JPS5547696A - Platinum-prednin complex and its preparation - Google Patents
Platinum-prednin complex and its preparationInfo
- Publication number
- JPS5547696A JPS5547696A JP12067378A JP12067378A JPS5547696A JP S5547696 A JPS5547696 A JP S5547696A JP 12067378 A JP12067378 A JP 12067378A JP 12067378 A JP12067378 A JP 12067378A JP S5547696 A JPS5547696 A JP S5547696A
- Authority
- JP
- Japan
- Prior art keywords
- prednin
- formula
- complex
- diaquoplatinum
- platinum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:A complex of diaquoplatinum (II) of the formula I [R1 and R2 are H, lower alkyl, or they form a group of formula II (R3 and R4 are H or lower alkyl groups)] with prednin of formula III.
EXAMPLE: Pt(prednin)4.(NO3)2(H2O)6.
USE: Antitumor agents, having a higher water-solubility and a lower toxicity than the diaquoplatinum (II) of formula I.
PROCESS: Prednin (P) of formula III having an antibacterial and an immunosuppresive actions is reacted with a diaquoplatinum (II) salt (S) of formula IV (X is anion having a smaller complexing ability than water and P; n is O or 1) of in an aqueous medium at a molar ratio of P to S preferably 1W4:1. X is preferably nitrate ion.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12067378A JPS5547696A (en) | 1978-09-29 | 1978-09-29 | Platinum-prednin complex and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12067378A JPS5547696A (en) | 1978-09-29 | 1978-09-29 | Platinum-prednin complex and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5547696A true JPS5547696A (en) | 1980-04-04 |
Family
ID=14792092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12067378A Pending JPS5547696A (en) | 1978-09-29 | 1978-09-29 | Platinum-prednin complex and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5547696A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS573051A (en) * | 1980-06-09 | 1982-01-08 | Matsushita Electric Ind Co Ltd | Potential measurement device of electronic copying machine |
EP0059911A1 (en) * | 1981-03-09 | 1982-09-15 | BASF Aktiengesellschaft | Cis-platinous(II) complexes with saccharide derivatives as ligands |
-
1978
- 1978-09-29 JP JP12067378A patent/JPS5547696A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS573051A (en) * | 1980-06-09 | 1982-01-08 | Matsushita Electric Ind Co Ltd | Potential measurement device of electronic copying machine |
EP0059911A1 (en) * | 1981-03-09 | 1982-09-15 | BASF Aktiengesellschaft | Cis-platinous(II) complexes with saccharide derivatives as ligands |
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