JPS57120578A - Separation of 1-carbamoyl-5-fluorouracils - Google Patents
Separation of 1-carbamoyl-5-fluorouracilsInfo
- Publication number
- JPS57120578A JPS57120578A JP56006479A JP647981A JPS57120578A JP S57120578 A JPS57120578 A JP S57120578A JP 56006479 A JP56006479 A JP 56006479A JP 647981 A JP647981 A JP 647981A JP S57120578 A JPS57120578 A JP S57120578A
- Authority
- JP
- Japan
- Prior art keywords
- hydrocarbon
- separation
- fluorouracil
- isocyanate
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A reaction mixture between 5-fluorouracil and an isocyanate is concentrated and diluted with an aliphatic or alicyclic hydrocarbon which keeps itself liquid at room temperature to precipitate the high-purity titled compound used as a carcinostatic agent in high yield.
CONSTITUTION: 5-Fluorouracyl is carbamoylized with an isocyanate of formulaI (R is 3W8C alkyl) or a carbamoyl halide of formula II (X is halogen) to give a compound of formula III, e.g., 1-n-hexylcarbamoyl-5-fluorouracil wherein, after being separated, the reaction mixture is diluted with a hydrocarbon which keeps itself liquid at room temperature to precipitate the objective compound for separation. The above hydrocarbon is preferably of 5W8 carbon atoms, such as n-hexane or ligroin.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56006479A JPS57120578A (en) | 1981-01-21 | 1981-01-21 | Separation of 1-carbamoyl-5-fluorouracils |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56006479A JPS57120578A (en) | 1981-01-21 | 1981-01-21 | Separation of 1-carbamoyl-5-fluorouracils |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57120578A true JPS57120578A (en) | 1982-07-27 |
JPS6221348B2 JPS6221348B2 (en) | 1987-05-12 |
Family
ID=11639604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56006479A Granted JPS57120578A (en) | 1981-01-21 | 1981-01-21 | Separation of 1-carbamoyl-5-fluorouracils |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57120578A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63200765A (en) * | 1987-02-16 | 1988-08-19 | カネキ燃料有限会社 | Treatment of wood using natural plant essential oil |
-
1981
- 1981-01-21 JP JP56006479A patent/JPS57120578A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6221348B2 (en) | 1987-05-12 |
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