JPS57185285A - Novel camptothecin derivative - Google Patents

Novel camptothecin derivative

Info

Publication number
JPS57185285A
JPS57185285A JP6759481A JP6759481A JPS57185285A JP S57185285 A JPS57185285 A JP S57185285A JP 6759481 A JP6759481 A JP 6759481A JP 6759481 A JP6759481 A JP 6759481A JP S57185285 A JPS57185285 A JP S57185285A
Authority
JP
Japan
Prior art keywords
camptothecin
formula
lower alkyl
camptothecin derivative
novel camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6759481A
Other languages
Japanese (ja)
Other versions
JPS6247189B2 (en
Inventor
Sada Miyasaka
Masahiko Mutai
Seigo Sawada
Kenichiro Nogata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP6759481A priority Critical patent/JPS57185285A/en
Priority to US06/336,494 priority patent/US4399276A/en
Priority to CA000393558A priority patent/CA1177487A/en
Priority to DE8282300104T priority patent/DE3265308D1/en
Priority to EP82300104A priority patent/EP0056692B1/en
Publication of JPS57185285A publication Critical patent/JPS57185285A/en
Publication of JPS6247189B2 publication Critical patent/JPS6247189B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formula[X is OH or group shown by the formula -NR1R2 (R1 is H and R2 is H, lower alkyl, aryl, etc., or R1 is lower alkyl and R2 is lower alkyl or aminoalkyl, or R1 and R2 together with N linked to them form cyclic group)], its quaternary salt or quaternary compound at N atom.
EXAMPLE: Camptothecin-7-aldehydoxime.
USE: A carcinostatic agent. Characteristically having lower toxocity than that of camptothecin, an alkaloid having an antitumor action.
PROCESS: Camptothecin-7-aldehyde is reacted with a carbonyl reagent such as hydroxylamine, hydrazine, etc., to give a compound shown by the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP6759481A 1981-01-09 1981-05-07 Novel camptothecin derivative Granted JPS57185285A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP6759481A JPS57185285A (en) 1981-05-07 1981-05-07 Novel camptothecin derivative
US06/336,494 US4399276A (en) 1981-01-09 1981-12-31 7-Substituted camptothecin derivatives
CA000393558A CA1177487A (en) 1981-01-09 1982-01-04 7-substituted camptothecin derivatives and process for preparing same
DE8282300104T DE3265308D1 (en) 1981-01-09 1982-01-08 7-substituted camptothecin derivatives and process for their preparation
EP82300104A EP0056692B1 (en) 1981-01-09 1982-01-08 7-substituted camptothecin derivatives and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6759481A JPS57185285A (en) 1981-05-07 1981-05-07 Novel camptothecin derivative

Publications (2)

Publication Number Publication Date
JPS57185285A true JPS57185285A (en) 1982-11-15
JPS6247189B2 JPS6247189B2 (en) 1987-10-06

Family

ID=13349385

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6759481A Granted JPS57185285A (en) 1981-01-09 1981-05-07 Novel camptothecin derivative

Country Status (1)

Country Link
JP (1) JPS57185285A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007518688A (en) * 2003-07-14 2007-07-12 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 7-polyaminoalkyl (oxy) iminomethylcamptothecin having a protecting group

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0310590U (en) * 1989-06-16 1991-01-31
JPH0573991U (en) * 1992-03-12 1993-10-08 富士通株式会社 Module card mounting structure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007518688A (en) * 2003-07-14 2007-07-12 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 7-polyaminoalkyl (oxy) iminomethylcamptothecin having a protecting group

Also Published As

Publication number Publication date
JPS6247189B2 (en) 1987-10-06

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