JPS5728091A - 1-carbapenam-3-carboxylic acid derivative and its preparation - Google Patents
1-carbapenam-3-carboxylic acid derivative and its preparationInfo
- Publication number
- JPS5728091A JPS5728091A JP10333080A JP10333080A JPS5728091A JP S5728091 A JPS5728091 A JP S5728091A JP 10333080 A JP10333080 A JP 10333080A JP 10333080 A JP10333080 A JP 10333080A JP S5728091 A JPS5728091 A JP S5728091A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- give
- carbapenam
- carboxylic acid
- compound shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by the formula I (R1 and R2 are lower alkyl, etc.; R3 is H, lower alkyl, etc.; R4 is H or trimethylsilyl; R5 is H, alkali metal, etc.).
EXAMPLE: 1,1-Dimethyl-2-hydroxy-1-carbapenam-3-carboxylic acid benzyl ester.
USE: An intermediate for synthesizing a thienamycin type antibiotic. Also having antibacterial activiey by itself.
PROCESS: 4-(1,1-Substituted-2-propenyl) azetidine-2-one is reacted with an acetic ester, and oxidized to give an aldehyde derivative shown by the formula II. This compound is reacted with a Grignard reagent, to give a compound shown by the formula III, which is subjected to intramolecular aldol reaction in the presence of a base, and, if necessary, the ester part is removed or converted, to give a compound shown by the formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10333080A JPS5728091A (en) | 1980-07-28 | 1980-07-28 | 1-carbapenam-3-carboxylic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10333080A JPS5728091A (en) | 1980-07-28 | 1980-07-28 | 1-carbapenam-3-carboxylic acid derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5728091A true JPS5728091A (en) | 1982-02-15 |
JPS6247184B2 JPS6247184B2 (en) | 1987-10-06 |
Family
ID=14351150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10333080A Granted JPS5728091A (en) | 1980-07-28 | 1980-07-28 | 1-carbapenam-3-carboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5728091A (en) |
-
1980
- 1980-07-28 JP JP10333080A patent/JPS5728091A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6247184B2 (en) | 1987-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE178058T1 (en) | METHOD FOR PRODUCING CERTAIN BIPHENYLTETRAZOLE DERIVATIVES | |
JPS5728091A (en) | 1-carbapenam-3-carboxylic acid derivative and its preparation | |
JPS557251A (en) | Preparation 2-azetidinone derivative | |
FR2359813A1 (en) | NEW ESTERS OF CYCLOBUTANE CARBOXYLIC ACID USEFUL FOR THE CONTROL OF PARASITES | |
JPS5227791A (en) | Synthesis of cephalosporins | |
JPS57134428A (en) | Production of alpha or beta-irone or its intermediate | |
EP0206765A3 (en) | Process for preparation of rooperol, hypoxoside and derivatives thereof | |
JPS56108743A (en) | 3-nitro-2-hydroxy-4-phenylbutyric acid derivative, its ester and preparation thereof | |
SE8503811D0 (en) | NOVEL PROCESS FOR THE PREPARATION OF AN AMINOLACTONE | |
ATE104959T1 (en) | PROCESS FOR PRODUCTION OF VITAMIN A ALDEHYDE. | |
JPS5573656A (en) | 4-substituted azetidine-2-one compound and its preparation | |
JPS5645465A (en) | Novel prostaglandin derivative | |
JPS5718683A (en) | 3,8-epoxy-7-keto-6-oxabicyclo 3,2,1 octane derivative and its preparation | |
JPS565457A (en) | Thienamycin intermediate | |
WO1998008800A3 (en) | Method of producing compounds containing acyloxyalkoxy groups from alcohols | |
JPS55160740A (en) | Preparation of cyclopentenolone | |
JPS57131779A (en) | Preparation of alpha-acetyllactone | |
JPS5592363A (en) | New 2-azetidinone derivative | |
JPS57192380A (en) | Preparation of 4-alkoxy-1,3-dioxane-5-carbonitriles | |
JPS53112868A (en) | Production of thienylacetic acid derivative | |
JPS5679668A (en) | 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation | |
JPS57130945A (en) | Preparation of tertiary alcoholic derivative | |
JPS55129234A (en) | Propargyl-type alcohol and preparation thereof | |
JPS56125325A (en) | Preparation of omega-hydroxy coenzyme q1 derivative | |
GB2009747A (en) | Tetrahydropyran Compounds |