JPS5740438A - Production of chlorophenylacetic derivative - Google Patents
Production of chlorophenylacetic derivativeInfo
- Publication number
- JPS5740438A JPS5740438A JP11550180A JP11550180A JPS5740438A JP S5740438 A JPS5740438 A JP S5740438A JP 11550180 A JP11550180 A JP 11550180A JP 11550180 A JP11550180 A JP 11550180A JP S5740438 A JPS5740438 A JP S5740438A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkylthio
- allyloxy
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The reaction between o-(allyloxy)chlorobenzene and an α-halo-α-(alkylthio) acetic ester in the presence of a Lewis acid is followed by reduction, when necessary, further hydrolysis to produce the titled compound without anxiety of pollution.
CONSTITUTION: o-(Allyloxy)chlorobenzene of formula I reacts with an α-halo-α (alkylthio)acetic ester of formula II (R1 is alkyl; COOR2 is esterified carboxyl) in the presence of a Lewis acid to give 2-alkylthio-(4-allyloxy-3-chlorophenyl)acetic ester of formula III. Then, the product is reduced to remove the alkylthio group to give a compound of formula VI, which is, when necessary, hydrolyzed to produce a compound of formula VI'. The compound of formula I, a starting material, is obtained by reaction between o-chlorophenol and an allyl halide in the presence of an alkali hydroxide and the compound of formula II is obtained by reaction between an α-alkylthioacetic ester and N-chlorosuccinimde as an example.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11550180A JPS5740438A (en) | 1980-08-21 | 1980-08-21 | Production of chlorophenylacetic derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11550180A JPS5740438A (en) | 1980-08-21 | 1980-08-21 | Production of chlorophenylacetic derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5740438A true JPS5740438A (en) | 1982-03-06 |
Family
ID=14664070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11550180A Pending JPS5740438A (en) | 1980-08-21 | 1980-08-21 | Production of chlorophenylacetic derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5740438A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
-
1980
- 1980-08-21 JP JP11550180A patent/JPS5740438A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002020366A (en) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | Method for producing alkylthiophenylacetic acid |
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