JPS5753466A - 2-substituted imidazole compound - Google Patents
2-substituted imidazole compoundInfo
- Publication number
- JPS5753466A JPS5753466A JP12874280A JP12874280A JPS5753466A JP S5753466 A JPS5753466 A JP S5753466A JP 12874280 A JP12874280 A JP 12874280A JP 12874280 A JP12874280 A JP 12874280A JP S5753466 A JPS5753466 A JP S5753466A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pyridyl
- reaction mixture
- substituted imidazole
- imidazole compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-substituted imidazole compound of formula I (R is cyclohexyl, phenyl or pyridyl) or an acid addition selt thereof.
EXAMPLE: 2-[2-(2-Pyridyl)-2-phenylethyl] imidazole dihydrochloride.
USE: Useful as an oral drug for diabetes having hypoglycemic action suitably in a dose of usually 100W750mg/kg for a man.
PROCESS: An imino ether of formula II (R' is lower alkyl) is reacted with diethyl aminoacetoacetal at room temperature to under heating at about 120°C, and hydrochloric acid or hydrobromic acid is added to make the reaction mixture strongly acidic. The reaction mixture is then heated at 100°C for 30min to 1hr to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12874280A JPS5753466A (en) | 1980-09-17 | 1980-09-17 | 2-substituted imidazole compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12874280A JPS5753466A (en) | 1980-09-17 | 1980-09-17 | 2-substituted imidazole compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5753466A true JPS5753466A (en) | 1982-03-30 |
JPS649990B2 JPS649990B2 (en) | 1989-02-21 |
Family
ID=14992325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12874280A Granted JPS5753466A (en) | 1980-09-17 | 1980-09-17 | 2-substituted imidazole compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5753466A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996026927A1 (en) * | 1995-03-01 | 1996-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazole derivatives and medicinal composition thereof |
-
1980
- 1980-09-17 JP JP12874280A patent/JPS5753466A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996026927A1 (en) * | 1995-03-01 | 1996-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazole derivatives and medicinal composition thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS649990B2 (en) | 1989-02-21 |
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