JPS5782400A - Erythromycin derivative - Google Patents
Erythromycin derivativeInfo
- Publication number
- JPS5782400A JPS5782400A JP55159128A JP15912880A JPS5782400A JP S5782400 A JPS5782400 A JP S5782400A JP 55159128 A JP55159128 A JP 55159128A JP 15912880 A JP15912880 A JP 15912880A JP S5782400 A JPS5782400 A JP S5782400A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- solvent
- reaction
- compound
- catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- MWBJRTBANFUBOX-SQYJNGITSA-N (3r,4s,5s,6r,7r,9r,10e,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclot Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/O)/[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MWBJRTBANFUBOX-SQYJNGITSA-N 0.000 abstract 1
- 229930006677 Erythromycin A Natural products 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- QSKWJTXWJJOJFP-UHFFFAOYSA-N chloroform;ethoxyethane Chemical compound ClC(Cl)Cl.CCOCC QSKWJTXWJJOJFP-UHFFFAOYSA-N 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004533 oil dispersion Substances 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55159128A JPS5782400A (en) | 1980-11-12 | 1980-11-12 | Erythromycin derivative |
| US06/266,060 US4331803A (en) | 1980-06-04 | 1981-05-19 | Novel erythromycin compounds |
| EP81302328A EP0041355B1 (en) | 1980-06-04 | 1981-05-27 | Novel erythromycin compounds |
| DE8181302328T DE3160084D1 (en) | 1980-06-04 | 1981-05-27 | Novel erythromycin compounds |
| AT81302328T ATE2623T1 (de) | 1980-06-04 | 1981-05-27 | Erythromycin-derivate. |
| NL930083C NL930083I2 (nl) | 1980-06-04 | 1993-06-21 | Nieuwe erytromycineverbindingen. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55159128A JPS5782400A (en) | 1980-11-12 | 1980-11-12 | Erythromycin derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5782400A true JPS5782400A (en) | 1982-05-22 |
| JPS6152839B2 JPS6152839B2 (ja) | 1986-11-14 |
Family
ID=15686846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55159128A Granted JPS5782400A (en) | 1980-06-04 | 1980-11-12 | Erythromycin derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5782400A (ja) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0915898A1 (en) | 1996-07-29 | 1999-05-19 | Abbott Laboratories | Crystal form i of clarithromycin |
| EP0915899A1 (en) | 1996-07-29 | 1999-05-19 | Abbott Laboratories | Preparation of crystal form ii of clarithromycin |
| EP1077988A1 (en) | 1997-01-17 | 2001-02-28 | Abbott Laboratories | Crystal form 0 of clarithromycin |
| WO2007129646A1 (ja) | 2006-05-01 | 2007-11-15 | Taisho Pharmaceutical Co., Ltd. | マクロライド誘導体 |
-
1980
- 1980-11-12 JP JP55159128A patent/JPS5782400A/ja active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0915898A1 (en) | 1996-07-29 | 1999-05-19 | Abbott Laboratories | Crystal form i of clarithromycin |
| EP0915899A1 (en) | 1996-07-29 | 1999-05-19 | Abbott Laboratories | Preparation of crystal form ii of clarithromycin |
| JP2009242411A (ja) * | 1996-07-29 | 2009-10-22 | Abbott Lab | クラリスロマイシンの結晶形態ｉｉの製造 |
| JP2010090156A (ja) * | 1996-07-29 | 2010-04-22 | Abbott Lab | クラリスロマイシンの結晶フォームｉ |
| JP2013151542A (ja) * | 1996-07-29 | 2013-08-08 | Abbott Lab | クラリスロマイシンの結晶形態ｉｉの製造 |
| EP1077988A1 (en) | 1997-01-17 | 2001-02-28 | Abbott Laboratories | Crystal form 0 of clarithromycin |
| WO2007129646A1 (ja) | 2006-05-01 | 2007-11-15 | Taisho Pharmaceutical Co., Ltd. | マクロライド誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6152839B2 (ja) | 1986-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0141057A1 (en) | Novel 4'-demethyl-4-epipodophyllotoxin derivatives, a process for their preparation and their use as medicaments | |
| US3338888A (en) | Rifamycin type antibiotic compounds | |
| JPS6345282A (ja) | アシル基及び置換アルキル基を有するリフアマイシン誘導体 | |
| JPS5782400A (en) | Erythromycin derivative | |
| Beélik et al. | Some new reactions and derivatives of kojic acid | |
| JP3466527B2 (ja) | 新規なアコニチン系化合物および鎮痛・抗炎症剤 | |
| JPS58189132A (ja) | ブテン誘導体の製造方法 | |
| DE2167181B1 (de) | Methyl-N-acetyl-6,7-aziridino-6-desamino-7-desoxy-2,3,4-tri-0-acetyl-alpha-thiolincosaminid und Verfahren zu dessen Herstellung | |
| JP2000503666A (ja) | Ｍａｐｐｉａ ｆｏｅｔｉｄａから単離したカンプトセシン―骨格化合物および新規な医薬ならびに治療薬のためのシントンとしてのその使用 | |
| Depreux et al. | Synthesis of benzil from benzoin with copper (II) acetate | |
| DE2524394A1 (de) | Alpha-aminomethyl-3-aethyl-4-hydroxybenzylalkoholderivate, verfahren zu ihrer herstellung und arzneimittel | |
| JPS577438A (en) | Production of acid chloride | |
| JPS55144422A (en) | Purification of cis-dichlorodiammineplatinum(2) | |
| JP2770357B2 (ja) | ヌクレオシド誘導体の製造方法 | |
| US4312862A (en) | Therapeutically active derivatives of benzamide | |
| US3759946A (en) | 1-aryloxy-4,5-diphenylimidazoles | |
| JPS5742697A (en) | Mycinamicin derivative | |
| AT300844B (de) | Verfahren zur Herstellung von neuen D-Arabitolverbindungen | |
| CN116804017A (zh) | 汉防己甲素的合成方法 | |
| CA1049035A (en) | Process for the preparation of triesters and products thus obtained | |
| JPS6413047A (en) | Selective hydroformylation | |
| Amstutz et al. | Communications-Synthesis of Ethyl 2-and 4-Pyridylpyruvates | |
| JPS57130996A (en) | Preparation of 5-bromouracil nucleoside | |
| JPS6018678B2 (ja) | ４−０−（２−アミノ−２−デオキシ−α−Ｄ−グルコピラノシル）−２，５−ジデオキシストレプタミンの製造法 | |
| JPS57149244A (en) | Purification of 4,4'-diphenyldicarboxylic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |