SE8503811D0 - NOVEL PROCESS FOR THE PREPARATION OF AN AMINOLACTONE - Google Patents

NOVEL PROCESS FOR THE PREPARATION OF AN AMINOLACTONE

Info

Publication number
SE8503811D0
SE8503811D0 SE8503811A SE8503811A SE8503811D0 SE 8503811 D0 SE8503811 D0 SE 8503811D0 SE 8503811 A SE8503811 A SE 8503811A SE 8503811 A SE8503811 A SE 8503811A SE 8503811 D0 SE8503811 D0 SE 8503811D0
Authority
SE
Sweden
Prior art keywords
compound
formula
yield
image
aminolactone
Prior art date
Application number
SE8503811A
Other languages
Swedish (sv)
Other versions
SE453193B (en
SE8503811L (en
Inventor
K Lempert
G Doleschall
J Fetter
G Hornyak
J Nyitrai
G Simig
K Zauer
Original Assignee
Richter Gedeon Vegyeszet
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet, Biogal Gyogyszergyar filed Critical Richter Gedeon Vegyeszet
Publication of SE8503811D0 publication Critical patent/SE8503811D0/en
Publication of SE8503811L publication Critical patent/SE8503811L/en
Publication of SE453193B publication Critical patent/SE453193B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

An aminolactone of the formula (I), <IMAGE> is produced by a process, in which a) a compound of the general formula (III), wherein R represents a C1-6 alkyl group, <IMAGE> is subjected to reduction to yield a compound of the general formula (II> <IMAGE> wherein R has the same meaning as defined above, and the compound so obtained, in the presence of an alkanecarboxylic acid having a lower alkyl chain in the alkane moiety, is treated with a complex hydride and then with concentrated aqueous hydrochloric acid to yield the compound of the formula (I), or a2) a compound of the general formula (II), wherein R has the same meaning as defined above, in the presence of an alkanecarboxylic acid having a lower alkyl chain in the alkane moiety, is treated with a complex hydride and then with concentrated aqueous hydrochloric acid to yield the compound of the formula (I). The compound (I) is an intermediate for the known biotic thienamycin and related compounds.
SE8503811A 1984-08-15 1985-08-14 PROCEDURE FOR PREPARING (2RS, 3RS, 4SR) -4-AMINO-2-METHYL-6-OXO-TETRAHYDROPYRANE-3-CARBOXYLIC ACID HYDROCHLORIDE SE453193B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU309084A HU194203B (en) 1984-08-15 1984-08-15 Process for producing amino-lactone

Publications (3)

Publication Number Publication Date
SE8503811D0 true SE8503811D0 (en) 1985-08-14
SE8503811L SE8503811L (en) 1986-02-16
SE453193B SE453193B (en) 1988-01-18

Family

ID=10962501

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8503811A SE453193B (en) 1984-08-15 1985-08-14 PROCEDURE FOR PREPARING (2RS, 3RS, 4SR) -4-AMINO-2-METHYL-6-OXO-TETRAHYDROPYRANE-3-CARBOXYLIC ACID HYDROCHLORIDE

Country Status (10)

Country Link
JP (1) JPS61246176A (en)
BE (1) BE903069A (en)
CH (1) CH666686A5 (en)
DE (1) DE3529159A1 (en)
ES (1) ES8609297A1 (en)
FR (1) FR2569194B3 (en)
GB (1) GB2163160A (en)
HU (1) HU194203B (en)
PT (1) PT80959B (en)
SE (1) SE453193B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531638D0 (en) * 1985-12-23 1986-02-05 Ici Plc Chemical compounds
DE60318663T2 (en) 2002-10-18 2008-06-05 Yokozawa, Tohru, Fujisawa Process for the preparation of optically active amino alcohols
WO2007086076A2 (en) * 2006-01-24 2007-08-02 Unichem Laboratories Limited An improved process for preparation of leflunomide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4360684A (en) * 1981-04-08 1982-11-23 Merck & Co., Inc. Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid

Also Published As

Publication number Publication date
JPS61246176A (en) 1986-11-01
BE903069A (en) 1986-02-14
GB8520403D0 (en) 1985-09-18
CH666686A5 (en) 1988-08-15
HUT37777A (en) 1986-02-28
GB2163160A (en) 1986-02-19
FR2569194A1 (en) 1986-02-21
ES8609297A1 (en) 1986-09-01
DE3529159A1 (en) 1986-02-27
FR2569194B3 (en) 1987-06-26
SE453193B (en) 1988-01-18
PT80959B (en) 1987-02-06
HU194203B (en) 1988-01-28
PT80959A (en) 1985-09-01
SE8503811L (en) 1986-02-16
ES546140A0 (en) 1986-09-01

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