JPS57130996A - Preparation of 5-bromouracil nucleoside - Google Patents
Preparation of 5-bromouracil nucleosideInfo
- Publication number
- JPS57130996A JPS57130996A JP1437981A JP1437981A JPS57130996A JP S57130996 A JPS57130996 A JP S57130996A JP 1437981 A JP1437981 A JP 1437981A JP 1437981 A JP1437981 A JP 1437981A JP S57130996 A JPS57130996 A JP S57130996A
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- formula
- acidic solvent
- bromouracil
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE:To prepare the titled compound useful as a radiation sensitizer for the radiotherapy of cancer, etc., with simple operation, without corrosion of the apparatus, suppressing the production of by-products, by reacting a specific uracil nucleoside with bromine in a wealky acidic solvent in the presence of basic ions. CONSTITUTION:5-Bromouracil nucleoside of formula III or formula IV can be prepared by (1) reacting uracil nucleoside of formulaI(R is H or OH) or formula II with bromine in a weakly acidic solvent (e.g. acetic acid) or a mixture of a weakly acidic solvent and other solvents in the presence of basic ions (e.g. sodium acetate) at room temp -60 deg.C, (2) after the completion of the reaction, distilling out the solvent from the reaction mixture under reduced pressure, (3) adding water to the residue, and separating the precipitated crystals, and (4) purifying the product by recrystallization.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1437981A JPS5930720B2 (en) | 1981-02-04 | 1981-02-04 | Method for producing 5-bromouracil nucleoside |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1437981A JPS5930720B2 (en) | 1981-02-04 | 1981-02-04 | Method for producing 5-bromouracil nucleoside |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57130996A true JPS57130996A (en) | 1982-08-13 |
JPS5930720B2 JPS5930720B2 (en) | 1984-07-28 |
Family
ID=11859404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1437981A Expired JPS5930720B2 (en) | 1981-02-04 | 1981-02-04 | Method for producing 5-bromouracil nucleoside |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5930720B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104788389A (en) * | 2015-04-09 | 2015-07-22 | 新乡市创新生物科技有限公司 | Preparation method of 5-bromouracil |
CN108117524A (en) * | 2016-11-29 | 2018-06-05 | 上海医药工业研究院 | The preparation method of 5-bromouracil |
-
1981
- 1981-02-04 JP JP1437981A patent/JPS5930720B2/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104788389A (en) * | 2015-04-09 | 2015-07-22 | 新乡市创新生物科技有限公司 | Preparation method of 5-bromouracil |
CN108117524A (en) * | 2016-11-29 | 2018-06-05 | 上海医药工业研究院 | The preparation method of 5-bromouracil |
CN108117524B (en) * | 2016-11-29 | 2021-06-25 | 上海医药工业研究院 | Preparation method of 5-bromouracil |
Also Published As
Publication number | Publication date |
---|---|
JPS5930720B2 (en) | 1984-07-28 |
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