JPS57185295A - Thiazolinoazetidinone derivative and its preparation - Google Patents
Thiazolinoazetidinone derivative and its preparationInfo
- Publication number
- JPS57185295A JPS57185295A JP56069687A JP6968781A JPS57185295A JP S57185295 A JPS57185295 A JP S57185295A JP 56069687 A JP56069687 A JP 56069687A JP 6968781 A JP6968781 A JP 6968781A JP S57185295 A JPS57185295 A JP S57185295A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- thiazolinoazetidinone
- derivative shown
- give
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:A derivative shown by the formulaI[R1 is aryl(oxy); R2 is a group shown by the formula II, III, or IV; R3 is aryl(oxy) lower alkyl or lower alkyl].
USE: An intermediate for synthesizing antibiotics of the penicillin or cephalosporin type.
PROCESS: For example, a compound shown by the formula V is electrolyzed in a mixed solvent in the presence of hydrochloric acid or chloride (e.g., methylene chloride, etc.) at 20W100°C to give a novel thiazolinoazetidinone chloride derivative shown by the formula VI, which is reacted with chlorine under irradiation of light in a solvent at -20W100°C to give a thiazolinoazetidinone derivative shown by the formula VII. The derivative shown by the formula VII is further reacted with a basic compound (e.g., triethylamine, etc.) with stirring at -20W 80°C, to give a thiazolinoazetidinone derivative shown by the formula VIII, which is reacted with zinc in the presence of acetic acid in a solvent at -50W30°C with stirring.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069687A JPS57185295A (en) | 1981-05-08 | 1981-05-08 | Thiazolinoazetidinone derivative and its preparation |
US06/370,034 US4482491A (en) | 1981-05-01 | 1982-04-20 | Thiazolinoazetidinone derivatives and process for the preparation of the same |
GB08212330A GB2101986B (en) | 1981-05-01 | 1982-04-28 | Thiazolinoazetidinone derivatives |
FR8207398A FR2504927B1 (en) | 1981-05-01 | 1982-04-29 | THIAZOLINOAZETIDINONE DERIVATIVES, METHODS FOR THEIR PREPARATIONS AND THEIR USE IN THE PREPARATION OF CEPHALOSPORINS |
DE3249934A DE3249934C2 (en) | 1981-05-01 | 1982-04-30 | |
DE3216256A DE3216256A1 (en) | 1981-05-01 | 1982-04-30 | THIAZOLINOAZETIDINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
DE3249933A DE3249933C2 (en) | 1981-05-01 | 1982-04-30 | Process for the preparation of 2- [4- (aryl or heteroaryldithio) -2-azetidinon-1-yl] -3-halomethyl-3-butenoic acid derivatives |
FR8220933A FR2522662B1 (en) | 1981-05-01 | 1982-12-14 | PROCESS FOR THE PREPARATION OF CEPHALOSPORINS |
US06/625,621 US4603014A (en) | 1981-05-01 | 1984-06-28 | Thiazolinoazetidinone derivatives and process for the preparation of the same |
GB08418485A GB2144418B (en) | 1981-05-01 | 1984-07-19 | Thiazolinoazetidinone derivatives and process for the preparation of the same |
GB08500025A GB2152051B (en) | 1981-05-01 | 1985-01-02 | Process for the preparation of azetidinone derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069687A JPS57185295A (en) | 1981-05-08 | 1981-05-08 | Thiazolinoazetidinone derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57185295A true JPS57185295A (en) | 1982-11-15 |
JPS632435B2 JPS632435B2 (en) | 1988-01-19 |
Family
ID=13410024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56069687A Granted JPS57185295A (en) | 1981-05-01 | 1981-05-08 | Thiazolinoazetidinone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57185295A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55147293A (en) * | 1979-04-30 | 1980-11-17 | Lilly Co Eli | Novel thiazolinoazetidinone compound |
JPS57183793A (en) * | 1981-05-01 | 1982-11-12 | Otsuka Chem Co Ltd | Chlorinated thiazolinoazetidinone derivative and its preparation |
JPS57183794A (en) * | 1981-05-01 | 1982-11-12 | Otsuka Chem Co Ltd | Thiazolinoazetidinone derivative and its preparation |
-
1981
- 1981-05-08 JP JP56069687A patent/JPS57185295A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55147293A (en) * | 1979-04-30 | 1980-11-17 | Lilly Co Eli | Novel thiazolinoazetidinone compound |
JPS57183793A (en) * | 1981-05-01 | 1982-11-12 | Otsuka Chem Co Ltd | Chlorinated thiazolinoazetidinone derivative and its preparation |
JPS57183794A (en) * | 1981-05-01 | 1982-11-12 | Otsuka Chem Co Ltd | Thiazolinoazetidinone derivative and its preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS632435B2 (en) | 1988-01-19 |
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