JPS58105911A - 無水チキソトロピ−性組成物 - Google Patents
無水チキソトロピ−性組成物Info
- Publication number
- JPS58105911A JPS58105911A JP57141170A JP14117082A JPS58105911A JP S58105911 A JPS58105911 A JP S58105911A JP 57141170 A JP57141170 A JP 57141170A JP 14117082 A JP14117082 A JP 14117082A JP S58105911 A JPS58105911 A JP S58105911A
- Authority
- JP
- Japan
- Prior art keywords
- formulation according
- glycol
- polymer
- formulation
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims description 39
- 230000009974 thixotropic effect Effects 0.000 title description 2
- 238000009472 formulation Methods 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 241001465754 Metazoa Species 0.000 claims description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 14
- 239000000194 fatty acid Substances 0.000 claims description 14
- 229930195729 fatty acid Natural products 0.000 claims description 14
- 150000004665 fatty acids Chemical class 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 5
- 229920003169 water-soluble polymer Polymers 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- -1 fatty acid ester Chemical class 0.000 claims 2
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007721 medicinal effect Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229940057400 trihydroxystearin Drugs 0.000 claims 1
- 239000000273 veterinary drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 125000002947 alkylene group Chemical group 0.000 description 4
- 150000002334 glycols Chemical class 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 150000005691 triesters Chemical class 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000003872 feeding technique Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33054181A | 1981-12-14 | 1981-12-14 | |
| US330,541 | 1981-12-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58105911A true JPS58105911A (ja) | 1983-06-24 |
| JPH0536416B2 JPH0536416B2 (enrdf_load_stackoverflow) | 1993-05-31 |
Family
ID=23290213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57141170A Granted JPS58105911A (ja) | 1981-12-14 | 1982-08-16 | 無水チキソトロピ−性組成物 |
Country Status (15)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63203162A (ja) * | 1987-02-20 | 1988-08-23 | 久光製薬株式会社 | ゲルマトリツクス |
| JPS63203613A (ja) * | 1987-02-20 | 1988-08-23 | Hisamitsu Pharmaceut Co Inc | 親水性経皮投与製剤 |
| JP2005529901A (ja) * | 2002-05-01 | 2005-10-06 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の潤滑剤抗真菌ゲル組成物 |
| JP2005530747A (ja) * | 2002-05-01 | 2005-10-13 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の潤滑剤組成物および刺激を比較する方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU592065B2 (en) * | 1984-10-09 | 1990-01-04 | Dow Chemical Company, The | Sustained release dosage form based on highly plasticized cellulose ether gels |
| US5460802A (en) * | 1994-07-18 | 1995-10-24 | Minnesota Mining And Manufacturing Company | Oral disinfectant for companion animals |
| PT971690E (pt) | 1996-12-18 | 2002-12-31 | Bimeda Res And Dev Ltd | Composicao veterinaria intramamaria sem anti-infectantes |
| NZ548748A (en) | 2004-02-02 | 2010-09-30 | Bimeda Res & Dev Ltd | Method and device for treating a teat canal of an animal |
| CN1980614B (zh) | 2004-02-02 | 2011-12-28 | 百美达研究与发展有限公司 | 用于治疗动物的乳头管的装置 |
| US7854943B2 (en) | 2004-06-24 | 2010-12-21 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US7858115B2 (en) | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US7618651B2 (en) | 2004-06-24 | 2009-11-17 | Idexx Laboratories | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA952430A (en) * | 1971-03-29 | 1974-08-06 | General Foods Corporation | Non-aqueous gelled compositions |
-
1982
- 1982-07-26 IE IE1796/82A patent/IE53610B1/en not_active IP Right Cessation
- 1982-07-27 AU AU86445/82A patent/AU551641B2/en not_active Expired
- 1982-07-27 CA CA000408127A patent/CA1206414A/en not_active Expired
- 1982-07-27 DK DK335782A patent/DK335782A/da not_active Application Discontinuation
- 1982-07-28 NZ NZ201415A patent/NZ201415A/en unknown
- 1982-07-29 DE DE8282304017T patent/DE3276047D1/de not_active Expired
- 1982-07-29 EP EP82304017A patent/EP0081896B1/en not_active Expired
- 1982-08-02 GR GR68921A patent/GR76273B/el unknown
- 1982-08-02 ZA ZA825557A patent/ZA825557B/xx unknown
- 1982-08-03 AR AR290199A patent/AR231798A1/es active
- 1982-08-12 PT PT75418A patent/PT75418A/pt unknown
- 1982-08-13 ES ES514976A patent/ES8400028A1/es not_active Expired
- 1982-08-16 JP JP57141170A patent/JPS58105911A/ja active Granted
-
1987
- 1987-11-04 SG SG984/87A patent/SG98487G/en unknown
-
1988
- 1988-03-03 HK HK174/88A patent/HK17488A/en not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63203162A (ja) * | 1987-02-20 | 1988-08-23 | 久光製薬株式会社 | ゲルマトリツクス |
| JPS63203613A (ja) * | 1987-02-20 | 1988-08-23 | Hisamitsu Pharmaceut Co Inc | 親水性経皮投与製剤 |
| JP2005529901A (ja) * | 2002-05-01 | 2005-10-06 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の潤滑剤抗真菌ゲル組成物 |
| JP2005530747A (ja) * | 2002-05-01 | 2005-10-13 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の潤滑剤組成物および刺激を比較する方法 |
| JP2005531541A (ja) * | 2002-05-01 | 2005-10-20 | マクニール−ピーピーシー・インコーポレイテッド | 加温性で無刺激性の無水の潤滑性組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU551641B2 (en) | 1986-05-08 |
| IE821796L (en) | 1983-06-14 |
| EP0081896B1 (en) | 1987-04-15 |
| DK335782A (da) | 1983-06-15 |
| AR231798A1 (es) | 1985-03-29 |
| JPH0536416B2 (enrdf_load_stackoverflow) | 1993-05-31 |
| PT75418A (en) | 1982-09-01 |
| EP0081896A2 (en) | 1983-06-22 |
| SG98487G (en) | 1988-07-15 |
| HK17488A (en) | 1988-03-11 |
| ES514976A0 (es) | 1983-10-16 |
| GR76273B (enrdf_load_stackoverflow) | 1984-08-04 |
| IE53610B1 (en) | 1988-12-21 |
| NZ201415A (en) | 1985-09-13 |
| ES8400028A1 (es) | 1983-10-16 |
| CA1206414A (en) | 1986-06-24 |
| ZA825557B (en) | 1984-03-28 |
| DE3276047D1 (en) | 1987-05-21 |
| EP0081896A3 (en) | 1984-09-12 |
| AU8644582A (en) | 1983-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018305C1 (ru) | Способ получения твердой желатиновой капсулы | |
| EP0804170B1 (en) | Method for making freeze dried drug dosage forms | |
| DE69419260T2 (de) | Orale dosierungsform für tiere, verfahren zu ihrer herstellung und verwendungen | |
| EP1292381B1 (en) | Process and device for producing liquid dosage formulations | |
| US5102666A (en) | Calcium polycarbophil controlled release composition and method | |
| DE69505671T2 (de) | Ein neues arzneimittelabgabesystem | |
| US5110605A (en) | Calcium polycarbophil-alginate controlled release composition and method | |
| TW553746B (en) | Powdery nasal composition | |
| FI101596B (fi) | Menetelmä valmistaa stabiili injisoitava florfenikolin farmaseuttinen seos | |
| TW438603B (en) | Microemulsion preparation containing peptide pharmaceuticals | |
| JP3678745B2 (ja) | 高濃度アセトアミノフェン溶液含有ゼラチンカプセル | |
| CZ345295A3 (en) | Soft gelatin pharmaceutical dosing form | |
| TW589199B (en) | Process for preparing pharmaceutical compositions for use with soft gelatin formulations | |
| KR0163423B1 (ko) | 신규한 다공성 제약학적 형태 및 그의 제조방법 | |
| JPS58105911A (ja) | 無水チキソトロピ−性組成物 | |
| HUT63539A (en) | Bioactive compositions and process for forming bioactive coatings | |
| JPS61225137A (ja) | 活性剤の解放が制御された活性剤と可吸収性マトリックスからなる組成物 | |
| RO112991B1 (ro) | Preparat tip hidrogel, cu eliberare sustinuta | |
| EP1811995B1 (en) | A transmucosal veterinary composition comprising detomidine | |
| CN108619142B (zh) | 一种长效复方氟苯尼考注射液及其制备方法 | |
| CN101106976A (zh) | 用于输送活性成分的新型药物体系，其制备方法和用途 | |
| JP2511577B2 (ja) | アルギン酸プロピレングリコ―ルエステルからなる徐放性製剤 | |
| TW524696B (en) | Sustained-release drug formulations | |
| CA2126519A1 (en) | Nutritional supplement for calving ruminant animals | |
| JP3182229B2 (ja) | 動物用懸濁型ペースト剤 |