JPS57185285A - Novel camptothecin derivative - Google Patents
Novel camptothecin derivativeInfo
- Publication number
- JPS57185285A JPS57185285A JP6759481A JP6759481A JPS57185285A JP S57185285 A JPS57185285 A JP S57185285A JP 6759481 A JP6759481 A JP 6759481A JP 6759481 A JP6759481 A JP 6759481A JP S57185285 A JPS57185285 A JP S57185285A
- Authority
- JP
- Japan
- Prior art keywords
- camptothecin
- formula
- lower alkyl
- camptothecin derivative
- novel camptothecin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by the formula[X is OH or group shown by the formula -NR1R2 (R1 is H and R2 is H, lower alkyl, aryl, etc., or R1 is lower alkyl and R2 is lower alkyl or aminoalkyl, or R1 and R2 together with N linked to them form cyclic group)], its quaternary salt or quaternary compound at N atom.
EXAMPLE: Camptothecin-7-aldehydoxime.
USE: A carcinostatic agent. Characteristically having lower toxocity than that of camptothecin, an alkaloid having an antitumor action.
PROCESS: Camptothecin-7-aldehyde is reacted with a carbonyl reagent such as hydroxylamine, hydrazine, etc., to give a compound shown by the formula.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6759481A JPS57185285A (en) | 1981-05-07 | 1981-05-07 | Novel camptothecin derivative |
US06/336,494 US4399276A (en) | 1981-01-09 | 1981-12-31 | 7-Substituted camptothecin derivatives |
CA000393558A CA1177487A (en) | 1981-01-09 | 1982-01-04 | 7-substituted camptothecin derivatives and process for preparing same |
DE8282300104T DE3265308D1 (en) | 1981-01-09 | 1982-01-08 | 7-substituted camptothecin derivatives and process for their preparation |
EP82300104A EP0056692B1 (en) | 1981-01-09 | 1982-01-08 | 7-substituted camptothecin derivatives and process for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6759481A JPS57185285A (en) | 1981-05-07 | 1981-05-07 | Novel camptothecin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57185285A true JPS57185285A (en) | 1982-11-15 |
JPS6247189B2 JPS6247189B2 (en) | 1987-10-06 |
Family
ID=13349385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6759481A Granted JPS57185285A (en) | 1981-01-09 | 1981-05-07 | Novel camptothecin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57185285A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007518688A (en) * | 2003-07-14 | 2007-07-12 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 7-polyaminoalkyl (oxy) iminomethylcamptothecin having a protecting group |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0310590U (en) * | 1989-06-16 | 1991-01-31 | ||
JPH0573991U (en) * | 1992-03-12 | 1993-10-08 | 富士通株式会社 | Module card mounting structure |
-
1981
- 1981-05-07 JP JP6759481A patent/JPS57185285A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007518688A (en) * | 2003-07-14 | 2007-07-12 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 7-polyaminoalkyl (oxy) iminomethylcamptothecin having a protecting group |
Also Published As
Publication number | Publication date |
---|---|
JPS6247189B2 (en) | 1987-10-06 |
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