JPS5753466A - 2-substituted imidazole compound - Google Patents

2-substituted imidazole compound

Info

Publication number
JPS5753466A
JPS5753466A JP12874280A JP12874280A JPS5753466A JP S5753466 A JPS5753466 A JP S5753466A JP 12874280 A JP12874280 A JP 12874280A JP 12874280 A JP12874280 A JP 12874280A JP S5753466 A JPS5753466 A JP S5753466A
Authority
JP
Japan
Prior art keywords
formula
pyridyl
reaction mixture
substituted imidazole
imidazole compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12874280A
Other languages
Japanese (ja)
Other versions
JPS649990B2 (en
Inventor
Fumiyoshi Ishikawa
Kinya Kameda
Minoru Nakaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP12874280A priority Critical patent/JPS5753466A/en
Publication of JPS5753466A publication Critical patent/JPS5753466A/en
Publication of JPS649990B2 publication Critical patent/JPS649990B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A 2-substituted imidazole compound of formula I (R is cyclohexyl, phenyl or pyridyl) or an acid addition selt thereof.
EXAMPLE: 2-[2-(2-Pyridyl)-2-phenylethyl] imidazole dihydrochloride.
USE: Useful as an oral drug for diabetes having hypoglycemic action suitably in a dose of usually 100W750mg/kg for a man.
PROCESS: An imino ether of formula II (R' is lower alkyl) is reacted with diethyl aminoacetoacetal at room temperature to under heating at about 120°C, and hydrochloric acid or hydrobromic acid is added to make the reaction mixture strongly acidic. The reaction mixture is then heated at 100°C for 30min to 1hr to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP12874280A 1980-09-17 1980-09-17 2-substituted imidazole compound Granted JPS5753466A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12874280A JPS5753466A (en) 1980-09-17 1980-09-17 2-substituted imidazole compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12874280A JPS5753466A (en) 1980-09-17 1980-09-17 2-substituted imidazole compound

Publications (2)

Publication Number Publication Date
JPS5753466A true JPS5753466A (en) 1982-03-30
JPS649990B2 JPS649990B2 (en) 1989-02-21

Family

ID=14992325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12874280A Granted JPS5753466A (en) 1980-09-17 1980-09-17 2-substituted imidazole compound

Country Status (1)

Country Link
JP (1) JPS5753466A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026927A1 (en) * 1995-03-01 1996-09-06 Yamanouchi Pharmaceutical Co., Ltd. Imidazole derivatives and medicinal composition thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026927A1 (en) * 1995-03-01 1996-09-06 Yamanouchi Pharmaceutical Co., Ltd. Imidazole derivatives and medicinal composition thereof

Also Published As

Publication number Publication date
JPS649990B2 (en) 1989-02-21

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