JPS5645465A - Novel prostaglandin derivative - Google Patents

Novel prostaglandin derivative

Info

Publication number
JPS5645465A
JPS5645465A JP12071479A JP12071479A JPS5645465A JP S5645465 A JPS5645465 A JP S5645465A JP 12071479 A JP12071479 A JP 12071479A JP 12071479 A JP12071479 A JP 12071479A JP S5645465 A JPS5645465 A JP S5645465A
Authority
JP
Japan
Prior art keywords
formula
compound
valence bond
prostaglandin derivative
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12071479A
Other languages
Japanese (ja)
Other versions
JPS5931504B2 (en
Inventor
Kiyotaka Ono
Hisao Nishiyama
Hisashi Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP12071479A priority Critical patent/JPS5931504B2/en
Publication of JPS5645465A publication Critical patent/JPS5645465A/en
Publication of JPS5931504B2 publication Critical patent/JPS5931504B2/en
Expired legal-status Critical Current

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  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A prostaglandin derivative expressed by formula I [R1 is H, alkyl, cycloalkyl, cation, etc.; W is -CH2CH2- or -CH=CH-; A and B are H or OH; A+B is OXO; X is O, NH or valence bond; R2 is -C(=0) NHR3 (R3 is alkyl, phenyl, etc.) when X is O or NH, or -R3 when X is valence bond]. EXAMPLEMethyl (Z)-7-[(1'S, 4'R, 5'S, 6'R)-5'-(S)-(α-hydroxybenzyl)-2'-oxabicyclo[2.2.1] heptan-6'-yl]-5-heptenoate.
USE: A compound having an anticoagulation action on platelets, and effective for preventing and treating cerebral thrombosis and myocardial infarction.
PROCESS: For example, the compound of formula I (X is valence bond) is obtained as follows: The compound of formula II is reacted with a Grignard reagent of the formula R2MgX (X is Cl, Br or I) to give compounds of formulas III and IV, which are converted into compounds of formulas VI and VII. Alternatively, the compound of formula III or IV is oxidized to give a compound of formula V, which is then hydrolyzed to afford a compound of formula VIII.
COPYRIGHT: (C)1981,JPO&Japio
JP12071479A 1979-09-21 1979-09-21 Novel prostaglandin derivative Expired JPS5931504B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12071479A JPS5931504B2 (en) 1979-09-21 1979-09-21 Novel prostaglandin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12071479A JPS5931504B2 (en) 1979-09-21 1979-09-21 Novel prostaglandin derivative

Publications (2)

Publication Number Publication Date
JPS5645465A true JPS5645465A (en) 1981-04-25
JPS5931504B2 JPS5931504B2 (en) 1984-08-02

Family

ID=14793175

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12071479A Expired JPS5931504B2 (en) 1979-09-21 1979-09-21 Novel prostaglandin derivative

Country Status (1)

Country Link
JP (1) JPS5931504B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551065A1 (en) * 1983-08-29 1985-03-01 Squibb & Sons Inc PROSTAGLANDIN-ANALOGING COMPOUNDS OF THE 7-OXABICYCLOHEPTANE-SUBSTITUTED THIOCARBAMATE TYPE AND THERAPEUTIC APPLICATIONS THEREOF, IN PARTICULAR THERMOBOLYTIC DISEASE TREATMENT
JPH0218374U (en) * 1988-07-18 1990-02-07
JP4856280B1 (en) * 2011-06-03 2012-01-18 等 川上 scissors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102702852B1 (en) * 2021-09-06 2024-09-03 쉬 쥔민 Adjustable artificial bait for fishing

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551065A1 (en) * 1983-08-29 1985-03-01 Squibb & Sons Inc PROSTAGLANDIN-ANALOGING COMPOUNDS OF THE 7-OXABICYCLOHEPTANE-SUBSTITUTED THIOCARBAMATE TYPE AND THERAPEUTIC APPLICATIONS THEREOF, IN PARTICULAR THERMOBOLYTIC DISEASE TREATMENT
JPH0218374U (en) * 1988-07-18 1990-02-07
JP4856280B1 (en) * 2011-06-03 2012-01-18 等 川上 scissors

Also Published As

Publication number Publication date
JPS5931504B2 (en) 1984-08-02

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