ionized phosphate | |
| JP6676056B2 (ja) | 胃腸でのナトリウム再吸収及びリン酸塩再吸収の同時減少のためのマグヘマイトをベースとする医薬品 | |
| JP2001064182A (ja) | スクラルファート懸濁液製剤 | |
| US4215143A (en) | Anti-ulcer pharmaceutical composition containing inositol hexasulfate aluminum or sodium aluminum salt as active ingredient | |
| KR930001802B1 (ko) | 슈크랄페이트 현탁액의 안정화방법 | |
| CA1176984A (en) | Pharmaceutical compositions for the treatment of gastric hyperacidity, gastritis and gastroduodenal ulcers | |
| JP2688770B2 (ja) | 鉄吸収促進剤 | |
| JPH05105632A (ja) | ホスフオネート型化合物を含有する医薬組成物 |